sulfasalazine has been researched along with Pancreatitis in 27 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In patients with inflammatory bowel diseases, the use of 5-aminosalicylic acid or sulfasalazine was not associated with increased risk of acute pancreatitis." | 7.72 | Inflammatory bowel diseases, 5-aminosalicylic acid and sulfasalazine treatment and risk of acute pancreatitis: a population-based case-control study. ( Floyd, A; Munk, EM; Nørgård, B; Pedersen, L; Rasmussen, HH; Sørensen, HT, 2004) |
| "We report the simultaneous development of fulminant hepatic failure and necrotizing pancreatitis in a patient treated with sulfasalazine." | 7.69 | Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis. ( Rubin, R, 1994) |
| " In patients with inflammatory bowel diseases, the use of 5-aminosalicylic acid or sulfasalazine was not associated with increased risk of acute pancreatitis." | 3.72 | Inflammatory bowel diseases, 5-aminosalicylic acid and sulfasalazine treatment and risk of acute pancreatitis: a population-based case-control study. ( Floyd, A; Munk, EM; Nørgård, B; Pedersen, L; Rasmussen, HH; Sørensen, HT, 2004) |
| "We report the simultaneous development of fulminant hepatic failure and necrotizing pancreatitis in a patient treated with sulfasalazine." | 3.69 | Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis. ( Rubin, R, 1994) |
| "A patient treated with sulfasalazine for new-onset ulcerative colitis developed self-limited pancreatitis." | 3.68 | Pancreatitis after rectal administration of 5-aminosalicylic acid. ( Isaacs, KL; Murphy, D, 1990) |
| "The main aim of this study was to examine the differences between triple therapy (T: SSZ and HCQ added to MTX) and etanercept (E) added to MTX with regard to the infectious and gastrointestinal (GI) adverse events (AEs) reported in The Rheumatoid Arthritis Comparison of Active Therapies Trial." | 2.84 | Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events. ( Brophy, MT; Chang, BH; Hannagan, K; O'Dell, JR; Quach, LT; Soe Thwin, S, 2017) |
| "Crohn's disease and ulcerative colitis, together popularly known as inflammatory bowel disease (IBD), are characterized by a number of extraintestinal manifestations." | 2.46 | Pancreatitis in inflammatory bowel diseases. ( Das, K; Pitchumoni, CS; Rubin, A, 2010) |
| "Acute pancreatitis is a serious disease with fatality rate up to 15%." | 1.35 | [A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis]. ( Choi, HS; Hahm, JS; Han, DS; Joo, YW; Lee, HL; Lee, OY; Son, CN; Yoon, BC, 2008) |
| " Medical treatment, including increased dosage of steroids, failed to control UC and acute thrombocytopenia in this patient." | 1.33 | Acute thrombocytopenia associated with preexisting ulcerative colitis successfully treated with colectomy. ( Hisada, T; Iida, T; Ishizuka, T; Kusano, M; Masuo, T; Miyamae, Y; Mizuide, M; Mori, M; Okada, S; Sagawa, T; Shibusawa, N, 2006) |
| "5-aminosalicylates are extensively prescribed for the treatment of ulcerative colitis but have a wide range of described adverse effects." | 1.31 | Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines. ( Langman, MJ; Ransford, RA, 2002) |
| "Pancreatitis was significantly more frequent in girls as compared to boys (P = 0." | 1.31 | [Pancreatic involvement in inflammatory bowel diseases in children]. ( Cézard, JP; Faure, C; Hugot, JP; Le Large-Guiheneuf, C; Mougenot, JF; Munck, A; Navarro, J, 2002) |
| "Among 1613 patients treated for acute pancreatitis in 1993, drug induced acute pancreatitis was diagnosed in 22 patients (incidence 1." | 1.29 | Drug induced acute pancreatitis: incidence and severity. ( Dröge, M; Gottesleben, F; Lankisch, PG, 1995) |
| "Pancreatitis is generally regarded to be an extra-intestinal complication of Crohn's disease unless the duodenum is directly involved." | 1.29 | Crohn's disease associated with pancreatitis of unknown etiology: a case report. ( Arakawa, S; Omata, F; Takahashi, H; Ueno, F, 1993) |
| " Upon recovery, sulfasalazine was reintroduced at lower dosage (2 Gm/day), and the patient repeated the clinical and biological picture of acute pancreatitis (serum amylase of 710 and lipase 1010 u." | 1.28 | [Acute pancreatitis caused by salazopyrine. An unusual association]. ( Delgado Fontaneda, E; García Campos, F; Ibarra Peña, B; Moretó Canela, M; Ruiz Rebollo, L, 1991) |
| "Pancreatitis was painless (or was associated with moderate and atypical abdominal pain) in four of our six cases; no pancreatic calcification was found in any case; in three patients a total or subtotal exocrine pancreatic insufficiency was evidenced." | 1.27 | Idiopathic pancreatitis associated with inflammatory bowel disease. ( Bitoun, A; Florent, C; Golfain, D; Jian, R; Messing, B; Modigliani, R; Seyrig, JA, 1985) |
| " LST was negative before attempting desensitization and became positive when the dosage of SASP increased to 100 mg daily." | 1.27 | A case of salicylazosulfapyridine (Salazopyrin)-induced acute pancreatitis with positive lymphocyte stimulation test (LST). ( Arakawa, H; Chiba, M; Horie, Y; Ishida, H; Masamune, O, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (33.33) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Shelat, VG | 1 |
| Quach, LT | 1 |
| Chang, BH | 1 |
| Brophy, MT | 1 |
| Soe Thwin, S | 1 |
| Hannagan, K | 1 |
| O'Dell, JR | 1 |
| Son, CN | 1 |
| Lee, HL | 1 |
| Joo, YW | 1 |
| Lee, OY | 1 |
| Han, DS | 1 |
| Yoon, BC | 1 |
| Choi, HS | 1 |
| Hahm, JS | 1 |
| Pitchumoni, CS | 1 |
| Rubin, A | 1 |
| Das, K | 1 |
| Uittenbogaart, SB | 1 |
| Klemt-Kropp, M | 1 |
| Ransford, RA | 1 |
| Langman, MJ | 1 |
| Lewis, JD | 1 |
| Munk, EM | 1 |
| Pedersen, L | 1 |
| Floyd, A | 1 |
| Nørgård, B | 1 |
| Rasmussen, HH | 1 |
| Sørensen, HT | 1 |
| Hisada, T | 1 |
| Miyamae, Y | 1 |
| Mizuide, M | 1 |
| Shibusawa, N | 1 |
| Iida, T | 1 |
| Masuo, T | 1 |
| Okada, S | 1 |
| Sagawa, T | 1 |
| Ishizuka, T | 1 |
| Kusano, M | 1 |
| Mori, M | 1 |
| Sleisenger, MH | 1 |
| Wuchter, J | 1 |
| Lankisch, PG | 1 |
| Dröge, M | 1 |
| Gottesleben, F | 1 |
| Garau, P | 1 |
| Orenstein, SR | 1 |
| Neigut, DA | 1 |
| Kocoshis, SA | 1 |
| Debongnie, JC | 1 |
| Dekoninck, X | 1 |
| Rubin, R | 1 |
| Yamagiwa, I | 1 |
| Obata, K | 1 |
| Hatanaka, Y | 1 |
| Saito, H | 1 |
| Washio, M | 1 |
| Omata, F | 1 |
| Arakawa, S | 1 |
| Takahashi, H | 1 |
| Ueno, F | 1 |
| Le Large-Guiheneuf, C | 1 |
| Hugot, JP | 1 |
| Faure, C | 1 |
| Munck, A | 1 |
| Mougenot, JF | 1 |
| Navarro, J | 1 |
| Cézard, JP | 1 |
| Sturdevant, RA | 1 |
| Singleton, JW | 1 |
| Deren, JL | 1 |
| Law, DH | 1 |
| McCleery, JL | 1 |
| Delgado Fontaneda, E | 1 |
| García Campos, F | 1 |
| Ruiz Rebollo, L | 1 |
| Ibarra Peña, B | 1 |
| Moretó Canela, M | 1 |
| Isaacs, KL | 1 |
| Murphy, D | 1 |
| Aubry, A | 1 |
| Alandry, C | 1 |
| Lemiere, C | 1 |
| Seyrig, JA | 1 |
| Jian, R | 1 |
| Modigliani, R | 1 |
| Golfain, D | 1 |
| Florent, C | 1 |
| Messing, B | 1 |
| Bitoun, A | 1 |
| Woodhouse, KW | 1 |
| Chiba, M | 1 |
| Horie, Y | 1 |
| Ishida, H | 1 |
| Arakawa, H | 1 |
| Masamune, O | 1 |
| Meyers, S | 1 |
| Block, MB | 1 |
| Genant, HK | 1 |
| Kirsner, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CSP #551 - Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy[NCT00405275] | 353 participants (Actual) | Interventional | 2007-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Average difference between 48-week and Baseline DAS28.~The Disease Activity Score for 28 Joints (DAS28) is a well-validated composite outcome measure ranging from 2-10 (higher scores indicating more disease) that incorporates a tender and swollen joint count of 28 joints, a laboratory measure of systemic inflammation (ESR) and a patient-reported general assessment of health on a visual analog scale (ranging from 0-10cm) all into one measure.~Low disease activity is defined as DAS28 ≤ 3.2 units." (NCT00405275)
Timeframe: 48 weeks after baseline assessment
| Intervention | units on a scale (Mean) |
|---|---|
| Triple | -2.12 |
| Etanercept | -2.29 |
2 reviews available for sulfasalazine and Pancreatitis
| Article | Year |
|---|---|
Pancreatitis in inflammatory bowel diseases.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Crohn Dis | 2010 |
Drugs and the ageing gut, liver and pancreas.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Animals; Antacids; Anti-Ulcer Agen | 1985 |
3 trials available for sulfasalazine and Pancreatitis
| Article | Year |
|---|---|
Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events.
Topics: Abscess; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etaner | 2017 |
How should we treat Crohn's disease?
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Clinical Trials as Topic; Crohn Disease; Double-Blind | 1980 |
Azathioprine-related pancreatitis in patients with Crohn's disease.
Topics: Adult; Amylases; Azathioprine; Clinical Trials as Topic; Crohn Disease; Double-Blind Method; Female; | 1979 |
22 other studies available for sulfasalazine and Pancreatitis
| Article | Year |
|---|---|
Sulfasalazine induced acute pancreatitis in a patient with prior cholecystectomy.
Topics: Acute Disease; Cholecystectomy; Humans; Length of Stay; Pancreatitis; Sulfasalazine | 2021 |
[A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis].
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Azathioprine; Colitis, Ulce | 2008 |
[Mesalazine and sulphasalazine for Crohn's disease: few indications, severe adverse reactions].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Female; Humans; Lung Diseases, Inters | 2011 |
Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Inju | 2002 |
How safe are the safest IBD drugs?
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal A | 2003 |
Inflammatory bowel diseases, 5-aminosalicylic acid and sulfasalazine treatment and risk of acute pancreatitis: a population-based case-control study.
Topics: Acute Disease; Adult; Age Distribution; Aged; Aminosalicylic Acids; Case-Control Studies; Confidence | 2004 |
Acute thrombocytopenia associated with preexisting ulcerative colitis successfully treated with colectomy.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Colectomy; Colitis, Ulcerative; Glucocorticoids; Hum | 2006 |
[Conservative therapy of Crohn disease].
Topics: Adrenal Cortex Hormones; Azathioprine; Crohn Disease; Humans; Pancreatitis; Psychotherapy; Pyridazin | 1982 |
Drug induced acute pancreatitis: incidence and severity.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Azathioprine; Didanosine; Estrogens; Female; Furosemi | 1995 |
Pancreatitis associated with olsalazine and sulfasalazine in children with ulcerative colitis.
Topics: Acute Disease; Adolescent; Aminosalicylic Acids; Amylases; Child; Colitis, Ulcerative; Female; Human | 1994 |
Sulfasalazine, 5-ASA and acute pancreatitis in crohn's disease.
Topics: Acute Disease; Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; | 1994 |
Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis.
Topics: Adult; Colitis, Ulcerative; Drug Hypersensitivity; Hepatic Encephalopathy; Humans; Male; Necrosis; P | 1994 |
Ischemic colitis complicating severe acute pancreatitis in a child.
Topics: Acute Disease; Child, Preschool; Colitis, Ischemic; Colon; Colonoscopy; Female; Gabexate; Humans; Pa | 1993 |
Crohn's disease associated with pancreatitis of unknown etiology: a case report.
Topics: Acute Disease; Adult; Crohn Disease; Humans; Male; Metronidazole; Pancreatitis; Parenteral Nutrition | 1993 |
[Pancreatic involvement in inflammatory bowel diseases in children].
Topics: Adolescent; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Child; Colitis, Ulcerat | 2002 |
[Acute pancreatitis caused by salazopyrine. An unusual association].
Topics: Acute Disease; Adult; Drug Combinations; Glucosamine; Humans; Male; Pancreatitis; Sulfasalazine | 1991 |
Pancreatitis after rectal administration of 5-aminosalicylic acid.
Topics: Administration, Rectal; Adult; Aminosalicylic Acids; Colitis, Ulcerative; Female; Humans; Pancreatit | 1990 |
[Acute pancreatitis during treatment with salazosulfapyridine].
Topics: Acute Disease; Adult; Colitis, Ulcerative; Humans; Male; Pancreatitis; Sulfasalazine | 1989 |
Idiopathic pancreatitis associated with inflammatory bowel disease.
Topics: Adolescent; Adult; Colitis, Ulcerative; Crohn Disease; Exocrine Pancreatic Insufficiency; Female; Hu | 1985 |
A case of salicylazosulfapyridine (Salazopyrin)-induced acute pancreatitis with positive lymphocyte stimulation test (LST).
Topics: Acute Disease; Adult; Colitis, Ulcerative; Drug Hypersensitivity; Humans; In Vitro Techniques; Lymph | 1987 |
Disodium azodisalicylate and sulfasalazine.
Topics: Aminosalicylic Acids; Drug Hypersensitivity; Humans; Pancreatitis; Sulfasalazine | 1988 |
Pancreatitis as an adverse reaction to salicylazosulfapyridine.
Topics: Adult; Amylases; Crohn Disease; Female; Humans; Pancreatitis; Sulfasalazine | 1970 |