sulfasalazine has been researched along with Liver Failure in 3 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present an unusual case of a patient with extreme lymphoplasmacytosis and hepatic failure in association with a reaction to sulfasalazine and a concurrent Epstein-Barr virus (EBV) infection." | 8.82 | Extreme lymphoplasmacytosis and hepatic failure associated with sulfasalazine hypersensitivity reaction and a concurrent EBV infection--case report and review of the literature. ( Anastopoulos, HT; Ballesteros, E; Halmos, B; Schnipper, LE, 2004) |
| "We present an unusual case of a patient with extreme lymphoplasmacytosis and hepatic failure in association with a reaction to sulfasalazine and a concurrent Epstein-Barr virus (EBV) infection." | 4.82 | Extreme lymphoplasmacytosis and hepatic failure associated with sulfasalazine hypersensitivity reaction and a concurrent EBV infection--case report and review of the literature. ( Anastopoulos, HT; Ballesteros, E; Halmos, B; Schnipper, LE, 2004) |
| "Spontaneous reporting systems for adverse drug reactions (ADRs) are handicapped by under-reporting and limited detail on individual cases." | 1.35 | Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events. ( Amarasena, R; Bowman, S; Filer, A; Homer, D; Jobanputra, P; Jubb, R; Maggs, F; Rankin, E; Raza, K, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halmos, B | 1 |
| Anastopoulos, HT | 1 |
| Schnipper, LE | 1 |
| Ballesteros, E | 1 |
| Kampmann, P | 1 |
| Højlyng, N | 1 |
| Pedersen, M | 1 |
| Jobanputra, P | 1 |
| Amarasena, R | 1 |
| Maggs, F | 1 |
| Homer, D | 1 |
| Bowman, S | 1 |
| Rankin, E | 1 |
| Filer, A | 1 |
| Raza, K | 1 |
| Jubb, R | 1 |
1 review available for sulfasalazine and Liver Failure
| Article | Year |
|---|---|
Extreme lymphoplasmacytosis and hepatic failure associated with sulfasalazine hypersensitivity reaction and a concurrent EBV infection--case report and review of the literature.
Topics: Adult; Diagnosis, Differential; Drug Hypersensitivity; Epstein-Barr Virus Infections; Humans; Leukoc | 2004 |
2 other studies available for sulfasalazine and Liver Failure
| Article | Year |
|---|---|
[Life-threatening liver failure and severe dyscrasias in blood and lymph nodes caused by sulphasalazine].
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Cell Count; Chemical and Drug Induced Live | 2006 |
Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 2008 |