sulfasalazine has been researched along with Neuroblastoma in 3 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis." | 5.40 | TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI. ( Abramovitch, R; Corchia, N; Dery, E; Fried, I; Gross, E; Komar-Stossel, C; Meir, K, 2014) |
| " TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis." | 1.40 | TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI. ( Abramovitch, R; Corchia, N; Dery, E; Fried, I; Gross, E; Komar-Stossel, C; Meir, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mooney, MR | 1 |
| Geerts, D | 2 |
| Kort, EJ | 1 |
| Bachmann, AS | 2 |
| Komar-Stossel, C | 1 |
| Gross, E | 1 |
| Dery, E | 1 |
| Corchia, N | 1 |
| Meir, K | 1 |
| Fried, I | 1 |
| Abramovitch, R | 1 |
| Yco, LP | 1 |
| Mocz, G | 1 |
| Koster, J | 1 |
3 other studies available for sulfasalazine and Neuroblastoma
| Article | Year |
|---|---|
Anti-tumor effect of sulfasalazine in neuroblastoma.
Topics: Alcohol Oxidoreductases; Animals; Antineoplastic Agents; Cell Line, Tumor; Humans; Male; Mice; Mice, | 2019 |
TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Prolifera | 2014 |
Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target.
Topics: Alcohol Oxidoreductases; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Child; Child, Prescho | 2015 |