sulfasalazine has been researched along with Innate Inflammatory Response in 74 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)." | 7.88 | Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model. ( Bae, JH; Kim, HJ; Kim, SE; Lee, JY; Lee, S; Min, K; Park, K; Shim, KS; Song, HR, 2018) |
| "In the current study, the overall prevalence and the main underlying etiologies of inflammatory low back pain (ILBP) were determined, and the effectiveness of treatment with sulfasalazine was investigated in patients with inflammatory versus mechanical low back pain (LBP)." | 7.83 | Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation. ( Ghorbani, R; Moghimi, J; Pahlevan, D; Razavi, MR; Rezaei, AA, 2016) |
| "To investigate the effects of sulfasalazine (SF) on pancreatic inflammation and fibrogenesis." | 7.83 | Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury. ( Fan, JH; Kuang, RG; Li, YQ; Tian, FL; Wang, LY; Wang, YR; Yan, MX, 2016) |
| "The anti-inflammatory effect of three flavonoids from the root of Scutellaria baicalensis (baicalein, baicalin and wogonin) was evaluated in a murine model of acute experimental colitis induced by dextran sulfate sodium (DSS)." | 7.71 | Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. ( Cho, S; Cyong, JC; Hong, T; Jin, GB, 2002) |
| "Patients with axSpA, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4, were recruited." | 5.72 | Adalimumab and sulfasalazine in alleviating sacroiliac and aortic inflammation detected in PET/CT in patients with axial spondyloarthritis: PETSPA. ( Eklund, K; Kaijasilta, JP; Kauppi, MJ; Kerola, AM; Kerola, T; Koivu, H; Loimaala, A; Nieminen, TVM; Relas, H; Schildt, J; Tuompo, R, 2022) |
| "Sulfasalazine is a recognized therapy for inflammatory bowel disease and is of paramount importance for maintaining intestinal barrier homeostasis." | 5.62 | Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC/D3 cells. ( Cao, Y; Chang, S, 2021) |
| "Allicin has anti-inflammatory, antioxidative and proapoptotic properties." | 5.42 | Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. ( Guo, Y; Lei, S; Li, C; Lun, W; Ma, J; Zhao, X; Zhi, F, 2015) |
| "Mesalamine suppositories have been used widely for the treatment of distal ulcerative colitis and considered to be safer than systemic administration for its limited systemic absorption." | 5.40 | Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity. ( Ding, H; Hu, J; Hu, XY; Liu, XC; Mei, Q; Xu, JM, 2014) |
| "Curcumin is a widely used spice with anti-inflammatory and anticancer properties." | 5.39 | Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway. ( Chen, L; Liao, H; Lv, X; Zeng, Z; Zhan, L, 2013) |
| "Sulphasalazine, THC and CBD proved beneficial in this model of colitis with the dose-response relationship for the phytocannabinoids showing a bell-shaped pattern on the majority of parameters (optimal THC and CBD dose, 10 mg." | 5.36 | The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. ( Jamontt, JM; Molleman, A; Parsons, ME; Pertwee, RG, 2010) |
| "To investigate the relationships between inflammation, nocturnal back pain and fatigue in ankylosing spondylitis (AS) and the impact of 12 weeks' etanercept treatment versus sulfasalazine or placebo." | 4.89 | Associations between inflammation, nocturnal back pain and fatigue in ankylosing spondylitis and improvements with etanercept therapy. ( Hammoudeh, M; Koenig, AS; Li, W; Stewart, VM; Zack, DJ, 2013) |
| " We investigated the effect of melittin peptide alone and in combination with sulfasalazine on improving the clinical symptoms among DSS-induced colitis models." | 4.12 | Evaluation of the therapeutic effect of melittin peptide on the ulcerative colitis mouse model. ( Amel Jamehdar, S; Ghazvini, K; Reza Akbari Eidgahi, M; Yaghoubi, A, 2022) |
| "The aim of this study was to investigate the effects of a sulfasalazine-containing hyaluronic acid (SASP/HA) systems on in vitro anti-inflammation and the alleviation of cartilage degradation in both lipopolysaccharide (LPS)-stimulated synoviocytes and a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA)." | 3.88 | Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model. ( Bae, JH; Kim, HJ; Kim, SE; Lee, JY; Lee, S; Min, K; Park, K; Shim, KS; Song, HR, 2018) |
| "In the current study, the overall prevalence and the main underlying etiologies of inflammatory low back pain (ILBP) were determined, and the effectiveness of treatment with sulfasalazine was investigated in patients with inflammatory versus mechanical low back pain (LBP)." | 3.83 | Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation. ( Ghorbani, R; Moghimi, J; Pahlevan, D; Razavi, MR; Rezaei, AA, 2016) |
| "To investigate the effects of sulfasalazine (SF) on pancreatic inflammation and fibrogenesis." | 3.83 | Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury. ( Fan, JH; Kuang, RG; Li, YQ; Tian, FL; Wang, LY; Wang, YR; Yan, MX, 2016) |
| "It has been previously reported that aspirin inhibited the development of diabetic retinopathy in diabetic animals, raising the possibility that anti-inflammatory drugs may have beneficial effects on diabetic retinopathy." | 3.74 | Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. ( Hatala, DA; Howell, SJ; Huang, K; Kern, TS; Zheng, L, 2007) |
| "The anti-inflammatory effect of three flavonoids from the root of Scutellaria baicalensis (baicalein, baicalin and wogonin) was evaluated in a murine model of acute experimental colitis induced by dextran sulfate sodium (DSS)." | 3.71 | Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. ( Cho, S; Cyong, JC; Hong, T; Jin, GB, 2002) |
| "Rheumatoid arthritis is a chronic, systemic inflammatory disease that carries an increased risk of mortality due to cardiovascular disease." | 2.72 | Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation. ( Chen, J; Cooper, D; Norling, LV, 2021) |
| "It is concluded that maintenance treatment of ulcerative colitis with sulphasalazine should be continued indefinitely unless contraindicated by side effects." | 2.64 | A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin). ( Dissanayake, AS; Truelove, SC, 1973) |
| "In contrast to other agents used in the treatment of ulcerative colitis, 5-ASA does not have any known anti-inflammatory effect on other organs or other colonic inflammatory diseases like diverticulitis." | 2.52 | 5-Aminosalicylic acid, a specific drug for ulcerative colitis. ( Hauso, Ø; Martinsen, TC; Waldum, H, 2015) |
| "Patients with axSpA, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4, were recruited." | 1.72 | Adalimumab and sulfasalazine in alleviating sacroiliac and aortic inflammation detected in PET/CT in patients with axial spondyloarthritis: PETSPA. ( Eklund, K; Kaijasilta, JP; Kauppi, MJ; Kerola, AM; Kerola, T; Koivu, H; Loimaala, A; Nieminen, TVM; Relas, H; Schildt, J; Tuompo, R, 2022) |
| "Sulfasalazine is a recognized therapy for inflammatory bowel disease and is of paramount importance for maintaining intestinal barrier homeostasis." | 1.62 | Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC/D3 cells. ( Cao, Y; Chang, S, 2021) |
| "The potential of probiotics for treating ulcerative colitis (UC) has attracted increasing attention." | 1.56 | Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function. ( Cui, J; Ma, W; Ning, K; Wang, Y; Xiang, H; Xiang, JY; Xie, Q; Zhang, Y, 2020) |
| "Allicin has anti-inflammatory, antioxidative and proapoptotic properties." | 1.42 | Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells. ( Guo, Y; Lei, S; Li, C; Lun, W; Ma, J; Zhao, X; Zhi, F, 2015) |
| " The multi-layered enteric polymer coating could potentially protect nanoparticle dissolution at gastric pH and accelerate the dissolution velocity, which would improve the drug bioavailability in the colon." | 1.42 | Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice. ( Deng, JP; Jeng, CC; Kankala, RK; Kankala, S; Kuthati, Y; Lee, CH; Liu, CL; Lue, SI; Shih, HY; Sie, HW; Weng, CF, 2015) |
| "Mesalamine suppositories have been used widely for the treatment of distal ulcerative colitis and considered to be safer than systemic administration for its limited systemic absorption." | 1.40 | Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity. ( Ding, H; Hu, J; Hu, XY; Liu, XC; Mei, Q; Xu, JM, 2014) |
| "Cachexia is a relevant comorbid condition of chronic diseases including cancer." | 1.40 | Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness. ( Barreiro, E; Chacon-Cabrera, A; de Kier Joffé, ED; Diament, MJ; Fermoselle, C; Mateu-Jimenez, M; Sandri, M; Urtreger, AJ, 2014) |
| "Curcumin is a widely used spice with anti-inflammatory and anticancer properties." | 1.39 | Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway. ( Chen, L; Liao, H; Lv, X; Zeng, Z; Zhan, L, 2013) |
| "Sulphasalazine, THC and CBD proved beneficial in this model of colitis with the dose-response relationship for the phytocannabinoids showing a bell-shaped pattern on the majority of parameters (optimal THC and CBD dose, 10 mg." | 1.36 | The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. ( Jamontt, JM; Molleman, A; Parsons, ME; Pertwee, RG, 2010) |
| "Colitis was induced by a single intracolonic administration of TNBS dissolved in 35% ethanol." | 1.35 | Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. ( Avti, PK; Khanduja, KL; Medhi, B; Pandhi, P; Prakash, A; Saikia, UN, 2008) |
| "Cotreatment with sulfasalazine, which inhibited nuclear translocation of NF-kappaB p65, had a rapid and marked inhibitory effect on the rate of cytokine accumulation in the maternal compartment, with lesser but significant effects observed in the fetal compartment." | 1.35 | Prevention of inflammatory activation of human gestational membranes in an ex vivo model using a pharmacological NF-kappaB inhibitor. ( Keelan, JA; Khan, S; Mitchell, MD; Yosaatmadja, F, 2009) |
| "The 'aggressive' drug treatment consisted of institution of relatively fast-acting disease-modifying anti-rheumatic drugs (DMARDs) (sulphasalazine, methotrexate) immediately after diagnosis, and rapid adjustment of dosage and/or drug in the case of insufficient response as measured by a change in C-reactive protein (CRP) level." | 1.30 | Early effective suppression of inflammation in rheumatoid arthritis reduces radiographic progression. ( Barendsen, BC; Bruyn, GA; Houtman, PM; Speerstra, F; Stenger, AA; Van Leeuwen, MA; van Rijswijk, MH; Velthuysen, E, 1998) |
| "Twenty-nine patients with ankylosing spondylitis (AS) were studied in an attempt to evaluate the role of T lymphocytes in this disease and a possible influence of treatment." | 1.27 | T lymphocytes in ankylosing spondylitis and the influence of sulphasalazine treatment. ( Feltelius, N; Hällgren, R; Sjöberg, O, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (20.27) | 18.7374 |
| 1990's | 8 (10.81) | 18.2507 |
| 2000's | 11 (14.86) | 29.6817 |
| 2010's | 27 (36.49) | 24.3611 |
| 2020's | 13 (17.57) | 2.80 |
| Authors | Studies |
|---|---|
| Junek, R | 1 |
| Kverka, M | 1 |
| Jandera, A | 1 |
| Panajotová, V | 1 |
| Satinský, D | 1 |
| Machácek, M | 1 |
| Kuchar, M | 1 |
| Quang, TH | 1 |
| Ngan, NT | 1 |
| Minh, CV | 1 |
| Kiem, PV | 1 |
| Tai, BH | 1 |
| Thao, NP | 1 |
| Song, SB | 1 |
| Kim, YH | 1 |
| Ma, L | 1 |
| Gong, H | 1 |
| Zhu, H | 1 |
| Ji, Q | 1 |
| Su, P | 1 |
| Liu, P | 1 |
| Cao, S | 1 |
| Yao, J | 1 |
| Jiang, L | 1 |
| Han, M | 1 |
| Ma, X | 1 |
| Xiong, D | 1 |
| Luo, HR | 1 |
| Wang, F | 2 |
| Zhou, J | 1 |
| Xu, Y | 1 |
| AlFadly, ED | 1 |
| Elzahhar, PA | 1 |
| Tramarin, A | 1 |
| Elkazaz, S | 1 |
| Shaltout, H | 1 |
| Abu-Serie, MM | 1 |
| Janockova, J | 1 |
| Soukup, O | 1 |
| Ghareeb, DA | 1 |
| El-Yazbi, AF | 1 |
| Rafeh, RW | 1 |
| Bakkar, NZ | 1 |
| Kobeissy, F | 1 |
| Iriepa, I | 1 |
| Moraleda, I | 1 |
| Saudi, MNS | 1 |
| Bartolini, M | 1 |
| Belal, ASF | 1 |
| Kaijasilta, JP | 1 |
| Kerola, AM | 1 |
| Tuompo, R | 1 |
| Relas, H | 1 |
| Loimaala, A | 1 |
| Koivu, H | 1 |
| Schildt, J | 1 |
| Kerola, T | 1 |
| Eklund, K | 1 |
| Kauppi, MJ | 1 |
| Nieminen, TVM | 1 |
| Mikkelsen, RR | 1 |
| Hundahl, MP | 1 |
| Torp, CK | 1 |
| Rodríguez-Carrio, J | 1 |
| Kjolby, M | 1 |
| Bruun, JM | 1 |
| Kragstrup, TW | 1 |
| Yaghoubi, A | 1 |
| Amel Jamehdar, S | 1 |
| Reza Akbari Eidgahi, M | 1 |
| Ghazvini, K | 1 |
| Wang, W | 2 |
| Ning, Y | 1 |
| Wang, Y | 3 |
| Deng, G | 2 |
| Pace, S | 1 |
| Barth, SA | 1 |
| Menge, C | 1 |
| Zhang, K | 1 |
| Dai, Y | 1 |
| Cai, Y | 2 |
| Chen, X | 3 |
| Werz, O | 1 |
| Li, L | 1 |
| Zhao, L | 1 |
| Ye, G | 1 |
| Shi, F | 1 |
| Li, Y | 1 |
| Zou, Y | 1 |
| Song, X | 1 |
| Zhao, X | 2 |
| Yin, Z | 1 |
| Wu, X | 3 |
| Li, W | 2 |
| Tang, H | 1 |
| Feria-Garzón, MG | 1 |
| Rugeles, MT | 1 |
| Hernandez, JC | 1 |
| Lujan, JA | 1 |
| Taborda, NA | 1 |
| Hoy, Z | 1 |
| Wright, TW | 1 |
| Elliott, M | 1 |
| Malone, J | 1 |
| Bhagwat, S | 1 |
| Wang, J | 1 |
| Gigliotti, F | 1 |
| Wang, ZG | 1 |
| Ying, XG | 1 |
| Gao, P | 1 |
| Wang, CL | 1 |
| Wang, YF | 1 |
| Yu, XW | 1 |
| Chen, J | 2 |
| Wang, B | 1 |
| Luo, HY | 1 |
| Lee, SB | 1 |
| Han, YR | 1 |
| Jeon, HJ | 1 |
| Jun, CH | 1 |
| Kim, SK | 1 |
| Chin, J | 1 |
| Lee, SJ | 1 |
| Jeong, M | 1 |
| Lee, JE | 1 |
| Lee, CH | 2 |
| Cho, SJ | 1 |
| Kim, DS | 1 |
| Jeon, YH | 1 |
| Xie, Q | 1 |
| Zhang, Y | 1 |
| Ma, W | 1 |
| Ning, K | 1 |
| Xiang, JY | 1 |
| Cui, J | 1 |
| Xiang, H | 1 |
| Wang, Z | 1 |
| Liang, Y | 1 |
| Yu, J | 1 |
| Zhang, D | 1 |
| Ren, L | 1 |
| Zhang, Z | 1 |
| Liu, Y | 1 |
| Liu, L | 1 |
| Tang, Z | 1 |
| Yu, H | 1 |
| Hu, K | 1 |
| Zhang, T | 1 |
| Ren, H | 1 |
| Lin, G | 1 |
| Li, M | 1 |
| Xu, N | 1 |
| Liu, J | 1 |
| Wu, Y | 1 |
| Zhang, Q | 1 |
| Cai, J | 1 |
| Gao, C | 1 |
| Su, Z | 1 |
| Xu, T | 1 |
| Lv, X | 2 |
| Zhang, J | 1 |
| Liu, S | 1 |
| Chang, S | 1 |
| Cao, Y | 1 |
| Norling, LV | 1 |
| Cooper, D | 1 |
| Kim, SE | 1 |
| Lee, JY | 1 |
| Shim, KS | 1 |
| Lee, S | 1 |
| Min, K | 1 |
| Bae, JH | 1 |
| Kim, HJ | 1 |
| Park, K | 1 |
| Song, HR | 1 |
| Yang, X | 1 |
| Wu, D | 1 |
| Li, J | 1 |
| Shen, M | 1 |
| Zhang, W | 1 |
| Hammoudeh, M | 1 |
| Zack, DJ | 1 |
| Stewart, VM | 1 |
| Koenig, AS | 1 |
| Chacon-Cabrera, A | 1 |
| Fermoselle, C | 1 |
| Urtreger, AJ | 1 |
| Mateu-Jimenez, M | 1 |
| Diament, MJ | 1 |
| de Kier Joffé, ED | 1 |
| Sandri, M | 1 |
| Barreiro, E | 1 |
| Xu, J | 1 |
| Weng, Z | 1 |
| Arumugam, A | 1 |
| Tang, X | 1 |
| Chaudhary, SC | 1 |
| Li, C | 2 |
| Christiano, AM | 1 |
| Elmets, CA | 1 |
| Bickers, DR | 1 |
| Athar, M | 1 |
| Ding, H | 1 |
| Liu, XC | 1 |
| Mei, Q | 1 |
| Xu, JM | 1 |
| Hu, XY | 1 |
| Hu, J | 1 |
| Ficjan, A | 1 |
| Husic, R | 1 |
| Gretler, J | 1 |
| Lackner, A | 1 |
| Graninger, WB | 1 |
| Gutierrez, M | 1 |
| Duftner, C | 1 |
| Hermann, J | 1 |
| Dejaco, C | 1 |
| Lun, W | 1 |
| Lei, S | 1 |
| Guo, Y | 1 |
| Ma, J | 1 |
| Zhi, F | 1 |
| Hauso, Ø | 1 |
| Martinsen, TC | 1 |
| Waldum, H | 1 |
| Brenol, CV | 1 |
| da Chakr, RM | 1 |
| Andrade, NP | 1 |
| Toni, M | 1 |
| Laurindo, IM | 1 |
| Brenol, JC | 1 |
| Xavier, RM | 1 |
| Latremoliere, A | 1 |
| Latini, A | 1 |
| Andrews, N | 1 |
| Cronin, SJ | 1 |
| Fujita, M | 1 |
| Gorska, K | 1 |
| Hovius, R | 1 |
| Romero, C | 1 |
| Chuaiphichai, S | 1 |
| Painter, M | 1 |
| Miracca, G | 1 |
| Babaniyi, O | 1 |
| Remor, AP | 1 |
| Duong, K | 1 |
| Riva, P | 1 |
| Barrett, LB | 1 |
| Ferreirós, N | 1 |
| Naylor, A | 1 |
| Penninger, JM | 1 |
| Tegeder, I | 1 |
| Zhong, J | 1 |
| Blagg, J | 1 |
| Channon, KM | 1 |
| Johnsson, K | 1 |
| Costigan, M | 1 |
| Woolf, CJ | 1 |
| Kankala, RK | 1 |
| Kuthati, Y | 1 |
| Sie, HW | 1 |
| Shih, HY | 1 |
| Lue, SI | 1 |
| Kankala, S | 1 |
| Jeng, CC | 1 |
| Deng, JP | 1 |
| Weng, CF | 1 |
| Liu, CL | 1 |
| Pandrea, I | 1 |
| Xu, C | 1 |
| Stock, JL | 1 |
| Frank, DN | 1 |
| Ma, D | 1 |
| Policicchio, BB | 1 |
| He, T | 1 |
| Kristoff, J | 1 |
| Cornell, E | 1 |
| Haret-Richter, GS | 1 |
| Trichel, A | 1 |
| Ribeiro, RM | 1 |
| Tracy, R | 1 |
| Wilson, C | 1 |
| Landay, AL | 1 |
| Apetrei, C | 1 |
| Yang, Q | 1 |
| Liao, M | 1 |
| Wang, H | 1 |
| Zhang, C | 1 |
| Nambi, S | 1 |
| Zhang, M | 1 |
| Wu, J | 1 |
| Deng, Q | 1 |
| Liu, H | 1 |
| Zhou, B | 1 |
| Jin, Q | 1 |
| Feng, CG | 1 |
| Sassetti, CM | 1 |
| Wang, YR | 1 |
| Tian, FL | 1 |
| Yan, MX | 1 |
| Fan, JH | 1 |
| Wang, LY | 1 |
| Kuang, RG | 1 |
| Li, YQ | 1 |
| Moghimi, J | 1 |
| Rezaei, AA | 1 |
| Ghorbani, R | 1 |
| Razavi, MR | 1 |
| Pahlevan, D | 1 |
| Prakash, A | 1 |
| Medhi, B | 1 |
| Avti, PK | 1 |
| Saikia, UN | 1 |
| Pandhi, P | 1 |
| Khanduja, KL | 1 |
| Akar, S | 1 |
| Birlik, M | 1 |
| Sari, I | 1 |
| Onen, F | 1 |
| Akkoc, N | 1 |
| Keelan, JA | 1 |
| Khan, S | 1 |
| Yosaatmadja, F | 1 |
| Mitchell, MD | 1 |
| Rodríguez-Reyna, TS | 1 |
| Martínez-Reyes, C | 1 |
| Yamamoto-Furusho, JK | 1 |
| Jamontt, JM | 1 |
| Molleman, A | 1 |
| Pertwee, RG | 1 |
| Parsons, ME | 1 |
| Bertucci, MC | 1 |
| Loose, JM | 1 |
| Wallace, EM | 1 |
| Jenkin, G | 1 |
| Miller, SL | 1 |
| Söderlin, MK | 1 |
| Bergman, S | 1 |
| Abdallah, DM | 1 |
| Ismael, NR | 1 |
| Zeng, Z | 1 |
| Zhan, L | 1 |
| Liao, H | 1 |
| Chen, L | 1 |
| Lappas, M | 1 |
| Yee, K | 1 |
| Permezel, M | 1 |
| Rice, GE | 1 |
| Joshi, R | 1 |
| Kumar, S | 1 |
| Unnikrishnan, M | 1 |
| Mukherjee, T | 1 |
| Zheng, L | 1 |
| Howell, SJ | 1 |
| Hatala, DA | 1 |
| Huang, K | 1 |
| Kern, TS | 1 |
| Kirsner, JB | 1 |
| Ali, AT | 1 |
| Basran, GS | 1 |
| Morley, J | 1 |
| Janowitz, HD | 1 |
| Sachar, DB | 1 |
| Petrelli, EA | 1 |
| McKinley, M | 1 |
| Troncale, FJ | 1 |
| Cosentino, MJ | 1 |
| Chey, WY | 1 |
| Takihara, H | 1 |
| Cockett, AT | 1 |
| Cronstein, BN | 2 |
| Cairns, BA | 1 |
| Herbst, CA | 1 |
| Sartor, BR | 1 |
| Briggaman, RA | 1 |
| Koruda, MJ | 1 |
| Leirisalo-Repo, M | 1 |
| Stenger, AA | 1 |
| Van Leeuwen, MA | 1 |
| Houtman, PM | 1 |
| Bruyn, GA | 1 |
| Speerstra, F | 1 |
| Barendsen, BC | 1 |
| Velthuysen, E | 1 |
| van Rijswijk, MH | 1 |
| Montesinos, MC | 1 |
| Weissmann, G | 1 |
| Kerr, SW | 1 |
| Wolyniec, WW | 1 |
| Filipovic, Z | 1 |
| Nodop, SG | 1 |
| Braza, F | 1 |
| Winquist, RJ | 1 |
| Noonan, TC | 1 |
| Boers, M | 1 |
| Kostense, PJ | 1 |
| Verhoeven, AC | 1 |
| van der Linden, S | 1 |
| Hong, T | 1 |
| Jin, GB | 1 |
| Cho, S | 1 |
| Cyong, JC | 1 |
| Haddad, JJ | 1 |
| Tamai, H | 1 |
| Levin, S | 1 |
| Gaginella, TS | 1 |
| Wallace, JL | 1 |
| Keenan, CM | 1 |
| Donowitz, M | 1 |
| Del Soldato, P | 1 |
| Foschi, D | 1 |
| Varin, L | 1 |
| Daniotti, S | 1 |
| Modigliani, R | 1 |
| Rambaud, JC | 1 |
| Feltelius, N | 2 |
| Hällgren, R | 2 |
| Venge, P | 1 |
| Gendre, JP | 1 |
| Sjöberg, O | 1 |
| Dissanayake, AS | 1 |
| Truelove, SC | 1 |
| Gall, DG | 1 |
| Hamilton, JR | 1 |
| Miller, B | 1 |
| Martini, GA | 1 |
| Demling, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Exploratory, Randomized, Double-blind, Parallel-group, Multicenter Study to Compare Secukinumab 300 mg With Placebo After 16 Weeks of Treatment in Adults With Moderate to Severe Plaque Psoriasis and Subclinical Enthesitis Measured by Musculoskeletal Ul[NCT04488185] | Phase 4 | 0 participants (Actual) | Interventional | 2020-11-02 | Withdrawn (stopped due to low recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for sulfasalazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Immunomodulatory and immunosuppressive therapies in cardiovascular disease and type 2 diabetes mellitus: A bedside-to-bench approach.
Topics: Animals; Antibodies, Monoclonal, Humanized; Cardiovascular Diseases; Colchicine; Diabetes Mellitus, | 2022 |
Cardiac Dysfunction in Rheumatoid Arthritis: The Role of Inflammation.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheuma | 2021 |
A Chinese case series of Yao syndrome and literature review.
Topics: Adult; Asian People; China; Female; Fever; Foot; Genetic Variation; Genotype; Glucocorticoids; Hered | 2018 |
Associations between inflammation, nocturnal back pain and fatigue in ankylosing spondylitis and improvements with etanercept therapy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; C-Reactive Protein; Etanercept; Fatigue; | 2013 |
5-Aminosalicylic acid, a specific drug for ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colon; Humans; Inflammation; | 2015 |
Rheumatic manifestations of inflammatory bowel disease.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cadherins; Cytokines; Gastroenter | 2009 |
Observations on the medical treatment of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Clinical Trials as Topic; Colitis, Ulcerative; Crohn | 1980 |
Inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Adult; Child; Colectomy; Colitis, Ulcerative; Crohn Disease; Female; Humans | 1982 |
A novel approach to the development of anti-inflammatory agents: adenosine release at inflamed sites.
Topics: Adenosine; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Humans; Inflammation; Methotrexate; Sulf | 1995 |
Peristomal pyoderma gangrenosum and inflammatory bowel disease.
Topics: Adolescent; Adult; Biopsy; Colostomy; Crohn Disease; Dapsone; Female; Humans; Ileostomy; Inflammatio | 1994 |
Therapeutic aspects of spondyloarthropathies -- a review.
Topics: Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Infectious; Chlamydia Infections; Chlamydia | 1998 |
[New salazosulfapyridine derivatives. Progress in the treatment of chronic inflammatory diseases of the intestines?].
Topics: Administration, Oral; Administration, Rectal; Chronic Disease; Colitis, Ulcerative; Crohn Disease; D | 1987 |
[New forms of 5-aminosalicylate in inflammatory intestinal lesions].
Topics: Aminosalicylic Acids; Drug Combinations; Glucosamine; Humans; Inflammation; Intestinal Diseases; Mes | 1987 |
Chronic diarrhea in childhood: a new look at an old problem.
Topics: Celiac Disease; Chlorides; Chronic Disease; Cystic Fibrosis; Diarrhea; Diet Therapy; Food Hypersensi | 1974 |
[What is secured in the therapy of chronic inflammatory colonic diseases?].
Topics: Administration, Topical; Amebiasis; Azathioprine; Chronic Disease; Colitis; Colitis, Ulcerative; Col | 1974 |
3 trials available for sulfasalazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Observations on the medical treatment of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Clinical Trials as Topic; Colitis, Ulcerative; Crohn | 1980 |
Inflammation and damage in an individual joint predict further damage in that joint in patients with early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Therapy, Combina | 2001 |
A controlled therapeutic trial of long-term maintenance treatment of ulcerative colitis with sulphazalazine (Salazopyrin).
Topics: Biopsy; Blood Cell Count; Blood Sedimentation; Clinical Trials as Topic; Colitis, Ulcerative; Headac | 1973 |
57 other studies available for sulfasalazine and Innate Inflammatory Response
| Article | Year |
|---|---|
Antileukotrienic phenethylamido derivatives of arylalkanoic acids in the treatment of ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Carboxylic Acids; Cells, Cultured; Colitis, Ulcerative; Gastroint | 2009 |
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Topics: Anti-Inflammatory Agents; Asarum; Cyclooxygenase 2; Dose-Response Relationship, Drug; Furans; Hep G2 | 2012 |
A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.
Topics: Animals; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose- | 2014 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Cyclooxygenase 2 In | 2019 |
Adalimumab and sulfasalazine in alleviating sacroiliac and aortic inflammation detected in PET/CT in patients with axial spondyloarthritis: PETSPA.
Topics: Adalimumab; Aorta; Axial Spondyloarthritis; Humans; Inflammation; Positron Emission Tomography Compu | 2022 |
Evaluation of the therapeutic effect of melittin peptide on the ulcerative colitis mouse model.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mod | 2022 |
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cytokines; Dinoprostone; Humans; Inflammation; | 2022 |
Sanhuang xiexin decoction ameliorates secondary liver injury in DSS-induced colitis involve regulating inflammation and bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Mod | 2022 |
Sulfasalazine as an Immunomodulator of the Inflammatory Process during HIV-1 Infection.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Apoptosis Regulatory Proteins; CD4-Positive | 2019 |
Combination Immunotherapy with Passive Antibody and Sulfasalazine Accelerates Fungal Clearance and Promotes the Resolution of
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Cytokines; Female; Fungi; Immunologic Factors; Immuno | 2020 |
Anti-Inflammatory Activity of a Peptide from Skipjack (
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colo | 2019 |
Medical fluorophore 1 (MF1), a benzoquinolizinium-based fluorescent dye, as an inflammation imaging agent.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cytokines; Dexamethasone; Fibroblasts; Fluore | 2019 |
Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Dysbiosis; | 2020 |
Guchang Zhixie Wan protects mice against dextran sulfate sodium-induced colitis through modulating the gut microbiota in colon.
Topics: Animals; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Dose-Response Relations | 2020 |
Identification of Target Genes Related to Sulfasalazine in Triple-Negative Breast Cancer Through Network Pharmacology.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computational Biology; Female; Gene Regulatory Networks; Hu | 2020 |
Anti-Inflammatory Effects of
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Azathioprine; Chromatography, Liquid; Colitis; Colitis | 2020 |
Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3/miR-214 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disea | 2021 |
Sulfasalazine maintains blood-brain barrier integrity and relieves lipopolysaccharide-induced inflammation in hCMEC/D3 cells.
Topics: Anti-Inflammatory Agents; Blood-Brain Barrier; Cell Line; Cell Survival; Endothelial Cells; Humans; | 2021 |
Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model.
Topics: Animals; Cartilage; Hyaluronic Acid; Inflammation; Lipopolysaccharides; Osteoarthritis; Rats; Rats, | 2018 |
Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness.
Topics: Animals; Autophagy; Boronic Acids; Bortezomib; Butadienes; Cachexia; Cell Line, Tumor; Inflammation; | 2014 |
Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Basal Cell; Cell Proliferation; Fe | 2014 |
Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity.
Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colonoscopy; Di | 2014 |
Ultrasound composite scores for the assessment of inflammatory and structural pathologies in Psoriatic Arthritis (PsASon-Score).
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Bone and Bones; Feasibility Studies; Female; Foll | 2014 |
Allicin alleviates inflammation of trinitrobenzenesulfonic acid-induced rats and suppresses P38 and JNK pathways in Caco-2 cells.
Topics: Animals; Caco-2 Cells; Disulfides; Humans; Inflammation; Interleukin-1beta; JNK Mitogen-Activated Pr | 2015 |
Daily practice feasibility and effectiveness of treating long-standing rheumatoid arthritis to target with synthetic disease-modifying antirheumatic drugs: a prospective cohort study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Feasibility Stu | 2015 |
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Topics: Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopterins; Blood Pressur | 2015 |
Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Cell Line, Tumor; Drug Ca | 2015 |
Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Flow Cytometry; Immunohistochemistry; Infl | 2016 |
xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation.
Topics: Amino Acid Transport System y+; Animals; Anti-Infective Agents; Case-Control Studies; Cell Line, Tum | 2016 |
Sulfasalazine inhibits inflammation and fibrogenesis in pancreas via NF-κB signaling pathway in rats with oxidative stress-induced pancreatic injury.
Topics: Animals; Fibrosis; Inflammation; Injections, Intraperitoneal; NF-kappa B; Oxidative Stress; Pancreas | 2016 |
Efficacy of an acquainted drug in the treatment of inflammatory low back pain: sulfasalazine under investigation.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Inflammation; Low Back P | 2016 |
Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Colitis; Colon; Disease Models, Animal; Glutathione; Ho | 2008 |
M694V mutation may have a role in susceptibility to ankylosing spondylitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diclofenac; Drug Combinations; Female; F | 2009 |
Prevention of inflammatory activation of human gestational membranes in an ex vivo model using a pharmacological NF-kappaB inhibitor.
Topics: Amnion; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Cytokines; Female; Humans | 2009 |
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.
Topics: Animals; Cannabidiol; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Dron | 2010 |
Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation.
Topics: Activins; Amniotic Fluid; Animals; Anti-Inflammatory Agents; Dinoprostone; Disease Models, Animal; F | 2011 |
Absent "Window of Opportunity" in smokers with short disease duration. Data from BARFOT, a multicenter study of early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Health Status; Humans; Inflammatio | 2011 |
Resveratrol abrogates adhesion molecules and protects against TNBS-induced ulcerative colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cell Adhesion Molecules; Colitis, Ulc | 2011 |
Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Curcumin; Disease Models, Animal; Gastrointestina | 2013 |
Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro.
Topics: Adiponectin; Adipose Tissue; Adult; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cell | 2005 |
Free radical scavenging reactions of sulfasalazine, 5-aminosalicylic acid and sulfapyridine: mechanistic aspects and antioxidant activity.
Topics: Aminosalicylic Acids; Anions; Antioxidants; Electrons; Free Radical Scavengers; Free Radicals; Gluta | 2005 |
Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Death; Diabete | 2007 |
Mode of action of sulphasalazine: an alternative view.
Topics: Animals; Colitis, Ulcerative; Depression, Chemical; Guinea Pigs; Humans; Inflammation; Lymphocyte Ac | 1982 |
Ocular manifestations of inflammatory bowel disease.
Topics: Adult; Aged; Corneal Ulcer; Crohn Disease; Eye Diseases; Female; Humans; Hydrocortisone; Inflammatio | 1982 |
The effects of sulfasalazine on human male fertility potential and seminal prostaglandins.
Topics: Adult; Dinoprost; Dinoprostone; Fertility; Follicle Stimulating Hormone; Humans; Inflammation; Intes | 1984 |
Early effective suppression of inflammation in rheumatoid arthritis reduces radiographic progression.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Pro | 1998 |
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.
Topics: Adenosine Deaminase; Animals; Aspirin; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Female; Gluc | 1999 |
Repeated measurement of intestinal permeability as an assessment of colitis severity in HLA-B27 transgenic rats.
Topics: Animals; Biomarkers; Colitis; Colon; Contrast Media; Cyclosporine; Dose-Response Relationship, Drug; | 1999 |
Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Dextran Sulfate; Female; Fla | 2002 |
Nuclear factor (NF)-kappa B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)-1 beta biosynthesis in alveolar epithelial cells.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fetus; Inflammation; Interleukin-1 | 2002 |
Induction of colitis in rats by 2-2'-azobis(2-amidinopropane) dihydrochloride.
Topics: Amidines; Aminosalicylic Acids; Animals; Benzopyrans; Colitis; Inflammation; Intestinal Mucosa; Lipi | 1992 |
An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis.
Topics: Administration, Oral; Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Indoles; Inflamma | 1990 |
Arachidonic acid metabolites and their role in inflammatory bowel disease. An update requiring addition of a pathway.
Topics: Aminosalicylic Acids; Arachidonic Acid; Arachidonic Acids; Biological Transport; Bradykinin; Colitis | 1985 |
Indomethacin-induced intestinal ulcers in rats: effects of salicylazosulfapyridine and dexamethasone.
Topics: Animals; Dexamethasone; Female; Indomethacin; Inflammation; Intestinal Diseases; Rats; Sulfasalazine | 1985 |
Raised circulating levels of the eosinophil cationic protein in ankylosing spondylitis: relation with the inflammatory activity and the influence of sulphasalazine treatment.
Topics: Adult; Blood Proteins; Eosinophil Granule Proteins; Eosinophils; Female; Humans; Inflammation; Male; | 1987 |
T lymphocytes in ankylosing spondylitis and the influence of sulphasalazine treatment.
Topics: Adult; Antibodies, Monoclonal; Female; HLA-DR Antigens; Humans; Inflammation; Male; Middle Aged; Spo | 1987 |
[51. Inflammatory diseases of the large intestine. (Internistic report)].
Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Crohn Disease; Diagnosis, Differential; Humans; Inflam | 1967 |