sulfasalazine has been researched along with Disease Models, Animal in 114 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "w", given orally) of sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ) in alleviating both local/systemic non-immunological anaphylactic reactions and stress-induced gastric ulceration in mice, in comparison with sulfasalazine (SSZ) as a reference drug." | 8.02 | Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice. ( Mohammed, HA; Ramadan, G; Waheed, G, 2021) |
| " Lentinan decreased the number of tumours, inflammatory cell infiltration, atypical hyperplasia and nuclear atypia in azoxymethane/DSS-induced CAC model." | 7.91 | Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer. ( Chen, S; Jing, X; Li, M; Liu, H; Liu, Y; Sun, B; Sun, T; Tian, Y; Wang, H; Yang, C; Zhang, Q; Zhao, J; Zhao, Y; Zong, S, 2019) |
| " In light of the antioxidant and anti-inflammatory properties of esculetin and 4-methylesculetin, the aim of this study was to investigate the effects of these compounds in an experimental model of rat colitis induced by trinitrobenzenesulphonic acid (TNBS)." | 7.76 | Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis. ( Di Stasi, LC; Seito, LN; Witaicenis, A, 2010) |
| "Our findings suggest that UDCA rather than sulfasalazine could serve as an effective suppressing agent in colitis-related colon cancer development in mice." | 7.74 | Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. ( Kohno, H; Miyamoto, S; Suzuki, R; Tanaka, T; Wakabayashi, K; Yasui, Y, 2007) |
| "DSS was used to induce intestinal inflammation in conventional Balb/c mice and athymic nu/nu CD-1(BR) mice, and the well-documented 5-aminosalicylic acid (5-ASA) based anticolitis drugs sulphasalazine (SASP) and olsalazine (OLZ) were used to study therapeutic effects." | 7.70 | Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine. ( Axelsson, LG; Bylund-Fellenius, AC; Landström, E, 1998) |
| "In this mouse model of preeclampsia, sulfasalazine did not sustain reductions in blood pressure nor affect fetal parameters of size and weight, both desirable attributes of a viable preeclampsia therapeutic." | 5.91 | Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model. ( Beard, S; Binder, NK; Brownfoot, FC; de Alwis, N; Hannan, NJ; Harper, A; Kadife, E; Kaitu'u-Lino, TJ, 2023) |
| "Sulfasalazine (SASP) was used as the positive control." | 5.62 | The Regulatory Effects of Licochalcone A on the Intestinal Epithelium and Gut Microbiota in Murine Colitis. ( Cao, L; Li, N; Qing, DG; Si, JY; Sun, Y; Wang, JC; Xu, XQ; Zhang, J, 2021) |
| "Agastache mexicana is a popular plant of great demand in folk medicine, essentially due to its calming properties and for alleviating arthritic, muscular and abdominal pain." | 5.62 | Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis. ( Adriana Estrella, GR; Alberto, HL; Azucena, CV; Francisco Javier, LM; María Eva, GT; María Guadalupe, VD; Noé, AV; Sandra, OS, 2021) |
| "Fibrosis/contracture is associated with the abnormal persistence of myofibroblasts, which over-produce and contract collagen matrices." | 5.56 | Sulfasalazine Resolves Joint Stiffness in a Rabbit Model of Arthrofibrosis. ( Atluri, K; Brouillette, MJ; Fowler, TP; Fredericks, D; Khorsand, B; Martin, JA; Petersen, E; Salem, AK; Sander, E; Seol, D; Smith, S, 2020) |
| "Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-κB mRNA, IL-27 mRNA, TLR4 protein, NF-κB p65 protein, and IL-27 p28 protein (p < 0." | 5.39 | Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway. ( Chen, L; Liao, H; Lv, X; Zeng, Z; Zhan, L, 2013) |
| "Treatment with ectoine ameliorated the inflammatory changes in TNBS-induced colitis." | 5.39 | Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis. ( Abdallah, DM; Abdel-Aziz, H; Khayyal, MT; Lentzen, G; Wadie, W, 2013) |
| "Sulphasalazine, THC and CBD proved beneficial in this model of colitis with the dose-response relationship for the phytocannabinoids showing a bell-shaped pattern on the majority of parameters (optimal THC and CBD dose, 10 mg." | 5.36 | The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. ( Jamontt, JM; Molleman, A; Parsons, ME; Pertwee, RG, 2010) |
| "A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug." | 5.30 | Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. ( Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A, 1999) |
| " We investigated the effect of melittin peptide alone and in combination with sulfasalazine on improving the clinical symptoms among DSS-induced colitis models." | 4.12 | Evaluation of the therapeutic effect of melittin peptide on the ulcerative colitis mouse model. ( Amel Jamehdar, S; Ghazvini, K; Reza Akbari Eidgahi, M; Yaghoubi, A, 2022) |
| "w", given orally) of sodium R-lipoate (NaRLA) and enzymatically-modified isoquercitrin (EMIQ) in alleviating both local/systemic non-immunological anaphylactic reactions and stress-induced gastric ulceration in mice, in comparison with sulfasalazine (SSZ) as a reference drug." | 4.02 | Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice. ( Mohammed, HA; Ramadan, G; Waheed, G, 2021) |
| "To test whether sulpiride (SP), an anti-psychotic and prokinetic drug, shows beneficial effects on experimental murine colitis, a colon-targeted prodrug of SP, 5-(aminoethanoylsulfamoyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide (glycylsulpiride (GSP)), was synthesized and its colonic delivery and therapeutic activity against 2,4-dinitrobenzenesulfonic acid (DNBS)-induced rat colitis were assessed." | 3.91 | Therapeutic switching of sulpiride, an anti-psychotic and prokinetic drug, to an anti-colitic drug using colon-specific drug delivery. ( Jeong, S; Jung, Y; Kim, D; Kim, W; Yoo, JW, 2019) |
| " Lentinan decreased the number of tumours, inflammatory cell infiltration, atypical hyperplasia and nuclear atypia in azoxymethane/DSS-induced CAC model." | 3.91 | Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer. ( Chen, S; Jing, X; Li, M; Liu, H; Liu, Y; Sun, B; Sun, T; Tian, Y; Wang, H; Yang, C; Zhang, Q; Zhao, J; Zhao, Y; Zong, S, 2019) |
| " The aim of this study was to evaluate the effect of AMFJ in a rat TNBSinduced colitis model and to compare the effect of the juice with that of sulfasalazine." | 3.88 | Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats. ( Kuzmanov, A; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S, 2018) |
| " The strong inhibitory activity of compound 55 against an in vivo colitis model was confirmed by its dose-dependent inhibitory activity in a rat model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, demonstrating compound 55 as a new potential candidate for the development of therapeutics against IBD." | 3.85 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. ( Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Shrestha, A; Thapa Magar, TB, 2017) |
| "Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease." | 3.85 | Sulfasalazine induces mitochondrial dysfunction and renal injury. ( Abdoli, N; Asadi, B; Azarpira, N; Heidari, R; Khodaei, F; Mohammadzadeh, R; Najibi, A; Niknahad, H; Ommati, MM; Rasti, M; Saeedi, A; Shirazi Yeganeh, B; Taheri, V; Zarei, M, 2017) |
| "ML (in moderate doses) and eucalyptol (dose-dependently) exerted protective effects against acetic acid-induced colitis in rats possibly through antioxidant and antiinflammatory properties suggesting a potential benefit in treatments of IBD." | 3.83 | Mentha longifolia protects against acetic-acid induced colitis in rats. ( Abdallah, HM; Ali, SS; Murad, HA, 2016) |
| "Sulfasalazine and FTY720 treatment did not prevent body weight loss or reduce clinical scores of diarrhea or intestinal gross pathology, when compared with vehicle treatment." | 3.77 | Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model. ( Benson, EL; Heuvelman, DM; Masferrer, JL; Radi, ZA, 2011) |
| " In light of the antioxidant and anti-inflammatory properties of esculetin and 4-methylesculetin, the aim of this study was to investigate the effects of these compounds in an experimental model of rat colitis induced by trinitrobenzenesulphonic acid (TNBS)." | 3.76 | Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis. ( Di Stasi, LC; Seito, LN; Witaicenis, A, 2010) |
| " Sulfasalazine which is used clinically to treat Crohn's disease has emerged as a potential inhibitor of NF-kappaB and has shown promising results in two pre-clinical studies to target primary brain tumors, gliomas." | 3.75 | Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. ( Chung, WJ; Sontheimer, H, 2009) |
| "Our findings suggest that UDCA rather than sulfasalazine could serve as an effective suppressing agent in colitis-related colon cancer development in mice." | 3.74 | Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. ( Kohno, H; Miyamoto, S; Suzuki, R; Tanaka, T; Wakabayashi, K; Yasui, Y, 2007) |
| " Clinically, pro-drugs such as olsalazine have been associated with dose-dependent diarrhea, which was likely secondary to ileal secretion induced by the azo linkages, in 17% of patients." | 3.73 | Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum. ( Chang, EB; Hanauer, SB; Kles, KA; Musch, MW; Turner, JR; Vavricka, SR, 2005) |
| "DSS was used to induce intestinal inflammation in conventional Balb/c mice and athymic nu/nu CD-1(BR) mice, and the well-documented 5-aminosalicylic acid (5-ASA) based anticolitis drugs sulphasalazine (SASP) and olsalazine (OLZ) were used to study therapeutic effects." | 3.70 | Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine. ( Axelsson, LG; Bylund-Fellenius, AC; Landström, E, 1998) |
| "Other patterns of uveitis have a worse prognosis, and systemic corticosteroids and/or immunosuppressive drugs are usually required." | 2.43 | Uveitis. ( Martín-Mola, E; Muñoz-Fernández, S, 2006) |
| "In this mouse model of preeclampsia, sulfasalazine did not sustain reductions in blood pressure nor affect fetal parameters of size and weight, both desirable attributes of a viable preeclampsia therapeutic." | 1.91 | Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model. ( Beard, S; Binder, NK; Brownfoot, FC; de Alwis, N; Hannan, NJ; Harper, A; Kadife, E; Kaitu'u-Lino, TJ, 2023) |
| "We observed previously established medical associations for MND and an inverse dose-response association between lovastatin and MND, with 28% reduced risk at 40 mg/day." | 1.91 | Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model. ( Kreple, CJ; Miller, TM; Racette, BA; Schoch, KM; Searles Nielsen, S; Shabsovich, M; Shen, T; Song, Y, 2023) |
| "To apply the metabolite for the treatment of colitis, 3-IPA was coupled with acidic amino acids to yield colon-targeted 3-IPA, 3-IPA-aspartic acid (IPA-AA) and 3-IPA-glutamic acid (IPA-GA)." | 1.62 | Preparation and Evaluation of Colon-Targeted Prodrugs of the Microbial Metabolite 3-Indolepropionic Acid as an Anticolitic Agent. ( Ju, S; Jung, Y; Kim, S; Lee, H; Min, DS; Park, S; Yoo, JW; Yoon, IS, 2021) |
| "Sulfasalazine (SASP) was used as the positive control." | 1.62 | The Regulatory Effects of Licochalcone A on the Intestinal Epithelium and Gut Microbiota in Murine Colitis. ( Cao, L; Li, N; Qing, DG; Si, JY; Sun, Y; Wang, JC; Xu, XQ; Zhang, J, 2021) |
| "Agastache mexicana is a popular plant of great demand in folk medicine, essentially due to its calming properties and for alleviating arthritic, muscular and abdominal pain." | 1.62 | Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis. ( Adriana Estrella, GR; Alberto, HL; Azucena, CV; Francisco Javier, LM; María Eva, GT; María Guadalupe, VD; Noé, AV; Sandra, OS, 2021) |
| "Sulfasalazine and JLC were administrated orally and initialized 6 h after TNBS enema, once a day for seven consecutive days." | 1.62 | Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis. ( Chen, G; Diao, F; Dong, M; Li, Y; Lin, W; Liu, T; Liu, Y; Mei, Q; Ruan, Y; Sun, Y; Tang, T; Zhou, H, 2021) |
| "Fibrosis/contracture is associated with the abnormal persistence of myofibroblasts, which over-produce and contract collagen matrices." | 1.56 | Sulfasalazine Resolves Joint Stiffness in a Rabbit Model of Arthrofibrosis. ( Atluri, K; Brouillette, MJ; Fowler, TP; Fredericks, D; Khorsand, B; Martin, JA; Petersen, E; Salem, AK; Sander, E; Seol, D; Smith, S, 2020) |
| "The potential of probiotics for treating ulcerative colitis (UC) has attracted increasing attention." | 1.56 | Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function. ( Cui, J; Ma, W; Ning, K; Wang, Y; Xiang, H; Xiang, JY; Xie, Q; Zhang, Y, 2020) |
| "Sulfasalazine (SAS) is an US Food and Drug Administration (FDA)-approved drug for the treatment of Crohn disease that has been shown to inhibit the cystine/glutamate antiporter system xc- (SXC) and decrease tumor-associated seizures." | 1.51 | Sulfasalazine decreases mouse cortical hyperexcitability. ( Alcoreza, O; Bouslog, A; Campbell, SL; Savoia, A; Sontheimer, H; Tewari, BP, 2019) |
| "To investigate the influences of probiotics combined with sulfasalazine (SASP) on the expression of the Wnt/β-catenin signaling pathway in rats with ulcerative colitis (UC)." | 1.51 | Influences of probiotics combined with sulfasalazine on rats with ulcerative colitis via the Wnt/β-catenin signaling pathway. ( Dong, LN; Guo, J; Wang, JP; Wang, M, 2019) |
| "For the efficient treatment of colitis, SFC was coupled with acidic amino acids to yield SFC-aspartic acid (SFC-AA) and SFC-glutamic acid, and their colon targetability and therapeutic effects were assessed as an anticolitic agent in a 2,4-dinitrobenezenesulfonic acid-induced rat colitis model." | 1.51 | Colon-Targeted Delivery Facilitates the Therapeutic Switching of Sofalcone, a Gastroprotective Agent, to an Anticolitic Drug via Nrf2 Activation. ( Jeong, S; Ju, S; Jung, Y; Kim, S; Kim, W; Lee, H; Yoo, JW; Yoon, IS, 2019) |
| "In sum, we demonstrate how breast cancer bone metastases upregulate a cystine/glutamate co-transporter to elevate extracellular glutamate." | 1.43 | The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain. ( BassiriRad, NM; Bui, L; Doyle, T; Forte, BL; Largent-Milnes, TM; Mantyh, PW; Neumann, WL; Salvemini, D; Slosky, LM; Staatz, WD; Symons, AM; Thompson, M; Vanderah, TW, 2016) |
| "Drugs used for treatment of Crohn's disease may be associated with serious side effects." | 1.43 | Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats. ( Abdel-Salam, LO; Kamel, MM; Khattab, A; Osman, AS; Tawfik, DI; Tolba, HM, 2016) |
| "Sulfasalazine is an anti-inflammatory and immune-modulating drug that is used in rheumatology and inflammatory bowel disease." | 1.42 | Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of Demyelination. ( Chang, KY; Cho, SC; Ha, YW; Kim, S; Lee, DW; Lee, YI; Na, JE; Park, HC; Park, SC; Rhyu, IJ, 2015) |
| "Treatment with ectoine ameliorated the inflammatory changes in TNBS-induced colitis." | 1.39 | Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis. ( Abdallah, DM; Abdel-Aziz, H; Khayyal, MT; Lentzen, G; Wadie, W, 2013) |
| "Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-κB mRNA, IL-27 mRNA, TLR4 protein, NF-κB p65 protein, and IL-27 p28 protein (p < 0." | 1.39 | Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway. ( Chen, L; Liao, H; Lv, X; Zeng, Z; Zhan, L, 2013) |
| "Colitis was induced by administration of 3% DSS in drinking water to mice for 7days followed by 5days of normal drinking water." | 1.39 | Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice. ( Igaki, K; Sha, T; Tsuchimori, N; Watanabe, T; Yamasaki, M, 2013) |
| "Sulfasalazine (500mg/kg) was used as reference drug." | 1.39 | Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats. ( ElSayed, MI; Khalifa, AE; Nagib, MM; Tadros, MG, 2013) |
| "Control of seizures in patients with gliomas is an essential component of clinical management; therefore, understanding the origin of seizures is vital." | 1.38 | Human glioma cells induce hyperexcitability in cortical networks. ( Buckingham, SC; Campbell, SL; Sontheimer, H, 2012) |
| "Posttraumatic stress disorder (PTSD) is characterized by acute and chronic changes in the stress response, manifested as conditioned fear memory." | 1.38 | Activation of NF-κB in basolateral amygdala is required for memory reconsolidation in auditory fear conditioning. ( Lu, L; Luo, Y; Shi, H; Si, J; Xue, L; Yang, C; Yang, J, 2012) |
| " We examined the possibility that concurrent blockade of free radicals and prostaglandin E(2) (PGE(2))-mediated inflammation might constitute a safe and effective therapeutic approach to ALS." | 1.38 | Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. ( Cho, W; Gwag, BJ; Im, DS; Lee, JH; Lee, JK; Lee, YA; Lee, YB; Shin, JH; Springer, JE; Yun, BS, 2012) |
| "Embelin treatment significantly decreased clinical activity score, gross lesion score, percent affected area and wet colon weight when compared to acetic acid induced controls." | 1.37 | Protective effect of embelin against acetic acid induced ulcerative colitis in rats. ( Badami, S; Biradar, MI; Mahendran, S; Raj, P; Srivastava, K; Thippeswamy, BS; Veerapur, VP, 2011) |
| "Colitis was induced in vivo by intrarectal administration of TNBS in male ICR mice." | 1.37 | Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways. ( Joh, EH; Kim, DH, 2011) |
| "Sulphasalazine, THC and CBD proved beneficial in this model of colitis with the dose-response relationship for the phytocannabinoids showing a bell-shaped pattern on the majority of parameters (optimal THC and CBD dose, 10 mg." | 1.36 | The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. ( Jamontt, JM; Molleman, A; Parsons, ME; Pertwee, RG, 2010) |
| "Colitis was induced by a single intracolonic administration of TNBS dissolved in 35% ethanol." | 1.35 | Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. ( Avti, PK; Khanduja, KL; Medhi, B; Pandhi, P; Prakash, A; Saikia, UN, 2008) |
| " Accordingly, noninvasive, serial quantification of colonic inflammation could advantageously guide dosing regimens and assess drug efficacy, thus enhancing the value of colitis models in research." | 1.35 | Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI. ( Hobson, AR; James, MF; Kruidenier, L; Lewis, HD; McCleary, S; Pohlmann, A; Robinson, A; Tilling, LC; Warnock, LC; Woolmer, O, 2009) |
| "Treatment with thalidomide restored malondialdehyde as well as reduction of myeloperoxidase and tumour necrosis factor-alpha towards normal levels." | 1.35 | Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats. ( Medhi, B; Pandhi, P; Prakash, O; Saikia, UN, 2008) |
| "Resolution of liver fibrosis is associated with clearance of hepatic myofibroblasts by apoptosis; development of strategies that promote this process in a selective way is therefore important." | 1.33 | Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. ( Green, K; Iredale, JP; Mann, DA; Marek, CJ; May, MJ; Meso, M; Millward-Sadler, H; Oakley, F; Wright, MC; Zhou, X, 2005) |
| "Colitis was induced by feeding a diet containing 0." | 1.31 | Dietary fiber fraction of germinated barley foodstuff attenuated mucosal damage and diarrhea, and accelerated the repair of the colonic mucosa in an experimental colitis. ( Andoh, A; Araki, Y; Bamba, T; Hibi, T; Iwanaga, T; Kanauchi, O; Mitsuyama, K; Nakamura, T; Suzuki, A, 2001) |
| "Colitis was induced in 29 rats by intracolonic administration of trinitrobenzensulfonic acid." | 1.30 | 5-ASA-glutamate protects rats from inflammatory bowel disease induced by intracolonic administration of trinitrobenzensulfonic acid. ( Aburbeh, AG; Balò, S; Bartoli, G; Clementi, M; Clerici, C; Gentili, G; Giansanti, M; Gresele, P; Mezzasoma, AM; Modesto, R; Morelli, A; Morelli, O; Pellicciari, R, 1998) |
| "A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug." | 1.30 | Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. ( Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A, 1999) |
| "Ethane breath tests were conducted on all animals on days 2, 4, 6, 8, and 10 (acute phase) and weeks 3, 6, and 9 (chronic phase) after commencement of DSS consumption." | 1.30 | An orally administered growth factor extract derived from bovine whey suppresses breath ethane in colitic rats. ( Butler, RN; Howarth, GS; Porter, SN, 1998) |
| "Sulfasalazine treatment decreased ICAM-1 and VCAM-1 protein expression." | 1.30 | Sulfasalazine inhibits reperfusion injury and prolongs allograft survival in rat cardiac transplants. ( Feeley, BT; Hoyt, EG; Park, AK; Robbins, RC, 1999) |
| "Spontaneous colitis and colon cancer in the cotton-top tamarin have been shown to resemble human ulcerative colitis and its associated cancer." | 1.29 | A prospective study of the epidemiology of colitis and colon cancer in cotton-top tamarins (Saguinus oedipus). ( Ausman, LM; Johnson, LD; King, NW; Sehgal, PK, 1996) |
| "Treatment with sulfasalazine markedly decreased the number of leukocytes that accumulated in the inflamed (carrageenan, 2 mg/ml) air pouch." | 1.29 | The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. ( Buckley, MT; Carlin, G; Cronstein, BN; Gadangi, P; Levin, RI; Longaker, M; Montesinos, MC; Naime, D; Recht, PA, 1996) |
| "An increased incidence of colonic cancer is associated with chronic inflammatory bowel disease." | 1.28 | The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model. ( Crouch, R; Davis, AE; Patterson, F, 1992) |
| "Drug treatment with sulfasalazine or 5-aminosalicylic acid improved enteritis score." | 1.28 | Chronic intrajejunal TNBS application in TNBS-sensitized rats: a new model of chronic inflammatory bowel diseases. ( Selve, N, 1992) |
| "The efficacy of various drugs used to treat ulcerative colitis, (sulfasalazine, 5-aminosalicylate, hydrocortisone) was investigated in a model of acetic acid-induced colitis in the rat." | 1.28 | Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. ( Bostwick, JS; Decktor, DL; Fitzpatrick, LR; Pendleton, RG; Renzetti, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.51) | 18.7374 |
| 1990's | 22 (19.30) | 18.2507 |
| 2000's | 19 (16.67) | 29.6817 |
| 2010's | 46 (40.35) | 24.3611 |
| 2020's | 23 (20.18) | 2.80 |
| Authors | Studies |
|---|---|
| Hibi, S | 1 |
| Okamoto, Y | 1 |
| Tagami, K | 1 |
| Numata, H | 1 |
| Kobayashi, N | 1 |
| Shinoda, M | 1 |
| Kawahara, T | 1 |
| Murakami, M | 1 |
| Oketani, K | 1 |
| Inoue, T | 1 |
| Junek, R | 1 |
| Brůnová, B | 1 |
| Kverka, M | 1 |
| Panajotová, V | 1 |
| Jandera, A | 1 |
| Kuchar, M | 1 |
| Ma, L | 1 |
| Gong, H | 1 |
| Zhu, H | 1 |
| Ji, Q | 1 |
| Su, P | 1 |
| Liu, P | 1 |
| Cao, S | 1 |
| Yao, J | 1 |
| Jiang, L | 1 |
| Han, M | 1 |
| Ma, X | 1 |
| Xiong, D | 1 |
| Luo, HR | 1 |
| Wang, F | 1 |
| Zhou, J | 1 |
| Xu, Y | 1 |
| Mu, HX | 1 |
| Liu, J | 1 |
| Fatima, S | 1 |
| Lin, CY | 1 |
| Shi, XK | 1 |
| Du, B | 1 |
| Xiao, HT | 1 |
| Fan, BM | 1 |
| Bian, ZX | 1 |
| Kadayat, TM | 2 |
| Banskota, S | 2 |
| Gurung, P | 2 |
| Bist, G | 2 |
| Thapa Magar, TB | 1 |
| Shrestha, A | 2 |
| Kim, JA | 2 |
| Lee, ES | 2 |
| Magar, TBT | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-30 | Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.) | ||
| To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)[NCT02201186] | Phase 2 | 10 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| A Randomised, Controlled Trial of Losartan as an Anti-fibrotic Agent in Non-alcoholic Steatohepatitis[NCT01051219] | Phase 3 | 45 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Cardiac Allograft Remodeling and Effects of Sirolimus on Its Progression[NCT01889992] | Phase 1 | 42 participants (Actual) | Interventional | 2013-04-24 | Terminated (stopped due to PI left University and project not continued) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for sulfasalazine and Disease Models, Animal
| Article | Year |
|---|---|
Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation | 2017 |
Uveitis.
Topics: Animals; Anterior Chamber; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Disease | 2006 |
5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Animals; Arachidonic Acid; Disease Models, Animal; Do | 1992 |
The effect of salicylazosulphapyridine (sulphasalazine) on male fertility. A review.
Topics: Acrosome; Animals; Bulbourethral Glands; Chemical Phenomena; Chemistry; Contraceptive Agents, Male; | 1986 |
1 trial available for sulfasalazine and Disease Models, Animal
| Article | Year |
|---|---|
5-Lipoxygenase inhibitors for the treatment of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Animals; Arachidonic Acid; Disease Models, Animal; Do | 1992 |
110 other studies available for sulfasalazine and Disease Models, Animal
| Article | Year |
|---|---|
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Topics: Animals; Blood Platelets; Cells, Cultured; Colitis; Dinoprostone; Disease Models, Animal; Humans; Le | 1994 |
Antileukotrienic N-arylethyl-2-arylacetamides in the treatment of ulcerative colitis.
Topics: Acetamides; Animals; Colitis, Ulcerative; Disease Models, Animal; Edema; Hydrophobic and Hydrophilic | 2007 |
A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.
Topics: Animals; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose- | 2014 |
Anti-inflammatory Actions of (+)-3'α-Angeloxy-4'-keto-3',4'-dihydroseselin (Pd-Ib) against Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Colitis; Colon; Coumarins; Cytokines; Dextran Sulfate; | 2016 |
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discov | 2017 |
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Colitis; Dise | 2018 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Effect of Huangqin decoction on regulating intestinal flora in colitis mice characterized as inhibition of the NOD2-dependent pathway.
Topics: Animals; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2022 |
Protective Effect of Probiotics Isolated from Traditional Fermented Tea Leaves (Miang) from Northern Thailand and Role of Synbiotics in Ameliorating Experimental Ulcerative Colitis in Mice.
Topics: Animals; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Fermented Beverages; Mice; Mi | 2022 |
Konjac oligosaccharides attenuate DSS-induced ulcerative colitis in mice: mechanistic insights.
Topics: Amorphophallus; Animals; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Mo | 2022 |
Evaluation of the therapeutic effect of melittin peptide on the ulcerative colitis mouse model.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mod | 2022 |
Linalyl acetate restores colon contractility and blood pressure in repeatedly stressed-ulcerative colitis rats.
Topics: Acetylcholine; Animals; Blood Pressure; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal | 2022 |
Sanhuang xiexin decoction ameliorates secondary liver injury in DSS-induced colitis involve regulating inflammation and bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Mod | 2022 |
Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Humans; Hypertension; Male; Mice; Nitric Ox | 2023 |
Protective Effects of Lovastatin in a Population-Based ALS Study and Mouse Model.
Topics: Aged; Amyotrophic Lateral Sclerosis; Animals; Case-Control Studies; Disease Models, Animal; Humans; | 2023 |
TRPV1 participates in the protective effect of propolis on colonic tissue of ulcerative colitis.
Topics: Animals; Antineoplastic Agents; Colitis, Ulcerative; Colon; Disease Models, Animal; Interleukin-6; M | 2023 |
Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation.
Topics: Amino Acid Transport System y+; Animals; Atrophy; Cell Line; Cell Transdifferentiation; Chief Cells, | 2020 |
Anti-Inflammatory Activity of a Peptide from Skipjack (
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colo | 2019 |
Sulfasalazine Resolves Joint Stiffness in a Rabbit Model of Arthrofibrosis.
Topics: Aminopropionitrile; Animals; Collagen; Contracture; Disease Models, Animal; Fibrosis; Hydroxyproline | 2020 |
Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Dysbiosis; | 2020 |
Therapeutic effects of combination of platelet lysate and sulfasalazine administration in TNBS-induced colitis in rat.
Topics: Animals; Apoptosis; Blood Platelets; Colitis; Combined Modality Therapy; Cytokines; Disease Models, | 2020 |
Guchang Zhixie Wan protects mice against dextran sulfate sodium-induced colitis through modulating the gut microbiota in colon.
Topics: Animals; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Dose-Response Relations | 2020 |
Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis.
Topics: Acetic Acid; Animals; Behavior, Animal; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Dinoprostone; | 2021 |
Preparation and Evaluation of Colon-Targeted Prodrugs of the Microbial Metabolite 3-Indolepropionic Acid as an Anticolitic Agent.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dinitrofluorobenzene; Disea | 2021 |
Ginsenoside Rh2 alleviates ulcerative colitis by regulating the STAT3/miR-214 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disea | 2021 |
Therapeutic effect of an anti-tuberculosis agent, isoniazid, and its nano-isoform in ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Antitubercular Agents; Colitis, Ulcerative; Dextran Sulfate; Dise | 2021 |
Sodium R-lipoate and enzymatically-modified isoquercitrin suppressed IgE-independent anaphylactic reactions and stress-induced gastric ulceration in mice.
Topics: Administration, Oral; Anaphylaxis; Animals; Anti-Allergic Agents; Cell Degranulation; Disease Models | 2021 |
The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity.
Topics: Animals; Anti-Inflammatory Agents; Cholestasis; Common Bile Duct; Cytokines; Disease Models, Animal; | 2021 |
The Regulatory Effects of Licochalcone A on the Intestinal Epithelium and Gut Microbiota in Murine Colitis.
Topics: Animals; Chalcones; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Ga | 2021 |
Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis.
Topics: Agastache; Analgesics; Animals; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relations | 2021 |
Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Brain Chemistry; | 2018 |
Sulfasalazine induces mitochondrial dysfunction and renal injury.
Topics: Acute Kidney Injury; Administration, Oral; Animals; Antioxidants; Arthritis, Rheumatoid; Biomarkers; | 2017 |
Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Disease Models, Animal; Fruit and Vegetabl | 2018 |
The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism.
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Cytokines; Disease Models, Animal; Dose-Respon | 2018 |
Therapeutic switching of sulpiride, an anti-psychotic and prokinetic drug, to an anti-colitic drug using colon-specific drug delivery.
Topics: Animals; Benzamides; Colitis; Colon; Dinitrofluorobenzene; Disease Models, Animal; Dose-Response Rel | 2019 |
Modulatory effects of methanolic fruit fraction of Pedalium murex on sulphasalazine-induced male reproductive disruption.
Topics: Animals; Disease Models, Animal; Female; Fertility; Follicle Stimulating Hormone; Infertility, Male; | 2019 |
Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer.
Topics: Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Azoxymethane; Carcinoembryonic Antigen; | 2019 |
An improved rat model for chronic inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Chronic Disease; Dextran Sulfate; Disease Models, Animal; Gastroi | 2019 |
Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation | 2019 |
Sulfasalazine decreases mouse cortical hyperexcitability.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potential | 2019 |
Influences of probiotics combined with sulfasalazine on rats with ulcerative colitis via the Wnt/β-catenin signaling pathway.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Drug Therapy, Combination; Gene Expression Reg | 2019 |
Colon-Targeted Delivery Facilitates the Therapeutic Switching of Sofalcone, a Gastroprotective Agent, to an Anticolitic Drug via Nrf2 Activation.
Topics: Administration, Oral; Amino Acids, Acidic; Animals; Anti-Ulcer Agents; Chalcones; Colitis; Dinitrofl | 2019 |
Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis.
Topics: Amino Acids, Diamino; Animals; Body Weight; Colitis; Colon; Dinoprostone; Disease Models, Animal; Do | 2013 |
Anti-inflammatory and anti-oxidant activities of olmesartan medoxomil ameliorate experimental colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis, Ulcerative; Dextran | 2013 |
Protective effect of apocynin in a mouse model of chemically-induced colitis.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 | 2013 |
The (13)C-butyrate breath test: a new non-invasive method for assessing colitis in a murine model.
Topics: Administration, Rectal; Animals; Biomarkers; Breath Tests; Butyrates; Carbon Dioxide; Carbon Isotope | 2013 |
Modulating effect of Biophytum sensitivum extract on rats with acetic acid-induced ulcerative colitis.
Topics: Acetic Acid; Animals; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
A diet with lactosucrose supplementation ameliorates trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Disease Models, Animal; Female; Ga | 2015 |
Evaluation of the protective effect of Pterocarpus marsupium on acetic acid-induced ulcerative colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis, Ulcerative; Disease Models, A | 2015 |
Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
Topics: Alcohol Oxidoreductases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biopterins; Blood Pressur | 2015 |
Promotion of Remyelination by Sulfasalazine in a Transgenic Zebrafish Model of Demyelination.
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents, Non-Steroidal; Axons; Disease Mode | 2015 |
Mentha longifolia protects against acetic-acid induced colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Colitis; Colon; Cyclohexan | 2016 |
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats.
Topics: Animals; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Comb | 2016 |
The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiporters; Bone Neoplasms; Breas | 2016 |
Anti-inflammatory effects of Brucea javanica oil emulsion by suppressing NF-κB activation on dextran sulfate sodium-induced ulcerative colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Brucea; Colitis, Ulcerative; Cytokines; Dextran Sul | 2017 |
Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Disease Models, Animal; Femal | 2008 |
Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Colitis; Colon; Disease Models, Animal; Glutathione; Ho | 2008 |
Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Disease Models, Animal; Honey; Male; Rats; Rats, Wistar; | 2008 |
Efficacy of sulphasalazine on lung histopathology in a murine model of chronic asthma.
Topics: Allergens; Animals; Anti-Asthmatic Agents; Asthma; Basement Membrane; Bronchi; Dexamethasone; Diseas | 2008 |
Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI.
Topics: Anesthetics, Inhalation; Animals; Colitis; Colon; Contrast Media; Disease Models, Animal; Disease Pr | 2009 |
Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colon; Dextran Sulfate; Disea | 2009 |
Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB.
Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Death; Cell Li | 2009 |
Effect of sulfasalazine on renal ischemia/reperfusion injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Kidney Diseases; Male; NF- | 2009 |
Can sulfasalazine prevent infection-mediated pre-term birth in a murine model?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; Disease Models, Animal; Escherichia | 2010 |
Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis; Disea | 2010 |
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.
Topics: Animals; Cannabidiol; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Dron | 2010 |
Comparison of prostaglandin E2 receptor subtype 4 agonist and sulfasalazine in mouse colitis prevention and treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cell Proliferation; Colitis; Colon; D | 2010 |
Protective effect of embelin against acetic acid induced ulcerative colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Benzoquinones; Colitis, Ulcerative; Di | 2011 |
Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relatio | 2011 |
Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation.
Topics: Activins; Amniotic Fluid; Animals; Anti-Inflammatory Agents; Dinoprostone; Disease Models, Animal; F | 2011 |
Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.
Topics: Animals; Antibodies, Monoclonal; Crohn Disease; Diarrhea; Disease Models, Animal; Female; Fingolimod | 2011 |
Effect of combination of thalidomide and sulfasalazine in experimentally induced inflammatory bowel disease in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Disease Models, Animal; Drug Therapy, Combi | 2011 |
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Infl | 2012 |
Human glioma cells induce hyperexcitability in cortical networks.
Topics: Action Potentials; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Electrophysiology; Femal | 2012 |
Activation of NF-κB in basolateral amygdala is required for memory reconsolidation in auditory fear conditioning.
Topics: Acoustic Stimulation; Amygdala; Animals; Conditioning, Classical; Disease Models, Animal; Fear; Hist | 2012 |
Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Colitis; Cytokines; Dextran Sulfate; Disease Models, | 2013 |
Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Curcumin; Disease Models, Animal; Gastrointestina | 2013 |
Kolaviron, a natural antioxidant and anti-inflammatory phytochemical prevents dextran sulphate sodium-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis, Ulcerative; Dextran Sulfate; Disease Model | 2013 |
The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors.
Topics: Animals; Antioxidants; Calcium; Cells, Cultured; Cerebral Cortex; Cyclooxygenase 2; Disease Models, | 2003 |
An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Cell Adhesion Molecules; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; | 2003 |
Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.
Topics: Animals; Anthracenes; Apoptosis; Cell Culture Techniques; Disease Models, Animal; Enzyme Inhibitors; | 2005 |
Comparative analysis of the in vitro prosecretory effects of balsalazide, sulfasalazine, olsalazine, and mesalamine in rabbit distal ileum.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Colitis, | 2005 |
The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cholestasis, Extrahepatic; Common Bile Duct; Disease M | 2006 |
Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colitis; Colonic Neoplasms; Cyclooxygenase 2; Diseas | 2007 |
[Study on the experimental ulcerative colitis model induced by dextran sulfate sodium in rats: estimation of mucosal erosions by the alcian blue-staining method].
Topics: Alcian Blue; Animals; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Intestinal Mucos | 1993 |
[Study on the experimental ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) in rats (2)].
Topics: Animals; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Male; Prednisolone; Rats; Rat | 1995 |
Suppression of proteinuria and prolongation of survival in MRL-lpr/lpr mice treated with sulphasalazine.
Topics: Animals; Disease Models, Animal; Lupus Erythematosus, Systemic; Mice; Proteinuria; Sulfasalazine; Su | 1995 |
Mechanisms of acute and chronic intestinal inflammation induced by indomethacin.
Topics: Acute Disease; Animals; Bacteria; Bile; Chronic Disease; Disease Models, Animal; Enteritis; Indometh | 1993 |
A prospective study of the epidemiology of colitis and colon cancer in cotton-top tamarins (Saguinus oedipus).
Topics: Adenocarcinoma; Animals; Body Weight; Campylobacter Infections; Colitis; Colonic Neoplasms; Disease | 1996 |
The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites.
Topics: Acyltransferases; Adenosine; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Ster | 1996 |
An orally administered growth factor extract derived from bovine whey suppresses breath ethane in colitic rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Br | 1998 |
Experimental colitis induced by dextran sulphate sodium in mice: beneficial effects of sulphasalazine and olsalazine.
Topics: Aminosalicylic Acids; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relat | 1998 |
5-ASA-glutamate protects rats from inflammatory bowel disease induced by intracolonic administration of trinitrobenzensulfonic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Colitis; Col | 1998 |
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chitin; Chitosan; | 1999 |
Sulfasalazine inhibits reperfusion injury and prolongs allograft survival in rat cardiac transplants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; E-Selectin; Graft Rejectio | 1999 |
Dietary fiber fraction of germinated barley foodstuff attenuated mucosal damage and diarrhea, and accelerated the repair of the colonic mucosa in an experimental colitis.
Topics: Animals; Cellulose; Colitis; Diarrhea; Dietary Fiber; Disease Models, Animal; Fatty Acids, Volatile; | 2001 |
Oral administration of avian tumor necrosis factor antibodies effectively treats experimental colitis in rats.
Topics: Administration, Oral; Animals; Antibodies; Chickens; Colitis; Dexamethasone; Disease Models, Animal; | 2000 |
Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Chronic Disease; Colitis; Colon; Disea | 2001 |
On the effect of sulphasalazine on the prostaglandin system and the defective prostaglandin inactivation observed in experimental ulcerative colitis.
Topics: Animals; Cecum; Colitis, Ulcerative; Colon; Disease Models, Animal; Guinea Pigs; Lung; Prostaglandin | 1979 |
Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Humans; | 1992 |
The effect of therapeutic drugs used in inflammatory bowel disease on the incidence and growth of colonic cancer in the dimethylhydrazine rat model.
Topics: Adenocarcinoma; Aminosalicylic Acids; Animals; Cocarcinogenesis; Colonic Neoplasms; Dimethylhydrazin | 1992 |
Chronic intrajejunal TNBS application in TNBS-sensitized rats: a new model of chronic inflammatory bowel diseases.
Topics: Aminosalicylic Acids; Animals; Disease Models, Animal; Female; Immunization; Inflammatory Bowel Dise | 1992 |
Inflammatory bowel disease induced by combined bacterial immunization and oral carrageenan in guinea pigs. Model development, histopathology, and effects of sulfasalazine.
Topics: Animals; Bacteroides; Carrageenan; Disease Models, Animal; Gastric Mucosa; Guinea Pigs; Immunization | 1991 |
The effect of long-term sulfasalazine therapy on type II collagen-induced arthritis in rats.
Topics: Animals; Arthritis; Arthritis, Experimental; Collagen; Disease Models, Animal; Female; Rats; Rats, I | 1990 |
Characteristics of immune-complex-induced chronic experimental colitis in rats with a therapeutic effect of sulphasalazine.
Topics: Animals; Chronic Disease; Colitis, Ulcerative; Disease Models, Animal; Female; Immune Complex Diseas | 1990 |
An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis.
Topics: Administration, Oral; Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Indoles; Inflamma | 1990 |
Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat.
Topics: Acetates; Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; | 1990 |
Experimental non-steroidal anti-inflammatory drug-induced enteropathy in the rat: similarities to inflammatory bowel disease and effect of thromboxane synthetase inhibitors.
Topics: Animals; Cell Membrane Permeability; Chromium Radioisotopes; Disease Models, Animal; Edetic Acid; Il | 1990 |
Arachidonic acid metabolites and their role in inflammatory bowel disease. An update requiring addition of a pathway.
Topics: Aminosalicylic Acids; Arachidonic Acid; Arachidonic Acids; Biological Transport; Bradykinin; Colitis | 1985 |
Role of T lymphocytes in murine collagen induced arthritis.
Topics: Animals; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Collagen; Disease Models, Animal | 1986 |