sulfasalazine has been researched along with Adverse Drug Event in 19 studies
Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis." | 8.12 | Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study. ( David, R; Jayachandran, M; Koshy, V; Marwaha, V; Mithun, CB; Nair, AS; Padmanabhan, DS; Palatty, PL; Santhakumari, V; Singh, SK; Singhal, A; Suman, SK; Surendran, S; Tiwari, A; Yadav, P, 2022) |
| "Combination treatments for patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX) alone include the addition of a tumor necrosis factor inhibitor (TNFi) or the addition of sulfasalazine (SSZ) and hydroxychloroquine to MTX (triple therapy)." | 7.91 | Low Persistence Rates in Patients With Rheumatoid Arthritis Treated With Triple Therapy and Adverse Drug Events Associated With Sulfasalazine. ( Cannon, GW; Curtis, JR; Erhardt, DP; Mikuls, TR; Sauer, BC; Teng, CC, 2019) |
| "Sulfasalazine has been widely used in treatment of rheumatoid arthritis and spondyloarthritis." | 4.12 | Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study. ( David, R; Jayachandran, M; Koshy, V; Marwaha, V; Mithun, CB; Nair, AS; Padmanabhan, DS; Palatty, PL; Santhakumari, V; Singh, SK; Singhal, A; Suman, SK; Surendran, S; Tiwari, A; Yadav, P, 2022) |
| "Combination treatments for patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX) alone include the addition of a tumor necrosis factor inhibitor (TNFi) or the addition of sulfasalazine (SSZ) and hydroxychloroquine to MTX (triple therapy)." | 3.91 | Low Persistence Rates in Patients With Rheumatoid Arthritis Treated With Triple Therapy and Adverse Drug Events Associated With Sulfasalazine. ( Cannon, GW; Curtis, JR; Erhardt, DP; Mikuls, TR; Sauer, BC; Teng, CC, 2019) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Dhaneshwar, SS | 1 |
| Chail, M | 1 |
| Patil, M | 1 |
| Naqvi, S | 1 |
| Vadnerkar, G | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Jayachandran, M | 1 |
| Koshy, V | 1 |
| David, R | 1 |
| Santhakumari, V | 1 |
| Padmanabhan, DS | 1 |
| Surendran, S | 1 |
| Tiwari, A | 1 |
| Mithun, CB | 1 |
| Singh, SK | 1 |
| Suman, SK | 1 |
| Yadav, P | 1 |
| Singhal, A | 1 |
| Nair, AS | 1 |
| Marwaha, V | 1 |
| Palatty, PL | 1 |
| Erhardt, DP | 1 |
| Cannon, GW | 1 |
| Teng, CC | 1 |
| Mikuls, TR | 1 |
| Curtis, JR | 1 |
| Sauer, BC | 1 |
| Parkins, G | 1 |
| White, B | 1 |
| McWilliams, DF | 1 |
| Kiely, PD | 1 |
| Young, A | 1 |
| Walsh, DA | 1 |
| Yang, F | 1 |
| Gu, B | 1 |
| Zhang, L | 1 |
| Xuan, J | 1 |
| Luo, H | 1 |
| Zhou, P | 1 |
| Zhu, Q | 1 |
| Yan, S | 1 |
| Chen, SA | 1 |
| Cao, Z | 1 |
| Xu, J | 1 |
| Xing, Q | 1 |
| Luo, X | 1 |
| Descamps, V | 1 |
| Mittal, N | 1 |
| Sharma, A | 1 |
| Jose, V | 1 |
| Mittal, R | 1 |
| Wanchu, A | 1 |
| Bambery, P | 1 |
| Krause, W | 1 |
| Erskine, IA | 1 |
| Mackay, JM | 1 |
| Fox, DP | 1 |
| Alarcón-Segovia, D | 1 |
| Kraus, A | 1 |
| Weber, WW | 1 |
| Hein, DW | 1 |
| Woodhouse, KW | 1 |
| Lewit, T | 1 |
4 reviews available for sulfasalazine and Adverse Drug Event
| Article | Year |
|---|---|
Drug-related lupus syndromes and their relationship to spontaneously occurring systemic lupus erythematosus.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hydralazine; Lupus Erythematosus, Systemic; | 1991 |
N-acetylation pharmacogenetics.
Topics: Acebutolol; Acetyl Coenzyme A; Acetylation; Acetyltransferases; Aminoglutethimide; Animals; Anti-Anx | 1985 |
Drugs and the ageing gut, liver and pancreas.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Animals; Antacids; Anti-Ulcer Agen | 1985 |
[Pulmonary diseases due to drugs. II].
Topics: Amines; Amitriptyline; Beclomethasone; Drug-Related Side Effects and Adverse Reactions; Heroin; Huma | 1974 |
15 other studies available for sulfasalazine and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Stability; Drug-Related S | 2009 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Adverse reaction profile of sulfasalazine and its persistence in chronic therapy of rheumatoid arthritis and spondyloarthritis: A multicentric observational study.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Drug-Related Side Effects an | 2022 |
Low Persistence Rates in Patients With Rheumatoid Arthritis Treated With Triple Therapy and Adverse Drug Events Associated With Sulfasalazine.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Drug-R | 2019 |
DRESS syndrome presenting like septic shock.
Topics: Adult; Diagnosis, Differential; Drug Eruptions; Drug Hypersensitivity Syndrome; Drug-Related Side Ef | 2013 |
Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disability Evaluation; Dru | 2013 |
HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population.
Topics: Adult; Alleles; Asian People; Drug Eruptions; Drug-Related Side Effects and Adverse Reactions; Eosin | 2014 |
Drug reaction with eosinophilia and systemic symptoms: a cause of human herpesvirus 6-related fulminant myocarditis and hepatitis in immunocompetent patients.
Topics: Adult; Anti-Infective Agents; Drug-Related Side Effects and Adverse Reactions; Eosinophilia; Female; | 2009 |
Causes of DMARD withdrawal following ADR within 6 months of initiation among Indian rheumatoid arthritis patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Th | 2012 |
[Effect of drugs and environmental pollutants on human spermatogenesis].
Topics: Androgens; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions; Environmental Pol | 1983 |
Monitoring patients on long-term drug therapy for genotoxic effects.
Topics: Atenolol; Azathioprine; Cells, Cultured; Chlorpropamide; Chronic Disease; Drug-Related Side Effects | 1984 |