sulfasalazine has been researched along with Intestinal Obstruction in 19 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The main aim of this study was to examine the differences between triple therapy (T: SSZ and HCQ added to MTX) and etanercept (E) added to MTX with regard to the infectious and gastrointestinal (GI) adverse events (AEs) reported in The Rheumatoid Arthritis Comparison of Active Therapies Trial." | 2.84 | Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events. ( Brophy, MT; Chang, BH; Hannagan, K; O'Dell, JR; Quach, LT; Soe Thwin, S, 2017) |
| "Crohn's disease is a perplexing panintestinal disease whose etiology is unknown." | 2.38 | Crohn's disease of the small bowel. ( Fazio, VW; Hyman, NH, 1991) |
| "Ulcerative colitis is not associated with a higher spontaneous abortion rate than the general population, although it is not clear whether certain subgroups of patients have a higher rate of abortion." | 2.36 | Inflammatory bowel disease and pregnancy. ( Spiro, HM; Vender, RJ, 1982) |
| "Crohn's disease is a perplexing disease with a high rate of morbidity and complications." | 2.35 | The protean manifestations of Crohn's disease. ( Farmer, RG, 1975) |
| "Recurrent Crohn's disease and that characterized by small bowel obstruction each displayed a characteristic appearance." | 1.26 | Radiographic findings of the National Cooperative Crohn's Disease Study. ( Caruthers, SB; Goldberg, HI; Nelson, JA; Singleton, JW, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (73.68) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quach, LT | 1 |
| Chang, BH | 1 |
| Brophy, MT | 1 |
| Soe Thwin, S | 1 |
| Hannagan, K | 1 |
| O'Dell, JR | 1 |
| Pilgrim, S | 1 |
| Velchuru, V | 1 |
| Waters, G | 1 |
| Tsiamis, A | 1 |
| Lal, R | 1 |
| Krivosheev, OG | 1 |
| Semenkova, EN | 1 |
| Guliaev, SV | 1 |
| Lenner, V | 1 |
| Vender, RJ | 1 |
| Spiro, HM | 1 |
| Navarro, J | 1 |
| Vargas, J | 1 |
| Cezard, JP | 1 |
| Charritat, JL | 1 |
| Polonovski, C | 1 |
| Berenguer, J | 2 |
| Harary, AM | 1 |
| Gluck, CA | 1 |
| Rogers, AI | 1 |
| Michell, NP | 1 |
| Routledge, H | 1 |
| Chesner, IM | 1 |
| Goldberg, HI | 1 |
| Caruthers, SB | 1 |
| Nelson, JA | 1 |
| Singleton, JW | 1 |
| Farmer, RG | 1 |
| Hyman, NH | 1 |
| Fazio, VW | 1 |
| Estrin, HM | 1 |
| Hughes, RW | 1 |
| Garrigues, V | 1 |
| Ponce, J | 1 |
| Brower, RA | 1 |
| Gall, DG | 1 |
| Hamilton, JR | 1 |
| Duhamel, J | 1 |
| Hoeffel, JC | 1 |
| Berndt, H | 1 |
| Fung, WP | 1 |
| Monteiro, EH | 1 |
| Ang, HB | 1 |
| Kho, KM | 1 |
| Lee, SK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CSP #551 - Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy[NCT00405275] | 353 participants (Actual) | Interventional | 2007-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Average difference between 48-week and Baseline DAS28.~The Disease Activity Score for 28 Joints (DAS28) is a well-validated composite outcome measure ranging from 2-10 (higher scores indicating more disease) that incorporates a tender and swollen joint count of 28 joints, a laboratory measure of systemic inflammation (ESR) and a patient-reported general assessment of health on a visual analog scale (ranging from 0-10cm) all into one measure.~Low disease activity is defined as DAS28 ≤ 3.2 units." (NCT00405275)
Timeframe: 48 weeks after baseline assessment
| Intervention | units on a scale (Mean) |
|---|---|
| Triple | -2.12 |
| Etanercept | -2.29 |
5 reviews available for sulfasalazine and Intestinal Obstruction
| Article | Year |
|---|---|
Inflammatory bowel disease and pregnancy.
Topics: Abortion, Spontaneous; Adolescent; Adrenocorticotropic Hormone; Adult; Colitis, Ulcerative; Crohn Di | 1982 |
The protean manifestations of Crohn's disease.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Arthritis; Azathioprine; Child; Colectomy; Colitis, | 1975 |
Crohn's disease of the small bowel.
Topics: Anti-Inflammatory Agents; Crohn Disease; Duodenitis; Humans; Ileitis; Intestinal Obstruction; Steroi | 1991 |
Chronic diarrhea in childhood: a new look at an old problem.
Topics: Celiac Disease; Chlorides; Chronic Disease; Cystic Fibrosis; Diarrhea; Diet Therapy; Food Hypersensi | 1974 |
[Diagnosis and therapy of ulcerative colitis].
Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Colonic Neoplasms; Diet Therapy; Diverticulitis; Gastr | 1969 |
1 trial available for sulfasalazine and Intestinal Obstruction
| Article | Year |
|---|---|
Rheumatoid arthritis triple therapy compared with etanercept: difference in infectious and gastrointestinal adverse events.
Topics: Abscess; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Etaner | 2017 |
13 other studies available for sulfasalazine and Intestinal Obstruction
| Article | Year |
|---|---|
Diaphragm disease and small bowel enteropathy due to nonsteroidal anti-inflammatory drugs: a surgical perspective.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Constriction, Pathologic; Diaphragm; Diclofe | 2011 |
[Abdominal emergencies in systemic vasculitis].
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Digestive System Surgical | 2002 |
[Treatment of early and late intestinal radiation injuries].
Topics: Humans; Intestinal Obstruction; Intestines; Postoperative Complications; Radiation Injuries; Sulfasa | 1980 |
Prolonged constant rate elemental enteral nutrition in Crohn's disease.
Topics: Adolescent; Body Height; Body Weight; Cecum; Child; Crohn Disease; Enteral Nutrition; Female; Food, | 1982 |
[Crohn's disease. Has there been progress in its treatment?].
Topics: Crohn Disease; Drug Combinations; Female; Glucocorticoids; Glucosamine; Humans; Intestinal Obstructi | 1984 |
Gastric retention of enteric-coated sulfasalazine tablets. A complication of gastroduodenal Crohn's disease.
Topics: Adult; Crohn Disease; Duodenal Diseases; Female; Humans; Intestinal Obstruction; Stomach Diseases; S | 1984 |
A case of intestinal obstruction.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Diclofenac; Drug Combinations; Fema | 2000 |
Radiographic findings of the National Cooperative Crohn's Disease Study.
Topics: Adult; Age Factors; Azathioprine; Colon; Crohn Disease; Duodenum; Female; Humans; Ileum; Intestinal | 1979 |
Oral manifestations in Crohn's disease: report of a case.
Topics: Adolescent; Barium Sulfate; Colon; Colonoscopy; Crohn Disease; Duodenoscopy; Esophagus; Gastrointest | 1985 |
Retention of sulfasalazine tablets.
Topics: Crohn Disease; Female; Humans; Intestinal Obstruction; Middle Aged; Sulfasalazine; Tablets, Enteric- | 1985 |
Hydrostatic balloon dilation of a terminal ileal stricture secondary to Crohn's disease.
Topics: Adult; Crohn Disease; Dilatation; Female; Follow-Up Studies; Humans; Ileal Diseases; Intestinal Obst | 1986 |
[Hemorrhagic rectocolitis in children].
Topics: Adolescent; Age Factors; Anus Diseases; Betamethasone; Blepharitis; Child; Child, Preschool; Colitis | 1969 |
Ulcerative postdysenteric colitis.
Topics: Adult; Biopsy; Colitis, Ulcerative; Colon; Dysentery, Amebic; Entamoeba histolytica; Humans; Intesti | 1972 |