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sulfasalazine and Folic Acid Deficiency

sulfasalazine has been researched along with Folic Acid Deficiency in 28 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research Excerpts

ExcerptRelevanceReference
"In an attempt to estimate the frequency of folate deficiency and haemolysis in a group of 25 outpatients with arthritis treated with sulphasalazine (SASP), haematological measurements, including plasma total homocysteine (tHcy) which is a sensitive marker of folate deficiency, serum folate (S-folate), erythrocyte (RBC) folate, S-cobalamin and routine indices of haemolysis were performed."7.69Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis. ( Ekelund, S; Krogh Jensen, M; Svendsen, L, 1996)
"In an attempt to estimate the frequency of folate deficiency and haemolysis in a group of 25 outpatients with arthritis treated with sulphasalazine (SASP), haematological measurements, including plasma total homocysteine (tHcy) which is a sensitive marker of folate deficiency, serum folate (S-folate), erythrocyte (RBC) folate, S-cobalamin and routine indices of haemolysis were performed."3.69Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis. ( Ekelund, S; Krogh Jensen, M; Svendsen, L, 1996)
"Hematologic studies, including serum and RBC folate assays, were done on 45 outpatients with chronic colitis who either took sulfasalazine (n = 27) or did not use it (n = 18)."3.66Folate status in patients receiving maintenance doses of sulfasalazine. ( Green, R; Longstreth, GF, 1983)
"Patients with ulcerative colitis commonly have decreased folate levels, which are partially due to sulfasalazine, a competitive inhibitor of folate absorption."1.28Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study. ( Hanauer, SB; Heidenreich, PA; Kane, SV; Lashner, BA; Su, GL, 1989)
" The syndrome appears to be associated with high dosage and slow acetylator status."1.27Sulphasalazine associated pancytopenia may be caused by acute folate deficiency. ( Logan, EC; Ryrie, DR; Williamson, LM, 1986)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199023 (82.14)18.7374
1990's3 (10.71)18.2507
2000's2 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakayama, S1
Yokote, T1
Kobayashi, K1
Hirata, Y1
Hara, S1
Akioka, T1
Miyoshi, T1
Tsuji, M1
Takubo, T1
Hanafusa, T1
Swinson, CM1
Perry, J1
Lumb, M1
Levi, AJ1
Halsted, CH1
Gandhi, G1
Tamura, T1
Goldberg, J1
Lindenbaum, J1
Spindel, E1
Bechi, P1
Briganti, S1
Borsotti, M1
Orsucci, S1
Masi, C1
Fazi, M1
Tonelli, P1
Pratesi, C1
Longstreth, GF1
Green, R1
Meenan, J1
Krogh Jensen, M1
Ekelund, S1
Svendsen, L1
Hoshino, J1
Sugawara, K1
Ishikawa, S1
Hayami, Y1
Sakurazawa, T1
Tanaka, T1
Yamamoto, N1
Hashimoto, M1
Yamamoto, T1
Hoshihara, Y1
Grasa, JM1
García-Erce, JA1
Herrero, L1
Giralt, M1
Freidin, N1
Mandel, EM1
Gafter, U1
Djaldetti, M1
Schneider, R1
Beeley, L1
Kane, SP1
Boots, MA1
Elsborg, L1
Larsen, L1
Jägerstad, M1
Lashner, BA1
Heidenreich, PA1
Su, GL1
Kane, SV1
Hanauer, SB1
Mason, JB1
Grindulis, KA1
McConkey, B1
Grieco, A1
Caputo, S1
Bertoli, A1
Caradonna, P1
Greco, AV1
Logan, EC1
Williamson, LM1
Ryrie, DR1
Prouse, PJ1
Shawe, D2
Gumpel, JM2
Prouse, P1
Pironi, L1
Cornia, GL1
Ursitti, MA1
Dallasta, MA1
Miniero, R1
Fasano, F1
Miglioli, M1
Barbara, L1
Franklin, JL1
Rosenberg, HH1
Robenberg, IH1

Reviews

2 reviews available for sulfasalazine and Folic Acid Deficiency

ArticleYear
Drugs and vitamin B12 and folate metabolism.
    Current concepts in nutrition, 1983, Volume: 12

    Topics: Alcoholism; Animals; Anticonvulsants; Ascorbic Acid; Contraceptives, Oral; Folic Acid; Folic Acid An

1983
[A case of ulcerative colitis with folate deficient megaloblastic anemia induced by sulfasalazine].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1999, Volume: 96, Issue:7

    Topics: Adult; Anemia, Megaloblastic; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Folic Ac

1999

Trials

1 trial available for sulfasalazine and Folic Acid Deficiency

ArticleYear
Does sulphasalazine cause folate deficiency in rheumatoid arthritis?
    Scandinavian journal of rheumatology, 1985, Volume: 14, Issue:3

    Topics: Arthritis, Rheumatoid; Erythrocyte Indices; Folic Acid Deficiency; Humans; Penicillamine; Sulfasalaz

1985

Other Studies

25 other studies available for sulfasalazine and Folic Acid Deficiency

ArticleYear
[Megaloblastic anemia associated with salazosulfapyridine treatment for rheumatoid arthritis].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2008, Volume: 49, Issue:12

    Topics: Aged; Anemia, Megaloblastic; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Def

2008
Role of sulphasalazine in the aetiology of folate deficiency in ulcerative colitis.
    Gut, 1981, Volume: 22, Issue:6

    Topics: Adult; Anemia, Megaloblastic; Colitis, Ulcerative; Female; Folic Acid; Folic Acid Deficiency; Humans

1981
Sulfasalazine inhibits the absorption of folates in ulcerative colitis.
    The New England journal of medicine, 1981, Dec-17, Volume: 305, Issue:25

    Topics: Adult; Aged; Colitis, Ulcerative; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Abso

1981
Sulfasalazine and folate deficiency.
    JAMA, 1983, Feb-11, Volume: 249, Issue:6

    Topics: Adult; Anemia; Colitis, Ulcerative; Female; Folic Acid Deficiency; Humans; Sulfasalazine

1983
Sulfasalazine and folate deficiency.
    JAMA, 1983, Aug-19, Volume: 250, Issue:7

    Topics: Colitis, Ulcerative; Folic Acid Deficiency; Humans; Sulfasalazine

1983
Folate deficiency in operated terminal ileitis (Crohn's disease).
    The Italian journal of surgical sciences, 1983, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Aged; Crohn Disease; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum

1983
Folate status in patients receiving maintenance doses of sulfasalazine.
    Archives of internal medicine, 1983, Volume: 143, Issue:5

    Topics: Colitis; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Sulfasalazine

1983
Co-carcinogenic effect of sulphasalazine.
    British journal of cancer, 1993, Volume: 68, Issue:5

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cocarcinogenesis; Dimethylhydrazines; Folic Acid Defici

1993
Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis.
    Scandinavian journal of clinical and laboratory investigation, 1996, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Colitis, Ulcerative; Erythrocytes; Female

1996
[Erythropoietin and hip surgery in an anemic Jehovah's Witness with ankylosing spondylitis, chronic liver disease, and Crohn's disease].
    Revista espanola de anestesiologia y reanimacion, 2002, Volume: 49, Issue:2

    Topics: Anemia, Hypochromic; Antirheumatic Agents; Autoimmune Diseases; Blood Loss, Surgical; Christianity;

2002
[Hemolytic anemia associated with folic acid deficiency due to salazopyrin].
    Harefuah, 1976, Volume: 91, Issue:3-4

    Topics: Anemia, Hemolytic; Folic Acid; Folic Acid Deficiency; Prednisone; Sulfasalazine

1976
Megaloblastic anaemia associated with sulphasalazine treatment.
    British medical journal, 1977, Aug-27, Volume: 2, Issue:6086

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Sulfasalazine

1977
Megaloblastic anaemia associated with sulphasalazine treatment.
    British medical journal, 1977, Nov-12, Volume: 2, Issue:6097

    Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Proctitis; Sulfasalazine; Ulcer

1977
Folate deficiency in chronic inflammatory bowel diseases.
    Scandinavian journal of gastroenterology, 1979, Volume: 14, Issue:8

    Topics: Bone Marrow; Bone Marrow Cells; Colitis, Ulcerative; Crohn Disease; Erythrocyte Aging; Erythrocytes;

1979
[Folic acid absorption].
    Lakartidningen, 1975, May-28, Volume: 72, Issue:22

    Topics: Adult; Anticonvulsants; Contraceptives, Oral; Diet; Female; Folic Acid; Folic Acid Deficiency; Human

1975
Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. A case-control study.
    Gastroenterology, 1989, Volume: 97, Issue:2

    Topics: Adult; Colitis, Ulcerative; Colon; Colonic Neoplasms; Female; Folic Acid; Folic Acid Deficiency; Hum

1989
Folate, colitis, dysplasia, and cancer.
    Nutrition reviews, 1989, Volume: 47, Issue:10

    Topics: Adenocarcinoma; Adult; Colitis, Ulcerative; Colonic Neoplasms; Female; Folic Acid Deficiency; Humans

1989
Megaloblastic anaemia due to sulphasalazine responding to drug withdrawal alone.
    Postgraduate medical journal, 1986, Volume: 62, Issue:726

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Male; Middle Aged; Sulfasa

1986
Sulphasalazine associated pancytopenia may be caused by acute folate deficiency.
    Gut, 1986, Volume: 27, Issue:7

    Topics: Adolescent; Adult; Bone Marrow; Female; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Male;

1986
Macrocytic anaemia in patients treated with sulphasalazine for rheumatoid arthritis.
    British medical journal (Clinical research ed.), 1986, Nov-29, Volume: 293, Issue:6559

    Topics: Adult; Aged; Anemia, Macrocytic; Arthritis, Rheumatoid; Female; Folic Acid Deficiency; Humans; Male;

1986
Macrocytic anaemia in patients treated with sulfasalazine for rheumatoid arthritis.
    British medical journal (Clinical research ed.), 1987, Apr-04, Volume: 294, Issue:6576

    Topics: Anemia, Macrocytic; Folic Acid Deficiency; Humans; Sulfasalazine

1987
Evaluation of oral administration of folic and folinic acid to prevent folate deficiency in patients with inflammatory bowel disease treated with salicylazosulfapyridine.
    International journal of clinical pharmacology research, 1988, Volume: 8, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Colitis; Female; Folic Acid; Folic Acid Deficiency; Humans;

1988
Sulfasalazine inhibits folate absorption.
    Nutrition reviews, 1988, Volume: 46, Issue:9

    Topics: Anemia, Macrocytic; Colitis, Ulcerative; Folic Acid Deficiency; Humans; Inflammatory Bowel Diseases;

1988
Impaired folic acid absorption in inflammatory bowel disease: effects of salicylazosulfapyridine (Azulfidine).
    Gastroenterology, 1973, Volume: 64, Issue:4

    Topics: Adolescent; Adult; Animals; Biological Assay; Colitis, Ulcerative; Crohn Disease; Depression, Chemic

1973
Drugs and folic acid absorption.
    Gastroenterology, 1972, Volume: 63, Issue:2

    Topics: Animals; Contraceptives, Oral; Folic Acid; Folic Acid Deficiency; Intestinal Absorption; Methotrexat

1972