sulfasalazine has been researched along with Pulmonary Fibrosis in 28 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The case history is described of an elderly man with rheumatoid arthritis receiving treatment with sulfasalazine and the cyclooxygenase-2 inhibitor celecoxib who presented with severe shortness of breath, cough, and decreased exercise tolerance." | 3.71 | Migratory pulmonary infiltrates in a patient with rheumatoid arthritis. ( Aranda, CP; Cassai, N; Mehandru, S; Sidhu, GS; Smith, RL, 2002) |
| "A patient with ulcerative colitis developed skin allergy to sulfasalazine, manifested by rash urticaria and generalized angioedema." | 3.67 | Sulfasalazine pneumonitis. ( Averbuch, M; Hallak, A; Halpern, Z; Levo, Y; Topilsky, M, 1985) |
| "Ulcerative colitis was diagnosed by colonoscopic and radiological examinations." | 1.32 | [A case of ulcerative colitis complicated with pulmonary involvement and successfully treated with salazosulfapyridine]. ( Chida, K; Hashimoto, D; Imokawa, S; Matsui, T; Nakamura, H; Shirai, T; Suzuki, K, 2003) |
| "A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine." | 1.28 | Pulmonary infiltrates and skin pigmentation associated with sulfasalazine. ( Gabazza, EC; Ibata, H; Kitagawa, T; Machishi, M; Matsumoto, K; Suzuki, S; Taguchi, O; Yamakami, T; Yamamoto, J, 1992) |
| "The first patient had a hypersensitivity pneumonitis, which was confirmed by challenge." | 1.28 | Sulphasalazine-induced reversible hypersensitivity pneumonitis and fatal fibrosing alveolitis: report of two cases. ( Ekfors, T; Leino, R; Liippo, K, 1991) |
| "Rheumatoid arthritis is being increasingly treated with sulphasalazine." | 1.28 | Fibrosing alveolitis due to sulphasalazine in a patient with rheumatoid arthritis. ( Boyd, O; Gibbs, AR; Smith, AP, 1990) |
| "A 50-yr-old woman with chronic ulcerative colitis developed severe restrictive lung disease, which progressed after total colectomy and cessation of sulfasalazine therapy." | 1.27 | Severe interstitial pulmonary fibrosis in a patient with chronic ulcerative colitis. ( Kalish, PE; McKee, AL; Pitchumoni, CS; Rajapaksa, A, 1983) |
| "Sulfasalazine has been widely used in the treatment of inflammatory bowel disease." | 1.27 | Sulfasalazine-induced pulmonary disease. ( Barwick, KW; DeLuca, VA; Dobuler, K; Moseley, RH, 1985) |
| "Sulfasalazine has been associated with bronchopulmonary complications of inflammatory bowel disease (IBD) in adults." | 1.27 | Desquamative interstitial pneumonitis complicating inflammatory bowel disease of childhood. ( Fechner, RE; Sutphen, JL; Teague, WG, 1985) |
| "A woman with ulcerative colitis was treated with sulphasalazine and prednisolone." | 1.25 | Fibrosing alveolitis and treatment with sulphasalazine. ( Davies, D; MacFarlane, A, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (50.00) | 18.7374 |
| 1990's | 9 (32.14) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Simões, RG | 1 |
| Maia, H | 1 |
| Hashimoto, D | 1 |
| Shirai, T | 1 |
| Matsui, T | 1 |
| Imokawa, S | 1 |
| Suzuki, K | 1 |
| Chida, K | 1 |
| Nakamura, H | 1 |
| Ayhan-Ardic, FF | 1 |
| Oken, O | 1 |
| Yorgancioglu, ZR | 1 |
| Ustun, N | 1 |
| Gokharman, FD | 1 |
| Avdeev, VG | 1 |
| Fomin, VV | 1 |
| Popova, EN | 1 |
| Iurkevich, LIu | 1 |
| Osipenko, VI | 1 |
| Sokolina, IA | 1 |
| Popova, IA | 1 |
| Matek, W | 1 |
| Rösch, W | 1 |
| Becker, V | 1 |
| Williams, T | 1 |
| Eidus, L | 1 |
| Thomas, P | 1 |
| McKee, AL | 1 |
| Rajapaksa, A | 1 |
| Kalish, PE | 1 |
| Pitchumoni, CS | 1 |
| Sigvaldason, A | 1 |
| Sörenson, S | 1 |
| Pannier, R | 1 |
| Büntzel, J | 1 |
| Liebetrau, G | 1 |
| Mazer, BD | 1 |
| Eigen, H | 1 |
| Gelfand, EW | 1 |
| Brugman, SM | 1 |
| Mehandru, S | 1 |
| Smith, RL | 1 |
| Sidhu, GS | 1 |
| Cassai, N | 1 |
| Aranda, CP | 1 |
| Hamadeh, MA | 1 |
| Atkinson, J | 1 |
| Smith, LJ | 1 |
| Gabazza, EC | 1 |
| Taguchi, O | 1 |
| Yamakami, T | 1 |
| Machishi, M | 1 |
| Ibata, H | 1 |
| Suzuki, S | 1 |
| Matsumoto, K | 1 |
| Kitagawa, T | 1 |
| Yamamoto, J | 1 |
| Moss, SF | 1 |
| Ind, PW | 1 |
| Leino, R | 1 |
| Liippo, K | 1 |
| Ekfors, T | 1 |
| Assouline, PS | 1 |
| Diot, P | 1 |
| Janvoie, B | 1 |
| Lemarié, E | 1 |
| Hamon, B | 1 |
| Asquier, E | 1 |
| Lavandier, M | 1 |
| Boyd, O | 1 |
| Gibbs, AR | 1 |
| Smith, AP | 1 |
| Lorente, JA | 1 |
| Pérez-Rodríguez, E | 1 |
| Badalá, G | 1 |
| Fogué, L | 1 |
| Averbuch, M | 1 |
| Halpern, Z | 1 |
| Hallak, A | 1 |
| Topilsky, M | 1 |
| Levo, Y | 1 |
| Moseley, RH | 1 |
| Barwick, KW | 1 |
| Dobuler, K | 1 |
| DeLuca, VA | 1 |
| Teague, WG | 1 |
| Sutphen, JL | 1 |
| Fechner, RE | 1 |
| Wiener, MD | 1 |
| Cooper, JA | 1 |
| Matthay, RA | 1 |
| Sullivan, SN | 1 |
| Davies, D | 1 |
| MacFarlane, A | 1 |
2 reviews available for sulfasalazine and Pulmonary Fibrosis
| Article | Year |
|---|---|
[Tubular-interstitial nephritis and fibrosing alveolitis induced by sulfasalazine in ulcerative colitis].
Topics: Colitis, Ulcerative; Gastrointestinal Agents; Humans; Nephritis, Interstitial; Pulmonary Fibrosis; S | 2006 |
Drug-induced pulmonary disease.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Antineoplastic Agents; Aspirin; Gold; Humans; Hydrochloroth | 1987 |
26 other studies available for sulfasalazine and Pulmonary Fibrosis
| Article | Year |
|---|---|
Rheumatoid lung.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Male; Methotrexate; M | 2015 |
[A case of ulcerative colitis complicated with pulmonary involvement and successfully treated with salazosulfapyridine].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Cryptogenic Organizing Pneumonia; Fema | 2003 |
Pulmonary involvement in lifelong non-smoking patients with rheumatoid arthritis and ankylosing spondylitis without respiratory symptoms.
Topics: Adult; Aged; Arthritis, Rheumatoid; C-Reactive Protein; Female; Humans; Lung; Male; Methotrexate; Mi | 2006 |
[Pathological changes in lungs and liver after therapy of ulcerative colitis].
Topics: Amitriptyline; Chlordiazepoxide; Colitis, Ulcerative; Humans; Jaundice; Male; Middle Aged; Penicilla | 1980 |
Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy.
Topics: Aged; Bronchitis; Humans; Male; Pulmonary Eosinophilia; Pulmonary Fibrosis; Sulfasalazine | 1982 |
Severe interstitial pulmonary fibrosis in a patient with chronic ulcerative colitis.
Topics: Bronchiectasis; Colectomy; Colitis, Ulcerative; Female; Humans; Middle Aged; Prednisone; Pulmonary F | 1983 |
Interstitial pneumonia due to sulfasalazine.
Topics: Humans; Lung; Male; Middle Aged; Pulmonary Fibrosis; Radiography; Sulfasalazine | 1983 |
Drug induced lung disease.
Topics: Alveolitis, Extrinsic Allergic; Amiodarone; Antineoplastic Agents; Asthma; Drug Hypersensitivity; Hu | 1983 |
[Alveolitis and pulmonary fibrosis in chronic diverticulitis and ulcerative colitis].
Topics: Adult; Biopsy; Colitis, Ulcerative; Diverticulitis, Colonic; Dose-Response Relationship, Drug; Drug | 1994 |
Remission of interstitial lung disease following therapy of associated ulcerative colitis.
Topics: Adolescent; Biopsy; Colitis, Ulcerative; Drug Therapy, Combination; Female; Humans; Lung; Prednisone | 1993 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1993. A 44-year-old man with pulmonary disease and proctitis.
Topics: Adult; Bronchi; Diagnosis, Differential; Eosinophils; Humans; Inflammatory Bowel Diseases; Lung; Mal | 1993 |
Migratory pulmonary infiltrates in a patient with rheumatoid arthritis.
Topics: Aged; Airway Obstruction; Antirheumatic Agents; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inh | 2002 |
Sulfasalazine-induced pulmonary disease.
Topics: Acute Disease; Aged; Arthritis, Rheumatoid; Crohn Disease; Female; Humans; Male; Pulmonary Fibrosis; | 1992 |
Pulmonary infiltrates and skin pigmentation associated with sulfasalazine.
Topics: Aged; Bronchiolitis Obliterans; Colitis, Ulcerative; Drug Eruptions; Humans; Male; Pigmentation Diso | 1992 |
Time course of recovery of lung function in sulphasalazine-induced alveolitis.
Topics: Aged; Colitis, Ulcerative; Humans; Male; Prognosis; Pulmonary Fibrosis; Pulmonary Gas Exchange; Resp | 1991 |
Sulphasalazine-induced reversible hypersensitivity pneumonitis and fatal fibrosing alveolitis: report of two cases.
Topics: Adult; Alveolitis, Extrinsic Allergic; Colitis, Ulcerative; Female; Humans; Male; Middle Aged; Progn | 1991 |
[Pneumopathy due to sulfasalazopyrine. A case with a challenge test].
Topics: Aged; Colitis, Ulcerative; Humans; Male; Pulmonary Fibrosis; Sulfasalazine | 1991 |
Fibrosing alveolitis due to sulphasalazine in a patient with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Bronchoalveolar Lavage Fluid; Female; Humans; Middle Aged; Pulmonary Alveoli; | 1990 |
[Pulmonary disease induced by salazopyrine coexisting with pulmonary tuberculosis].
Topics: Adult; Drug Combinations; Glucosamine; Humans; Male; Pulmonary Fibrosis; Sulfasalazine; Tuberculosis | 1989 |
Sulfasalazine pneumonitis.
Topics: Angioedema; Colitis, Ulcerative; Desensitization, Immunologic; Drug Administration Schedule; Follow- | 1985 |
Sulfasalazine-induced pulmonary disease.
Topics: Aged; Colitis, Ulcerative; Humans; Male; Prednisone; Pulmonary Fibrosis; Respiratory Function Tests; | 1985 |
Desquamative interstitial pneumonitis complicating inflammatory bowel disease of childhood.
Topics: Adolescent; Biopsy; Colitis, Ulcerative; Humans; Liver; Liver Cirrhosis; Lung; Male; Pulmonary Fibro | 1985 |
Collagenous colitis and pulmonary fibrosis. Manifestations of a single disease?
Topics: Aged; Colitis; Collagen Diseases; Diarrhea; Dyspnea; Humans; Intestinal Mucosa; Male; Pulmonary Fibr | 1986 |
Sulfasalazine lung. Desensitization to sulfasalazine and treatment with acrylic coated 5-ASA and azodisalicylate.
Topics: Adult; Aminosalicylic Acids; Bronchiolitis Obliterans; Colitis, Ulcerative; Desensitization, Immunol | 1987 |
Editorial: Sulphasalazine-induced lung disease.
Topics: Adult; Body Weight; Colitis, Ulcerative; Cough; Dyspnea; Eosinophilia; Female; Humans; Hypersensitiv | 1974 |
Fibrosing alveolitis and treatment with sulphasalazine.
Topics: Autopsy; Colitis, Ulcerative; Female; Humans; Lung; Middle Aged; Prednisolone; Pulmonary Fibrosis; R | 1974 |