Page last updated: 2024-11-04

sulfasalazine and DRESS Syndrome

sulfasalazine has been researched along with DRESS Syndrome in 28 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Research Excerpts

ExcerptRelevanceReference
"Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality."8.12Drug hypersensitivity syndrome induced by sulfasalazine: A case report. ( Chen, DH; Guan, CL; Shen, GY; Xu, C; Zhang, YG; Zhou, HR, 2022)
"DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a severe, rare and potentially lethal idiosyncratic condition associated with the use of some drugs."5.56[DRESS syndrome induced by sulfasalazine. Report of one case]. ( Arce, E; Blamey, R; Flores, L; Quera, R, 2020)
"Both DRESS and agranulocytosis were not reported previously with SSZ."5.42Sulfasalazine-induced DRESS and severe agranulocytosis successfully treated by granulocyte colony-stimulating factor. ( Ben Salem, C; Fathallah, N; Hachfi, W; Letaief, A; Rached, S; Slim, R, 2015)
"The most commonly reported drugs are allopurinol, sulfasalazine and minocycline, which pose a very high risk for DRESS syndrome development, followed by strontium ranelate and dapsone."4.95Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and the Rheumatologist. ( Adwan, MH, 2017)
"Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality."4.12Drug hypersensitivity syndrome induced by sulfasalazine: A case report. ( Chen, DH; Guan, CL; Shen, GY; Xu, C; Zhang, YG; Zhou, HR, 2022)
"Diagnosing drug reaction with eosinophilia and systemic symptoms (DRESS) is challenging."1.56Drug reaction with eosinophilia and systemic symptoms may occur within 2 weeks of drug exposure: A retrospective study. ( Barbaud, A; Bernier, C; Milpied, B; Puymirat, E; Soria, A; Veyrac, G, 2020)
"DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a severe, rare and potentially lethal idiosyncratic condition associated with the use of some drugs."1.56[DRESS syndrome induced by sulfasalazine. Report of one case]. ( Arce, E; Blamey, R; Flores, L; Quera, R, 2020)
"The histopathology of DRESS syndrome highlights various associated inflammatory patterns in a single biopsy."1.42Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study. ( Bastuji-Garin, S; Chosidow, O; de Feraudy, S; Delfau-Larue, MH; Duong, TA; Ortonne, N; Roujeau, JC; Valeyrie-Allanore, L; Wechsler, J; Wolkenstein, P, 2015)
"Both DRESS and agranulocytosis were not reported previously with SSZ."1.42Sulfasalazine-induced DRESS and severe agranulocytosis successfully treated by granulocyte colony-stimulating factor. ( Ben Salem, C; Fathallah, N; Hachfi, W; Letaief, A; Rached, S; Slim, R, 2015)
"We herein report a case of DRESS syndrome who presented with fever and rash, secondary to sulfasalazine ingestion."1.42DRESS Syndrome: Drug Rash with Eosinophilia and Systemic Symptoms. ( Shah, M; Thacker, H; Tulle, R, 2015)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (64.29)24.3611
2020's10 (35.71)2.80

Authors

AuthorsStudies
Sil, A1
Bhattacharjee, MS1
Chandra, A1
Pramanik, JD1
Khellaf, L1
Cosserat, J1
Calas, A1
Brasme, H1
Charles, P1
Chen, DH1
Zhou, HR1
Zhang, YG1
Shen, GY1
Xu, C1
Guan, CL1
Shimada, Y1
Suyama, Y1
Koizumi, M1
Hagiwara, K1
Soria, A1
Bernier, C1
Veyrac, G1
Barbaud, A1
Puymirat, E1
Milpied, B1
Nakamura, R1
Ozeki, T1
Hirayama, N1
Sekine, A2
Yamashita, T1
Mashimo, Y1
Mizukawa, Y1
Shiohara, T2
Watanabe, H1
Sueki, H1
Ogawa, K1
Asada, H1
Kaniwa, N1
Tsukagoshi, E1
Matsunaga, K1
Niihara, H1
Yamaguchi, Y1
Aihara, M1
Mushiroda, T1
Saito, Y1
Morita, E1
Sahm, J1
de Groot, K1
Schreiber, J1
Winward, J1
Lyckholm, L1
Brown, SM1
Mokadem, M1
Balconi, SN1
Lopes, NT1
Luzzatto, L1
Bonamigo, RR1
Arce, E1
Quera, R1
Flores, L1
Blamey, R1
Deschamps, A1
Samain, A1
Carvalho, P1
Courville, P1
Levesque, H1
Musette, P1
Joly, P1
Lang, M1
Fish, J1
Covelli, C1
Schreiber, BE1
Wu, X1
Yang, F1
Chen, S1
Xiong, H1
Zhu, Q1
Gao, X1
Xing, Q1
Luo, X1
Kenani, Z1
Lahouel, I1
Belhadjali, H1
Soua, Y1
Aouam, K1
Youssef, M1
Zili, J1
Jeimy, S1
McRae, K1
Pattani, R1
Lian, BS1
Busmanis, I1
Lee, HY1
Parkins, G1
White, B1
Hernández, N1
Borrego, L1
Soler, E1
Hernández, J1
Pirklbauer, M1
Gruber, J1
Raithatha, N1
Mehrtens, S1
Mouyis, M1
Manson, J1
Ortonne, N1
Valeyrie-Allanore, L1
Bastuji-Garin, S1
Wechsler, J1
de Feraudy, S1
Duong, TA1
Delfau-Larue, MH1
Chosidow, O1
Wolkenstein, P1
Roujeau, JC1
Chebbi, W1
Souissi, J1
Chelli, J1
Larbi, F1
Zantour, B1
Habib Sfar, M1
Fathallah, N1
Slim, R1
Rached, S1
Hachfi, W1
Letaief, A1
Ben Salem, C1
Thacker, H1
Shah, M1
Tulle, R1
Kato, M1
Kano, Y1
Sato, Y1
Sussman, S1
Devlin, V1
Dimitriades, VR1
Adwan, MH1
Saito, T1
Ito, S1
Tsunoda, Y1
Sumazaki, Y1
Tanaka, T1
Takoi, H1
Lin, SY1
Yatagai, Y1
Hayasihara, K1

Reviews

1 review available for sulfasalazine and DRESS Syndrome

ArticleYear
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and the Rheumatologist.
    Current rheumatology reports, 2017, Volume: 19, Issue:1

    Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Bone Density Conservatio

2017

Other Studies

27 other studies available for sulfasalazine and DRESS Syndrome

ArticleYear
Sulfasalazine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) with concomitant acute chikungunya virus infection: possible role of new viral trigger.
    BMJ case reports, 2021, Oct-12, Volume: 14, Issue:10

    Topics: Chikungunya Fever; Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Sulfasalazine

2021
Unusual neurological and cardiac complications of drug reaction with eosinophilia and systemic symptoms syndrome: a case report.
    European journal of dermatology : EJD, 2021, Oct-01, Volume: 31, Issue:5

    Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Drug Hyperse

2021
Drug hypersensitivity syndrome induced by sulfasalazine: A case report.
    Medicine, 2022, Aug-19, Volume: 101, Issue:33

    Topics: Colitis, Ulcerative; Drug Hypersensitivity; Drug Hypersensitivity Syndrome; Exanthema; Humans; Male;

2022
Laryngeal edema in drug reaction with eosinophilia and systemic symptoms syndrome due to sulfasalazine.
    International journal of rheumatic diseases, 2023, Volume: 26, Issue:11

    Topics: Drug Hypersensitivity Syndrome; Eosinophilia; Exanthema; Humans; Laryngeal Edema; Male; Middle Aged;

2023
Drug reaction with eosinophilia and systemic symptoms may occur within 2 weeks of drug exposure: A retrospective study.
    Journal of the American Academy of Dermatology, 2020, Volume: 82, Issue:3

    Topics: Adult; Aged; Allopurinol; Anti-Bacterial Agents; Contrast Media; Drug Hypersensitivity Syndrome; Fem

2020
Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:8

    Topics: Adult; Drug Hypersensitivity Syndrome; Female; Genetic Predisposition to Disease; HLA-A11 Antigen; H

2020
Sulfasalazine-induced mononucleosis-like-illness and haemolysis.
    Scandinavian journal of rheumatology, 2021, Volume: 50, Issue:1

    Topics: Adult; Antirheumatic Agents; Drug Hypersensitivity Syndrome; Epstein-Barr Virus Infections; Female;

2021
Case of relapsing sulfasalazine-induced hypersensitivity syndrome upon re-exposure.
    BMJ case reports, 2020, Sep-15, Volume: 13, Issue:9

    Topics: Drug Hypersensitivity Syndrome; Female; Humans; Middle Aged; Recurrence; Retreatment; Sulfasalazine

2020
Detection of SARS-CoV-2 in a case of DRESS by sulfasalazine: could there be a relationship with clinical importance?
    International journal of dermatology, 2021, Volume: 60, Issue:1

    Topics: COVID-19; Drug Hypersensitivity Syndrome; Female; Humans; SARS-CoV-2; Sulfasalazine; Young Adult

2021
[DRESS syndrome induced by sulfasalazine. Report of one case].
    Revista medica de Chile, 2020, Volume: 148, Issue:8

    Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Drug Hypersensitivity Syndrome; Eosinophilia; Female;

2020
A familial mediterranean fever flare induced by a drug reaction with eosinophilia and systemic symptoms.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2018, Volume: 32, Issue:1

    Topics: Adult; Antirheumatic Agents; Colchicine; Drug Hypersensitivity Syndrome; Familial Mediterranean Feve

2018
DRESS syndrome triple whammy: sulfasalazine, amoxicillin and HHV-7.
    British journal of hospital medicine (London, England : 2005), 2017, Nov-02, Volume: 78, Issue:11

    Topics: Adult; Amoxicillin; Anti-Infective Agents; Arthritis, Reactive; DNA, Viral; Dose-Response Relationsh

2017
Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China.
    Acta dermato-venereologica, 2018, Apr-16, Volume: 98, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Allopurinol; Carbamazepine; China; DNA, Vir

2018
Is p-phenylenediamine a marker of sulfasalazine allergy?
    Contact dermatitis, 2018, Volume: 78, Issue:2

    Topics: Adult; Anti-Infective Agents; Coloring Agents; Cross Reactions; Drug Hypersensitivity Syndrome; Huma

2018
A 63-year-old returned traveller with fever, rash, hepatitis and eosinophilia.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018, 07-09, Volume: 190, Issue:27

    Topics: Adrenal Cortex Hormones; Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Live

2018
Relapsing Course of Sulfasalazine-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Alopecia Universalis and Vitiligo.
    Annals of the Academy of Medicine, Singapore, 2018, Volume: 47, Issue:11

    Topics: Alopecia; Antirheumatic Agents; Arthritis, Rheumatoid; Biopsy; Cyclosporine; Dermatologic Agents; Dr

2018
DRESS syndrome presenting like septic shock.
    QJM : monthly journal of the Association of Physicians, 2013, Volume: 106, Issue:7

    Topics: Adult; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity Syndrome; Drug-Related Side Ef

2013
Sulfasalazine-induced linear immunoglobulin A bullous dermatosis with DRESS.
    Actas dermo-sifiliograficas, 2013, Volume: 104, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity Syndrome; Female; Humans; Immunoglobu

2013
[DRESS syndrome following sulfasalazine treatment].
    Zeitschrift fur Rheumatologie, 2014, Volume: 73, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Antirheumatic Agents; Drug Hypersensitivity Syndrome; Female; Humans

2014
Rash and fever after sulfasalazine use.
    BMJ (Clinical research ed.), 2014, Oct-08, Volume: 349

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity Syndrome; Exanthema; Female; F

2014
Histopathology of drug rash with eosinophilia and systemic symptoms syndrome: a morphological and phenotypical study.
    The British journal of dermatology, 2015, Volume: 173, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Anti-Bacterial Agents; B-Lymphocytes; Carba

2015
[DRESS syndrome: report of three cases].
    The Pan African medical journal, 2014, Volume: 19

    Topics: Adolescent; Adult; Carbamazepine; Drug Combinations; Drug Hypersensitivity Syndrome; Female; Glucosa

2014
Sulfasalazine-induced DRESS and severe agranulocytosis successfully treated by granulocyte colony-stimulating factor.
    International journal of clinical pharmacy, 2015, Volume: 37, Issue:4

    Topics: Adult; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Hypersens

2015
DRESS Syndrome: Drug Rash with Eosinophilia and Systemic Symptoms.
    The Journal of the Association of Physicians of India, 2015, Volume: 63, Issue:5

    Topics: Antirheumatic Agents; Drug Hypersensitivity Syndrome; Female; Humans; Middle Aged; Sulfasalazine

2015
Severe Agranulocytosis in Two Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms.
    Acta dermato-venereologica, 2016, 08-23, Volume: 96, Issue:6

    Topics: Aged; Aged, 80 and over; Agranulocytosis; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Anti

2016
A Teenager With Sulfasalazine-Associated DRESS Syndrome After the Introduction of Amoxicillin.
    Clinical pediatrics, 2017, Volume: 56, Issue:3

    Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypers

2017
Two cases of tuberculosis with multiple drug hypersensitivity after drug-induced hypersensitivity syndrome.
    Respiratory investigation, 2012, Volume: 50, Issue:2

    Topics: Aged; Allopurinol; Antitubercular Agents; Drug Hypersensitivity Syndrome; Female; Humans; Liver Cirr

2012