sulfasalazine has been researched along with Neuralgia in 3 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although intrathecal injection of SSZ to nerve-injured mice significantly alleviated mechanical pain hypersensitivity, no significant anti- neuropathic pain effects of SSZ were detected after oral administration due to its low bioavailability and limited spinal distribution, which were associated with efflux by the xenobiotic transporter breast cancer resistance protein (BCRP)." | 1.62 | Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord. ( Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Yasukochi, S, 2021) |
| "Neuropathic pain is a severe and chronic neurological disease caused by injury or disease of the somatosensory system." | 1.48 | Sulfasalazine attenuates chronic constriction injury-induced neuroinflammation and mechanical hypersensitivity in rats. ( Chen, G; Chen, M; Liu, D; Liu, H; Ma, L; Meng, C; Wang, L; Zhang, X, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yasukochi, S | 1 |
| Kusunose, N | 1 |
| Matsunaga, N | 1 |
| Koyanagi, S | 1 |
| Ohdo, S | 1 |
| Ma, L | 1 |
| Liu, H | 1 |
| Chen, G | 1 |
| Chen, M | 1 |
| Wang, L | 1 |
| Zhang, X | 1 |
| Liu, D | 1 |
| Meng, C | 1 |
| Latremoliere, A | 1 |
| Latini, A | 1 |
| Andrews, N | 1 |
| Cronin, SJ | 1 |
| Fujita, M | 1 |
| Gorska, K | 1 |
| Hovius, R | 1 |
| Romero, C | 1 |
| Chuaiphichai, S | 1 |
| Painter, M | 1 |
| Miracca, G | 1 |
| Babaniyi, O | 1 |
| Remor, AP | 1 |
| Duong, K | 1 |
| Riva, P | 1 |
| Barrett, LB | 1 |
| Ferreirós, N | 1 |
| Naylor, A | 1 |
| Penninger, JM | 1 |
| Tegeder, I | 1 |
| Zhong, J | 1 |
| Blagg, J | 1 |
| Channon, KM | 1 |
| Johnsson, K | 1 |
| Costigan, M | 1 |
| Woolf, CJ | 1 |
3 other studies available for sulfasalazine and Neuralgia
| Article | Year |
|---|---|
Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged Bicyclo Compounds, Heterocyclic | 2021 |
Sulfasalazine attenuates chronic constriction injury-induced neuroinflammation and mechanical hypersensitivity in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Chronic Disease; Constriction; Hyperal | 2018 |
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Topics: Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopterins; Blood Pressur | 2015 |