sulfapyridine has been researched along with Rheumatoid Arthritis in 26 studies
Sulfapyridine: Antibacterial, potentially toxic, used to treat certain skin diseases.
sulfapyridine : A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To carry out a pilot study to investigate the effect of short-term oral probiotic administration on the metabolism of sulfasalazine (SSZ) in patients with rheumatoid arthritis (RA) stabilized on SSZ." | 9.14 | The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study. ( Fawcett, JP; Highton, J; Lee, HJ; Orlovich, DA; Schmierer, D; Stebbings, S; Waller, RD, 2010) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 7.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "The pharmacokinetic disposition of sulfasalazine and its metabolites was studied in 8 young and 12 elderly patients with active rheumatoid arthritis." | 7.68 | The effect of age and acetylator phenotype on the pharmacokinetics of sulfasalazine in patients with rheumatoid arthritis. ( McDermott, BJ; Roberts, SD; Taggart, AJ, 1992) |
| "Sulfasalazine is now an established 2nd line agent in the treatment of rheumatoid arthritis (RA) but its mode of action is unknown." | 7.67 | Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis. ( Bacon, PA; Farr, M; Salmon, M; Symmons, DP, 1988) |
| "To carry out a pilot study to investigate the effect of short-term oral probiotic administration on the metabolism of sulfasalazine (SSZ) in patients with rheumatoid arthritis (RA) stabilized on SSZ." | 5.14 | The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study. ( Fawcett, JP; Highton, J; Lee, HJ; Orlovich, DA; Schmierer, D; Stebbings, S; Waller, RD, 2010) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 3.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "The pharmacokinetic disposition of sulfasalazine and its metabolites was studied in 8 young and 12 elderly patients with active rheumatoid arthritis." | 3.68 | The effect of age and acetylator phenotype on the pharmacokinetics of sulfasalazine in patients with rheumatoid arthritis. ( McDermott, BJ; Roberts, SD; Taggart, AJ, 1992) |
| "The effects of sulfasalazine (SASP) and its metabolites sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) were investigated on release of prostaglandins (PG) and leukotrienes (LT) from synovial tissue of 37 patients with osteoarthritis, chondrocalcinosis and rheumatoid arthritis." | 3.68 | [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue]. ( Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR, 1991) |
| "Sulfasalazine is now an established 2nd line agent in the treatment of rheumatoid arthritis (RA) but its mode of action is unknown." | 3.67 | Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis. ( Bacon, PA; Farr, M; Salmon, M; Symmons, DP, 1988) |
| "We assessed the in vitro effects of sulfasalazine and its 2 main metabolites, sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) on functional aspects of peripheral blood lymphocytes (PBM) of normal controls and patients with rheumatoid arthritis (RA)." | 3.67 | In vitro immunomodulatory effects of sulfasalazine and its metabolites. ( Comer, SS; Jasin, HE, 1988) |
| " The elimination half-life of sulphasalazine was prolonged in the elderly whilst renal clearance was increased in slow acetylators at 'steady-state'." | 2.66 | The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis. ( Ahnfelt, NO; Delargy, M; Elborn, S; Forbes, J; McDermott, B; Roberts, SD; Taggart, AJ, 1987) |
| "Current treatment for Rheumatoid arthritis (RA) utilizes Disease-modifying antirheumatic drugs, non-steroidal anti-inflammatory drugs or its combination, to decrease joint inflammation." | 1.72 | Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund's adjuvant induced arthritis rats. ( Babasahib, SK; Born, RW; Raghavendra, NM, 2022) |
| " Synovial tissue explants from RA patients secreted a decreased amount of the chemokines IL-8 and growth-related gene product alpha (GROalpha) when treated with SASP over a broad range of concentrations based on the typical clinical dosage of 2 g/day." | 1.31 | The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production. ( Campbell, PL; Connors, MA; Koch, AE; Volin, MV; Woodruff, DC, 2002) |
| "Cells were dosed with each compound for 24 h in the presence or absence of PMA inducer and messenger RNA (mRNA) extracted and subjected to Northern blot analysis." | 1.31 | Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts. ( Blackburn, WD; Minghetti, PP, 2000) |
| "Nausea was a frequent problem in patients taking SP." | 1.27 | A study to determine the active moiety of sulphasalazine in rheumatoid arthritis. ( Astbury, C; Bird, HA; Hill, J; Le Gallez, P; Neumann, VC; Taggart, AJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (46.15) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Knuckley, B | 1 |
| Luo, Y | 1 |
| Thompson, PR | 1 |
| Babasahib, SK | 1 |
| Born, RW | 1 |
| Raghavendra, NM | 1 |
| Kapoor, B | 1 |
| Gulati, M | 1 |
| Singh, SK | 1 |
| Khatik, GL | 1 |
| Gupta, R | 1 |
| Kumar, R | 2 |
| Gowthamarajan, K | 1 |
| Mahajan, S | 1 |
| Gupta, S | 1 |
| Lee, HJ | 1 |
| Waller, RD | 1 |
| Stebbings, S | 1 |
| Highton, J | 1 |
| Orlovich, DA | 1 |
| Schmierer, D | 1 |
| Fawcett, JP | 1 |
| Volin, MV | 2 |
| Campbell, PL | 2 |
| Connors, MA | 1 |
| Woodruff, DC | 1 |
| Koch, AE | 2 |
| Sheldon, P | 2 |
| Pell, P | 1 |
| Pirmohamed, M | 1 |
| Coleman, MD | 1 |
| Galvani, D | 1 |
| Bucknall, RC | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Box, SA | 1 |
| Pullar, T | 3 |
| Bradley, SM | 1 |
| le Gallez, P | 3 |
| Throughton, PR | 1 |
| Gooi, HC | 1 |
| Astbury, C | 5 |
| Bird, HA | 4 |
| Harlow, LA | 1 |
| Woods, JM | 1 |
| Amin, MA | 1 |
| Tokuhira, M | 1 |
| Minghetti, PP | 1 |
| Blackburn, WD | 1 |
| Taggart, AJ | 5 |
| McDermott, BJ | 1 |
| Roberts, SD | 2 |
| Wittenberg, HR | 1 |
| Kleemeyer, K | 1 |
| Peskar, BM | 1 |
| Peskar, BA | 1 |
| Juby, L | 1 |
| Zebouni, L | 1 |
| Hunter, JA | 2 |
| Capell, HA | 2 |
| Situnayake, RD | 1 |
| McConkey, B | 1 |
| Neumann, VC | 2 |
| Hill, J | 3 |
| Dixon, JS | 1 |
| Sheldon, PJ | 1 |
| Webb, C | 2 |
| Grindulis, KA | 2 |
| McDermott, B | 1 |
| Delargy, M | 1 |
| Elborn, S | 1 |
| Forbes, J | 1 |
| Ahnfelt, NO | 1 |
| Symmons, DP | 1 |
| Salmon, M | 1 |
| Farr, M | 2 |
| Bacon, PA | 2 |
| Comer, SS | 1 |
| Jasin, HE | 1 |
| Brodrick, A | 1 |
1 review available for sulfapyridine and Rheumatoid Arthritis
| Article | Year |
|---|---|
Sulphasalazine in the treatment of rheumatoid arthritis.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Sulfapyridine; Sulfasala | 1997 |
7 trials available for sulfapyridine and Rheumatoid Arthritis
| Article | Year |
|---|---|
The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bifidobacterium; Bio | 2010 |
Sulphasalazine in the treatment of rheumatoid arthritis.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Sulfapyridine; Sulfasala | 1997 |
The effect of sulphasalazine on neutrophil superoxide generation in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Neutrophils; Severity of Illness Index; Sulfani | 1997 |
Which component of sulphasalazine is active in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Humans; Mesalamine; Middle Aged; Sulfanila | 1985 |
Sulphasalazine in the treatment of rheumatoid arthritis: relationship of dose and serum levels to efficacy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Dose-Response Rel | 1985 |
The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis.
Topics: Acetylation; Adult; Aged; Aging; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Half-Life; | 1987 |
Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridine.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Combinations; Humans; Sulfamethoxazole; Sulfap | 1988 |
19 other studies available for sulfapyridine and Rheumatoid Arthritis
| Article | Year |
|---|---|
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Flu | 2008 |
Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund's adjuvant induced arthritis rats.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; | 2022 |
Fail-safe nano-formulation of prodrug of sulfapyridine: Preparation and evaluation for treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Liposomes; Prodrugs; Rats; Sulfapyridine; Synovial Membrane | 2021 |
The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C | 2002 |
Comparison of the effects of sulphasalazine, 5-aminosalicylic acid and sulphapyridine on the humoral response to antigen in vivo.
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibo | 1995 |
Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; | 1993 |
Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicyclic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biocompatible | 1999 |
Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Fibroblasts; Homeostasis; Humans; Inflammation Me | 2000 |
The effect of age and acetylator phenotype on the pharmacokinetics of sulfasalazine in patients with rheumatoid arthritis.
Topics: Acetylation; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Female; | 1992 |
[Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue].
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthrit | 1991 |
Comparison of the single dose pharmacokinetics of sulphasalazine in rheumatoid arthritis and inflammatory bowel disease.
Topics: Adult; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Female; Humans; Male; Middle Aged; | 1990 |
Which component of sulphasalazine is active in rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Humans; Sulfapyridine; Sulfasalazine | 1985 |
A study to determine the active moiety of sulphasalazine in rheumatoid arthritis.
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Female; Humans; Male; Mesalamine; Middle A | 1986 |
5-Aminosalicylic acid or sulphapyridine. Which is the active moiety of sulphasalazine in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; F | 1986 |
Sulphasalazine in rheumatoid arthritis: pointers to a gut-mediated immune effect.
Topics: Arthritis, Rheumatoid; Humans; Intestines; Lymphocyte Activation; Lymphocytes; Salicylates; Salicyli | 1987 |
Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Survival; Female; Humans; Lectins; Leukocyte Count | 1988 |
In vitro immunomodulatory effects of sulfasalazine and its metabolites.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Humans; Immune System; | 1988 |
Effect of sulphasalazine and its metabolites on mitogen induced transformation of lymphocytes--clues to its clinical action?
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells | 1988 |
Plasma and synovial fluid concentrations of sulphasalazine and two of its metabolites in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Sulfapyridine; Sulfasalazine; | 1985 |