sulfasalazine has been researched along with Neutropenia in 10 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Events included eight patients with malignancies, two with pancytopenia taking methotrexate, three with septic arthritis, and two with septicaemias." | 3.71 | Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience. ( Bevan, J; Homer, D; Jobanputra, P; Maggs, F, 2002) |
| " Therefore, we decided to decrease the TCZ dosage by 10-20% approximately." | 2.52 | Tocilizumab-induced neutropenia in rheumatoid arthritis patients with previous history of neutropenia: case series and review of literature. ( Langevitz, P; Shoenfeld, Y; Shovman, O, 2015) |
| " In this study we determined the activity and toxicity of melphalan in combination with another GST-activity inhibitor, sulfasalazine, an agent used to treat ulcerative colitis." | 1.29 | Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine. ( Awasthi, S; Awasthi, YC; Fields, L; Gupta, V; Jacobs, S; Jani, JP; Levitt, M; Singh, SV; Sreevardhan, M; Xu, BH, 1995) |
| "Neutropenia is a recognized complication of sulphasalazine therapy in patients with rheumatoid arthritis." | 1.28 | Fatal neutropenic enterocolitis associated with sulphasalazine therapy for rheumatoid arthritis. ( Chakravarty, K; McCann, BG; Scott, DG, 1992) |
| "Four with Felty's syndrome developed a further fall in the total WBC associated with thrombocytopenia in two." | 1.28 | Sulphasalazine in rheumatoid arthritis: haematological problems and changes in haematological indices associated with therapy. ( Bacon, PA; Farr, M; Scott, DG; Symmons, DP; Tunn, EJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shovman, O | 1 |
| Shoenfeld, Y | 1 |
| Langevitz, P | 1 |
| Jobanputra, P | 1 |
| Maggs, F | 1 |
| Homer, D | 1 |
| Bevan, J | 1 |
| Gupta, V | 1 |
| Jani, JP | 1 |
| Jacobs, S | 1 |
| Levitt, M | 1 |
| Fields, L | 1 |
| Awasthi, S | 1 |
| Xu, BH | 1 |
| Sreevardhan, M | 1 |
| Awasthi, YC | 1 |
| Singh, SV | 1 |
| Chakravarty, K | 1 |
| Scott, DG | 2 |
| McCann, BG | 1 |
| Marouf, ES | 1 |
| Morris, IM | 1 |
| Farr, M | 2 |
| Tunn, EJ | 1 |
| Symmons, DP | 2 |
| Bacon, PA | 2 |
| Guillemin, F | 1 |
| Aussedat, R | 1 |
| Guerci, A | 1 |
| Lederlin, P | 1 |
| Trechot, P | 1 |
| Pourel, J | 1 |
| Blake, DR | 1 |
| McConkey, B | 1 |
| Levi, S | 1 |
| Liberman, M | 1 |
| Levi, AJ | 1 |
| Bjarnason, I | 1 |
1 review available for sulfasalazine and Neutropenia
| Article | Year |
|---|---|
Tocilizumab-induced neutropenia in rheumatoid arthritis patients with previous history of neutropenia: case series and review of literature.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Etanercept; Female; | 2015 |
1 trial available for sulfasalazine and Neutropenia
| Article | Year |
|---|---|
Outcome of long-term treatment of rheumatoid arthritis with second-line agents.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Gastrointestinal Diseases | 1987 |
8 other studies available for sulfasalazine and Neutropenia
| Article | Year |
|---|---|
Monitoring and assessing the safety of disease-modifying antirheumatic drugs: a West Midlands experience.
Topics: Antirheumatic Agents; Arthritis, Infectious; Azathioprine; Drug Monitoring; Humans; Hypokalemia; Lun | 2002 |
Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine.
Topics: Drug Administration Schedule; Drug Therapy, Combination; Female; Glutathione Transferase; Humans; Ma | 1995 |
Fatal neutropenic enterocolitis associated with sulphasalazine therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Enterocolitis; Humans; Male; Neutropenia; Sulfasalazine | 1992 |
Neutropenia in patients with rheumatoid arthritis, treated with sulphasalazine.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Neutropenia; Sulfasalazine | 1990 |
Sulphasalazine in rheumatoid arthritis: haematological problems and changes in haematological indices associated with therapy.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Felty Syndrome; Female; Hematologic Diseases; Humans | 1989 |
Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis.
Topics: Agranulocytosis; Arthritis, Rheumatoid; Female; Humans; Middle Aged; Neutropenia; Sulfasalazine | 1989 |
Neutropenia in patients with inflammatory arthritis treated with sulphasalazine.
Topics: Acute Disease; Adult; Agranulocytosis; Arthritis; Humans; Leukopenia; Male; Middle Aged; Neutropenia | 1986 |
Reversible congenital neutropenia associated with maternal sulphasalazine therapy.
Topics: Adult; Agranulocytosis; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Neutropenia; | 1988 |