sulfasalazine has been researched along with Leukemia in 3 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Conceptually, it is accepted that MTX and folic acid are transported by folate receptors (FRs) in cancerous cells, but the exact mechanism of MTX uptake in human leukemia is unknown." | 3.75 | Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. ( Biswal, BK; Verma, RS, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biswal, BK | 1 |
| Verma, RS | 1 |
| ROSEN, RB | 1 |
| TEPLITZ, RL | 1 |
| Sykes, AP | 1 |
| Brampton, C | 1 |
| Klee, S | 1 |
| Chander, CL | 1 |
| Whelan, C | 1 |
| Parsons, ME | 1 |
3 other studies available for sulfasalazine and Leukemia
| Article | Year |
|---|---|
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells.
Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI | 2009 |
CHRONIC GRANULOCYTIC LEUKEMIA COMPLICATED BY ULCERATIVE COLITIS: ELEVATED LEUKOCYTE ALKALINE PHOSPHATASE AND POSSIBLE MODIFIER GENE DELETION.
Topics: Adolescent; Alkaline Phosphatase; Blood Cell Count; Chromosomes; Colitis, Ulcerative; Diet; Diet The | 1965 |
An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Inflammatory Bowel Diseases; Leukemia; Leu | 2000 |