sulfasalazine has been researched along with Agranulocytosis in 51 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
Excerpt | Relevance | Reference |
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"We report the use of granulocyte-macrophage colony stimulating factor (GM-CSF) in a case of rheumatoid arthritis with sulfasalazine induced agranulocytosis, leading to a rapid bone marrow recovery within 7 days." | 8.78 | Sulfasalazine induced agranulocytosis treated with granulocyte-macrophage colony stimulating factor. ( de Wolf, JT; Hazenberg, BP; Kuipers, EJ; Vellenga, E, 1992) |
"Agranulocytosis is a serious, although rare, adverse reaction to sulfasalazine, which is used to treat inflammatory joint and bowel disease." | 7.88 | Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus. ( Axelsson, T; Bengtsson, M; Bondon-Guitton, E; Carvajal, A; Eriksson, N; Hallberg, P; Ibañez, L; Kohnke, H; Kreutz, R; Lucena, MI; Magnusson, PKE; Martin, J; Molokhia, M; Sancho Ponce, E; Wadelius, M; Yue, QY, 2018) |
"Agranulocytosis is a rare but serious adverse effect of sulfasalazine treatment." | 7.81 | Hyperleucocytosis following G-CSF treatment for sulfasalazine-induced agranulocytosis. ( Chan, K; Farooq, R, 2015) |
"To report a case of sulfasalazine-induced agranulocytosis that was successfully treated with granulocyte-colony stimulating factor (G-CSF)." | 7.68 | Granulocyte-colony stimulating factor for sulfasalazine-induced agranulocytosis. ( Gales, BJ; Gales, MA, 1993) |
"We report a patient with ulcerative colitis in whom agranulocytosis was diagnosed 5 wk after the initiation of sulfasalazine therapy." | 7.67 | Sulfasalazine-induced agranulocytosis. ( Blyden, GT; Demirjian, ZN; Isselbacher, KJ; Jacobson, IM; Kelsey, PB, 1985) |
"A 55-year-old woman with rheumatoid arthritis in overlap with polymyositis received sulfasalazine for control of synovitis." | 7.67 | Cholestasis and fatal agranulocytosis complicating sulfasalazine therapy: case report and review of the literature. ( Mitrane, MP; Seibold, JR; Singh, A, 1986) |
"Agranulocytosis is a rare but potentially lethal adverse effect of sulfasalazine." | 7.67 | Agranulocytosis associated with sulfasalazine. ( Dery, CL; Schwinghammer, TL, 1988) |
"Both DRESS and agranulocytosis were not reported previously with SSZ." | 5.42 | Sulfasalazine-induced DRESS and severe agranulocytosis successfully treated by granulocyte colony-stimulating factor. ( Ben Salem, C; Fathallah, N; Hachfi, W; Letaief, A; Rached, S; Slim, R, 2015) |
"The incidence of agranulocytosis during the first 30 days was estimated to be 1/2400 patients, while it was 1/700 between Days 31-90 and 1/11200 during Days 91-365." | 5.28 | Sulfasalazine associated agranulocytosis in Sweden 1972-1989. Clinical features, and estimation of its incidence. ( Ekman, E; Keisu, M, 1992) |
"We report the use of granulocyte-macrophage colony stimulating factor (GM-CSF) in a case of rheumatoid arthritis with sulfasalazine induced agranulocytosis, leading to a rapid bone marrow recovery within 7 days." | 4.78 | Sulfasalazine induced agranulocytosis treated with granulocyte-macrophage colony stimulating factor. ( de Wolf, JT; Hazenberg, BP; Kuipers, EJ; Vellenga, E, 1992) |
"Agranulocytosis is a rare but serious adverse effect of sulfasalazine treatment." | 3.81 | Hyperleucocytosis following G-CSF treatment for sulfasalazine-induced agranulocytosis. ( Chan, K; Farooq, R, 2015) |
"We report a patient with ulcerative colitis in whom agranulocytosis was diagnosed 5 wk after the initiation of sulfasalazine therapy." | 3.67 | Sulfasalazine-induced agranulocytosis. ( Blyden, GT; Demirjian, ZN; Isselbacher, KJ; Jacobson, IM; Kelsey, PB, 1985) |
"A 55-year-old woman with rheumatoid arthritis in overlap with polymyositis received sulfasalazine for control of synovitis." | 3.67 | Cholestasis and fatal agranulocytosis complicating sulfasalazine therapy: case report and review of the literature. ( Mitrane, MP; Seibold, JR; Singh, A, 1986) |
"A 73-year-old woman developed ulcerative colitis with mesalazine intolerance a year ago." | 1.91 | [A case of ulcerative colitis with mesalazine intolerance complicated with agranulocytosis and septic shock during salazosulfapyridine administration]. ( Eizuka, K; Honta, S; Ikehata, A; Inomata, N; Masuo, T; Ono, S; Sekino, Y, 2023) |
"Both DRESS and agranulocytosis were not reported previously with SSZ." | 1.42 | Sulfasalazine-induced DRESS and severe agranulocytosis successfully treated by granulocyte colony-stimulating factor. ( Ben Salem, C; Fathallah, N; Hachfi, W; Letaief, A; Rached, S; Slim, R, 2015) |
"Drug-induced agranulocytosis (DIA) is a potentially fatal disorder." | 1.31 | Hematopoietic growth factors in drug-induced agranulocytosis. ( Pavithran, K; Thomas, M, 2002) |
"Thirty-nine patients reacted with agranulocytosis, while 75 patients had been treated for a minimum of 3 months without haematological side-effects." | 1.31 | Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. ( Rane, A; Stjernberg, E; Wadelius, M; Wiholm, BE, 2000) |
"Sulphasalazine-induced agranulocytosis is a rare but potentially life threatening complication." | 1.29 | Treatment of sulphasalazine-induced agranulocytosis with granulocyte macrophage-colony stimulating factor. ( Cook, MK; Dorrance, H; Rainey, JB; Roddie, P, 1995) |
"The relative risk for agranulocytosis during sulphasalazine treatment was calculated to be 107 and 123 by the spontaneous reporting system and the case-control study, respectively." | 1.28 | Comparing risk estimates of sulphonamide-induced agranulocytosis from the Swedish Drug Monitoring System and a case-control study. ( Ekman, E; Keisu, M; Wiholm, BE, 1992) |
"GM-CSF treatment for severe agranulocytosis deserves further investigation." | 1.28 | Treatment of drug-induced agranulocytosis with recombinant GM-CSF. ( Jonson, B; Kanerud, L; Palmblad, J, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 26 (50.98) | 18.7374 |
1990's | 15 (29.41) | 18.2507 |
2000's | 5 (9.80) | 29.6817 |
2010's | 4 (7.84) | 24.3611 |
2020's | 1 (1.96) | 2.80 |
Authors | Studies |
---|---|
Ikehata, A | 1 |
Honta, S | 1 |
Sekino, Y | 1 |
Masuo, T | 1 |
Eizuka, K | 1 |
Inomata, N | 1 |
Ono, S | 1 |
Wadelius, M | 2 |
Eriksson, N | 1 |
Kreutz, R | 1 |
Bondon-Guitton, E | 1 |
Ibañez, L | 1 |
Carvajal, A | 1 |
Lucena, MI | 1 |
Sancho Ponce, E | 1 |
Molokhia, M | 1 |
Martin, J | 1 |
Axelsson, T | 1 |
Kohnke, H | 1 |
Yue, QY | 1 |
Magnusson, PKE | 1 |
Bengtsson, M | 1 |
Hallberg, P | 1 |
Fathallah, N | 1 |
Slim, R | 1 |
Rached, S | 1 |
Hachfi, W | 1 |
Letaief, A | 1 |
Ben Salem, C | 1 |
Chan, K | 1 |
Farooq, R | 1 |
Kato, M | 1 |
Kano, Y | 1 |
Sato, Y | 1 |
Shiohara, T | 1 |
Pavithran, K | 1 |
Thomas, M | 1 |
EVANS, RS | 1 |
FORD, WP | 1 |
VINGGARD, HE | 1 |
THIRKETTLE, JL | 1 |
GOUGH, KR | 1 |
READ, AE | 1 |
PANITZ, F | 1 |
ROTH, DA | 1 |
LINDERT, ME | 1 |
Avery, JK | 1 |
Miller, B | 1 |
Maddocks, JL | 1 |
Slater, DN | 1 |
Wheelan, KR | 1 |
Cooper, B | 1 |
Stone, MJ | 1 |
Søndergaard, JO | 1 |
Stage, JG | 1 |
Sprechler, M | 1 |
Hutchinson, D | 1 |
Wyld, PJ | 1 |
Pullar, T | 1 |
Capell, HA | 1 |
Danielson, DA | 1 |
Douglas, SW | 1 |
Herzog, P | 1 |
Jick, H | 1 |
Porter, JB | 1 |
Gales, BJ | 1 |
Gales, MA | 1 |
te Gussinklo, JT | 1 |
Rospond, RM | 1 |
Glowacki, RC | 1 |
Mailliard, JA | 1 |
Canvin, JM | 1 |
el-Gabalawy, HS | 1 |
Chalmers, IM | 1 |
Crawford, GP | 1 |
Laurence, BL | 1 |
Roddie, P | 1 |
Dorrance, H | 1 |
Cook, MK | 1 |
Rainey, JB | 1 |
Murphy, PT | 2 |
Casey, MC | 1 |
Nakamura, K | 1 |
Takeshima, F | 1 |
Shiozawa, K | 1 |
Furusu, H | 1 |
Tomonaga, M | 1 |
Isomoto, H | 1 |
Ohmagari, K | 1 |
Mizuta, Y | 1 |
Murase, K | 1 |
Kohno, S | 1 |
van Rijthoven, AW | 1 |
Stjernberg, E | 1 |
Wiholm, BE | 2 |
Rane, A | 1 |
Kuipers, EJ | 1 |
Vellenga, E | 1 |
de Wolf, JT | 1 |
Hazenberg, BP | 1 |
Keisu, M | 2 |
Ekman, E | 2 |
Matsubayashi, Y | 1 |
Izumi, Y | 1 |
Mori, Y | 1 |
Itoh, K | 1 |
Morioka, A | 1 |
Tatsuta, H | 1 |
Hashimoto, A | 1 |
Kotera, T | 1 |
Itoh, A | 1 |
Jo, I | 1 |
Victorino, RM | 1 |
Maria, VA | 1 |
de Deus, J | 1 |
O'Donnell, JR | 1 |
Palmblad, J | 1 |
Jonson, B | 1 |
Kanerud, L | 1 |
Pointud, P | 1 |
Cauhape, P | 1 |
Favreau, A | 1 |
Guillemin, F | 1 |
Aussedat, R | 1 |
Guerci, A | 1 |
Lederlin, P | 1 |
Trechot, P | 1 |
Pourel, J | 1 |
Jacobson, IM | 1 |
Kelsey, PB | 1 |
Blyden, GT | 1 |
Demirjian, ZN | 1 |
Isselbacher, KJ | 1 |
Farr, M | 1 |
Symmons, DP | 1 |
Blake, DR | 1 |
Bacon, PA | 1 |
Mitrane, MP | 1 |
Singh, A | 1 |
Seibold, JR | 1 |
Dery, CL | 1 |
Schwinghammer, TL | 1 |
Levi, S | 1 |
Liberman, M | 1 |
Levi, AJ | 1 |
Bjarnason, I | 1 |
Kvarstein, G | 1 |
Hovdenak, N | 1 |
Das, KM | 1 |
Eastwood, MA | 1 |
McManus, JP | 1 |
Sircus, W | 1 |
Cochrane, P | 1 |
Atkins, P | 1 |
Ehsanullah, S | 1 |
Darling, VE | 1 |
Collins, JR | 1 |
Marstein, S | 1 |
Jamshidi, K | 1 |
Arlander, T | 1 |
Garcia, MC | 1 |
Windschitl, HW | 1 |
Swaim, WR | 1 |
2 reviews available for sulfasalazine and Agranulocytosis
Article | Year |
---|---|
Sulphasalazine: a 'new' antirheumatic drug.
Topics: Agranulocytosis; Anemia; Antibody Formation; Arthritis, Rheumatoid; Bile; Chemical and Drug Induced | 1984 |
Sulfasalazine induced agranulocytosis treated with granulocyte-macrophage colony stimulating factor.
Topics: Adult; Agranulocytosis; Arthritis, Rheumatoid; Bone Marrow; Female; Granulocyte-Macrophage Colony-St | 1992 |
49 other studies available for sulfasalazine and Agranulocytosis
Article | Year |
---|---|
[A case of ulcerative colitis with mesalazine intolerance complicated with agranulocytosis and septic shock during salazosulfapyridine administration].
Topics: Aged; Agranulocytosis; Colitis, Ulcerative; Female; Humans; Mesalamine; Shock, Septic; Sulfasalazine | 2023 |
Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus.
Topics: Adult; Aged; Agranulocytosis; Alleles; Case-Control Studies; Female; Genome-Wide Association Study; | 2018 |
Sulfasalazine-induced DRESS and severe agranulocytosis successfully treated by granulocyte colony-stimulating factor.
Topics: Adult; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Hypersens | 2015 |
Hyperleucocytosis following G-CSF treatment for sulfasalazine-induced agranulocytosis.
Topics: Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Female; Filgrastim; Granulocyte | 2015 |
Severe Agranulocytosis in Two Patients with Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms.
Topics: Aged; Aged, 80 and over; Agranulocytosis; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2016 |
Hematopoietic growth factors in drug-induced agranulocytosis.
Topics: Adolescent; Adult; Agranulocytosis; Chlorpromazine; Dapsone; Dipyrone; Female; Granulocyte-Macrophag | 2002 |
Studies of the bone marrow in immunological granulocytopenia; following administration of salicylazosulfapyridine.
Topics: Agranulocytosis; Anemia, Myelophthisic; Bone Marrow; Colitis; Colitis, Ulcerative; Sulfanilamide; Su | 1958 |
[3 cases of medicamentous agranulocytosis: Largactil, Cibalgin, Salazopyrine].
Topics: Agranulocytosis; Aminopyrine; Barbiturates; Chlorpromazine; Drug Combinations; Glucosamine; Humans; | 1962 |
Agranulocytosis associated with sulphasalazine ('Salazopyrin') therapy.
Topics: Agranulocytosis; Humans; Sulfanilamide; Sulfanilamides; Sulfasalazine; Sulfonamides | 1963 |
AGRANULOCYTOSIS DUE TO ADMINISTRATION OF SALICYLAZOSULFAPYRADINE (AZULFIDINE).
Topics: Agranulocytosis; Colitis; Colitis, Ulcerative; Humans; Sulfasalazine; Toxicology | 1963 |
A fatal case of azulfidine-induced agranulocytosis.
Topics: Agranulocytosis; Humans; Sulfanilamide; Sulfanilamides; Sulfasalazine; Sulfonamides | 1959 |
Loss prevention case of the month. Monitoring remains critical.
Topics: Acetaminophen; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Clini | 2004 |
[Side effects of salicylazosulfapyridine therapy].
Topics: Agranulocytosis; Colitis, Ulcerative; Crohn Disease; Exanthema; Fever; Humans; Sulfasalazine | 1980 |
Toxic epidermal necrolysis, agranulocytosis and erythroid hypoplasia associated with sulphasalazine.
Topics: Adult; Agranulocytosis; Autopsy; Bone Marrow Diseases; Colitis, Ulcerative; Humans; Male; Stevens-Jo | 1980 |
Multiple haematologic abnormalities associated with sulfasalazine.
Topics: Adult; Agranulocytosis; Anemia, Aplastic; Hematologic Diseases; Humans; Male; Myeloproliferative Dis | 1982 |
[Agranulocytosis in patients with ulcerative colitis treated with salazosulphapyridine].
Topics: Agranulocytosis; Colitis, Ulcerative; Humans; Male; Middle Aged; Sulfasalazine | 1983 |
Sulphasalazine induced agranulocytosis.
Topics: Acetylation; Adult; Agranulocytosis; Diarrhea; Humans; Male; Middle Aged; Phenotype; Sulfasalazine | 1983 |
Drug-induced blood disorders.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Anemia, Hemolytic; Child; Female; Hematologic Diseases; Hu | 1984 |
Granulocyte-colony stimulating factor for sulfasalazine-induced agranulocytosis.
Topics: Aged; Aged, 80 and over; Agranulocytosis; Female; Granulocyte Colony-Stimulating Factor; Humans; Inj | 1993 |
[Hematopoietic growth factors as supportive treatment in agranulocytosis as a result of administered drugs].
Topics: Aged; Agranulocytosis; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Sulfasalazi | 1994 |
Sargramostim for sulfasalazine-induced agranulocytosis.
Topics: Adolescent; Agranulocytosis; Drug Eruptions; Fever; Granulocyte-Macrophage Colony-Stimulating Factor | 1993 |
Fatal agranulocytosis with sulfasalazine therapy in rheumatoid arthritis.
Topics: Aged; Agranulocytosis; Arthritis, Rheumatoid; Female; Humans; Sulfasalazine | 1993 |
Sulphasalazine-induced agranulocytosis successfully treated with filgrastim.
Topics: Adolescent; Agranulocytosis; Anti-Inflammatory Agents; Female; Filgrastim; Granulocyte Colony-Stimul | 1996 |
Treatment of sulphasalazine-induced agranulocytosis with granulocyte macrophage-colony stimulating factor.
Topics: Adult; Agranulocytosis; Colitis, Ulcerative; Gastrointestinal Agents; Granulocyte-Macrophage Colony- | 1995 |
Sulphasalazine induced agranulocytosis revisited.
Topics: Agranulocytosis; Granulocyte Colony-Stimulating Factor; Humans; Male; Middle Aged; Sulfasalazine | 1998 |
[Remission for a patient with ulcerative colitis after agranulocytosis by the side effect of salazosulfapyridine].
Topics: Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Male; Middle | 2000 |
[Pharmacotherapy of patients with (early) rheumatoid arthritis].
Topics: Agranulocytosis; Antirheumatic Agents; Arthritis, Rheumatoid; Cyclosporine; Humans; Methotrexate; Su | 2000 |
Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis.
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Agranulocytosis; Alleles; Anti-Inflammatory | 2000 |
Comparing risk estimates of sulphonamide-induced agranulocytosis from the Swedish Drug Monitoring System and a case-control study.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Case-Control Studies; Drug Monitoring; Female; Humans; Mal | 1992 |
Sulfasalazine associated agranulocytosis in Sweden 1972-1989. Clinical features, and estimation of its incidence.
Topics: Agranulocytosis; Bone Marrow; Cohort Studies; Drug Monitoring; Drug Prescriptions; Humans; Risk; Sul | 1992 |
[Salazopyrine-induced agranulocytosis: clinical picture and incidence].
Topics: Adult; Agranulocytosis; Drug Combinations; Glucosamine; Humans; Incidence; Middle Aged; Prognosis; S | 1991 |
[Salicylazosulfapyridine-induced agranulocytosis in a patient with ulcerative colitis, successfully treated with granulocyte colony-stimulating factor].
Topics: Adult; Agranulocytosis; Bone Marrow; Colitis, Ulcerative; Female; Granulocyte Colony-Stimulating Fac | 1991 |
Immunologic mechanism in sulphasalazine-induced agranulocytosis.
Topics: Adult; Agranulocytosis; Drug Hypersensitivity; Female; Humans; Sulfasalazine | 1990 |
Sulphasalazine induced agranulocytosis in a patient with rheumatoid arthritis.
Topics: Adult; Agranulocytosis; Arthritis, Rheumatoid; Female; Humans; Sulfasalazine | 1990 |
Treatment of drug-induced agranulocytosis with recombinant GM-CSF.
Topics: Agranulocytosis; Arthritis, Rheumatoid; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ma | 1990 |
[Agranulocytosis in rheumatoid polyarthritis treated with sulfasalazine].
Topics: Agranulocytosis; Arthritis, Rheumatoid; Humans; Male; Middle Aged; Sulfasalazine | 1989 |
Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis.
Topics: Agranulocytosis; Arthritis, Rheumatoid; Female; Humans; Middle Aged; Neutropenia; Sulfasalazine | 1989 |
Sulfasalazine-induced agranulocytosis.
Topics: Agranulocytosis; Bone Marrow Examination; Colitis, Ulcerative; Humans; Male; Middle Aged; Sulfasalaz | 1985 |
Neutropenia in patients with inflammatory arthritis treated with sulphasalazine.
Topics: Acute Disease; Adult; Agranulocytosis; Arthritis; Humans; Leukopenia; Male; Middle Aged; Neutropenia | 1986 |
Cholestasis and fatal agranulocytosis complicating sulfasalazine therapy: case report and review of the literature.
Topics: Agranulocytosis; Arthritis, Rheumatoid; Cholestasis, Intrahepatic; Female; Humans; Middle Aged; Myos | 1986 |
Agranulocytosis associated with sulfasalazine.
Topics: Aged; Agranulocytosis; Female; Humans; Leukocyte Count; Sulfasalazine; Time Factors | 1988 |
Reversible congenital neutropenia associated with maternal sulphasalazine therapy.
Topics: Adult; Agranulocytosis; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Neutropenia; | 1988 |
[Granulocytopenia in treatment with salazopyrin].
Topics: Aged; Agranulocytosis; Colitis, Ulcerative; Humans; Male; Middle Aged; Sulfasalazine | 1988 |
Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype.
Topics: Acetylation; Agranulocytosis; Aminosalicylic Acids; Anemia, Hemolytic; Colitis, Ulcerative; Crohn Di | 1973 |
Agranulocytosis associated with sulphasalazine therapy.
Topics: Acetylation; Aged; Agranulocytosis; Antibodies; Female; Humans; Leukocytes; Sulfasalazine; Time Fact | 1973 |
Drug agranulocytosis. A case study.
Topics: Agranulocytosis; Female; Humans; Middle Aged; Nursing Care; Sulfasalazine | 1965 |
Adverse reactions to salicylazosulfapyridine (azulfidine) in the treatment of ulcerative colitis.
Topics: Adult; Agranulocytosis; Colitis, Ulcerative; Dermatitis; Exanthema; Headache; Hematologic Diseases; | 1968 |
[Agranulocytosis during treatment with salicylazosulfapyridine (Salazopyrin)].
Topics: Agranulocytosis; Blood Cell Count; Enterocolitis, Pseudomembranous; Humans; Male; Middle Aged; Sulfa | 1969 |
Azulfidine agranulocytosis with bone marrow, megakaryocytosis, histiocytosis and plasmacytosis.
Topics: Aged; Agranulocytosis; Bone Marrow Examination; Humans; Leukocyte Count; Lymphatic Diseases; Male; M | 1972 |