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sulfasalazine and Cardiomegaly

sulfasalazine has been researched along with Cardiomegaly in 1 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
" Angiotensin II (AngII) results in cardiac fibrosis and hypertrophy partly through activation of inflammation, which increases the fibroblasts and promotes extracellular matrix production."4.12Sulfasalazine exacerbates angiotensin II-induced cardiac remodelling by activating Akt signal pathway. ( Bai, Y; Chen, C; Gao, Z; Jiang, X; Meng, Y; Zhang, X; Zheng, C, 2022)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (100.00)2.80

Authors

AuthorsStudies
Chen, C1
Zhang, X1
Zheng, C1
Gao, Z1
Jiang, X1
Bai, Y1
Meng, Y1

Other Studies

1 other study available for sulfasalazine and Cardiomegaly

ArticleYear
Sulfasalazine exacerbates angiotensin II-induced cardiac remodelling by activating Akt signal pathway.
    Clinical and experimental pharmacology & physiology, 2022, Volume: 49, Issue:7

    Topics: Angiotensin II; Animals; Cardiomegaly; Fibrosis; Hypertrophy; Mice; Mice, Inbred C57BL; Myocardium;

2022