sulfasalazine has been researched along with Lupus Erythematosus, Systemic in 45 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the case of a 46-year-old woman with rheumatoid arthritis who developed a severe reaction to sulfasalazine, characterized by dysphasia, seizures, rash and the development of strongly positive pANCA (perinuclear antineutrophil cytoplasmic antibodies)." | 7.69 | Sulfasalazine induced seizures and dysphasia. ( Gordon, C; Heath, DA; Hill, ME; Situnayake, RD, 1994) |
| "We describe 2 cases of a lupus syndrome induced by sulfasalazine in rheumatoid arthritis." | 7.69 | Sulfasalazine induced lupus in rheumatoid arthritis. ( Andrieu, V; Caulier, M; Dromer, C; Fournie, B; Le Guennec, P, 1994) |
| " In this report we present a patient with an erosive seropositive rheumatoid arthritis developing the clinical and serological features of systemic lupus erythematosus including the occurrence of double-stranded DNA antibodies under sulfasalazine treatment." | 7.68 | Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment. ( Deicher, H; Hammer, M; Hartung, K; Mau, W; Schmidt, RE; Wildhagen, K; Zeidler, H, 1993) |
| "A female patient with IgM RF seropositive rheumatoid arthritis according to criteria of the American Rheumatism Association was treated for 133 months with Penicillamine and for 17 months also with Sulfasalazine." | 7.68 | [Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatment with penicillamine and sulfasalazine]. ( Hrncír, Z; Pintérová, E; Rejchrt, S, 1991) |
| " The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease." | 4.87 | [Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011) |
| "We describe the case of a 46-year-old woman with rheumatoid arthritis who developed a severe reaction to sulfasalazine, characterized by dysphasia, seizures, rash and the development of strongly positive pANCA (perinuclear antineutrophil cytoplasmic antibodies)." | 3.69 | Sulfasalazine induced seizures and dysphasia. ( Gordon, C; Heath, DA; Hill, ME; Situnayake, RD, 1994) |
| "We describe 2 cases of a lupus syndrome induced by sulfasalazine in rheumatoid arthritis." | 3.69 | Sulfasalazine induced lupus in rheumatoid arthritis. ( Andrieu, V; Caulier, M; Dromer, C; Fournie, B; Le Guennec, P, 1994) |
| " In this report we present a patient with an erosive seropositive rheumatoid arthritis developing the clinical and serological features of systemic lupus erythematosus including the occurrence of double-stranded DNA antibodies under sulfasalazine treatment." | 3.68 | Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment. ( Deicher, H; Hammer, M; Hartung, K; Mau, W; Schmidt, RE; Wildhagen, K; Zeidler, H, 1993) |
| "A female patient with IgM RF seropositive rheumatoid arthritis according to criteria of the American Rheumatism Association was treated for 133 months with Penicillamine and for 17 months also with Sulfasalazine." | 3.68 | [Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatment with penicillamine and sulfasalazine]. ( Hrncír, Z; Pintérová, E; Rejchrt, S, 1991) |
| "Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis." | 3.67 | Sulfasalazine-induced lupus erythematosus. ( Clementz, GL; Dolin, BJ, 1988) |
| "The development of systemic lupus erythematosus (SLE)-related syndromes during treatment with sulphasalazine has been described and demonstrated to be influenced by genetic factors." | 1.31 | Development of lupus-related side-effects in patients with early RA during sulphasalazine treatment-the role of IL-10 and HLA. ( Forslid, J; Gröndal, G; Gunnarsson, I; Hassan Bakri, A; Klareskog, L; Larsson, P; Nordmark, B; Ringertz, B, 2000) |
| "We described a 37-year-old man with Crohn's disease (CD) resembling systemic lupus erythematosus (SLE) at his disease onset." | 1.30 | [Crohn's disease with the onset resembling systemic lupus erythematosus]. ( Baba, M; Hiranuma, M; Horie, T; Kitamura, N; Nishinarita, S; Shimizu, T; Son, K; Tomita, Y, 1999) |
| "Since the association of idiopathic systemic lupus erythematosus with ulcerative colitis has rarely been reported, the combination of these two diseases may be coincidental." | 1.29 | Ulcerative colitis associated with preceding systemic lupus erythematosus. ( Fujita, K; Hirato, J; Ishikawa, O; Miyachi, Y; Nagamachi, Y; Takenoshita, S, 1995) |
| "Development of drug-induced systemic lupus erythematosus (SLE) is an uncommon complication of the use of D-penicillamine and sulphasalazine." | 1.29 | Combination therapy for rheumatoid arthritis and drug-induced systemic lupus erythematosus. ( Borg, AA; Davis, MJ; Dawes, PT; Shadforth, MF, 1994) |
| "In a 25-year old woman with ulcerative colitis a lupus erythematosus syndrome occurred during treatment with salazosulfapyridine." | 1.26 | [Salazosulfapyridine-induced lupus erythematosus syndrome in ulcerative colitis (author's transl)]. ( Jaup, BH, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (35.56) | 18.7374 |
| 1990's | 23 (51.11) | 18.2507 |
| 2000's | 4 (8.89) | 29.6817 |
| 2010's | 2 (4.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kiss, E | 1 |
| Kiss, CG | 1 |
| Poór, G | 1 |
| Handler, J | 1 |
| Tsai, WC | 1 |
| Chen, CJ | 1 |
| Yen, JH | 1 |
| Liu, HW | 1 |
| Haas, RM | 1 |
| Li, P | 1 |
| Chu, JW | 1 |
| Nieradko-Iwanicka, B | 1 |
| Majdan, M | 1 |
| Piotrowski, M | 1 |
| Radwan, P | 1 |
| Kwiatkowski, P | 1 |
| Rouleau, L | 1 |
| Ménard, H | 1 |
| Beaudry, R | 1 |
| Myhal, D | 1 |
| Crisp, AJ | 2 |
| Hoffbrand, BI | 1 |
| Rafferty, P | 1 |
| Young, AC | 1 |
| Haeney, MR | 1 |
| Carr-Locke, DL | 1 |
| Vanheule, BA | 1 |
| Carswell, F | 1 |
| Pannier, R | 1 |
| Ishikawa, O | 1 |
| Miyachi, Y | 1 |
| Fujita, K | 1 |
| Takenoshita, S | 1 |
| Nagamachi, Y | 1 |
| Hirato, J | 1 |
| Fritzler, MJ | 1 |
| Veale, DJ | 1 |
| Ho, M | 1 |
| Morley, KD | 1 |
| Laversuch, CJ | 1 |
| Collins, DA | 1 |
| Charles, PJ | 1 |
| Bourke, BE | 1 |
| Borg, AA | 2 |
| Davis, MJ | 1 |
| Dawes, PT | 1 |
| Shadforth, MF | 1 |
| Bray, VJ | 1 |
| West, SG | 1 |
| Schultz, KT | 1 |
| Boumpas, DT | 1 |
| Rubin, RL | 1 |
| Tsai, CY | 1 |
| Wu, TH | 1 |
| Huang, SF | 1 |
| Peng, SJ | 1 |
| Han, SH | 1 |
| Yu, CL | 1 |
| Mielke, H | 1 |
| Wildhagen, K | 2 |
| Mau, W | 2 |
| Zeidler, H | 2 |
| Walker, EM | 1 |
| Carty, JE | 1 |
| Hill, ME | 1 |
| Gordon, C | 1 |
| Situnayake, RD | 1 |
| Heath, DA | 1 |
| Caulier, M | 1 |
| Dromer, C | 2 |
| Andrieu, V | 1 |
| Le Guennec, P | 1 |
| Fournie, B | 2 |
| Mongey, AB | 1 |
| Hess, EV | 1 |
| Piette, JC | 1 |
| Frances, C | 1 |
| Papo, T | 1 |
| Godeau, P | 1 |
| Siam, AR | 1 |
| Hammoudeh, M | 1 |
| Hartung, K | 1 |
| Hammer, M | 1 |
| Schmidt, RE | 1 |
| Deicher, H | 1 |
| Khattak, FH | 1 |
| Morris, IM | 1 |
| Mattingly, PC | 1 |
| Gunnarsson, I | 2 |
| Kanerud, L | 1 |
| Pettersson, E | 1 |
| Lundberg, I | 1 |
| Lindblad, S | 1 |
| Ringertz, B | 2 |
| Gordon, MM | 1 |
| Porter, DR | 1 |
| Capell, HA | 1 |
| Nordmark, B | 1 |
| Hassan Bakri, A | 1 |
| Gröndal, G | 1 |
| Larsson, P | 1 |
| Forslid, J | 1 |
| Klareskog, L | 1 |
| Shimizu, T | 1 |
| Nishinarita, S | 1 |
| Son, K | 1 |
| Tomita, Y | 1 |
| Kitamura, N | 1 |
| Horie, T | 1 |
| Baba, M | 1 |
| Hiranuma, M | 1 |
| Drayer, DE | 1 |
| Reidenberg, MM | 1 |
| Griffiths, ID | 1 |
| Kane, SP | 1 |
| Jaup, BH | 1 |
| Weiller, PJ | 1 |
| Lammy, S | 1 |
| Weiller, M | 1 |
| Gabriel, B | 1 |
| Sayag, J | 1 |
| Mongin, M | 1 |
| Alarcón-Segovia, D | 1 |
| Kraus, A | 1 |
| Lassoued, S | 1 |
| Ludot, I | 1 |
| Pages, M | 1 |
| Jacquemier, JM | 1 |
| Fournié, A | 1 |
| Rejchrt, S | 1 |
| Hrncír, Z | 1 |
| Pintérová, E | 1 |
| Sugimoto, M | 1 |
| Sato, Y | 1 |
| Kumagai, Y | 1 |
| Suenaga, M | 1 |
| Hashimoto, H | 1 |
| Hirose, S | 1 |
| Lovisetto, P | 1 |
| Mairano, D | 1 |
| Cargnino, M | 1 |
| Biarese, V | 1 |
| Marchi, L | 1 |
| Lerda, R | 1 |
| Muirden, KD | 1 |
| Hobbs, RN | 1 |
| Clayton, AL | 1 |
| Bernstein, RM | 1 |
| Clementz, GL | 1 |
| Dolin, BJ | 1 |
7 reviews available for sulfasalazine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit | 2011 |
Drugs recently associated with lupus syndromes.
Topics: Deferiprone; Humans; Interferon-alpha; Interleukin-2; Leuprolide; Lupus Erythematosus, Systemic; Pen | 1994 |
Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease.
Topics: Adult; Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmunity; Female; Humans; Lupus Erythematosus | 1995 |
Drug-related lupus syndromes and their relationship to spontaneously occurring systemic lupus erythematosus.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hydralazine; Lupus Erythematosus, Systemic; | 1991 |
[Lupic serology caused by sulfasalazine].
Topics: Antibodies, Antinuclear; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Prospecti | 1991 |
[Drug-induced lupus].
Topics: Acetylation; Adrenergic beta-Antagonists; Antibodies, Antinuclear; Anticonvulsants; B-Lymphocytes; D | 1985 |
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T | 1986 |
2 trials available for sulfasalazine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Does sulphasalazine cause drug induced systemic lupus erythematosus? No effect evident in a prospective randomised trial of 200 rheumatoid patients treated with sulphasalazine or auranofin over five years.
Topics: Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Auranofin; Follow-Up Studies; | 1999 |
The use of chloroquine and D-penicillamine in the treatment of rheumatoid arthritis.
Topics: Anti-Glomerular Basement Membrane Disease; Arthritis, Rheumatoid; Captopril; Chloroquine; Clinical T | 1986 |
37 other studies available for sulfasalazine and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Hydralazine-induced lupus erythematosis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Drug Therapy, Combination; F | 2012 |
Sulphasalazine-induced systemic lupus erythematous in a patient with ankylosing spondylitis.
Topics: Adult; Antirheumatic Agents; Humans; Lupus Erythematosus, Systemic; Male; Spondylitis, Ankylosing; S | 2002 |
Glucose-lowering effects of sulfasalazine in type 2 diabetes.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diabetes Mellitus, Type 2; Female; Hu | 2005 |
[Association of ulcerative colitis and lupus nephropathy--report of two cases].
Topics: Adult; Antibodies, Antinuclear; Antibodies, Antiphospholipid; Autoimmune Diseases; Colitis, Ulcerati | 2006 |
[Colitis and drug-induced lupus: the role of salazopyrine].
Topics: Adult; Crohn Disease; Drug Combinations; Female; Glucosamine; Humans; Lupus Erythematosus, Systemic; | 1980 |
Sulphasalazine-induced systemic lupus erythematosus in a patient with Sjögren's syndrome.
Topics: Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Sjogren's Syndrome; Sulfasalazine | 1980 |
Sulphasalazine-induced cerebral lupus erythematosus.
Topics: Adult; Brain Diseases; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine | 1982 |
Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease.
Topics: Adolescent; Antibodies, Antinuclear; Crohn Disease; Female; Humans; Lupus Erythematosus, Systemic; S | 1982 |
Sulphasalazine-induced systemic lupus erythematosus in a child.
Topics: Adolescent; Age Factors; Colitis, Ulcerative; Female; Humans; Lupus Erythematosus, Systemic; Sulfasa | 1983 |
Drug induced lung disease.
Topics: Alveolitis, Extrinsic Allergic; Amiodarone; Antineoplastic Agents; Asthma; Drug Hypersensitivity; Hu | 1983 |
Sulphasalazine in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Colitis, Ulcerative; Humans; Lupus Erythematosus, Systemic; Sulfasalazine | 1984 |
Ulcerative colitis associated with preceding systemic lupus erythematosus.
Topics: Adrenal Cortex Hormones; Age of Onset; Biopsy; Colitis, Ulcerative; Colonoscopy; Female; Humans; Int | 1995 |
Sulphasalazine-induced lupus in psoriatic arthritis.
Topics: Adult; Arthritis, Psoriatic; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine | 1995 |
Combination therapy for rheumatoid arthritis and drug-induced systemic lupus erythematosus.
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; Lupus Erythematosus, System | 1994 |
Antihistone antibody profile in sulfasalazine induced lupus.
Topics: Adolescent; Autoantibodies; Female; Histones; Humans; Lupus Erythematosus, Systemic; Middle Aged; Su | 1994 |
Suppression of proteinuria and prolongation of survival in MRL-lpr/lpr mice treated with sulphasalazine.
Topics: Animals; Disease Models, Animal; Lupus Erythematosus, Systemic; Mice; Proteinuria; Sulfasalazine; Su | 1995 |
Follow-up of patients with double stranded DNA antibodies induced by sulfasalazine during the treatment of inflammatory rheumatic diseases.
Topics: Adult; Aged; Antibodies, Antinuclear; DNA; Female; Follow-Up Studies; Humans; Lupus Erythematosus, S | 1993 |
Sulphasalazine-induced systemic lupus erythematosus in a patient with erosive arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine | 1994 |
Sulfasalazine induced seizures and dysphasia.
Topics: Antibodies, Antineutrophil Cytoplasmic; Aphasia; Arthritis, Rheumatoid; Autoantibodies; Female; Huma | 1994 |
Sulfasalazine induced lupus in rheumatoid arthritis.
Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Antibody Specificity; Arthrit | 1994 |
Sulphasalazine-induced systemic lupus erythematosus.
Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Sulfa | 1994 |
[Sulfasalazine or interferon in the treatment of lupus: the hen, the egg and the wolf].
Topics: Antibodies, Antinuclear; Humans; Interferon-alpha; Lupus Erythematosus, Discoid; Lupus Erythematosus | 1994 |
Sulfasalazine induced systemic lupus erythematosus in a patient with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Sulfasalazine | 1993 |
Drug-related lupus in a patient with rheumatoid arthritis under sulfasalazine treatment.
Topics: Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; DNA; Female; Humans; Lupus Erythematosus, Sys | 1993 |
Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Humans; Lupus Erythematosus, Syste | 1995 |
Sulphasalazine-induced systemic lupus erythematosus in a patient with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Middle A | 1996 |
Predisposing factors in sulphasalazine-induced systemic lupus erythematosus.
Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Arthritis, Juvenile; Arthritis, Psoriatic; Arthrit | 1997 |
Development of lupus-related side-effects in patients with early RA during sulphasalazine treatment-the role of IL-10 and HLA.
Topics: Adult; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Coh | 2000 |
[Crohn's disease with the onset resembling systemic lupus erythematosus].
Topics: Administration, Oral; Adult; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combination; Huma | 1999 |
Clinical consequences of polymorphic acetylation of basic drugs.
Topics: Acetylation; Antibodies, Antinuclear; Biotransformation; Chemical and Drug Induced Liver Injury; Hum | 1977 |
Sulphasalazine-induced lupus syndrome in ulcerative colitis.
Topics: Colitis, Ulcerative; Female; Humans; Lupus Erythematosus, Systemic; Middle Aged; Sulfasalazine; Synd | 1977 |
[Salazosulfapyridine-induced lupus erythematosus syndrome in ulcerative colitis (author's transl)].
Topics: Adult; Colitis, Ulcerative; Diagnosis, Differential; Female; Humans; Lupus Erythematosus, Systemic; | 1978 |
[Lupos erythematosus discovered during the course of a toxicodermia (author's transl)].
Topics: Adult; Aged; Ampicillin; Aprindine; Drug Eruptions; Female; Humans; Lupus Erythematosus, Systemic; M | 1979 |
[Rheumatoid arthritis developing into systemic lupus erythematosus during long-term treatment with penicillamine and sulfasalazine].
Topics: Adult; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; Penicillamine; Sulfasal | 1991 |
[A case of systemic lupus erythematosus with lupus nephritis occurring in Crohn's disease].
Topics: Adult; Crohn Disease; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Sulfasalazine | 1989 |
Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis.
Topics: Antibodies, Antinuclear; Histones; Humans; Hydralazine; Lupus Erythematosus, Systemic; Nucleoside Di | 1987 |
Sulfasalazine-induced lupus erythematosus.
Topics: Adult; Antibodies, Antinuclear; Cardiac Tamponade; Colitis, Ulcerative; Humans; Lupus Erythematosus, | 1988 |