sulfasalazine has been researched along with Aging in 5 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The elimination half-life of sulphasalazine was prolonged in the elderly whilst renal clearance was increased in slow acetylators at 'steady-state'." | 2.66 | The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis. ( Ahnfelt, NO; Delargy, M; Elborn, S; Forbes, J; McDermott, B; Roberts, SD; Taggart, AJ, 1987) |
| "Sulfasalazine is a prodrug which is enzymatically split in the bowel to form sulfapyridine (the principal active metabolite) and 5-aminosalicylic acid." | 2.39 | Disease-modifying antirheumatic drugs. Potential effects in older patients. ( Furst, DE; Gardner, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ranganath, VK | 1 |
| Furst, DE | 2 |
| Pilin, A | 1 |
| Pudil, F | 1 |
| Bencko, V | 1 |
| Gorbach, SL | 1 |
| Gardner, G | 1 |
| Taggart, AJ | 1 |
| McDermott, B | 1 |
| Delargy, M | 1 |
| Elborn, S | 1 |
| Forbes, J | 1 |
| Roberts, SD | 1 |
| Ahnfelt, NO | 1 |
3 reviews available for sulfasalazine and Aging
| Article | Year |
|---|---|
Disease-modifying antirheumatic drug use in the elderly rheumatoid arthritis patient.
Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Glomerular Filtration Rate; | 2007 |
Perturbation of intestinal microflora.
Topics: Aging; Animals; Anti-Bacterial Agents; Bacteria; Diet; Digoxin; Drug Resistance, Microbial; Estrogen | 1993 |
Disease-modifying antirheumatic drugs. Potential effects in older patients.
Topics: Aged; Aging; Antimalarials; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Sulfa | 1995 |
1 trial available for sulfasalazine and Aging
| Article | Year |
|---|---|
The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis.
Topics: Acetylation; Adult; Aged; Aging; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Half-Life; | 1987 |
1 other study available for sulfasalazine and Aging
| Article | Year |
|---|---|
The image analysis of colour changes of different human tissues in the relation to the age. Part 1. Methodological approach.
Topics: Achilles Tendon; Aging; Cartilage; Forensic Medicine; Image Processing, Computer-Assisted; Intervert | 2007 |