sulfasalazine has been researched along with Gastric Ulcer in 11 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "w", given orally) of sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ) in alleviating both local/systemic non-immunological anaphylactic reactions and stress-induced gastric ulceration in mice, in comparison with sulfasalazine (SSZ) as a reference drug." | 8.02 | Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice. ( Mohammed, HA; Ramadan, G; Waheed, G, 2021) |
| " The effects of sulphasalazine (SZP) and PhCL28A on macroscopic lesion formation and ex vivo prostaglandin inactivation were studied in the ethanol (ETOH) and phenylbutazone (PBT) models of gastric ulcers in the rat." | 7.67 | Sulphasalazine and PhCL28A inhibit the formation of ethanol- and phenylbutazone-induced rat gastric ulcers: lack of involvement of endogenous prostaglandins? ( Berry, CN; Lloyd, KG; Prouteau, M, 1988) |
| "w", given orally) of sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ) in alleviating both local/systemic non-immunological anaphylactic reactions and stress-induced gastric ulceration in mice, in comparison with sulfasalazine (SSZ) as a reference drug." | 4.02 | Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice. ( Mohammed, HA; Ramadan, G; Waheed, G, 2021) |
| "The role of gastric glandular mucosal leukotriene C4 in gastric ulceration, produced by restraint at 4 degrees C (stress) for 2 h in rats, was studied in relation to the ulcer-preventing effects of ethacrynic acid, sulphasalazine and its constituents (sulphapyridine and 5-aminosalicylic acid), AA-861 and ONO-1078." | 3.68 | Ethacrynic acid and sulphasalazine inhibit the generation of leukotriene C4 in rat stomachs: a possible gastric anti-ulcer mechanism in cold-restraint-stressed rats. ( Cho, CH; Garg, GP; Ogle, CW, 1992) |
| " The effects of sulphasalazine (SZP) and PhCL28A on macroscopic lesion formation and ex vivo prostaglandin inactivation were studied in the ethanol (ETOH) and phenylbutazone (PBT) models of gastric ulcers in the rat." | 3.67 | Sulphasalazine and PhCL28A inhibit the formation of ethanol- and phenylbutazone-induced rat gastric ulcers: lack of involvement of endogenous prostaglandins? ( Berry, CN; Lloyd, KG; Prouteau, M, 1988) |
| "Indomethacin pretreatment (20 mg/kg, p." | 1.27 | Sulphasalazine and experimental stress ulcers. ( Cho, CH; Dai, S; Ogle, CW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Waheed, G | 1 |
| Ramadan, G | 1 |
| Mohammed, HA | 1 |
| Schiemann, U | 1 |
| Kellner, H | 1 |
| Bennett, A | 1 |
| Taha, AS | 1 |
| Sturrock, RD | 1 |
| Russell, RI | 1 |
| Garg, GP | 3 |
| Cho, CH | 6 |
| Ogle, CW | 6 |
| Dai, S | 1 |
| Sevilla, EL | 1 |
| Berry, CN | 1 |
| Prouteau, M | 1 |
| Lloyd, KG | 1 |
2 reviews available for sulfasalazine and Gastric Ulcer
| Article | Year |
|---|---|
[Gastrointestinal side effects in the therapy of rheumatologic diseases].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antirheumatic | 2002 |
Prostaglandins as factors in diseases of the alimentary tract.
Topics: Aminosalicylic Acids; Bacterial Toxins; Carcinoma; Colonic Neoplasms; Diarrhea; Gallbladder Diseases | 1976 |
9 other studies available for sulfasalazine and Gastric Ulcer
| Article | Year |
|---|---|
Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice.
Topics: Administration, Oral; Anaphylaxis; Animals; Anti-Allergic Agents; Cell Degranulation; Disease Models | 2021 |
Helicobacter pylori and peptic ulcers in rheumatoid arthritis patients receiving gold, sulfasalazine, and nonsteroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Duodenal Ulcer; Female; Gold S | 1992 |
Ethacrynic acid and sulphasalazine inhibit the generation of leukotriene C4 in rat stomachs: a possible gastric anti-ulcer mechanism in cold-restraint-stressed rats.
Topics: Animals; Ethacrynic Acid; Female; Gastric Mucins; Gastric Mucosa; Rats; Rats, Sprague-Dawley; SRS-A; | 1992 |
The role of the gastric mucosal sulfhydryls in the ulcer-protecting effects of sulphasalazine.
Topics: Animals; Anti-Ulcer Agents; Female; Gastric Mucosa; Rats; Rats, Inbred Strains; Stomach Ulcer; Sulfa | 1991 |
Inhibition of stress-induced gastric ulcers by sulphasalazine and its constituents (sulphapyridine and 5-aminosalicylic acid) in rats.
Topics: Aminosalicylic Acids; Animals; Cold Temperature; Drug Combinations; Female; Mesalamine; Premedicatio | 1990 |
Effects of sulphasalazine on stress ulceration and mast cell degranulation in rat stomach.
Topics: Animals; Anti-Ulcer Agents; Cytoplasmic Granules; Female; Mast Cells; Rats; Rats, Inbred Strains; Re | 1985 |
Sulphasalazine and experimental stress ulcers.
Topics: Administration, Oral; Animals; Dinoprostone; Female; Indomethacin; Injections, Subcutaneous; Prostag | 1985 |
The protective effects of sulphasalazine against ethanol-induced gastric damage in rats.
Topics: Aminosalicylic Acids; Animals; Dinoprostone; Ethanol; Female; Gastric Acid; Gastric Emptying; Gastri | 1987 |
Sulphasalazine and PhCL28A inhibit the formation of ethanol- and phenylbutazone-induced rat gastric ulcers: lack of involvement of endogenous prostaglandins?
Topics: Animals; Azo Compounds; Ethanol; Female; Phenylbutazone; Prostaglandins; Rats; Rats, Inbred Strains; | 1988 |