sulfasalazine has been researched along with Hepatic Encephalopathy in 5 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the simultaneous development of fulminant hepatic failure and necrotizing pancreatitis in a patient treated with sulfasalazine." | 7.69 | Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis. ( Rubin, R, 1994) |
| "Development of hepatic encephalopathy led to urgent liver transplantation in both cases." | 5.30 | [Fulminant hepatitis in two children treated with sulfasalazine for Crohn disease]. ( Besnard, M; Cézard, JP; Chardot, C; Debray, D; Durand, P; Fabre, M, 1999) |
| "We report the simultaneous development of fulminant hepatic failure and necrotizing pancreatitis in a patient treated with sulfasalazine." | 3.69 | Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis. ( Rubin, R, 1994) |
| "The pathogenic mechanisms of hepatic encephalopathy remain to be elucidated." | 1.32 | Increased oro-cecal transit time in grade I or II hepatic encephalopathy. ( Bouhier, K; Bouin, M; Dao, T; Debruyne, D; Fatome, A; Piquet, MA; Verwaerde, JC; Vincent, C, 2004) |
| "A 12-year-old girl with juvenile rheumatoid arthritis developed fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia, which was confirmed by liver histology and bone marrow examination, 2 weeks after initiation of sulphasalazine therapy." | 1.30 | Successfully treated sulphasalazine-induced fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia with intravenous immunoglobulin. ( Chen, LC; Hsieh, KH; Hsueh, C; Huang, JL; Hung, IJ; Lee, WY, 1998) |
| "Development of hepatic encephalopathy led to urgent liver transplantation in both cases." | 1.30 | [Fulminant hepatitis in two children treated with sulfasalazine for Crohn disease]. ( Besnard, M; Cézard, JP; Chardot, C; Debray, D; Durand, P; Fabre, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bouin, M | 1 |
| Vincent, C | 1 |
| Bouhier, K | 1 |
| Debruyne, D | 1 |
| Fatome, A | 1 |
| Piquet, MA | 1 |
| Verwaerde, JC | 1 |
| Dao, T | 1 |
| Rubin, R | 1 |
| Huang, JL | 1 |
| Hung, IJ | 1 |
| Chen, LC | 1 |
| Lee, WY | 1 |
| Hsueh, C | 1 |
| Hsieh, KH | 1 |
| Besnard, M | 1 |
| Debray, D | 1 |
| Durand, P | 1 |
| Fabre, M | 1 |
| Chardot, C | 1 |
| Cézard, JP | 1 |
| Marinos, G | 1 |
| Riley, J | 1 |
| Painter, DM | 1 |
| McCaughan, GW | 1 |
1 review available for sulfasalazine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Sulfasalazine-induced fulminant hepatic failure.
Topics: Adult; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Female; Hepatic Encephalopathy; | 1992 |
4 other studies available for sulfasalazine and Hepatic Encephalopathy
| Article | Year |
|---|---|
Increased oro-cecal transit time in grade I or II hepatic encephalopathy.
Topics: Case-Control Studies; Female; Gastrointestinal Agents; Gastrointestinal Transit; Hepatic Encephalopa | 2004 |
Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis.
Topics: Adult; Colitis, Ulcerative; Drug Hypersensitivity; Hepatic Encephalopathy; Humans; Male; Necrosis; P | 1994 |
Successfully treated sulphasalazine-induced fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia with intravenous immunoglobulin.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Child; Female; Follow-Up Studies; Hepatic Encephalopathy; | 1998 |
[Fulminant hepatitis in two children treated with sulfasalazine for Crohn disease].
Topics: Child; Crohn Disease; Female; Gastrointestinal Agents; Hepatic Encephalopathy; Humans; Liver Transpl | 1999 |