sulfasalazine has been researched along with Benign Neoplasms in 21 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Investigation determined her illness was likely a delayed hypersensitivity reaction caused by sulfasalazine." | 8.31 | Sulfasalazine-Induced Delayed Hypersensitivity Reaction Presenting as Fever, Aseptic Meningitis, and Mesenteric Panniculitis in a Patient with Seronegative Arthritis. ( Davel, S; Ng, TTW; O'Connor, KD, 2023) |
| " Investigation determined her illness was likely a delayed hypersensitivity reaction caused by sulfasalazine." | 4.31 | Sulfasalazine-Induced Delayed Hypersensitivity Reaction Presenting as Fever, Aseptic Meningitis, and Mesenteric Panniculitis in a Patient with Seronegative Arthritis. ( Davel, S; Ng, TTW; O'Connor, KD, 2023) |
| "Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism." | 2.61 | Discovery and development of small molecule modulators targeting glutamine metabolism. ( Bi, X; Bian, J; Dai, W; Li, L; Li, Z; Meng, Y; Xu, X, 2019) |
| "One possible reason is existence of cancer stem cells, which have self-renewal activity and resistance to chemotherapy and radiotherapy." | 1.42 | [Clinical research of targeting therapy for cancer stem cells]. ( Doi, T; Shitara, K, 2015) |
| "However, the role of xCT in tumor metastasis remains largely unknown." | 1.35 | Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. ( Chen, RS; Dong, LJ; Fu, M; Guo, XL; He, X; Li, W; Li, Y; Qiao, HX; Song, YM; Tong, T; Zhan, QM; Zhou, ZY, 2009) |
| " In this study we determined the activity and toxicity of melphalan in combination with another GST-activity inhibitor, sulfasalazine, an agent used to treat ulcerative colitis." | 1.29 | Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine. ( Awasthi, S; Awasthi, YC; Fields, L; Gupta, V; Jacobs, S; Jani, JP; Levitt, M; Singh, SV; Sreevardhan, M; Xu, BH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 6 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 2 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Li, L | 1 |
| Meng, Y | 1 |
| Li, Z | 1 |
| Dai, W | 1 |
| Xu, X | 1 |
| Bi, X | 1 |
| Bian, J | 1 |
| Zhu, X | 1 |
| Chen, Q | 2 |
| Xie, L | 1 |
| Chen, W | 1 |
| Jiang, Y | 1 |
| Song, E | 1 |
| Song, Y | 1 |
| Ng, TTW | 1 |
| Davel, S | 1 |
| O'Connor, KD | 1 |
| Liu, L | 1 |
| Liu, R | 1 |
| Liu, Y | 1 |
| Li, G | 1 |
| Liu, X | 1 |
| Ma, S | 1 |
| Koppula, P | 1 |
| Zhuang, L | 1 |
| Gan, B | 1 |
| Zhu, J | 1 |
| Xiong, Y | 1 |
| Zhang, Y | 1 |
| Wen, J | 1 |
| Cai, N | 1 |
| Cheng, K | 1 |
| Liang, H | 1 |
| Zhang, W | 1 |
| Zheng, J | 1 |
| Sato, M | 1 |
| Mishima, E | 1 |
| Sato, H | 1 |
| Proneth, B | 1 |
| Conrad, M | 1 |
| Rosario, SR | 1 |
| Long, MD | 1 |
| Affronti, HC | 1 |
| Rowsam, AM | 1 |
| Eng, KH | 1 |
| Smiraglia, DJ | 1 |
| Xia, X | 1 |
| Fan, X | 1 |
| Zhao, M | 1 |
| Zhu, P | 1 |
| Kou, L | 1 |
| Sun, R | 1 |
| Xiao, S | 1 |
| Zheng, Y | 1 |
| Chen, Z | 1 |
| Cai, A | 1 |
| Zheng, H | 1 |
| Yao, Q | 1 |
| Ganapathy, V | 1 |
| Chen, R | 1 |
| Uutela, T | 1 |
| Kautiainen, H | 1 |
| Järvenpää, S | 1 |
| Salomaa, S | 1 |
| Hakala, M | 1 |
| Häkkinen, A | 1 |
| Shitara, K | 1 |
| Doi, T | 1 |
| Chen, RS | 1 |
| Song, YM | 1 |
| Zhou, ZY | 1 |
| Tong, T | 1 |
| Fu, M | 1 |
| Guo, XL | 1 |
| Dong, LJ | 1 |
| He, X | 1 |
| Qiao, HX | 1 |
| Zhan, QM | 1 |
| Li, W | 1 |
| Peinado, C | 1 |
| Kang, X | 1 |
| Hardamon, C | 1 |
| Arora, S | 1 |
| Mah, S | 1 |
| Zhang, H | 1 |
| Ngolab, J | 1 |
| Bui, JD | 1 |
| SVARTZ, N | 1 |
| ROSEN, RB | 1 |
| TEPLITZ, RL | 1 |
| Gupta, V | 1 |
| Jani, JP | 1 |
| Jacobs, S | 1 |
| Levitt, M | 1 |
| Fields, L | 1 |
| Awasthi, S | 1 |
| Xu, BH | 1 |
| Sreevardhan, M | 1 |
| Awasthi, YC | 1 |
| Singh, SV | 1 |
| Matuchansky, C | 1 |
| Truelove, SC | 1 |
| Gall, DG | 1 |
| Hamilton, JR | 1 |
7 reviews available for sulfasalazine and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Discovery and development of small molecule modulators targeting glutamine metabolism.
Topics: Animals; Antineoplastic Agents; Drug Discovery; Energy Metabolism; Glutamine; Humans; Neoplasms | 2019 |
Cystine-glutamate antiporter xCT as a therapeutic target for cancer.
Topics: Amino Acid Transport System y+; Anti-Inflammatory Agents, Non-Steroidal; Ferroptosis; Glutathione; H | 2021 |
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Topics: Amino Acid Transport System y+; Antineoplastic Agents; Cystine; DNA Methylation; Ferroptosis; Gene E | 2021 |
The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors.
Topics: Acetaminophen; Antineoplastic Agents; Antioxidants; Apoptosis; Artemisinins; Auranofin; Cell Death; | 2020 |
The Relationship between Ferroptosis and Tumors: A Novel Landscape for Therapeutic Approach.
Topics: Apoptosis; Artesunate; Autophagy; Cell Death; Ferroptosis; Humans; Iron; Neoplasms; Phospholipid Hyd | 2019 |
Chronic diarrhea in childhood: a new look at an old problem.
Topics: Celiac Disease; Chlorides; Chronic Disease; Cystic Fibrosis; Diarrhea; Diet Therapy; Food Hypersensi | 1974 |
14 other studies available for sulfasalazine and Benign Neoplasms
| Article | Year |
|---|---|
Iron ion and sulfasalazine-loaded polydopamine nanoparticles for Fenton reaction and glutathione peroxidase 4 inactivation for enhanced cancer ferrotherapy.
Topics: Cell Line, Tumor; Humans; Indoles; Ions; Iron; Nanoparticles; Neoplasms; Phospholipid Hydroperoxide | 2022 |
Sulfasalazine-Induced Delayed Hypersensitivity Reaction Presenting as Fever, Aseptic Meningitis, and Mesenteric Panniculitis in a Patient with Seronegative Arthritis.
Topics: Aged, 80 and over; Arthritis; Fatigue; Female; Fever; Humans; Hypersensitivity, Delayed; Meningitis, | 2023 |
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.
Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, N | 2021 |
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas.
Topics: Cell Line; Cell Survival; Cellular Reprogramming; Citric Acid Cycle; Computational Biology; Drug Eva | 2018 |
Ambidextrous Approach To Disrupt Redox Balance in Tumor Cells with Increased ROS Production and Decreased GSH Synthesis for Cancer Therapy.
Topics: Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine; Cy | 2019 |
Patients with rheumatoid arthritis have better functional and working ability but poorer general health and higher comorbidity rates today than in the late 1990s.
Topics: Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Produc | 2015 |
[Clinical research of targeting therapy for cancer stem cells].
Topics: Antineoplastic Agents; Cisplatin; Humans; Molecular Targeted Therapy; Neoplasms; Neoplastic Stem Cel | 2015 |
Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway.
Topics: Amino Acid Transport System y+; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Cave | 2009 |
The nuclear factor-κB pathway down-regulates expression of the NKG2D ligand H60a in vitro: implications for use of nuclear factor-κB inhibitors in cancer therapy.
Topics: Animals; Cell Line, Tumor; Cysteine Endopeptidases; Cytotoxicity, Immunologic; DNA-Binding Proteins; | 2013 |
ULCERATIVE COLITIS: CHANGES IN THE INTESTINAL WALLS AND THERAPEUTIC CONSIDERATIONS.
Topics: Adrenal Cortex Hormones; Carbon Isotopes; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Mice; Neo | 1964 |
CHRONIC GRANULOCYTIC LEUKEMIA COMPLICATED BY ULCERATIVE COLITIS: ELEVATED LEUKOCYTE ALKALINE PHOSPHATASE AND POSSIBLE MODIFIER GENE DELETION.
Topics: Adolescent; Alkaline Phosphatase; Blood Cell Count; Chromosomes; Colitis, Ulcerative; Diet; Diet The | 1965 |
Activity of melphalan in combination with the glutathione transferase inhibitor sulfasalazine.
Topics: Drug Administration Schedule; Drug Therapy, Combination; Female; Glutathione Transferase; Humans; Ma | 1995 |
Inflammatory bowel diseases 1977.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Diet; Eye Diseases; Humans; Joint | 1977 |
Proceedings: Medical aspects of ulcerative colitis in childhood.
Topics: Adolescent; Child; Colectomy; Colitis, Ulcerative; Humans; Hydrocortisone; Male; Neoplasms; Predniso | 1973 |