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sulfasalazine and Methemoglobinemia

sulfasalazine has been researched along with Methemoglobinemia in 6 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Azad Khan, AK1
Nurazzaman, M1
Truelove, SC1
Dunn, RJ1
Miller, B2
Pounder, RE1
Craven, ER1
Henthorn, JS1
Bannatyne, JM1
Kater, F1
Engelhart, A1
Goebel, KM1
Schmidt, J1
Martini, GA1

Trials

1 trial available for sulfasalazine and Methemoglobinemia

ArticleYear
The effect of the acetylator phenotype on the metabolism of sulphasalazine in man.
    Journal of medical genetics, 1983, Volume: 20, Issue:1

    Topics: Acetylation; Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Humans; Mesalamine

1983

Other Studies

5 other studies available for sulfasalazine and Methemoglobinemia

ArticleYear
Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia.
    Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Acidosis, Lactic; Acute Disease; Adult; Anti-Inflammatory Agents; Blo

1998
[Side effects of azulfidine therapy].
    Die Medizinische Welt, 1976, Jul-02, Volume: 27, Issue:27

    Topics: Adult; Colitis, Ulcerative; Female; Humans; Methemoglobinemia; Pregnancy; Sulfasalazine

1976
Red cell abnormalities associated with sulphasalazine maintenance therapy for ulcerative colitis.
    Gut, 1975, Volume: 16, Issue:3

    Topics: Anemia, Hemolytic; Colitis, Ulcerative; Erythrocyte Count; Erythrocytes, Abnormal; Heinz Bodies; Hem

1975
[Hemolysis, formation of Heinz bodies and of methemoglobin under therapy with Azulfidine (author's transl)].
    Medizinische Klinik, 1974, Mar-15, Volume: 69, Issue:11

    Topics: Adult; Colitis, Ulcerative; Cyanosis; Diarrhea; Erythrocytes; Female; Headache; Heinz Bodies; Hemato

1974
[Methemoglobin synthesis during azulfidine therapy].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1971, Volume: 77

    Topics: Adult; Colitis, Ulcerative; Female; Humans; Intestinal Diseases; Male; Methemoglobin; Methemoglobine

1971