sulfasalazine has been researched along with Peptic Ulcer in 5 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 7.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 3.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "These are all beneficial in treating gastroduodenal ulceration." | 1.27 | The role of arachidonic acid metabolites in gastrointestinal homeostasis. Biochemical, histological and clinical gastrointestinal effects. ( Isselbacher, KJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pirmohamed, M | 1 |
| Coleman, MD | 1 |
| Galvani, D | 1 |
| Bucknall, RC | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Sternon, J | 1 |
| Adler, M | 1 |
| Taha, AS | 1 |
| Capell, HA | 1 |
| Sturrock, RD | 1 |
| Russell, RI | 1 |
| Lewis, JH | 1 |
| Weingold, AB | 1 |
| Isselbacher, KJ | 1 |
2 reviews available for sulfasalazine and Peptic Ulcer
| Article | Year |
|---|---|
[Digestive and extra-digestive complications of nonsteroidal anti-inflammatory drugs. Preventive and curative strategies].
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase | 1997 |
The use of gastrointestinal drugs during pregnancy and lactation.
Topics: Adrenal Cortex Hormones; Animals; Antidiarrheals; Antiemetics; Cathartics; Diuretics; Female; Gastro | 1985 |
3 other studies available for sulfasalazine and Peptic Ulcer
| Article | Year |
|---|---|
Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; | 1993 |
Nonsteroidal peptic damage in rheumatoid patients receiving second-line drugs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Therapy, Combination; Endoscopy | 1991 |
The role of arachidonic acid metabolites in gastrointestinal homeostasis. Biochemical, histological and clinical gastrointestinal effects.
Topics: Animals; Colitis, Ulcerative; Diarrhea; Gastric Mucosa; Gastrointestinal Diseases; Homeostasis; Huma | 1987 |