sulfasalazine has been researched along with Folic Acid Deficiency in 28 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to estimate the frequency of folate deficiency and haemolysis in a group of 25 outpatients with arthritis treated with sulphasalazine (SASP), haematological measurements, including plasma total homocysteine (tHcy) which is a sensitive marker of folate deficiency, serum folate (S-folate), erythrocyte (RBC) folate, S-cobalamin and routine indices of haemolysis were performed." | 7.69 | Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis. ( Ekelund, S; Krogh Jensen, M; Svendsen, L, 1996) |
| "In an attempt to estimate the frequency of folate deficiency and haemolysis in a group of 25 outpatients with arthritis treated with sulphasalazine (SASP), haematological measurements, including plasma total homocysteine (tHcy) which is a sensitive marker of folate deficiency, serum folate (S-folate), erythrocyte (RBC) folate, S-cobalamin and routine indices of haemolysis were performed." | 3.69 | Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis. ( Ekelund, S; Krogh Jensen, M; Svendsen, L, 1996) |
| "Hematologic studies, including serum and RBC folate assays, were done on 45 outpatients with chronic colitis who either took sulfasalazine (n = 27) or did not use it (n = 18)." | 3.66 | Folate status in patients receiving maintenance doses of sulfasalazine. ( Green, R; Longstreth, GF, 1983) |
| "Patients with ulcerative colitis commonly have decreased folate levels, which are partially due to sulfasalazine, a competitive inhibitor of folate absorption." | 1.28 | Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study. ( Hanauer, SB; Heidenreich, PA; Kane, SV; Lashner, BA; Su, GL, 1989) |
| " The syndrome appears to be associated with high dosage and slow acetylator status." | 1.27 | Sulphasalazine associated pancytopenia may be caused by acute folate deficiency. ( Logan, EC; Ryrie, DR; Williamson, LM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (82.14) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakayama, S | 1 |
| Yokote, T | 1 |
| Kobayashi, K | 1 |
| Hirata, Y | 1 |
| Hara, S | 1 |
| Akioka, T | 1 |
| Miyoshi, T | 1 |
| Tsuji, M | 1 |
| Takubo, T | 1 |
| Hanafusa, T | 1 |
| Swinson, CM | 1 |
| Perry, J | 1 |
| Lumb, M | 1 |
| Levi, AJ | 1 |
| Halsted, CH | 1 |
| Gandhi, G | 1 |
| Tamura, T | 1 |
| Goldberg, J | 1 |
| Lindenbaum, J | 1 |
| Spindel, E | 1 |
| Bechi, P | 1 |
| Briganti, S | 1 |
| Borsotti, M | 1 |
| Orsucci, S | 1 |
| Masi, C | 1 |
| Fazi, M | 1 |
| Tonelli, P | 1 |
| Pratesi, C | 1 |
| Longstreth, GF | 1 |
| Green, R | 1 |
| Meenan, J | 1 |
| Krogh Jensen, M | 1 |
| Ekelund, S | 1 |
| Svendsen, L | 1 |
| Hoshino, J | 1 |
| Sugawara, K | 1 |
| Ishikawa, S | 1 |
| Hayami, Y | 1 |
| Sakurazawa, T | 1 |
| Tanaka, T | 1 |
| Yamamoto, N | 1 |
| Hashimoto, M | 1 |
| Yamamoto, T | 1 |
| Hoshihara, Y | 1 |
| Grasa, JM | 1 |
| García-Erce, JA | 1 |
| Herrero, L | 1 |
| Giralt, M | 1 |
| Freidin, N | 1 |
| Mandel, EM | 1 |
| Gafter, U | 1 |
| Djaldetti, M | 1 |
| Schneider, R | 1 |
| Beeley, L | 1 |
| Kane, SP | 1 |
| Boots, MA | 1 |
| Elsborg, L | 1 |
| Larsen, L | 1 |
| Jägerstad, M | 1 |
| Lashner, BA | 1 |
| Heidenreich, PA | 1 |
| Su, GL | 1 |
| Kane, SV | 1 |
| Hanauer, SB | 1 |
| Mason, JB | 1 |
| Grindulis, KA | 1 |
| McConkey, B | 1 |
| Grieco, A | 1 |
| Caputo, S | 1 |
| Bertoli, A | 1 |
| Caradonna, P | 1 |
| Greco, AV | 1 |
| Logan, EC | 1 |
| Williamson, LM | 1 |
| Ryrie, DR | 1 |
| Prouse, PJ | 1 |
| Shawe, D | 2 |
| Gumpel, JM | 2 |
| Prouse, P | 1 |
| Pironi, L | 1 |
| Cornia, GL | 1 |
| Ursitti, MA | 1 |
| Dallasta, MA | 1 |
| Miniero, R | 1 |
| Fasano, F | 1 |
| Miglioli, M | 1 |
| Barbara, L | 1 |
| Franklin, JL | 1 |
| Rosenberg, HH | 1 |
| Robenberg, IH | 1 |
2 reviews available for sulfasalazine and Folic Acid Deficiency
| Article | Year |
|---|---|
Drugs and vitamin B12 and folate metabolism.
Topics: Alcoholism; Animals; Anticonvulsants; Ascorbic Acid; Contraceptives, Oral; Folic Acid; Folic Acid An | 1983 |
[A case of ulcerative colitis with folate deficient megaloblastic anemia induced by sulfasalazine].
Topics: Adult; Anemia, Megaloblastic; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Folic Ac | 1999 |
1 trial available for sulfasalazine and Folic Acid Deficiency
| Article | Year |
|---|---|
Does sulphasalazine cause folate deficiency in rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Erythrocyte Indices; Folic Acid Deficiency; Humans; Penicillamine; Sulfasalaz | 1985 |
25 other studies available for sulfasalazine and Folic Acid Deficiency
| Article | Year |
|---|---|
[Megaloblastic anemia associated with salazosulfapyridine treatment for rheumatoid arthritis].
Topics: Aged; Anemia, Megaloblastic; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Def | 2008 |
Role of sulphasalazine in the aetiology of folate deficiency in ulcerative colitis.
Topics: Adult; Anemia, Megaloblastic; Colitis, Ulcerative; Female; Folic Acid; Folic Acid Deficiency; Humans | 1981 |
Sulfasalazine inhibits the absorption of folates in ulcerative colitis.
Topics: Adult; Aged; Colitis, Ulcerative; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Abso | 1981 |
Sulfasalazine and folate deficiency.
Topics: Adult; Anemia; Colitis, Ulcerative; Female; Folic Acid Deficiency; Humans; Sulfasalazine | 1983 |
Sulfasalazine and folate deficiency.
Topics: Colitis, Ulcerative; Folic Acid Deficiency; Humans; Sulfasalazine | 1983 |
Folate deficiency in operated terminal ileitis (Crohn's disease).
Topics: Adolescent; Adult; Aged; Crohn Disease; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum | 1983 |
Folate status in patients receiving maintenance doses of sulfasalazine.
Topics: Colitis; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Sulfasalazine | 1983 |
Co-carcinogenic effect of sulphasalazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Dimethylhydrazines; Folic Acid Defici | 1993 |
Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Colitis, Ulcerative; Erythrocytes; Female | 1996 |
[Erythropoietin and hip surgery in an anemic Jehovah's Witness with ankylosing spondylitis, chronic liver disease, and Crohn's disease].
Topics: Anemia, Hypochromic; Antirheumatic Agents; Autoimmune Diseases; Blood Loss, Surgical; Christianity; | 2002 |
[Hemolytic anemia associated with folic acid deficiency due to salazopyrin].
Topics: Anemia, Hemolytic; Folic Acid; Folic Acid Deficiency; Prednisone; Sulfasalazine | 1976 |
Megaloblastic anaemia associated with sulphasalazine treatment.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Sulfasalazine | 1977 |
Megaloblastic anaemia associated with sulphasalazine treatment.
Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Proctitis; Sulfasalazine; Ulcer | 1977 |
Folate deficiency in chronic inflammatory bowel diseases.
Topics: Bone Marrow; Bone Marrow Cells; Colitis, Ulcerative; Crohn Disease; Erythrocyte Aging; Erythrocytes; | 1979 |
[Folic acid absorption].
Topics: Adult; Anticonvulsants; Contraceptives, Oral; Diet; Female; Folic Acid; Folic Acid Deficiency; Human | 1975 |
Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study.
Topics: Adult; Colitis, Ulcerative; Colon; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; Hum | 1989 |
Folate, colitis, dysplasia, and cancer.
Topics: Adenocarcinoma; Adult; Colitis, Ulcerative; Colonic Neoplasms; Female; Folic Acid Deficiency; Humans | 1989 |
Megaloblastic anaemia due to sulphasalazine responding to drug withdrawal alone.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Male; Middle Aged; Sulfasa | 1986 |
Sulphasalazine associated pancytopenia may be caused by acute folate deficiency.
Topics: Adolescent; Adult; Bone Marrow; Female; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Male; | 1986 |
Macrocytic anaemia in patients treated with sulphasalazine for rheumatoid arthritis.
Topics: Adult; Aged; Anemia, Macrocytic; Arthritis, Rheumatoid; Female; Folic Acid Deficiency; Humans; Male; | 1986 |
Macrocytic anaemia in patients treated with sulfasalazine for rheumatoid arthritis.
Topics: Anemia, Macrocytic; Folic Acid Deficiency; Humans; Sulfasalazine | 1987 |
Evaluation of oral administration of folic and folinic acid to prevent folate deficiency in patients with inflammatory bowel disease treated with salicylazosulfapyridine.
Topics: Administration, Oral; Adolescent; Adult; Colitis; Female; Folic Acid; Folic Acid Deficiency; Humans; | 1988 |
Sulfasalazine inhibits folate absorption.
Topics: Anemia, Macrocytic; Colitis, Ulcerative; Folic Acid Deficiency; Humans; Inflammatory Bowel Diseases; | 1988 |
Impaired folic acid absorption in inflammatory bowel disease: effects of salicylazosulfapyridine (Azulfidine).
Topics: Adolescent; Adult; Animals; Biological Assay; Colitis, Ulcerative; Crohn Disease; Depression, Chemic | 1973 |
Drugs and folic acid absorption.
Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexat | 1972 |