sulfasalazine and Sterility, Male studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Research Excerpts

Excerpt	Relevance	Reference
"Use of sulphasalazine in ulcerative colitis patients is hampered by a variety of side-effects, including male infertility."	1.31	Sulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerance and side-effects. ( Crispino, P; Di Paolo, MC; Iacopini, F; Paoluzi, OA; Paoluzi, P; Pica, R; Rivera, M; Spera, G, 2001)
"A male patient suffering from ulcerative colitis, presented with primary infertility due to sulphasalazine therapy."	1.28	Sulphasalazine-induced reversible male infertility. ( Delaere, KP; Meuleman, EJ; Strijbos, WE, 1989)
"The fertility of 70 men with Crohn's disease and a group of age matched controls were compared."	1.27	Male fertility in Crohn's disease. ( Burnell, D; Calcraft, BJ; Mayberry, J; Morris, JS; Rhodes, J, 1986)
"Sixteen patients with quiescent ulcerative colitis were studied."	1.27	Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution. ( Goodman, MJ; Lecarpentier, J; Mandal, BK; Mani, V; Riley, SA; Turnberg, LA, 1987)
"We report the case of a man with ulcerative colitis in whom infertility and a markedly abnormal SPA were demonstrated while he was taking sulfasalazine."	1.27	Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas. ( Batzer, FR; Chatzinoff, M; Corson, SL; Friedman, LS; Guarino, JM, 1988)
" A possible reversible toxic effect of salicylazosulfapyridine on semen quality is discussed."	1.26	Reversible toxic effect of salicylazosulfapyridine on semen quality. ( Toth, A, 1979)
"Four young immigrants whose ulcerative colitis was controlled by sulphasalazine had oligospermia and infertility."	1.26	Male infertility due to sulphasalazine. ( Fisher, AM; Hendry, WF; Hughes, L; Levi, AJ, 1979)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (83.33)	18.7374
1990's	1 (2.08)	18.2507
2000's	5 (10.42)	29.6817
2010's	1 (2.08)	24.3611
2020's	1 (2.08)	2.80

Authors	Studies
Hammami, MB	1
Mahadevan, U	1
Sharma, M	1
Arya, D	1
Bhagour, K	1
Gupta, RS	1
Marteau, P	1
Alonso, V	1
Linares, V	1
Bellés, M	1
Albina, ML	1
Sirvent, JJ	1
Domingo, JL	1
Sánchez, DJ	1
Saha, S	1
Esposti, SD	1
Alstead, EM	1
Nelson-Piercy, C	1
Boëtius, G	1
Stuurman, A	1
Bol, J	1
Soule, JC	1
Genot, JY	1
Toovey, S	2
Hudson, E	2
Hendry, WF	2
Levi, AJ	4
Birnie, GG	1
McLeod, TI	1
Watkinson, G	1
Fettes, PW	1
Heineman, MJ	2
Dony, JM	2
Rolland, R	2
Baeyertz, JD	1
Doré, C	1
Sowter, C	1
Tobias, R	1
Sapire, KE	1
Coetzee, T	1
Marks, IN	1
Lange, OJ	1
Taffet, SL	1
Das, KM	1
Mudge, TJ	1
Pullar, T	1
Capell, HA	1
McIntyre, PB	1
Lennard-Jones, JE	1
Cann, PA	1
Holdsworth, CD	1
Shaffer, JL	1
Kershaw, A	1
Berrisford, MH	1
O'Moráin, C	1
Smethurst, P	1
Doré, CJ	1
Beeley, L	1
Steeno, OP	1
Malchow, H	1
Moody, GA	1
Probert, C	1
Jayanthi, V	1
Mayberry, JF	1
Di Paolo, MC	1
Paoluzi, OA	1
Pica, R	1
Iacopini, F	1
Crispino, P	1
Rivera, M	1
Spera, G	1
Paoluzi, P	1
Toth, A	2
Fisher, AM	1
Hughes, L	1
Grieve, J	1
Friedman, LS	2
Delaere, KP	1
Strijbos, WE	1
Meuleman, EJ	1
Chiba, M	1
Igarashi, K	1
Masamune, O	1
Ito, Y	1
Wu, FC	1
Aitken, RJ	1
Ferguson, A	1
Korelitz, BI	1
Margalioth, EJ	1
Navot, D	1
Beyth, Y	1
Eliasson, R	1
Virji, N	1
Burnell, D	1
Mayberry, J	1
Calcraft, BJ	1
Morris, JS	1
Rhodes, J	1
Riley, SA	2
Lecarpentier, J	1
Mani, V	1
Goodman, MJ	1
Mandal, BK	1
Turnberg, LA	1
Claman, P	1
Chatzinoff, M	1
Guarino, JM	1
Corson, SL	1
Batzer, FR	1
Lam, HG	1
Dekker, W	1
de Nooijer, CC	1
Nurmi, H	1
Suominen, J	1
Leino, R	1
Pinals, RS	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Investigation of Sexual Function in Crohn's Disease Patients With Perianal Fistulas[NCT01635543]				0 participants (Actual)	Observational	2011-10-31	Withdrawn (stopped due to This study was terminated due to some challenges in recruitment process)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Men With Inflammatory Bowel Disease: Sexual Function, Fertility, Medication Safety, and Prostate Cancer. The American journal of gastroenterology, 2020, Volume: 115, Issue:4 Topics: Depression; Gastrointestinal Agents; Humans; Infertility, Male; Inflammatory Bowel Diseases; Male; M	2020
Reproductive issues in inflammatory bowel disease. Medicine and health, Rhode Island, 2009, Volume: 92, Issue:4 Topics: Adaptation, Psychological; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Azathio	2009
Sulfasalazine. Adverse effects and desensitization. Digestive diseases and sciences, 1983, Volume: 28, Issue:9 Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Gastrointestinal D	1983
Sulphasalazine: a 'new' antirheumatic drug. British journal of rheumatology, 1984, Volume: 23, Issue:1 Topics: Agranulocytosis; Anemia; Antibody Formation; Arthritis, Rheumatoid; Bile; Chemical and Drug Induced	1984
Drug-induced sexual dysfunction and infertility. Adverse drug reactions and acute poisoning reviews, 1984,Spring, Volume: 3, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzothiadiazines; Child; Cimetidine;	1984
Sulfasalazine in the rheumatic disease. Seminars in arthritis and rheumatism, 1988, Volume: 17, Issue:4 Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Central Nervous System; Chemical and Drug Induced Liver	1988

Article	Year
Modulatory effects of methanolic fruit fraction of Pedalium murex on sulphasalazine-induced male reproductive disruption. Andrologia, 2019, Volume: 51, Issue:2 Topics: Animals; Disease Models, Animal; Female; Fertility; Follicle Stimulating Hormone; Infertility, Male;	2019
IBD and pregnancy. Inflammatory bowel diseases, 2008, Volume: 14 Suppl 2 Topics: Adult; Fecal Incontinence; Female; Gastrointestinal Agents; Humans; Infertility, Male; Inflammatory	2008
Sulfasalazine induced oxidative stress: a possible mechanism of male infertility. Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 27, Issue:1 Topics: Administration, Oral; Animals; Catalase; Epididymis; Gastrointestinal Agents; Glutathione Reductase;	2009
Inflammatory bowel disease in pregnancy. Gut, 2003, Volume: 52, Issue:2 Topics: Aminosalicylic Acids; Azathioprine; Colitis, Ulcerative; Crohn Disease; Female; Humans; Infertility,	2003
[Male infertility during treatment with salazosulfapyridine]. Nederlands tijdschrift voor geneeskunde, 1980, Oct-25, Volume: 124, Issue:43 Topics: Adult; Crohn Disease; Humans; Infertility, Male; Male; Proctitis; Sulfasalazine	1980
[Anomalies of the spermogram and sterility caused by salazopyrine]. La Nouvelle presse medicale, 1981, May-02, Volume: 10, Issue:20 Topics: Adult; Humans; Infertility, Male; Male; Spermatozoa; Sulfasalazine	1981
Sulphasalazine and male infertility: reversibility and possible mechanism. Gut, 1981, Volume: 22, Issue:6 Topics: Adult; Colitis, Ulcerative; Crohn Disease; Female; Humans; Infertility, Male; Male; Middle Aged; Pre	1981
Incidence of sulphasalazine-induced male infertility. Gut, 1981, Volume: 22, Issue:6 Topics: Adolescent; Adult; Colitis, Ulcerative; Crohn Disease; Humans; Infertility, Male; Male; Middle Aged;	1981
Reversible male infertility. The New Zealand medical journal, 1981, Nov-25, Volume: 94, Issue:696 Topics: Colitis, Ulcerative; Humans; Infertility, Male; Male; Sulfasalazine	1981
Salicylazosulfapyridine and male infertility. European journal of obstetrics, gynecology, and reproductive biology, 1981, Volume: 12, Issue:5 Topics: Adult; Colitis, Ulcerative; Crohn Disease; Humans; Infertility, Male; Male; Semen; Sulfasalazine	1981
Reversible male infertility. The New Zealand medical journal, 1982, Jan-13, Volume: 95, Issue:699 Topics: Female; Humans; Infertility, Male; Male; Pregnancy; Sperm Motility; Sulfasalazine	1982
Sperm size in patients with inflammatory bowel disease on sulfasalazine therapy. Fertility and sterility, 1982, Volume: 38, Issue:1 Topics: Adult; Analysis of Variance; Colitis; Computers; Fertility; Humans; Infertility, Male; Male; Semen;	1982
Male infertility due to sulphasalazine. Postgraduate medical journal, 1982, Volume: 58, Issue:676 Topics: Adult; Humans; Infertility, Male; Male; Oligospermia; Sulfasalazine	1982
[Sulfasalazine-induced male infertility]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1982, Feb-20, Volume: 102, Issue:5 Topics: Adult; Humans; Infertility, Male; Male; Spermatogenesis; Sulfasalazine	1982
Semen and sulphasalazine. Clinical reproduction and fertility, 1982, Volume: 1, Issue:2 Topics: Colitis, Ulcerative; Crohn Disease; Humans; Infertility, Male; Male; Semen; Sulfasalazine	1982
Reversal with balsalazide of infertility caused by sulphsalazine. British medical journal (Clinical research ed.), 1984, Jun-02, Volume: 288, Issue:6431 Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Humans; Infertility, Male; Male; Mesalamine; Pheny	1984
Reversal of male infertility on changing treatment from sulphasalazine to 5-aminosalicylic acid. Lancet (London, England), 1984, May-19, Volume: 1, Issue:8386 Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Humans; Infertility, Male; Male; Mesalamine; Sulfa	1984
Sulphasalazine-induced infertility reversed on transfer to 5-aminosalicylic acid. Lancet (London, England), 1984, Jun-02, Volume: 1, Issue:8388 Topics: Adult; Aminosalicylic Acids; Delayed-Action Preparations; Humans; Infertility, Male; Male; Mesalamin	1984
Reversible male infertility due to sulphasalazine: studies in man and rat. Gut, 1984, Volume: 25, Issue:10 Topics: Adult; Aminosalicylic Acids; Animals; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship	1984
Side-effects of salazopyrin on male fertility. European journal of obstetrics, gynecology, and reproductive biology, 1984, Volume: 18, Issue:5-6 Topics: Adult; Colitis, Ulcerative; Drug Combinations; Glucosamine; Humans; Infertility, Male; Male; Oligosp	1984
[The effect of salazosulfapyridine on fertility]. Zeitschrift fur Gastroenterologie. Verhandlungsband, 1981, Volume: 19 Topics: Adult; Colitis, Ulcerative; Female; Humans; Infertility, Male; Male; Pregnancy; Sperm Count; Sperm M	1981
The effects of chronic ill health and treatment with sulphasalazine on fertility amongst men and women with inflammatory bowel disease in Leicestershire. International journal of colorectal disease, 1997, Volume: 12, Issue:4 Topics: Abnormalities, Drug-Induced; Adult; Chronic Disease; Female; Fertility; Humans; Infant, Newborn; Inf	1997
Sulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerance and side-effects. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2001, Volume: 33, Issue:7 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Desensitization, Im	2001
Reversible toxic effect of salicylazosulfapyridine on semen quality. Fertility and sterility, 1979, Volume: 31, Issue:5 Topics: Colitis, Ulcerative; Humans; Infertility, Male; Male; Semen; Sperm Motility; Spermatozoa; Sulfasalaz	1979
Male infertility due to sulphasalazine. Lancet (London, England), 1979, Aug-11, Volume: 2, Issue:8137 Topics: Adult; Colitis, Ulcerative; Emigration and Immigration; Humans; India; Infertility, Male; Iran; Male	1979
Male infertility due to sulphasalazine. Lancet (London, England), 1979, Sep-01, Volume: 2, Issue:8140 Topics: Adult; Humans; Infertility, Male; Male; Sperm Immobilizing Agents; Spermatozoa; Sulfasalazine	1979
Male infertility due to sulphasalazine. Lancet (London, England), 1979, Oct-27, Volume: 2, Issue:8148 Topics: Humans; Infertility, Male; Male; Sulfasalazine	1979
[Disorders in male fertility during treatment with sulfasalazine]. Nederlands tijdschrift voor geneeskunde, 1989, Mar-04, Volume: 133, Issue:9 Topics: Colitis, Ulcerative; Humans; Infertility, Male; Male; Sperm Capacitation; Sulfasalazine	1989
Male infertility related to 5-ASA enemas. Digestive diseases and sciences, 1989, Volume: 34, Issue:5 Topics: Aminosalicylic Acids; Colitis, Ulcerative; Enema; Humans; Infertility, Male; Male; Mesalamine; Sulfa	1989
Sulphasalazine-induced reversible male infertility. Acta urologica Belgica, 1989, Volume: 57, Issue:1 Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Follicle Stimulating Hormone; Humans; Infertility,	1989
[Salicylazosulfapyridine-induced male infertility in a patient with ulcerative colitis]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1989, Volume: 86, Issue:1 Topics: Adult; Colitis, Ulcerative; Humans; Infertility, Male; Male; Sulfasalazine	1989
Inflammatory bowel disease and male infertility: effects of sulfasalazine and 5-aminosalicylic acid on sperm-fertilizing capacity and reactive oxygen species generation. Fertility and sterility, 1989, Volume: 52, Issue:5 Topics: Adult; Aminosalicylic Acids; Animals; Cricetinae; Female; Free Radicals; Humans; Infertility, Male;	1989
Pregnancy, fertility, and inflammatory bowel disease. The American journal of gastroenterology, 1985, Volume: 80, Issue:5 Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Fe	1985
Diagnosis of drug-related male infertility by zona-free hamster egg sperm penetration assay. Lancet (London, England), 1985, Aug-03, Volume: 2, Issue:8449 Topics: Adult; Allopurinol; Colchicine; Female; Humans; Infertility, Male; Male; Middle Aged; Sperm-Ovum Int	1985
LDH-C4 in human seminal plasma and its relationship to testicular function. II. Clinical aspects. International journal of andrology, 1985, Volume: 8, Issue:3 Topics: Adult; Hot Temperature; Humans; Infertility, Male; Isoenzymes; L-Lactate Dehydrogenase; Male; Semen;	1985
Male fertility in Crohn's disease. Postgraduate medical journal, 1986, Volume: 62, Issue:726 Topics: Adrenal Cortex Hormones; Adult; Aged; Crohn Disease; Family Characteristics; Humans; Infertility, Ma	1986
Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution. Gut, 1987, Volume: 28, Issue:8 Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Humans; Infertility, Male; Male; Mesalamine; Oligo	1987
Sulfasalazine and male infertility. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1988, Jan-15, Volume: 138, Issue:2 Topics: Humans; Infertility, Male; Male; Sulfasalazine	1988
Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas. Digestive diseases and sciences, 1988, Volume: 33, Issue:1 Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Enema; Female; Humans; Infant, Newborn; Infertilit	1988
Sulfasalazine-induced abnormal sperm penetration. Digestive diseases and sciences, 1988, Volume: 33, Issue:11 Topics: Aminosalicylic Acids; Female; Humans; Infertility, Male; Male; Mesalamine; Sperm-Ovum Interactions;	1988
[Fertility disorders in man during treatment with sufasalazine]. Nederlands tijdschrift voor geneeskunde, 1988, Dec-31, Volume: 132, Issue:53 Topics: Adult; Colitis, Ulcerative; Humans; Infertility, Male; Male; Sperm Motility; Spermatozoa; Sulfasalaz	1988
[Male infertility caused by sulfasalazine]. Duodecim; laaketieteellinen aikakauskirja, 1988, Volume: 104, Issue:23-24 Topics: Adult; Humans; Infertility, Male; Male; Sulfasalazine	1988

sulfasalazine and Sterility, Male

Research Excerpts

Research

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Clinical Trials (1)

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