sulfasalazine has been researched along with Sensitivity and Specificity in 16 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "New treatment options for patients with methotrexate (MTX)-naive rheumatoid arthritis (RA) have become available." | 7.71 | A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis. ( Choi, HK; Kuntz, KM; Seeger, JD, 2002) |
| "The Combinatietherapie Bij Reumatoide Artritis (COBRA) trial demonstrated that step-down combination therapy with prednisolone, methotrexate, and sulfasalazine (SSZ) was superior to SSZ monotherapy for suppressing disease activity and radiologic progression of rheumatoid arthritis (RA)." | 5.10 | COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. ( Boers, M; Boonen, A; Dijkmans, BA; Jacobs, P; Landewé, RB; Markusse, HM; Peeters, AJ; van de Laar, MA; van Denderen, JC; van der Heijde, DM; van der Linden, S; Verhoeven, AC; Westedt, ML; Westhovens, R, 2002) |
| "This is a case of a 65-year-old man with seropositive erosive rheumatoid arthritis (RA), well controlled on methotrexate, sulfasalazine, low-dose prednisolone and monthly infusions of tocilizumab." | 4.89 | C reactive protein may not be reliable as a marker of severe bacterial infection in patients receiving tocilizumab. ( Bari, SF; Khan, A; Lawson, T, 2013) |
| "Sulfasalazine is a safe and effective drug in the short term treatment of AS." | 3.76 | Meta-analysis of sulfasalazine in ankylosing spondylitis. ( Atra, E; Ferraz, MB; Goldsmith, CH; Tugwell, P, 1990) |
| "New treatment options for patients with methotrexate (MTX)-naive rheumatoid arthritis (RA) have become available." | 3.71 | A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis. ( Choi, HK; Kuntz, KM; Seeger, JD, 2002) |
| " Using data from the randomized double-blind Ankylosing Spondylitis Study Comparing Enbrel with Sulfasalazine Dosed Weekly (ASCEND) trial, we tested ASDAS validity and assessed its capacity to discriminate between treatment effects and change-from-baseline improvements." | 2.77 | Sensitivity and discriminatory ability of the Ankylosing Spondylitis Disease Activity Score in patients treated with etanercept or sulphasalazine in the ASCEND trial. ( Braun, J; Dougados, M; Koenig, AS; Pedersen, R; Sieper, J; Szumski, A; van der Heijde, D, 2012) |
| " Adverse events requiring the withdrawal of therapy seem to occur less frequently with balsalazide, mesalamine, and olsalazine compared with sulfasalazine." | 2.42 | The short- and long-term safety of 5-aminosalicylate products in the treatment of ulcerative colitis. ( Baker, DE; Kane, S, 2004) |
| " Four chemicals, using three different routes of exposure (in utero [accomplished by feeding the dam dosed feed], dosed feed, and gavage) were used to 1) evaluate the effect of diet restriction on the sensitivity of the bioassay toward chemically-induced chronic toxicity and carcinogenicity; and 2) evaluate the effect of weight-matched control groups on the sensitivity of the bioassays." | 1.29 | The sensitivity of the NTP bioassay for carcinogen hazard evaluation can be modulated by dietary restriction. ( Abdo, KM; Kari, FW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelrahman, MM | 1 |
| Habib, NM | 1 |
| Emam, AA | 1 |
| Mahmoud, HM | 1 |
| Abdelwhab, NS | 1 |
| Bari, SF | 1 |
| Khan, A | 1 |
| Lawson, T | 1 |
| Güler-Yüksel, M | 1 |
| Klarenbeek, NB | 1 |
| Goekoop-Ruiterman, YP | 1 |
| de Vries-Bouwstra, JK | 1 |
| van der Kooij, SM | 1 |
| Gerards, AH | 1 |
| Ronday, HK | 1 |
| Huizinga, TW | 1 |
| Dijkmans, BA | 2 |
| Allaart, CF | 1 |
| Lems, WF | 1 |
| Gu, GZ | 1 |
| Xia, HM | 1 |
| Pang, ZQ | 1 |
| Liu, ZY | 1 |
| Jiang, XG | 1 |
| Chen, J | 1 |
| van der Heijde, D | 3 |
| Braun, J | 1 |
| Dougados, M | 1 |
| Sieper, J | 1 |
| Pedersen, R | 1 |
| Szumski, A | 1 |
| Koenig, AS | 1 |
| Garnero, P | 1 |
| Landewé, R | 1 |
| Boers, M | 4 |
| Verhoeven, A | 1 |
| Van Der Linden, S | 3 |
| Christgau, S | 1 |
| Boonen, A | 4 |
| Geusens, P | 1 |
| Baker, DE | 1 |
| Kane, S | 1 |
| Korthals-de Bos, I | 1 |
| Van Tulder, M | 1 |
| Verhoeven, AC | 3 |
| Adèr, HJ | 1 |
| Bibo, J | 1 |
| Wick, MC | 1 |
| Lindblad, S | 1 |
| Weiss, RJ | 1 |
| Klareskog, L | 1 |
| van Vollenhoven, RF | 1 |
| Tweats, DJ | 1 |
| Blakey, D | 1 |
| Heflich, RH | 1 |
| Jacobs, A | 1 |
| Jacobsen, SD | 1 |
| Morita, T | 1 |
| Nohmi, T | 1 |
| O'Donovan, MR | 1 |
| Sasaki, YF | 1 |
| Sofuni, T | 1 |
| Tice, R | 1 |
| Abdo, KM | 1 |
| Kari, FW | 1 |
| Lassere, M | 1 |
| Edmonds, J | 1 |
| Saudan, A | 1 |
| Landewé, RB | 1 |
| Westhovens, R | 1 |
| van de Laar, MA | 1 |
| Markusse, HM | 1 |
| van Denderen, JC | 1 |
| Westedt, ML | 1 |
| Peeters, AJ | 1 |
| Jacobs, P | 1 |
| van der Heijde, DM | 2 |
| Choi, HK | 1 |
| Seeger, JD | 1 |
| Kuntz, KM | 1 |
| van Riel, PL | 1 |
| van de Putte, LB | 1 |
| Ferraz, MB | 1 |
| Tugwell, P | 1 |
| Goldsmith, CH | 1 |
| Atra, E | 1 |
4 reviews available for sulfasalazine and Sensitivity and Specificity
| Article | Year |
|---|---|
C reactive protein may not be reliable as a marker of severe bacterial infection in patients receiving tocilizumab.
Topics: Aged; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Inf | 2013 |
The short- and long-term safety of 5-aminosalicylate products in the treatment of ulcerative colitis.
Topics: Adolescent; Adult; Aminosalicylic Acids; Child; Clinical Trials as Topic; Colitis, Ulcerative; Dose- | 2004 |
Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test.
Topics: Animals; Benzene; Bone Marrow; Enzyme Inhibitors; Glutamates; Guanine; MAP Kinase Kinase Kinases; Mi | 2007 |
Meta-analysis of sulfasalazine in ankylosing spondylitis.
Topics: Double-Blind Method; Humans; Meta-Analysis as Topic; Outcome and Process Assessment, Health Care; Pa | 1990 |
8 trials available for sulfasalazine and Sensitivity and Specificity
| Article | Year |
|---|---|
Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis.
Topics: Absorptiometry, Photon; Adult; Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Bone Density; Di | 2010 |
Sensitivity and discriminatory ability of the Ankylosing Spondylitis Disease Activity Score in patients treated with etanercept or sulphasalazine in the ASCEND trial.
Topics: Adult; Antirheumatic Agents; Double-Blind Method; Etanercept; Female; Humans; Immunoglobulin G; Male | 2012 |
Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study.
Topics: Arthritis, Rheumatoid; Biomarkers; Blood Sedimentation; Collagen Type I; Collagen Type II; Disease P | 2002 |
Indirect and total costs of early rheumatoid arthritis: a randomized comparison of combined step-down prednisolone, methotrexate, and sulfasalazine with sulfasalazine alone.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cost-Benefit Ana | 2004 |
Smallest detectable difference in radiological progression.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Progression; Double-Bl | 1999 |
COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; D | 2002 |
Sensitivity of a Dutch Health Assessment Questionnaire in a trial comparing hydroxychloroquine vs. sulphasalazine.
Topics: Adult; Aged; Arthritis, Rheumatoid; Double-Blind Method; Female; Health Surveys; Humans; Hydroxychlo | 1990 |
Meta-analysis of sulfasalazine in ankylosing spondylitis.
Topics: Double-Blind Method; Humans; Meta-Analysis as Topic; Outcome and Process Assessment, Health Care; Pa | 1990 |
5 other studies available for sulfasalazine and Sensitivity and Specificity
| Article | Year |
|---|---|
Chromatographic determination of sulfasalazine and its active metabolites: greenness assessment and application to spiked human plasma.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Densitometry; Drug Stability; Gree | 2020 |
Determination of sulphasalazine and its main metabolite sulphapyridine and 5-aminosalicylic acid in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
Topics: Chromatography, Liquid; Dimenhydrinate; Drug Stability; Humans; Linear Models; Mesalamine; Reproduci | 2011 |
Clinical and radiological disease-course in a Swedish DMARD-treated early RA-inception cohort: an observational study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Dose- | 2004 |
The sensitivity of the NTP bioassay for carcinogen hazard evaluation can be modulated by dietary restriction.
Topics: Animals; Body Weight; Carcinogenicity Tests; Dose-Response Relationship, Drug; Eating; Female; Food | 1996 |
A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis.
Topics: Analysis of Variance; Arthritis, Rheumatoid; Cohort Studies; Cost-Benefit Analysis; Decision Making; | 2002 |