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sulfasalazine and Lichen Planus

sulfasalazine has been researched along with Lichen Planus in 9 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a saw-tooth pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.

Research Excerpts

ExcerptRelevanceReference
"Oral sulfasalazine has been reported to be effective in patients with idiopathic cutaneous lichen planus (LP)."9.14Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients. ( Ayoobi, A; Cheraghian, B; Feily, A; Mapar, MA; Omidian, M, 2010)
"Sulfasalazine is a successful therapeutic option for cutaneous LP, constituting an alternative to corticosteroids and retinoids."5.33Successful treatment of lichen planus with sulfasalazine in 20 patients. ( Bauzá, A; España, A; Gil, P; Lloret, P; Vázquez Doval, FJ, 2005)
"Oral sulfasalazine has been reported to be effective in patients with idiopathic cutaneous lichen planus (LP)."5.14Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients. ( Ayoobi, A; Cheraghian, B; Feily, A; Mapar, MA; Omidian, M, 2010)
"Lichen planus is a recognized complication of sulfasalazine therapy."3.68Lichen planus and mesalazine. ( Alstead, EM; Farthing, MJ; Wilson, AG, 1991)
"Sulfasalazine is a successful therapeutic option for cutaneous LP, constituting an alternative to corticosteroids and retinoids."1.33Successful treatment of lichen planus with sulfasalazine in 20 patients. ( Bauzá, A; España, A; Gil, P; Lloret, P; Vázquez Doval, FJ, 2005)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atzmony, L1
Reiter, O1
Hodak, E1
Gdalevich, M1
Mimouni, D1
Omidian, M1
Ayoobi, A1
Mapar, MA1
Feily, A1
Cheraghian, B1
Marino, C2
McDonald, E2
Bauzá, A1
España, A1
Gil, P1
Lloret, P1
Vázquez Doval, FJ1
Burkhart, CG1
Kaplan, S1
Alstead, EM1
Wilson, AG1
Farthing, MJ1
Cox, NH1
Finlay, AY1
Watkinson, G1
Thompson, DM1
Robinson, TW1
Lennard-Jones, J1

Reviews

1 review available for sulfasalazine and Lichen Planus

ArticleYear
Treatments for Cutaneous Lichen Planus: A Systematic Review and Meta-Analysis.
    American journal of clinical dermatology, 2016, Volume: 17, Issue:1

    Topics: Acitretin; Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Ca

2016

Trials

1 trial available for sulfasalazine and Lichen Planus

ArticleYear
Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2010, Volume: 24, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Lichen Planus;

2010

Other Studies

7 other studies available for sulfasalazine and Lichen Planus

ArticleYear
Late onset hypersensitivity to sulfasalazine in a patient with ankylosing spondylitis: comment on the article by Paul et al.
    Arthritis care and research : the official journal of the Arthritis Health Professions Association, 2000, Volume: 13, Issue:5

    Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Drug Eruptions; Female

2000
Successful treatment of lichen planus with sulfasalazine in 20 patients.
    International journal of dermatology, 2005, Volume: 44, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Dose-Resp

2005
Mesalamine may be preferable to sulfasalazine in dermatologic therapeutics.
    International journal of dermatology, 2006, Volume: 45, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Lichen Planus; Mesalamine; Sulfasalazine; Treatment

2006
Lichen planus in patients with rheumatoid arthritis treated with sulfasalazine.
    The Journal of rheumatology, 1995, Volume: 22, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Lichen Planus; Male; Middle Aged; Predn

1995
Lichen planus and mesalazine.
    Journal of clinical gastroenterology, 1991, Volume: 13, Issue:3

    Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Female; Humans; Lichen Planus; Male; Mesalamine; M

1991
Atypical lichen planus associated with ulcerative colitis.
    Dermatologica, 1986, Volume: 173, Issue:6

    Topics: Colitis, Ulcerative; Female; Humans; Lichen Planus; Middle Aged; Sulfasalazine

1986
Alopecia areata, vitiligo, scleroderma and ulcerative colitis.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:10

    Topics: Adult; Alopecia Areata; Barium Sulfate; Colitis, Ulcerative; Enema; Humans; Lichen Planus; Male; Pre

1974