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sulfasalazine and Intestinal Obstruction

sulfasalazine has been researched along with Intestinal Obstruction in 19 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.

Research Excerpts

ExcerptRelevanceReference
"The main aim of this study was to examine the differences between triple therapy (T: SSZ and HCQ added to MTX) and etanercept (E) added to MTX with regard to the infectious and gastrointestinal (GI) adverse events (AEs) reported in The Rheumatoid Arthritis Comparison of Active Therapies Trial."2.84Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events. ( Brophy, MT; Chang, BH; Hannagan, K; O'Dell, JR; Quach, LT; Soe Thwin, S, 2017)
"Crohn's disease is a perplexing panintestinal disease whose etiology is unknown."2.38Crohn's disease of the small bowel. ( Fazio, VW; Hyman, NH, 1991)
"Ulcerative colitis is not associated with a higher spontaneous abortion rate than the general population, although it is not clear whether certain subgroups of patients have a higher rate of abortion."2.36Inflammatory bowel disease and pregnancy. ( Spiro, HM; Vender, RJ, 1982)
"Crohn's disease is a perplexing disease with a high rate of morbidity and complications."2.35The protean manifestations of Crohn's disease. ( Farmer, RG, 1975)
"Recurrent Crohn's disease and that characterized by small bowel obstruction each displayed a characteristic appearance."1.26Radiographic findings of the National Cooperative Crohn's Disease Study. ( Caruthers, SB; Goldberg, HI; Nelson, JA; Singleton, JW, 1979)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199014 (73.68)18.7374
1990's1 (5.26)18.2507
2000's2 (10.53)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Quach, LT1
Chang, BH1
Brophy, MT1
Soe Thwin, S1
Hannagan, K1
O'Dell, JR1
Pilgrim, S1
Velchuru, V1
Waters, G1
Tsiamis, A1
Lal, R1
Krivosheev, OG1
Semenkova, EN1
Guliaev, SV1
Lenner, V1
Vender, RJ1
Spiro, HM1
Navarro, J1
Vargas, J1
Cezard, JP1
Charritat, JL1
Polonovski, C1
Berenguer, J2
Harary, AM1
Gluck, CA1
Rogers, AI1
Michell, NP1
Routledge, H1
Chesner, IM1
Goldberg, HI1
Caruthers, SB1
Nelson, JA1
Singleton, JW1
Farmer, RG1
Hyman, NH1
Fazio, VW1
Estrin, HM1
Hughes, RW1
Garrigues, V1
Ponce, J1
Brower, RA1
Gall, DG1
Hamilton, JR1
Duhamel, J1
Hoeffel, JC1
Berndt, H1
Fung, WP1
Monteiro, EH1
Ang, HB1
Kho, KM1
Lee, SK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
CSP #551 - Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy[NCT00405275]353 participants (Actual)Interventional2007-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mean 48-week Change in DAS28

"Average difference between 48-week and Baseline DAS28.~The Disease Activity Score for 28 Joints (DAS28) is a well-validated composite outcome measure ranging from 2-10 (higher scores indicating more disease) that incorporates a tender and swollen joint count of 28 joints, a laboratory measure of systemic inflammation (ESR) and a patient-reported general assessment of health on a visual analog scale (ranging from 0-10cm) all into one measure.~Low disease activity is defined as DAS28 ≤ 3.2 units." (NCT00405275)
Timeframe: 48 weeks after baseline assessment

Interventionunits on a scale (Mean)
Triple-2.12
Etanercept-2.29

Reviews

5 reviews available for sulfasalazine and Intestinal Obstruction

ArticleYear
Inflammatory bowel disease and pregnancy.
    Journal of clinical gastroenterology, 1982, Volume: 4, Issue:3

    Topics: Abortion, Spontaneous; Adolescent; Adrenocorticotropic Hormone; Adult; Colitis, Ulcerative; Crohn Di

1982
The protean manifestations of Crohn's disease.
    Postgraduate medicine, 1975, Volume: 57, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Arthritis; Azathioprine; Child; Colectomy; Colitis,

1975
Crohn's disease of the small bowel.
    Comprehensive therapy, 1991, Volume: 17, Issue:4

    Topics: Anti-Inflammatory Agents; Crohn Disease; Duodenitis; Humans; Ileitis; Intestinal Obstruction; Steroi

1991
Chronic diarrhea in childhood: a new look at an old problem.
    Pediatric clinics of North America, 1974, Volume: 21, Issue:4

    Topics: Celiac Disease; Chlorides; Chronic Disease; Cystic Fibrosis; Diarrhea; Diet Therapy; Food Hypersensi

1974
[Diagnosis and therapy of ulcerative colitis].
    Zeitschrift fur arztliche Fortbildung, 1969, Dec-15, Volume: 63, Issue:24

    Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Colonic Neoplasms; Diet Therapy; Diverticulitis; Gastr

1969

Trials

1 trial available for sulfasalazine and Intestinal Obstruction

ArticleYear
Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events.
    Rheumatology (Oxford, England), 2017, 03-01, Volume: 56, Issue:3

    Topics: Abscess; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etaner

2017

Other Studies

13 other studies available for sulfasalazine and Intestinal Obstruction

ArticleYear
Diaphragm disease and small bowel enteropathy due to nonsteroidal anti-inflammatory drugs: a surgical perspective.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2011, Volume: 13, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Constriction, Pathologic; Diaphragm; Diclofe

2011
[Abdominal emergencies in systemic vasculitis].
    Klinicheskaia meditsina, 2002, Volume: 80, Issue:8

    Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Digestive System Surgical

2002
[Treatment of early and late intestinal radiation injuries].
    Deutsche medizinische Wochenschrift (1946), 1980, Jun-27, Volume: 105, Issue:26

    Topics: Humans; Intestinal Obstruction; Intestines; Postoperative Complications; Radiation Injuries; Sulfasa

1980
Prolonged constant rate elemental enteral nutrition in Crohn's disease.
    Journal of pediatric gastroenterology and nutrition, 1982, Volume: 1, Issue:4

    Topics: Adolescent; Body Height; Body Weight; Cecum; Child; Crohn Disease; Enteral Nutrition; Female; Food,

1982
[Crohn's disease. Has there been progress in its treatment?].
    Medicina clinica, 1984, Jun-09, Volume: 83, Issue:2

    Topics: Crohn Disease; Drug Combinations; Female; Glucocorticoids; Glucosamine; Humans; Intestinal Obstructi

1984
Gastric retention of enteric-coated sulfasalazine tablets. A complication of gastroduodenal Crohn's disease.
    Digestive diseases and sciences, 1984, Volume: 29, Issue:11

    Topics: Adult; Crohn Disease; Duodenal Diseases; Female; Humans; Intestinal Obstruction; Stomach Diseases; S

1984
A case of intestinal obstruction.
    Postgraduate medical journal, 2000, Volume: 76, Issue:893

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Drug Combinations; Fema

2000
Radiographic findings of the National Cooperative Crohn's Disease Study.
    Gastroenterology, 1979, Volume: 77, Issue:4 Pt 2

    Topics: Adult; Age Factors; Azathioprine; Colon; Crohn Disease; Duodenum; Female; Humans; Ileum; Intestinal

1979
Oral manifestations in Crohn's disease: report of a case.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:5

    Topics: Adolescent; Barium Sulfate; Colon; Colonoscopy; Crohn Disease; Duodenoscopy; Esophagus; Gastrointest

1985
Retention of sulfasalazine tablets.
    Digestive diseases and sciences, 1985, Volume: 30, Issue:12

    Topics: Crohn Disease; Female; Humans; Intestinal Obstruction; Middle Aged; Sulfasalazine; Tablets, Enteric-

1985
Hydrostatic balloon dilation of a terminal ileal stricture secondary to Crohn's disease.
    Gastrointestinal endoscopy, 1986, Volume: 32, Issue:1

    Topics: Adult; Crohn Disease; Dilatation; Female; Follow-Up Studies; Humans; Ileal Diseases; Intestinal Obst

1986
[Hemorrhagic rectocolitis in children].
    La Presse medicale, 1969, Oct-04, Volume: 77, Issue:41

    Topics: Adolescent; Age Factors; Anus Diseases; Betamethasone; Blepharitis; Child; Child, Preschool; Colitis

1969
Ulcerative postdysenteric colitis.
    The American journal of gastroenterology, 1972, Volume: 57, Issue:4

    Topics: Adult; Biopsy; Colitis, Ulcerative; Colon; Dysentery, Amebic; Entamoeba histolytica; Humans; Intesti

1972