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sulfasalazine and Liver Dysfunction

sulfasalazine has been researched along with Liver Dysfunction in 14 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Research Excerpts

ExcerptRelevanceReference
"Leflunomide(Arava) is a novel immunomodulatory drug, the primary action of which is inhibition of de-novo pyrimidine synthesis by selective inhibition of dihydro-orotate dehydrogenase."2.41[Efficacy of leflunomide]. ( Hirohata, S, 2002)
"Sulfasalazine was loaded into the fucosylated MWCNTs after subsequential functionalization (carboxylation, acylation and amidation) using dialysis membrane technique."1.40Fucosylated multiwalled carbon nanotubes for Kupffer cells targeting for the treatment of cytokine-induced liver damage. ( Gupta, R; Jain, NK; Mehra, NK, 2014)
"Spontaneous reporting systems for adverse drug reactions (ADRs) are handicapped by under-reporting and limited detail on individual cases."1.35Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events. ( Amarasena, R; Bowman, S; Filer, A; Homer, D; Jobanputra, P; Jubb, R; Maggs, F; Rankin, E; Raza, K, 2008)
" In both instances there was an interval of three weeks between receiving the drug for the first time and the onset of the toxic reaction."1.26Combined hepatotoxicity and neurotoxicity following sulphasalazine administration. ( Gibson, GE; Rowland, R; Smith, MD, 1982)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's1 (7.14)18.2507
2000's3 (21.43)29.6817
2010's1 (7.14)24.3611
2020's1 (7.14)2.80

Authors

AuthorsStudies
Capelletti, MM1
Manceau, H1
Puy, H1
Peoc'h, K1
Gupta, R1
Mehra, NK1
Jain, NK1
Hirohata, S1
STAUFFER, MH1
SAUER, WG1
DEARING, WH1
BAGGENSTOSS, AH1
Demirbilek, S1
Akin, M1
Gürünlüoğlu, K1
Aydin, NE1
Emre, MH1
Taş, E1
Aksoy, RT1
Ay, S1
Jobanputra, P1
Amarasena, R1
Maggs, F1
Homer, D1
Bowman, S1
Rankin, E1
Filer, A1
Raza, K1
Jubb, R1
Namias, A1
Bhalotra, R1
Donowitz, M1
Smith, MD1
Gibson, GE1
Rowland, R1
Sentürk, T1
Aydintuğ, AO1
Düzgün, N1
Tokgöz, G1
Ribe, J1
Benkov, KJ1
Thung, SN1
Shen, SC1
LeLeiko, NS1
Haines, JD1
Arvanitakis, C1
Manier, JW1
Rafoth, RJ1
Truelove, SC1

Reviews

3 reviews available for sulfasalazine and Liver Dysfunction

ArticleYear
Ferroptosis in Liver Diseases: An Overview.
    International journal of molecular sciences, 2020, Jul-11, Volume: 21, Issue:14

    Topics: alpha-Tocopherol; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Cyclohexylamines; Cyst

2020
[Efficacy of leflunomide].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:12

    Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Double-Bli

2002
Ulcerative colitis. Medical management.
    British medical journal, 1971, Mar-20, Volume: 1, Issue:5750

    Topics: Adrenocorticotropic Hormone; Allergens; Animals; Arthritis; Blood Transfusion; Colitis, Ulcerative;

1971

Other Studies

11 other studies available for sulfasalazine and Liver Dysfunction

ArticleYear
Fucosylated multiwalled carbon nanotubes for Kupffer cells targeting for the treatment of cytokine-induced liver damage.
    Pharmaceutical research, 2014, Volume: 31, Issue:2

    Topics: Animals; Cell Line; Cytokines; Delayed-Action Preparations; Humans; Kupffer Cells; Liver Diseases; M

2014
THE SPECTRUM OF CHOLESTATIC HEPATIC DISEASE.
    JAMA, 1965, Mar-08, Volume: 191

    Topics: Adolescent; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Duct Neoplasms; Bilirubin; Blood

1965
The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats.
    Pediatric surgery international, 2006, Volume: 22, Issue:8

    Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cholestasis, Extrahepatic; Common Bile Duct; Disease M

2006
Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events.
    BMC musculoskeletal disorders, 2008, Apr-11, Volume: 9

    Topics: Adult; Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Arthritis,

2008
Reversible sulfasalazine-induced granulomatous hepatitis.
    Journal of clinical gastroenterology, 1981, Volume: 3, Issue:2

    Topics: Adult; Chemical and Drug Induced Liver Injury; Granuloma; Hepatitis; Humans; Liver Diseases; Male; S

1981
Combined hepatotoxicity and neurotoxicity following sulphasalazine administration.
    Australian and New Zealand journal of medicine, 1982, Volume: 12, Issue:1

    Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Liver

1982
Seizures and hepatotoxicity following sulphasalazine administration.
    Rheumatology international, 1997, Volume: 17, Issue:2

    Topics: Adult; Antirheumatic Agents; Arthritis; Chemical and Drug Induced Liver Injury; Chronic Disease; Fem

1997
Fatal massive hepatic necrosis: a probable hypersensitivity reaction to sulfasalazine.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:3

    Topics: Adolescent; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Drug Hypersensitivity; Huma

1986
Hepatotoxicity after treatment with sulfasalazine.
    Postgraduate medicine, 1986, May-01, Volume: 79, Issue:6

    Topics: Adult; Chemical and Drug Induced Liver Injury; Crohn Disease; Drug Eruptions; Drug Hypersensitivity;

1986
Crohn's disease: a clinical study of 75 patients.
    The American journal of gastroenterology, 1973, Volume: 59, Issue:6

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Child; Crohn Disease; Female; Fol

1973
Systemic granulomatous reaction to salicylazosulfapyridine (Azulfidine) in a patient with Crohn's disease.
    The American journal of digestive diseases, 1974, Volume: 19, Issue:5

    Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Crohn Disease; Diagnosis, Differential; Femal

1974