sulfasalazine has been researched along with Motor Neuron Disease in 1 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Motor Neuron Disease: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We observed previously established medical associations for MND and an inverse dose-response association between lovastatin and MND, with 28% reduced risk at 40 mg/day." | 1.91 | Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model. ( Kreple, CJ; Miller, TM; Racette, BA; Schoch, KM; Searles Nielsen, S; Shabsovich, M; Shen, T; Song, Y, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kreple, CJ | 1 |
| Searles Nielsen, S | 1 |
| Schoch, KM | 1 |
| Shen, T | 1 |
| Shabsovich, M | 1 |
| Song, Y | 1 |
| Racette, BA | 1 |
| Miller, TM | 1 |
1 other study available for sulfasalazine and Motor Neuron Disease
| Article | Year |
|---|---|
Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Case-Control Studies; Disease Models, Animal; Humans; | 2023 |