Page last updated: 2024-11-04

sulfasalazine and Arthritis, Spinal

sulfasalazine has been researched along with Arthritis, Spinal in 22 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Research Excerpts

ExcerptRelevanceReference
"To assess the effect of sulfasalazine (SSZ) on inflammatory back pain (IBP) due to active undifferentiated spondyloarthritis (uSpA) or ankylosing spondylitis in patients with symptom duration <5 years."9.12Efficacy of sulfasalazine in patients with inflammatory back pain due to undifferentiated spondyloarthritis and early ankylosing spondylitis: a multicentre randomised controlled trial. ( Alten, R; Baraliakos, X; Baumgaertner, M; Beck, E; Brandt, J; Braun, J; Burmester, G; Ebner, W; Gömör, B; Grasedyck, K; Haibel, H; Hammer, M; Hermann, J; Krause, A; Mielke, F; Sieper, J; Tony, HP; Zeidler, H; Zochling, J, 2006)
"Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis."8.12Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study. ( David, R; Jayachandran, M; Koshy, V; Marwaha, V; Mithun, CB; Nair, AS; Padmanabhan, DS; Palatty, PL; Santhakumari, V; Singh, SK; Singhal, A; Suman, SK; Surendran, S; Tiwari, A; Yadav, P, 2022)
"To assess the effect of sulfasalazine (SSZ) on inflammatory back pain (IBP) due to active undifferentiated spondyloarthritis (uSpA) or ankylosing spondylitis in patients with symptom duration <5 years."5.12Efficacy of sulfasalazine in patients with inflammatory back pain due to undifferentiated spondyloarthritis and early ankylosing spondylitis: a multicentre randomised controlled trial. ( Alten, R; Baraliakos, X; Baumgaertner, M; Beck, E; Brandt, J; Braun, J; Burmester, G; Ebner, W; Gömör, B; Grasedyck, K; Haibel, H; Hammer, M; Hermann, J; Krause, A; Mielke, F; Sieper, J; Tony, HP; Zeidler, H; Zochling, J, 2006)
"Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis."4.12Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study. ( David, R; Jayachandran, M; Koshy, V; Marwaha, V; Mithun, CB; Nair, AS; Padmanabhan, DS; Palatty, PL; Santhakumari, V; Singh, SK; Singhal, A; Suman, SK; Surendran, S; Tiwari, A; Yadav, P, 2022)
"A FREQUENT AFFECTION: Ankylosing spondylitis is a chronic inflammatory rheumatism usually affecting young adults and characterized by an inflammatory enthesiopathy progressing towards ossification and ankylosis."2.42[Ankylosing spondylitis]. ( El Maghraoui, A, 2004)
"Age and uveitis are related to conversion to biologics therapy."1.91Cause analysis of conversion to biologics in spondyloarthritis patients with poor response to conventional treatment. ( Huang, D; Huang, W; Luo, L; Ren, F; Tang, L; Zhang, Z; Zhou, J, 2023)
"Sacroiliitis is an important sign of spondylarthritis (SpA) of which the prototype disease is ankylosing spondylitis."1.35Efficacy of SLZ and MTX (alone or combination) on the treatment of active sacroiliitis in early AS. ( Argin, M; Gumusdis, G; Kabasakal, Y; Kitapcioglu, G; Taylan, A; Yargucu, F, 2009)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (18.18)29.6817
2010's11 (50.00)24.3611
2020's7 (31.82)2.80

Authors

AuthorsStudies
Khellaf, L1
Cosserat, J1
Calas, A1
Brasme, H1
Charles, P1
Caterson, HC1
Youssef, P1
Jayachandran, M1
Koshy, V1
David, R1
Santhakumari, V1
Padmanabhan, DS1
Surendran, S1
Tiwari, A1
Mithun, CB1
Singh, SK1
Suman, SK1
Yadav, P1
Singhal, A1
Nair, AS1
Marwaha, V1
Palatty, PL1
G S Saad, C1
S R Silva, M1
Sampaio-Barros, PD1
C B Moraes, J1
G Schainberg, C1
Gonçalves, CR1
Shimabuco, AY1
Aikawa, NE1
F N Yuki, E1
G Pasoto, S1
V K Kupa, L1
K Aoyama, R1
S R Araujo, C1
Silva, CA1
Medeiros-Ribeiro, AC1
Bonfa, E1
Armağan, B1
Atalar, E1
Güven, SC1
Özdemir, B1
Konak, HE1
Akyüz Dağlı, P1
Erden, A1
Gök, K1
Maraş, Y1
Doğan, İ1
Küçükşahin, O1
Erten, Ş1
Omma, A1
Zhou, J1
Huang, W1
Zhang, Z1
Luo, L1
Ren, F1
Huang, D1
Tang, L1
Ganapati, A1
Gowri, M1
Antonisamy, B1
Danda, D1
Banse, C1
Armengol-Debeir, L1
Vittecoq, O1
Felice, C1
Pugliese, D1
Papparella, LG1
Pizzolante, F1
Onori, E1
Gasbarrini, A1
Rapaccini, GL1
Guidi, L1
Armuzzi, A1
John, KJ1
Sadiq, M1
Thomas, M1
Turaka, VP1
Krohn, M1
Braum, LS1
Sieper, J5
Song, IH3
Weiss, A2
Callhoff, J1
Althoff, CE3
Hamm, B1
Hermann, KG2
Fagerli, KM1
van der Heijde, D1
Heiberg, MS1
Wierød, A1
Kalstad, S1
Rødevand, E1
Mikkelsen, K1
Kvien, TK1
Lie, E2
Kristensen, LE1
Forsblad-d'Elia, H1
Zverkova-Sandström, T1
Askling, J1
Jacobsson, LT1
Kabasakal, Y1
Kitapcioglu, G1
Yargucu, F1
Taylan, A1
Argin, M1
Gumusdis, G1
Karmakar, GC1
Wong, CA1
Horwood, F1
Anderson, G1
Hermann, K1
Haibel, H3
Althoff, C1
Listing, J2
Burmester, G2
Krause, A2
Bohl-Bühler, M1
Freundlich, B2
Rudwaleit, M2
Poddubnyy, D1
Tayel, MY1
Soliman, E1
El Baz, WF1
El Labaan, A1
Hamaad, Y1
Ahmed, MH1
Castro Villegas, Mdel C1
Escudero Contreras, A1
Miranda García, MD1
Collantes Estévez, E1
El Maghraoui, A1
Braun, J2
Zochling, J1
Baraliakos, X1
Alten, R1
Grasedyck, K1
Brandt, J1
Hammer, M1
Mielke, F1
Tony, HP1
Ebner, W1
Gömör, B1
Hermann, J1
Zeidler, H1
Beck, E1
Baumgaertner, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Immunogenicity and Safety of the CoronaVac Vacccine in Patients With Autoimmune Rheumatic Diseases and People Living With HIV/AIDS[NCT04754698]Phase 42,067 participants (Anticipated)Interventional2021-02-09Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for sulfasalazine and Arthritis, Spinal

ArticleYear
Effectiveness of vedolizumab for Crohn's disease with spondyloarthritis in fail with two TNF blocking agents.
    Joint bone spine, 2018, Volume: 85, Issue:4

    Topics: Adrenal Cortex Hormones; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Crohn Dis

2018
Clinical management of rheumatologic conditions co-occurring with inflammatory bowel diseases.
    Expert review of clinical immunology, 2018, Volume: 14, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Evidence-Based

2018
[How to optimize the antiTNF alpha therapy in spondylitis?].
    Reumatologia clinica, 2012, Volume: 8 Suppl 1

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheu

2012
[Ankylosing spondylitis].
    Presse medicale (Paris, France : 1983), 2004, Nov-20, Volume: 33, Issue:20

    Topics: Acquired Hyperostosis Syndrome; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

2004

Trials

5 trials available for sulfasalazine and Arthritis, Spinal

ArticleYear
Interaction of TNFi and conventional synthetic DMARD in SARS-CoV-2 vaccine response in axial spondyloarthritis and psoriatic arthritis.
    Joint bone spine, 2023, Volume: 90, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Psoriatic; Axial Spondyloarthritis; COVID-19; COVID-19 Vaccines; Fe

2023
Erosions and fatty lesions of sacroiliac joints in patients with axial spondyloarthritis: evaluation of different MRI techniques and two scoring methods.
    The Journal of rheumatology, 2014, Volume: 41, Issue:3

    Topics: Antirheumatic Agents; Etanercept; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Receptors, T

2014
Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial.
    Annals of the rheumatic diseases, 2011, Volume: 70, Issue:4

    Topics: Adolescent; Adult; Antirheumatic Agents; Epidemiologic Methods; Etanercept; Female; Humans; Immunogl

2011
Relationship between active inflammatory lesions in the spine and sacroiliac joints and new development of chronic lesions on whole-body MRI in early axial spondyloarthritis: results of the ESTHER trial at week 48.
    Annals of the rheumatic diseases, 2011, Volume: 70, Issue:7

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Bone Marrow Diseases; Chronic

2011
Efficacy of sulfasalazine in patients with inflammatory back pain due to undifferentiated spondyloarthritis and early ankylosing spondylitis: a multicentre randomised controlled trial.
    Annals of the rheumatic diseases, 2006, Volume: 65, Issue:9

    Topics: Adolescent; Adult; Antirheumatic Agents; Back Pain; Female; Humans; Male; Middle Aged; Severity of I

2006

Other Studies

13 other studies available for sulfasalazine and Arthritis, Spinal

ArticleYear
Unusual neurological and cardiac complications of drug reaction with eosinophilia and systemic symptoms syndrome: a case report.
    European journal of dermatology : EJD, 2021, Oct-01, Volume: 31, Issue:5

    Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Drug Hyperse

2021
Sulfasalazine-induced myopathy in a patient with an acute spondyloarthritis.
    Internal medicine journal, 2022, Volume: 52, Issue:1

    Topics: Antirheumatic Agents; Humans; Muscular Diseases; Spondylarthritis; Sulfasalazine

2022
Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study.
    International journal of clinical pharmacology and therapeutics, 2022, Volume: 60, Issue:8

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects an

2022
Effects of sulfasalazine in axial spondyloarthritis on COVID-19 outcomes: real-life data from a single center.
    Immunopharmacology and immunotoxicology, 2023, Volume: 45, Issue:4

    Topics: Axial Spondyloarthritis; Biological Products; COVID-19; Female; Humans; Male; Middle Aged; Retrospec

2023
Cause analysis of conversion to biologics in spondyloarthritis patients with poor response to conventional treatment.
    Clinical rheumatology, 2023, Volume: 42, Issue:12

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Biological Factors; Biolo

2023
Combination of methotrexate and sulfasalazine is an efficacious option for axial spondyloarthritis in a resource-limited, real-world clinical setting: a prospective cohort study.
    Clinical rheumatology, 2021, Volume: 40, Issue:5

    Topics: Antirheumatic Agents; Cohort Studies; Humans; Methotrexate; Prospective Studies; Spondylarthritis; S

2021
Henoch-Schonlein purpura associated with HLA-B27 positive axial spondyloarthritis in a young man.
    BMJ case reports, 2019, May-24, Volume: 12, Issue:5

    Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; HLA-B27 Antige

2019
Is there a role for sulphasalazine in axial spondyloarthritis in the era of TNF inhibition? Data from the NOR-DMARD longitudinal observational study.
    Rheumatology (Oxford, England), 2014, Volume: 53, Issue:6

    Topics: Adult; Antirheumatic Agents; Biological Products; Drug Substitution; Female; Humans; Kaplan-Meier Es

2014
The effect of comedication with conventional synthetic disease modifying antirheumatic drugs on TNF inhibitor drug survival in patients with ankylosing spondylitis and undifferentiated spondyloarthritis: results from a nationwide prospective study.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:6

    Topics: Adalimumab; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents;

2015
Efficacy of SLZ and MTX (alone or combination) on the treatment of active sacroiliitis in early AS.
    Rheumatology international, 2009, Volume: 29, Issue:12

    Topics: Adult; Antirheumatic Agents; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging;

2009
Sulphasalazine lung toxicity: report of two cases.
    The New Zealand medical journal, 2010, Aug-13, Volume: 123, Issue:1320

    Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Bronchiectasis; Cough; Crohn Disease; Female; Hu

2010
Registry of the clinical characteristics of spondyloarthritis in a cohort of Egyptian population.
    Rheumatology international, 2012, Volume: 32, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Cross-Sectional Studies; Disability

2012
[Spondylarthritides].
    Zeitschrift fur Rheumatologie, 2006, Volume: 65, Issue:7

    Topics: Adalimumab; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Mono

2006