sulfasalazine has been researched along with Liver Dysfunction in 14 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide(Arava) is a novel immunomodulatory drug, the primary action of which is inhibition of de-novo pyrimidine synthesis by selective inhibition of dihydro-orotate dehydrogenase." | 2.41 | [Efficacy of leflunomide]. ( Hirohata, S, 2002) |
| "Sulfasalazine was loaded into the fucosylated MWCNTs after subsequential functionalization (carboxylation, acylation and amidation) using dialysis membrane technique." | 1.40 | Fucosylated multiwalled carbon nanotubes for Kupffer cells targeting for the treatment of cytokine-induced liver damage. ( Gupta, R; Jain, NK; Mehra, NK, 2014) |
| "Spontaneous reporting systems for adverse drug reactions (ADRs) are handicapped by under-reporting and limited detail on individual cases." | 1.35 | Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events. ( Amarasena, R; Bowman, S; Filer, A; Homer, D; Jobanputra, P; Jubb, R; Maggs, F; Rankin, E; Raza, K, 2008) |
| " In both instances there was an interval of three weeks between receiving the drug for the first time and the onset of the toxic reaction." | 1.26 | Combined hepatotoxicity and neurotoxicity following sulphasalazine administration. ( Gibson, GE; Rowland, R; Smith, MD, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Capelletti, MM | 1 |
| Manceau, H | 1 |
| Puy, H | 1 |
| Peoc'h, K | 1 |
| Gupta, R | 1 |
| Mehra, NK | 1 |
| Jain, NK | 1 |
| Hirohata, S | 1 |
| STAUFFER, MH | 1 |
| SAUER, WG | 1 |
| DEARING, WH | 1 |
| BAGGENSTOSS, AH | 1 |
| Demirbilek, S | 1 |
| Akin, M | 1 |
| Gürünlüoğlu, K | 1 |
| Aydin, NE | 1 |
| Emre, MH | 1 |
| Taş, E | 1 |
| Aksoy, RT | 1 |
| Ay, S | 1 |
| Jobanputra, P | 1 |
| Amarasena, R | 1 |
| Maggs, F | 1 |
| Homer, D | 1 |
| Bowman, S | 1 |
| Rankin, E | 1 |
| Filer, A | 1 |
| Raza, K | 1 |
| Jubb, R | 1 |
| Namias, A | 1 |
| Bhalotra, R | 1 |
| Donowitz, M | 1 |
| Smith, MD | 1 |
| Gibson, GE | 1 |
| Rowland, R | 1 |
| Sentürk, T | 1 |
| Aydintuğ, AO | 1 |
| Düzgün, N | 1 |
| Tokgöz, G | 1 |
| Ribe, J | 1 |
| Benkov, KJ | 1 |
| Thung, SN | 1 |
| Shen, SC | 1 |
| LeLeiko, NS | 1 |
| Haines, JD | 1 |
| Arvanitakis, C | 1 |
| Manier, JW | 1 |
| Rafoth, RJ | 1 |
| Truelove, SC | 1 |
3 reviews available for sulfasalazine and Liver Dysfunction
| Article | Year |
|---|---|
Ferroptosis in Liver Diseases: An Overview.
Topics: alpha-Tocopherol; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Cyclohexylamines; Cyst | 2020 |
[Efficacy of leflunomide].
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials, Phase II as Topic; Double-Bli | 2002 |
Ulcerative colitis. Medical management.
Topics: Adrenocorticotropic Hormone; Allergens; Animals; Arthritis; Blood Transfusion; Colitis, Ulcerative; | 1971 |
11 other studies available for sulfasalazine and Liver Dysfunction
| Article | Year |
|---|---|
Fucosylated multiwalled carbon nanotubes for Kupffer cells targeting for the treatment of cytokine-induced liver damage.
Topics: Animals; Cell Line; Cytokines; Delayed-Action Preparations; Humans; Kupffer Cells; Liver Diseases; M | 2014 |
THE SPECTRUM OF CHOLESTATIC HEPATIC DISEASE.
Topics: Adolescent; Alkaline Phosphatase; Aspartate Aminotransferases; Bile Duct Neoplasms; Bilirubin; Blood | 1965 |
The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cholestasis, Extrahepatic; Common Bile Duct; Disease M | 2006 |
Hepatotoxicity associated with sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 2008 |
Reversible sulfasalazine-induced granulomatous hepatitis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Granuloma; Hepatitis; Humans; Liver Diseases; Male; S | 1981 |
Combined hepatotoxicity and neurotoxicity following sulphasalazine administration.
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Female; Humans; Liver; Liver Diseases; Liver | 1982 |
Seizures and hepatotoxicity following sulphasalazine administration.
Topics: Adult; Antirheumatic Agents; Arthritis; Chemical and Drug Induced Liver Injury; Chronic Disease; Fem | 1997 |
Fatal massive hepatic necrosis: a probable hypersensitivity reaction to sulfasalazine.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Drug Hypersensitivity; Huma | 1986 |
Hepatotoxicity after treatment with sulfasalazine.
Topics: Adult; Chemical and Drug Induced Liver Injury; Crohn Disease; Drug Eruptions; Drug Hypersensitivity; | 1986 |
Crohn's disease: a clinical study of 75 patients.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Child; Crohn Disease; Female; Fol | 1973 |
Systemic granulomatous reaction to salicylazosulfapyridine (Azulfidine) in a patient with Crohn's disease.
Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Crohn Disease; Diagnosis, Differential; Femal | 1974 |