sulfasalazine has been researched along with Methemoglobinemia in 6 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (83.33) | 18.7374 |
1990's | 1 (16.67) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Azad Khan, AK | 1 |
Nurazzaman, M | 1 |
Truelove, SC | 1 |
Dunn, RJ | 1 |
Miller, B | 2 |
Pounder, RE | 1 |
Craven, ER | 1 |
Henthorn, JS | 1 |
Bannatyne, JM | 1 |
Kater, F | 1 |
Engelhart, A | 1 |
Goebel, KM | 1 |
Schmidt, J | 1 |
Martini, GA | 1 |
1 trial available for sulfasalazine and Methemoglobinemia
Article | Year |
---|---|
The effect of the acetylator phenotype on the metabolism of sulphasalazine in man.
Topics: Acetylation; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Humans; Mesalamine | 1983 |
5 other studies available for sulfasalazine and Methemoglobinemia
Article | Year |
---|---|
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blo | 1998 |
[Side effects of azulfidine therapy].
Topics: Adult; Colitis, Ulcerative; Female; Humans; Methemoglobinemia; Pregnancy; Sulfasalazine | 1976 |
Red cell abnormalities associated with sulphasalazine maintenance therapy for ulcerative colitis.
Topics: Anemia, Hemolytic; Colitis, Ulcerative; Erythrocyte Count; Erythrocytes, Abnormal; Heinz Bodies; Hem | 1975 |
[Hemolysis, formation of Heinz bodies and of methemoglobin under therapy with Azulfidine (author's transl)].
Topics: Adult; Colitis, Ulcerative; Cyanosis; Diarrhea; Erythrocytes; Female; Headache; Heinz Bodies; Hemato | 1974 |
[Methemoglobin synthesis during azulfidine therapy].
Topics: Adult; Colitis, Ulcerative; Female; Humans; Intestinal Diseases; Male; Methemoglobin; Methemoglobine | 1971 |