sulfasalazine has been researched along with Lichen Planus in 9 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a saw-tooth pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral sulfasalazine has been reported to be effective in patients with idiopathic cutaneous lichen planus (LP)." | 9.14 | Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients. ( Ayoobi, A; Cheraghian, B; Feily, A; Mapar, MA; Omidian, M, 2010) |
| "Sulfasalazine is a successful therapeutic option for cutaneous LP, constituting an alternative to corticosteroids and retinoids." | 5.33 | Successful treatment of lichen planus with sulfasalazine in 20 patients. ( Bauzá, A; España, A; Gil, P; Lloret, P; Vázquez Doval, FJ, 2005) |
| "Oral sulfasalazine has been reported to be effective in patients with idiopathic cutaneous lichen planus (LP)." | 5.14 | Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients. ( Ayoobi, A; Cheraghian, B; Feily, A; Mapar, MA; Omidian, M, 2010) |
| "Lichen planus is a recognized complication of sulfasalazine therapy." | 3.68 | Lichen planus and mesalazine. ( Alstead, EM; Farthing, MJ; Wilson, AG, 1991) |
| "Sulfasalazine is a successful therapeutic option for cutaneous LP, constituting an alternative to corticosteroids and retinoids." | 1.33 | Successful treatment of lichen planus with sulfasalazine in 20 patients. ( Bauzá, A; España, A; Gil, P; Lloret, P; Vázquez Doval, FJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atzmony, L | 1 |
| Reiter, O | 1 |
| Hodak, E | 1 |
| Gdalevich, M | 1 |
| Mimouni, D | 1 |
| Omidian, M | 1 |
| Ayoobi, A | 1 |
| Mapar, MA | 1 |
| Feily, A | 1 |
| Cheraghian, B | 1 |
| Marino, C | 2 |
| McDonald, E | 2 |
| Bauzá, A | 1 |
| España, A | 1 |
| Gil, P | 1 |
| Lloret, P | 1 |
| Vázquez Doval, FJ | 1 |
| Burkhart, CG | 1 |
| Kaplan, S | 1 |
| Alstead, EM | 1 |
| Wilson, AG | 1 |
| Farthing, MJ | 1 |
| Cox, NH | 1 |
| Finlay, AY | 1 |
| Watkinson, G | 1 |
| Thompson, DM | 1 |
| Robinson, TW | 1 |
| Lennard-Jones, J | 1 |
1 review available for sulfasalazine and Lichen Planus
| Article | Year |
|---|---|
Treatments for Cutaneous Lichen Planus: A Systematic Review and Meta-Analysis.
Topics: Acitretin; Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Ca | 2016 |
1 trial available for sulfasalazine and Lichen Planus
| Article | Year |
|---|---|
Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Lichen Planus; | 2010 |
7 other studies available for sulfasalazine and Lichen Planus
| Article | Year |
|---|---|
Late onset hypersensitivity to sulfasalazine in a patient with ankylosing spondylitis: comment on the article by Paul et al.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Drug Eruptions; Female | 2000 |
Successful treatment of lichen planus with sulfasalazine in 20 patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Dose-Resp | 2005 |
Mesalamine may be preferable to sulfasalazine in dermatologic therapeutics.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Lichen Planus; Mesalamine; Sulfasalazine; Treatment | 2006 |
Lichen planus in patients with rheumatoid arthritis treated with sulfasalazine.
Topics: Aged; Arthritis, Rheumatoid; Drug Eruptions; Female; Humans; Lichen Planus; Male; Middle Aged; Predn | 1995 |
Lichen planus and mesalazine.
Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Female; Humans; Lichen Planus; Male; Mesalamine; M | 1991 |
Atypical lichen planus associated with ulcerative colitis.
Topics: Colitis, Ulcerative; Female; Humans; Lichen Planus; Middle Aged; Sulfasalazine | 1986 |
Alopecia areata, vitiligo, scleroderma and ulcerative colitis.
Topics: Adult; Alopecia Areata; Barium Sulfate; Colitis, Ulcerative; Enema; Humans; Lichen Planus; Male; Pre | 1974 |