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sulfasalazine and Lupus Erythematosus, Systemic

sulfasalazine has been researched along with Lupus Erythematosus, Systemic in 45 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Research Excerpts

ExcerptRelevanceReference
"We describe the case of a 46-year-old woman with rheumatoid arthritis who developed a severe reaction to sulfasalazine, characterized by dysphasia, seizures, rash and the development of strongly positive pANCA (perinuclear antineutrophil cytoplasmic antibodies)."7.69Sulfasalazine induced seizures and dysphasia. ( Gordon, C; Heath, DA; Hill, ME; Situnayake, RD, 1994)
"We describe 2 cases of a lupus syndrome induced by sulfasalazine in rheumatoid arthritis."7.69Sulfasalazine induced lupus in rheumatoid arthritis. ( Andrieu, V; Caulier, M; Dromer, C; Fournie, B; Le Guennec, P, 1994)
" In this report we present a patient with an erosive seropositive rheumatoid arthritis developing the clinical and serological features of systemic lupus erythematosus including the occurrence of double-stranded DNA antibodies under sulfasalazine treatment."7.68Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment. ( Deicher, H; Hammer, M; Hartung, K; Mau, W; Schmidt, RE; Wildhagen, K; Zeidler, H, 1993)
"A female patient with IgM RF seropositive rheumatoid arthritis according to criteria of the American Rheumatism Association was treated for 133 months with Penicillamine and for 17 months also with Sulfasalazine."7.68[Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatment with penicillamine and sulfasalazine]. ( Hrncír, Z; Pintérová, E; Rejchrt, S, 1991)
" The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease."4.87[Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011)
"We describe the case of a 46-year-old woman with rheumatoid arthritis who developed a severe reaction to sulfasalazine, characterized by dysphasia, seizures, rash and the development of strongly positive pANCA (perinuclear antineutrophil cytoplasmic antibodies)."3.69Sulfasalazine induced seizures and dysphasia. ( Gordon, C; Heath, DA; Hill, ME; Situnayake, RD, 1994)
"We describe 2 cases of a lupus syndrome induced by sulfasalazine in rheumatoid arthritis."3.69Sulfasalazine induced lupus in rheumatoid arthritis. ( Andrieu, V; Caulier, M; Dromer, C; Fournie, B; Le Guennec, P, 1994)
" In this report we present a patient with an erosive seropositive rheumatoid arthritis developing the clinical and serological features of systemic lupus erythematosus including the occurrence of double-stranded DNA antibodies under sulfasalazine treatment."3.68Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment. ( Deicher, H; Hammer, M; Hartung, K; Mau, W; Schmidt, RE; Wildhagen, K; Zeidler, H, 1993)
"A female patient with IgM RF seropositive rheumatoid arthritis according to criteria of the American Rheumatism Association was treated for 133 months with Penicillamine and for 17 months also with Sulfasalazine."3.68[Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatment with penicillamine and sulfasalazine]. ( Hrncír, Z; Pintérová, E; Rejchrt, S, 1991)
"Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis."3.67Sulfasalazine-induced lupus erythematosus. ( Clementz, GL; Dolin, BJ, 1988)
"The development of systemic lupus erythematosus (SLE)-related syndromes during treatment with sulphasalazine has been described and demonstrated to be influenced by genetic factors."1.31Development of lupus-related side-effects in patients with early RA during sulphasalazine treatment-the role of IL-10 and HLA. ( Forslid, J; Gröndal, G; Gunnarsson, I; Hassan Bakri, A; Klareskog, L; Larsson, P; Nordmark, B; Ringertz, B, 2000)
"We described a 37-year-old man with Crohn's disease (CD) resembling systemic lupus erythematosus (SLE) at his disease onset."1.30[Crohn's disease with the onset resembling systemic lupus erythematosus]. ( Baba, M; Hiranuma, M; Horie, T; Kitamura, N; Nishinarita, S; Shimizu, T; Son, K; Tomita, Y, 1999)
"Since the association of idiopathic systemic lupus erythematosus with ulcerative colitis has rarely been reported, the combination of these two diseases may be coincidental."1.29Ulcerative colitis associated with preceding systemic lupus erythematosus. ( Fujita, K; Hirato, J; Ishikawa, O; Miyachi, Y; Nagamachi, Y; Takenoshita, S, 1995)
"Development of drug-induced systemic lupus erythematosus (SLE) is an uncommon complication of the use of D-penicillamine and sulphasalazine."1.29Combination therapy for rheumatoid arthritis and drug-induced systemic lupus erythematosus. ( Borg, AA; Davis, MJ; Dawes, PT; Shadforth, MF, 1994)
"In a 25-year old woman with ulcerative colitis a lupus erythematosus syndrome occurred during treatment with salazosulfapyridine."1.26[Salazosulfapyridine-induced lupus erythematosus syndrome in ulcerative colitis (author's transl)]. ( Jaup, BH, 1978)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199016 (35.56)18.7374
1990's23 (51.11)18.2507
2000's4 (8.89)29.6817
2010's2 (4.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kiss, E1
Kiss, CG1
Poór, G1
Handler, J1
Tsai, WC1
Chen, CJ1
Yen, JH1
Liu, HW1
Haas, RM1
Li, P1
Chu, JW1
Nieradko-Iwanicka, B1
Majdan, M1
Piotrowski, M1
Radwan, P1
Kwiatkowski, P1
Rouleau, L1
Ménard, H1
Beaudry, R1
Myhal, D1
Crisp, AJ2
Hoffbrand, BI1
Rafferty, P1
Young, AC1
Haeney, MR1
Carr-Locke, DL1
Vanheule, BA1
Carswell, F1
Pannier, R1
Ishikawa, O1
Miyachi, Y1
Fujita, K1
Takenoshita, S1
Nagamachi, Y1
Hirato, J1
Fritzler, MJ1
Veale, DJ1
Ho, M1
Morley, KD1
Laversuch, CJ1
Collins, DA1
Charles, PJ1
Bourke, BE1
Borg, AA2
Davis, MJ1
Dawes, PT1
Shadforth, MF1
Bray, VJ1
West, SG1
Schultz, KT1
Boumpas, DT1
Rubin, RL1
Tsai, CY1
Wu, TH1
Huang, SF1
Peng, SJ1
Han, SH1
Yu, CL1
Mielke, H1
Wildhagen, K2
Mau, W2
Zeidler, H2
Walker, EM1
Carty, JE1
Hill, ME1
Gordon, C1
Situnayake, RD1
Heath, DA1
Caulier, M1
Dromer, C2
Andrieu, V1
Le Guennec, P1
Fournie, B2
Mongey, AB1
Hess, EV1
Piette, JC1
Frances, C1
Papo, T1
Godeau, P1
Siam, AR1
Hammoudeh, M1
Hartung, K1
Hammer, M1
Schmidt, RE1
Deicher, H1
Khattak, FH1
Morris, IM1
Mattingly, PC1
Gunnarsson, I2
Kanerud, L1
Pettersson, E1
Lundberg, I1
Lindblad, S1
Ringertz, B2
Gordon, MM1
Porter, DR1
Capell, HA1
Nordmark, B1
Hassan Bakri, A1
Gröndal, G1
Larsson, P1
Forslid, J1
Klareskog, L1
Shimizu, T1
Nishinarita, S1
Son, K1
Tomita, Y1
Kitamura, N1
Horie, T1
Baba, M1
Hiranuma, M1
Drayer, DE1
Reidenberg, MM1
Griffiths, ID1
Kane, SP1
Jaup, BH1
Weiller, PJ1
Lammy, S1
Weiller, M1
Gabriel, B1
Sayag, J1
Mongin, M1
Alarcón-Segovia, D1
Kraus, A1
Lassoued, S1
Ludot, I1
Pages, M1
Jacquemier, JM1
Fournié, A1
Rejchrt, S1
Hrncír, Z1
Pintérová, E1
Sugimoto, M1
Sato, Y1
Kumagai, Y1
Suenaga, M1
Hashimoto, H1
Hirose, S1
Lovisetto, P1
Mairano, D1
Cargnino, M1
Biarese, V1
Marchi, L1
Lerda, R1
Muirden, KD1
Hobbs, RN1
Clayton, AL1
Bernstein, RM1
Clementz, GL1
Dolin, BJ1

Reviews

7 reviews available for sulfasalazine and Lupus Erythematosus, Systemic

ArticleYear
[Systemic autoimmune disorders and pregnancy].
    Orvosi hetilap, 2011, Oct-23, Volume: 152, Issue:43

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit

2011
Drugs recently associated with lupus syndromes.
    Lupus, 1994, Volume: 3, Issue:6

    Topics: Deferiprone; Humans; Interferon-alpha; Interleukin-2; Leuprolide; Lupus Erythematosus, Systemic; Pen

1994
Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease.
    British journal of rheumatology, 1995, Volume: 34, Issue:5

    Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Female; Humans; Lupus Erythematosus

1995
Drug-related lupus syndromes and their relationship to spontaneously occurring systemic lupus erythematosus.
    Bailliere's clinical rheumatology, 1991, Volume: 5, Issue:1

    Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hydralazine; Lupus Erythematosus, Systemic;

1991
[Lupic serology caused by sulfasalazine].
    Revue du rhumatisme et des maladies osteo-articulaires, 1991, Volume: 58, Issue:1

    Topics: Antibodies, Antinuclear; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Prospecti

1991
[Drug-induced lupus].
    Recenti progressi in medicina, 1985, Volume: 76, Issue:2

    Topics: Acetylation; Adrenergic beta-Antagonists; Antibodies, Antinuclear; Anticonvulsants; B-Lymphocytes; D

1985
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T

1986

Trials

2 trials available for sulfasalazine and Lupus Erythematosus, Systemic

ArticleYear
Does sulphasalazine cause drug induced systemic lupus erythematosus? No effect evident in a prospective randomised trial of 200 rheumatoid patients treated with sulphasalazine or auranofin over five years.
    Annals of the rheumatic diseases, 1999, Volume: 58, Issue:5

    Topics: Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Follow-Up Studies;

1999
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
    The Medical journal of Australia, 1986, Jan-06, Volume: 144, Issue:1

    Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T

1986

Other Studies

37 other studies available for sulfasalazine and Lupus Erythematosus, Systemic

ArticleYear
Hydralazine-induced lupus erythematosis.
    Journal of clinical hypertension (Greenwich, Conn.), 2012, Volume: 14, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Drug Therapy, Combination; F

2012
Sulphasalazine-induced systemic lupus erythematous in a patient with ankylosing spondylitis.
    Clinical rheumatology, 2002, Volume: 21, Issue:4

    Topics: Adult; Antirheumatic Agents; Humans; Lupus Erythematosus, Systemic; Male; Spondylitis, Ankylosing; S

2002
Glucose-lowering effects of sulfasalazine in type 2 diabetes.
    Diabetes care, 2005, Volume: 28, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diabetes Mellitus, Type 2; Female; Hu

2005
[Association of ulcerative colitis and lupus nephropathy--report of two cases].
    Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 115, Issue:6

    Topics: Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Autoimmune Diseases; Colitis, Ulcerati

2006
[Colitis and drug-induced lupus: the role of salazopyrine].
    L'union medicale du Canada, 1980, Volume: 109, Issue:9

    Topics: Adult; Crohn Disease; Drug Combinations; Female; Glucosamine; Humans; Lupus Erythematosus, Systemic;

1980
Sulphasalazine-induced systemic lupus erythematosus in a patient with Sjögren's syndrome.
    Journal of the Royal Society of Medicine, 1980, Volume: 73, Issue:1

    Topics: Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Sjogren's Syndrome; Sulfasalazine

1980
Sulphasalazine-induced cerebral lupus erythematosus.
    Postgraduate medical journal, 1982, Volume: 58, Issue:676

    Topics: Adult; Brain Diseases; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine

1982
Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease.
    The American journal of gastroenterology, 1982, Volume: 77, Issue:9

    Topics: Adolescent; Antibodies, Antinuclear; Crohn Disease; Female; Humans; Lupus Erythematosus, Systemic; S

1982
Sulphasalazine-induced systemic lupus erythematosus in a child.
    European journal of pediatrics, 1983, Volume: 140, Issue:1

    Topics: Adolescent; Age Factors; Colitis, Ulcerative; Female; Humans; Lupus Erythematosus, Systemic; Sulfasa

1983
Drug induced lung disease.
    European journal of respiratory diseases. Supplement, 1983, Volume: 126

    Topics: Alveolitis, Extrinsic Allergic; Amiodarone; Antineoplastic Agents; Asthma; Drug Hypersensitivity; Hu

1983
Sulphasalazine in rheumatoid arthritis.
    British journal of rheumatology, 1984, Volume: 23, Issue:3

    Topics: Arthritis, Rheumatoid; Colitis, Ulcerative; Humans; Lupus Erythematosus, Systemic; Sulfasalazine

1984
Ulcerative colitis associated with preceding systemic lupus erythematosus.
    The Journal of dermatology, 1995, Volume: 22, Issue:4

    Topics: Adrenal Cortex Hormones; Age of Onset; Biopsy; Colitis, Ulcerative; Colonoscopy; Female; Humans; Int

1995
Sulphasalazine-induced lupus in psoriatic arthritis.
    British journal of rheumatology, 1995, Volume: 34, Issue:4

    Topics: Adult; Arthritis, Psoriatic; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine

1995
Combination therapy for rheumatoid arthritis and drug-induced systemic lupus erythematosus.
    Clinical rheumatology, 1994, Volume: 13, Issue:3

    Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Lupus Erythematosus, System

1994
Antihistone antibody profile in sulfasalazine induced lupus.
    The Journal of rheumatology, 1994, Volume: 21, Issue:11

    Topics: Adolescent; Autoantibodies; Female; Histones; Humans; Lupus Erythematosus, Systemic; Middle Aged; Su

1994
Suppression of proteinuria and prolongation of survival in MRL-lpr/lpr mice treated with sulphasalazine.
    British journal of rheumatology, 1995, Volume: 34, Issue:1

    Topics: Animals; Disease Models, Animal; Lupus Erythematosus, Systemic; Mice; Proteinuria; Sulfasalazine; Su

1995
Follow-up of patients with double stranded DNA antibodies induced by sulfasalazine during the treatment of inflammatory rheumatic diseases.
    Scandinavian journal of rheumatology, 1993, Volume: 22, Issue:6

    Topics: Adult; Aged; Antibodies, Antinuclear; DNA; Female; Follow-Up Studies; Humans; Lupus Erythematosus, S

1993
Sulphasalazine-induced systemic lupus erythematosus in a patient with erosive arthritis.
    British journal of rheumatology, 1994, Volume: 33, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine

1994
Sulfasalazine induced seizures and dysphasia.
    The Journal of rheumatology, 1994, Volume: 21, Issue:4

    Topics: Antibodies, Antineutrophil Cytoplasmic; Aphasia; Arthritis, Rheumatoid; Autoantibodies; Female; Huma

1994
Sulfasalazine induced lupus in rheumatoid arthritis.
    The Journal of rheumatology, 1994, Volume: 21, Issue:4

    Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Antibody Specificity; Arthrit

1994
Sulphasalazine-induced systemic lupus erythematosus.
    British journal of rheumatology, 1994, Volume: 33, Issue:8

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Sulfa

1994
[Sulfasalazine or interferon in the treatment of lupus: the hen, the egg and the wolf].
    Presse medicale (Paris, France : 1983), 1994, May-28, Volume: 23, Issue:20

    Topics: Antibodies, Antinuclear; Humans; Interferon-alpha; Lupus Erythematosus, Discoid; Lupus Erythematosus

1994
Sulfasalazine induced systemic lupus erythematosus in a patient with rheumatoid arthritis.
    The Journal of rheumatology, 1993, Volume: 20, Issue:1

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine

1993
Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment.
    Clinical rheumatology, 1993, Volume: 12, Issue:2

    Topics: Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; DNA; Female; Humans; Lupus Erythematosus, Sys

1993
Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease.
    British journal of rheumatology, 1995, Volume: 34, Issue:11

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Lupus Erythematosus, Syste

1995
Sulphasalazine-induced systemic lupus erythematosus in a patient with rheumatoid arthritis.
    British journal of rheumatology, 1996, Volume: 35, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Middle A

1996
Predisposing factors in sulphasalazine-induced systemic lupus erythematosus.
    British journal of rheumatology, 1997, Volume: 36, Issue:10

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Arthritis, Juvenile; Arthritis, Psoriatic; Arthrit

1997
Development of lupus-related side-effects in patients with early RA during sulphasalazine treatment-the role of IL-10 and HLA.
    Rheumatology (Oxford, England), 2000, Volume: 39, Issue:8

    Topics: Adult; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Coh

2000
[Crohn's disease with the onset resembling systemic lupus erythematosus].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 1999, Volume: 22, Issue:3

    Topics: Administration, Oral; Adult; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; Huma

1999
Clinical consequences of polymorphic acetylation of basic drugs.
    Clinical pharmacology and therapeutics, 1977, Volume: 22, Issue:3

    Topics: Acetylation; Antibodies, Antinuclear; Biotransformation; Chemical and Drug Induced Liver Injury; Hum

1977
Sulphasalazine-induced lupus syndrome in ulcerative colitis.
    British medical journal, 1977, Nov-05, Volume: 2, Issue:6096

    Topics: Colitis, Ulcerative; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Sulfasalazine; Synd

1977
[Salazosulfapyridine-induced lupus erythematosus syndrome in ulcerative colitis (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1978, Jul-28, Volume: 103, Issue:30

    Topics: Adult; Colitis, Ulcerative; Diagnosis, Differential; Female; Humans; Lupus Erythematosus, Systemic;

1978
[Lupos erythematosus discovered during the course of a toxicodermia (author's transl)].
    Annales de medecine interne, 1979, Volume: 130, Issue:12

    Topics: Adult; Aged; Ampicillin; Aprindine; Drug Eruptions; Female; Humans; Lupus Erythematosus, Systemic; M

1979
[Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatment with penicillamine and sulfasalazine].
    Vnitrni lekarstvi, 1991, Volume: 37, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Penicillamine; Sulfasal

1991
[A case of systemic lupus erythematosus with lupus nephritis occurring in Crohn's disease].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1989, Volume: 78, Issue:4

    Topics: Adult; Crohn Disease; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Sulfasalazine

1989
Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis.
    Annals of the rheumatic diseases, 1987, Volume: 46, Issue:5

    Topics: Antibodies, Antinuclear; Histones; Humans; Hydralazine; Lupus Erythematosus, Systemic; Nucleoside Di

1987
Sulfasalazine-induced lupus erythematosus.
    The American journal of medicine, 1988, Volume: 84, Issue:3 Pt 1

    Topics: Adult; Antibodies, Antinuclear; Cardiac Tamponade; Colitis, Ulcerative; Humans; Lupus Erythematosus,

1988