Page last updated: 2024-11-04

sulfasalazine and Exanthem

sulfasalazine has been researched along with Exanthem in 26 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Research Excerpts

ExcerptRelevanceReference
" We report a case in a 63-year-old woman who had been on sulfasalazine for 2 months to treat rheumatoid arthritis."8.82DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis. ( Ferraud, D; Michel, F; Navellou, JC; Toussirot, E; Wendling, D, 2005)
"Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality."8.12Drug hypersensitivity syndrome induced by sulfasalazine: A case report. ( Chen, DH; Guan, CL; Shen, GY; Xu, C; Zhang, YG; Zhou, HR, 2022)
"A 24-year-old female developed DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) as a result of sulfasalazine use."7.76[DRESS syndrome as a result of sulfasalazine use]. ( Bakker, RC; Segers, D; van der Mark, SC; van Wijngaarden, P, 2010)
" Two patients presented severe febrile skin eruption following drug intake (carbamazepine or sulfazalazine), with hypereosinophilia and hepatitis."7.71[DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome after sulfasalazine and carmazepine: report of two cases]. ( Catteau, B; Delcey, V; Devulder, B; Fauchais, AL; Hachulla, E; Hatron, PY; Launay, D; Legout, L; Michon-Pasturel, U; Queyrel, V, 2001)
" We report a case in a 63-year-old woman who had been on sulfasalazine for 2 months to treat rheumatoid arthritis."4.82DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis. ( Ferraud, D; Michel, F; Navellou, JC; Toussirot, E; Wendling, D, 2005)
"Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality."4.12Drug hypersensitivity syndrome induced by sulfasalazine: A case report. ( Chen, DH; Guan, CL; Shen, GY; Xu, C; Zhang, YG; Zhou, HR, 2022)
"A 24-year-old female developed DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) as a result of sulfasalazine use."3.76[DRESS syndrome as a result of sulfasalazine use]. ( Bakker, RC; Segers, D; van der Mark, SC; van Wijngaarden, P, 2010)
" Two patients presented severe febrile skin eruption following drug intake (carbamazepine or sulfazalazine), with hypereosinophilia and hepatitis."3.71[DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome after sulfasalazine and carmazepine: report of two cases]. ( Catteau, B; Delcey, V; Devulder, B; Fauchais, AL; Hachulla, E; Hatron, PY; Launay, D; Legout, L; Michon-Pasturel, U; Queyrel, V, 2001)
"The histopathology of DRESS syndrome highlights various associated inflammatory patterns in a single biopsy."1.42Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study. ( Bastuji-Garin, S; Chosidow, O; de Feraudy, S; Delfau-Larue, MH; Duong, TA; Ortonne, N; Roujeau, JC; Valeyrie-Allanore, L; Wechsler, J; Wolkenstein, P, 2015)
"To evaluate rates on the adverse side effect and discontinuation of second-line drugs frequently used in the treatment of rheumatoid arthritis (RA)."1.31[Retrospective study of adverse events in patients with rheumatoid arthritis treated with second-line drugs]. ( Jiang, L; Ni, L; Zhao, N, 2002)
" Four patients with connective tissue diseases were treated with salazopyrin in desensitisation doses, as management with full dosage had previously been followed by a skin rash."1.29[Salazopyrine desensitization]. ( Schydlowsky, P, 1993)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19903 (11.54)18.7374
1990's2 (7.69)18.2507
2000's9 (34.62)29.6817
2010's9 (34.62)24.3611
2020's3 (11.54)2.80

Authors

AuthorsStudies
Sil, A1
Bhattacharjee, MS1
Chandra, A1
Pramanik, JD1
Chen, DH1
Zhou, HR1
Zhang, YG1
Shen, GY1
Xu, C1
Guan, CL1
Shimada, Y1
Suyama, Y1
Koizumi, M1
Hagiwara, K1
Jeimy, S1
McRae, K1
Pattani, R1
Nath, PI1
Coop, CA1
Raithatha, N1
Mehrtens, S1
Mouyis, M1
Manson, J1
Yang, F1
Gu, B1
Zhang, L1
Xuan, J1
Luo, H1
Zhou, P1
Zhu, Q1
Yan, S1
Chen, SA1
Cao, Z1
Xu, J1
Xing, Q1
Luo, X1
Ortonne, N1
Valeyrie-Allanore, L1
Bastuji-Garin, S1
Wechsler, J1
de Feraudy, S1
Duong, TA1
Delfau-Larue, MH1
Chosidow, O1
Wolkenstein, P1
Roujeau, JC1
Suresh, R1
Gupta, S1
Sathananthan, R1
Santiago, F1
Gonçalo, M1
Vieira, R1
Coelho, S1
Figueiredo, A1
Rosenbaum, J1
Alex, G1
Roberts, H1
Orchard, D1
Khaled, A1
Souissi, A1
Zeglaoui, F1
El Fekih, N1
Daghfous, R1
Fazaa, B1
van der Mark, SC1
Segers, D1
Bakker, RC1
van Wijngaarden, P1
Jiang, L1
Zhao, N1
Ni, L1
Michel, F1
Navellou, JC1
Ferraud, D1
Toussirot, E1
Wendling, D1
Condat, B1
Zanditenas, D1
Collot, V1
Legoupil, N1
Cazals-Hatem, D1
Hauuy, MP1
Bonnet, J1
Ngo, Y1
Roucoules, J1
Blazquez, M1
Teo, L1
Tan, E1
Bejia, I1
Ben Hammouda, S1
Riahi, K1
Zinelabidine, F1
Mediouni, B1
Touzi, M1
Bergaoui, N1
Iemoli, E1
Piconi, S1
Ardizzone, S1
Bianchi Porro, G1
Raimond, F1
Singh, S1
Samant, R1
Joshi, VR1
Miller, B1
Nielsen, OH1
Schydlowsky, P1
Queyrel, V1
Catteau, B1
Michon-Pasturel, U1
Fauchais, AL1
Delcey, V1
Launay, D1
Legout, L1
Hachulla, E1
Hatron, PY1
Devulder, B1
Bodokh, I1
Lacour, JP1
Perrin, C1
Gallais, V1
Ortonne, JP1
Collins, JR1

Reviews

1 review available for sulfasalazine and Exanthem

ArticleYear
DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis.
    Joint bone spine, 2005, Volume: 72, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Eosinophilia; Exanthema; Female; Herpes

2005

Other Studies

25 other studies available for sulfasalazine and Exanthem

ArticleYear
Sulfasalazine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) with concomitant acute chikungunya virus infection: possible role of new viral trigger.
    BMJ case reports, 2021, Oct-12, Volume: 14, Issue:10

    Topics: Chikungunya Fever; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Sulfasalazine

2021
Drug hypersensitivity syndrome induced by sulfasalazine: A case report.
    Medicine, 2022, Aug-19, Volume: 101, Issue:33

    Topics: Colitis, Ulcerative; Drug Hypersensitivity; Drug Hypersensitivity Syndrome; Exanthema; Humans; Male;

2022
Laryngeal edema in drug reaction with eosinophilia and systemic symptoms syndrome due to sulfasalazine.
    International journal of rheumatic diseases, 2023, Volume: 26, Issue:11

    Topics: Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Laryngeal Edema; Male; Middle Aged;

2023
A 63-year-old returned traveller with fever, rash, hepatitis and eosinophilia.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018, 07-09, Volume: 190, Issue:27

    Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Live

2018
Rash and a patch test result positive for cobalt in a patient with a hip replacement.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2014, Volume: 113, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Cetirizine; Cobalt; Dapsone

2014
Rash and fever after sulfasalazine use.
    BMJ (Clinical research ed.), 2014, Oct-08, Volume: 349

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity Syndrome; Exanthema; Female; F

2014
HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population.
    Pharmacogenomics, 2014, Volume: 15, Issue:11

    Topics: Adult; Alleles; Asian People; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Eosin

2014
Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study.
    The British journal of dermatology, 2015, Volume: 173, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Bacterial Agents; B-Lymphocytes; Carba

2015
Sulphasalazine induced three-week syndrome.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2009, Volume: 15, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Edema; Exanthema; Female; Hum

2009
Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS).
    Contact dermatitis, 2010, Volume: 62, Issue:1

    Topics: Allopurinol; Amoxicillin; Anticonvulsants; Drug Hypersensitivity; Eosinophilia; Exanthema; Female; H

2010
Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine.
    Journal of paediatrics and child health, 2010, Volume: 46, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Cholangitis, Sclerosing; Colitis, Ulcerative; Diagno

2010
[DRESS syndrome].
    La Tunisie medicale, 2012, Volume: 90, Issue:10

    Topics: Adolescent; Adult; Allopurinol; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti

2012
[DRESS syndrome as a result of sulfasalazine use].
    Nederlands tijdschrift voor geneeskunde, 2010, Volume: 154, Issue:18

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Eosinophilia; Exanthema; Female; Glu

2010
[Retrospective study of adverse events in patients with rheumatoid arthritis treated with second-line drugs].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2002, Volume: 23, Issue:3

    Topics: Adult; Anorexia; Antirheumatic Agents; Arthritis, Rheumatoid; Exanthema; Female; Gastrointestinal Di

2002
[A new cause of intra and extrahepatic cholangitis: the drug hypersensitivity syndrome or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms)].
    Gastroenterologie clinique et biologique, 2006, Volume: 30, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cholangitis; Drug Hypersensitivity; Eosinophilia; Ex

2006
Sulphasalazine-induced DRESS.
    Singapore medical journal, 2006, Volume: 47, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Eosinophilia; Exanthema; Female; Humans; Mi

2006
DRESS syndrome induced by sulphasalazine in rheumatoid arthritis.
    Joint bone spine, 2006, Volume: 73, Issue:6

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Eruptions; Eosinophilia; Exanthema; Female; Humans

2006
Erythroderma and toxic epidermal necrolysis caused by to 5-aminosalacylic acid.
    Inflammatory bowel diseases, 2006, Volume: 12, Issue:10

    Topics: Colitis, Ulcerative; Dermatitis, Exfoliative; Exanthema; Humans; Male; Mesalamine; Stevens-Johnson S

2006
Adult onset Still's disease: a study of 14 cases.
    Clinical rheumatology, 2008, Volume: 27, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cyclosporine; Diagnos

2008
[Side effects of salicylazosulfapyridine therapy].
    Deutsche medizinische Wochenschrift (1946), 1980, Nov-14, Volume: 105, Issue:46

    Topics: Agranulocytosis; Colitis, Ulcerative; Crohn Disease; Exanthema; Fever; Humans; Sulfasalazine

1980
Sulfasalazine intolerance. A retrospective survey of the reasons for discontinuing treatment with sulfasalazine in patients with chronic inflammatory bowel disease.
    Scandinavian journal of gastroenterology, 1982, Volume: 17, Issue:3

    Topics: Colitis, Ulcerative; Crohn Disease; Diarrhea; Drug Tolerance; Dyspepsia; Exanthema; Fever; Humans; R

1982
[Salazopyrine desensitization].
    Ugeskrift for laeger, 1993, Feb-15, Volume: 155, Issue:7

    Topics: Connective Tissue Diseases; Desensitization, Immunologic; Exanthema; Female; Humans; Male; Sulfasala

1993
[DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) syndrome after sulfasalazine and carmazepine: report of two cases].
    La Revue de medecine interne, 2001, Volume: 22, Issue:6

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants

2001
[Hazards of treatment of psoriasis with sulfasalozine].
    Presse medicale (Paris, France : 1983), 1992, Apr-04, Volume: 21, Issue:13

    Topics: Acute Disease; Exanthema; Humans; Male; Middle Aged; Psoriasis; Risk Factors; Sulfasalazine

1992
Adverse reactions to salicylazosulfapyridine (azulfidine) in the treatment of ulcerative colitis.
    Southern medical journal, 1968, Volume: 61, Issue:4

    Topics: Adult; Agranulocytosis; Colitis, Ulcerative; Dermatitis; Exanthema; Headache; Hematologic Diseases;

1968