Page last updated: 2024-11-04

sulfasalazine and Ache

sulfasalazine has been researched along with Ache in 25 studies

Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
sulfasalazine : An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.

Research Excerpts

ExcerptRelevanceReference
"Bucillamine (Buc), developed in Japan, is a disease-modifying antirheumatic drug (DMARD) which has been used to treat numerous patients with rheumatoid arthritis (RA) in Japan and Korea with favorable results."9.14A comparative study of the effects of bucillamine and salazosulfapyridine in the treatment of rheumatoid arthritis. ( Abe, M; Kinoshita, M; Nakajima, M; Ohara, H; Ueda, N, 2009)
"Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan."9.12Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA. ( Hara, M; Inoue, E; Iwatani, M; Kamatani, N; Nakajima, A; Nakamura, T; Tomatsu, T; Yamanaka, H, 2006)
"One hundred eight-six patients with active rheumatoid arthritis were evaluated in a double-blind, randomized study that compared treatment with sulfasalazine (SSZ) (2 mg/day), gold sodium thiomalate (GST) (50 mg/week), and placebo (PBO)."9.06A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis. ( Clegg, DO; Dahl, SL; Luggen, ME; Michaels, RM; Oglesby, T; Schlegel, S; Ward, JR; Weisman, MH; Williams, HJ; Willkens, RF, 1988)
" Immunodeficient mice were inoculated intrafemorally with the human breast adenocarcinoma cell line MDA-MB-231, then treated 14days later via mini-osmotic pumps inserted intraperitoneally with sulfasalazine, (S)-4-carboxyphenylglycine, or vehicle."7.80Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. ( Seidlitz, EP; Singh, G; Ungard, RG, 2014)
"Agastache mexicana is a popular plant of great demand in folk medicine, essentially due to its calming properties and for alleviating arthritic, muscular and abdominal pain."5.62Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis. ( Adriana Estrella, GR; Alberto, HL; Azucena, CV; Francisco Javier, LM; María Eva, GT; María Guadalupe, VD; Noé, AV; Sandra, OS, 2021)
"Bucillamine (Buc), developed in Japan, is a disease-modifying antirheumatic drug (DMARD) which has been used to treat numerous patients with rheumatoid arthritis (RA) in Japan and Korea with favorable results."5.14A comparative study of the effects of bucillamine and salazosulfapyridine in the treatment of rheumatoid arthritis. ( Abe, M; Kinoshita, M; Nakajima, M; Ohara, H; Ueda, N, 2009)
"Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan."5.12Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA. ( Hara, M; Inoue, E; Iwatani, M; Kamatani, N; Nakajima, A; Nakamura, T; Tomatsu, T; Yamanaka, H, 2006)
"One hundred eight-six patients with active rheumatoid arthritis were evaluated in a double-blind, randomized study that compared treatment with sulfasalazine (SSZ) (2 mg/day), gold sodium thiomalate (GST) (50 mg/week), and placebo (PBO)."5.06A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis. ( Clegg, DO; Dahl, SL; Luggen, ME; Michaels, RM; Oglesby, T; Schlegel, S; Ward, JR; Weisman, MH; Williams, HJ; Willkens, RF, 1988)
" Immunodeficient mice were inoculated intrafemorally with the human breast adenocarcinoma cell line MDA-MB-231, then treated 14days later via mini-osmotic pumps inserted intraperitoneally with sulfasalazine, (S)-4-carboxyphenylglycine, or vehicle."3.80Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain. ( Seidlitz, EP; Singh, G; Ungard, RG, 2014)
"Sulfasalazine is a safe and effective drug in the short term treatment of AS."3.76Meta-analysis of sulfasalazine in ankylosing spondylitis. ( Atra, E; Ferraz, MB; Goldsmith, CH; Tugwell, P, 1990)
"Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease."2.41Conventional treatments for ankylosing spondylitis. ( Brandt, J; Dijkmans, B; Dougados, M; Khan, M; Maksymowych, W; van der Linden, S, 2002)
"Sulfasalazine and JLC were administrated orally and initialized 6 h after TNBS enema, once a day for seven consecutive days."1.62Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis. ( Chen, G; Diao, F; Dong, M; Li, Y; Lin, W; Liu, T; Liu, Y; Mei, Q; Ruan, Y; Sun, Y; Tang, T; Zhou, H, 2021)
"Agastache mexicana is a popular plant of great demand in folk medicine, essentially due to its calming properties and for alleviating arthritic, muscular and abdominal pain."1.62Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis. ( Adriana Estrella, GR; Alberto, HL; Azucena, CV; Francisco Javier, LM; María Eva, GT; María Guadalupe, VD; Noé, AV; Sandra, OS, 2021)
"We diagnosed late onset spondyloarthropathy according to clinic and radiographic findings."1.38Late onset spondyloarthropathy mimicking polymyalgia rheumatica. ( Altındağ, O; Aydeniz, A; Gürsoy, S; Oğüt, E, 2012)
"Sulfasalazine treatment also increased inosine levels in sciatic nerves of diabetic rats."1.35Sulfasalazine blocks the development of tactile allodynia in diabetic rats. ( Berti-Mattera, LN; Kern, TS; Mitchell, R; Nemet, I; Siegel, RE, 2008)
"To define a possible association between familial Mediterranean fever (FMF) and seronegative spondyloarthropathy (SNSA) and to study features of SNSA in FMF patients, we screened for the presence and manifestations of SNSA in 3,000 FMF patients attending the National Center for FMF in our institution."1.30Seronegative spondyloarthropathy in familial Mediterranean fever. ( Langevitz, P; Livneh, A; Pras, M; Shemer, J; Zemer, D, 1997)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19904 (16.00)18.7374
1990's10 (40.00)18.2507
2000's6 (24.00)29.6817
2010's3 (12.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Li, Y1
Sun, Y1
Diao, F1
Ruan, Y1
Chen, G1
Tang, T1
Liu, Y1
Zhou, H1
Lin, W1
Dong, M1
Liu, T1
Mei, Q1
Adriana Estrella, GR1
María Eva, GT1
Alberto, HL1
María Guadalupe, VD1
Azucena, CV1
Sandra, OS1
Noé, AV1
Francisco Javier, LM1
Ungard, RG1
Seidlitz, EP1
Singh, G1
Agarwal, NN1
Patil, D1
Nagendra, S1
Jadhav, SM1
Berti-Mattera, LN1
Kern, TS1
Siegel, RE1
Nemet, I1
Mitchell, R1
Nakajima, M1
Ueda, N1
Ohara, H1
Abe, M1
Kinoshita, M1
Aydeniz, A1
Altındağ, O1
Oğüt, E1
Gürsoy, S1
Ferraccioli, GF1
Gremese, E1
Tomietto, P1
Favret, G1
Damato, R1
Di Poi, E1
Dougados, M1
Dijkmans, B1
Khan, M1
Maksymowych, W1
van der Linden, S1
Brandt, J1
Iwatani, M1
Inoue, E1
Nakamura, T1
Nakajima, A1
Hara, M1
Tomatsu, T1
Kamatani, N1
Yamanaka, H1
Strum, WB1
van der Heijde, DM2
van 't Hof, M1
van Riel, PL1
van de Putte, LB1
Nicassio, PM1
Radojevic, V1
Weisman, MH2
Culbertson, AL1
Lewis, C1
Clemmey, P1
Fraser, SM1
Hopkins, R2
Hunter, JA1
Neumann, V1
Capell, HA1
Bird, HA1
Taggart, A1
Gardiner, P1
McEvoy, F1
Bird, H1
Collange, C1
Brantus, JF1
Sidot, C1
Meunier, PJ1
Egsmose, C1
Hansen, TM1
Andersen, LS1
Beier, JM1
Christensen, L1
Ejstrup, L1
Peters, ND1
Langevitz, P1
Livneh, A1
Zemer, D1
Shemer, J1
Pras, M1
Coinde, E1
David, L1
Cottalorda, J1
Allard, D1
Bost, M1
Lucht, F1
Stéphan, JL1
Corkill, MM1
Jobanputra, P1
Gibson, T1
Macfarlane, DG1
Farr, M1
Kitas, GD1
Waterhouse, L1
Jubb, R1
Felix-Davies, D1
Bacon, PA1
Ferraz, MB1
Tugwell, P1
Goldsmith, CH1
Atra, E1
Hanan, IM1
Kirsner, JB1
Williams, HJ1
Ward, JR1
Dahl, SL1
Clegg, DO1
Willkens, RF1
Oglesby, T1
Schlegel, S1
Michaels, RM1
Luggen, ME1
Tumen, HJ1

Reviews

2 reviews available for sulfasalazine and Ache

ArticleYear
Conventional treatments for ankylosing spondylitis.
    Annals of the rheumatic diseases, 2002, Volume: 61 Suppl 3

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Azathioprine; Dipho

2002
Meta-analysis of sulfasalazine in ankylosing spondylitis.
    The Journal of rheumatology, 1990, Volume: 17, Issue:11

    Topics: Double-Blind Method; Humans; Meta-Analysis as Topic; Outcome and Process Assessment, Health Care; Pa

1990

Trials

12 trials available for sulfasalazine and Ache

ArticleYear
A comparative study of the effects of bucillamine and salazosulfapyridine in the treatment of rheumatoid arthritis.
    Modern rheumatology, 2009, Volume: 19, Issue:4

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; C-Reactive Protein; Cysteine; Drug Therapy, Combination

2009
Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:8

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid;

2002
Efficacy profile of bucillamine in rheumatoid arthritis patients in a large observational cohort study, IORRA.
    Modern rheumatology, 2006, Volume: 16, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cohort Studies; Cysteine; Drug Thera

2006
Validity of single variables and indices to measure disease activity in rheumatoid arthritis.
    The Journal of rheumatology, 1993, Volume: 20, Issue:3

    Topics: Arthritis, Rheumatoid; Azathioprine; Blood Sedimentation; C-Reactive Protein; Disabled Persons; Hemo

1993
The role of helplessness in the response to disease modifying drugs in rheumatoid arthritis.
    The Journal of rheumatology, 1993, Volume: 20, Issue:7

    Topics: Adult; Aged; Arthritis, Rheumatoid; Behavior; Cognition; Disability Evaluation; Female; Gold; Helple

1993
Sulphasalazine in the management of psoriatic arthritis.
    British journal of rheumatology, 1993, Volume: 32, Issue:10

    Topics: Adolescent; Adult; Aged; Arthritis, Psoriatic; Blood Sedimentation; Female; Humans; Joints; Male; Mi

1993
Which is the active moiety of sulfasalazine in ankylosing spondylitis? A randomized, controlled study.
    Arthritis and rheumatism, 1996, Volume: 39, Issue:8

    Topics: Adolescent; Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Binding Site

1996
Limited effect of sulphasalazine treatment in reactive arthritis. A randomised double blind placebo controlled trial.
    Annals of the rheumatic diseases, 1997, Volume: 56, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Arthritis, Reactive; Blood Sedimentation; Double-Blind Method; Fema

1997
A controlled trial of sulphasalazine treatment of chronic ankylosing spondylitis: failure to demonstrate a clinical effect.
    British journal of rheumatology, 1990, Volume: 29, Issue:1

    Topics: Chronic Disease; Clinical Trials as Topic; Female; Follow-Up Studies; Humans; Male; Pain; Spine; Spo

1990
Sulphasalazine in psoriatic arthritis: a double-blind placebo-controlled study.
    British journal of rheumatology, 1990, Volume: 29, Issue:1

    Topics: Arthritis; Clinical Trials as Topic; Double-Blind Method; Humans; Immunoglobulins; Joints; Pain; Pla

1990
Meta-analysis of sulfasalazine in ankylosing spondylitis.
    The Journal of rheumatology, 1990, Volume: 17, Issue:11

    Topics: Double-Blind Method; Humans; Meta-Analysis as Topic; Outcome and Process Assessment, Health Care; Pa

1990
A controlled trial comparing sulfasalazine, gold sodium thiomalate, and placebo in rheumatoid arthritis.
    Arthritis and rheumatism, 1988, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Gold Sodium

1988

Other Studies

12 other studies available for sulfasalazine and Ache

ArticleYear
Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis.
    Journal of ethnopharmacology, 2021, Apr-06, Volume: 269

    Topics: Acetic Acid; Animals; Behavior, Animal; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Dinoprostone;

2021
Limonene from Agastache mexicana essential oil produces antinociceptive effects, gastrointestinal protection and improves experimental ulcerative colitis.
    Journal of ethnopharmacology, 2021, Nov-15, Volume: 280

    Topics: Agastache; Analgesics; Animals; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relations

2021
Inhibition of breast cancer-cell glutamate release with sulfasalazine limits cancer-induced bone pain.
    Pain, 2014, Volume: 155, Issue:1

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bone and Bones; Breast

2014
Bilateral hip pain in a young man? It may be worth considering juvenile-onset ankylosing spondylitis (JAS).
    BMJ case reports, 2015, Oct-28, Volume: 2015

    Topics: Adolescent; Anti-Inflammatory Agents; Arthritis, Juvenile; Hip Joint; Humans; Male; Methylprednisolo

2015
Sulfasalazine blocks the development of tactile allodynia in diabetic rats.
    Diabetes, 2008, Volume: 57, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Chromatography, High P

2008
Late onset spondyloarthropathy mimicking polymyalgia rheumatica.
    Rheumatology international, 2012, Volume: 32, Issue:5

    Topics: Age of Onset; Anti-Inflammatory Agents; Biomarkers; Blood Sedimentation; C-Reactive Protein; Diagnos

2012
Nine years of diarrhea and abdominal pain.
    Hospital practice (Office ed.), 1983, Volume: 18, Issue:5

    Topics: Aged; Crohn Disease; Diarrhea; Duodenal Diseases; Female; Humans; Joint Diseases; Pain; Prednisone;

1983
Sapho syndrome with femoral hyperostosis. Two case-reports.
    Revue du rhumatisme (English ed.), 1996, Volume: 63, Issue:5

    Topics: Adult; Antirheumatic Agents; Diphosphonates; Female; Femur; Humans; Hyperostosis; Magnetic Resonance

1996
Seronegative spondyloarthropathy in familial Mediterranean fever.
    Seminars in arthritis and rheumatism, 1997, Volume: 27, Issue:2

    Topics: Achilles Tendon; Adrenal Cortex Hormones; Adult; Ankle; Anti-Inflammatory Agents, Non-Steroidal; Ant

1997
[Chronic recurrent multifocal osteomyelitis in children: report of 17 cases].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2001, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Bone and Bones; Child; Child, Pr

2001
Inflammatory bowel disease in the pregnant woman.
    Clinics in perinatology, 1985, Volume: 12, Issue:3

    Topics: Abdomen; Adrenal Cortex Hormones; Adult; Animals; Breast Feeding; Colitis, Ulcerative; Crohn Disease

1985
The drug therapy of ulcerative colitis and of Crohn's disease.
    Seminars in drug treatment, 1974,Spring, Volume: 3, Issue:4

    Topics: Adrenocorticotropic Hormone; Atropine; Azathioprine; Colitis, Ulcerative; Crohn Disease; Diarrhea; D

1974