sulfapyridine has been researched along with Arthritis, Rheumatoid in 26 studies
Sulfapyridine: Antibacterial, potentially toxic, used to treat certain skin diseases.
sulfapyridine : A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To carry out a pilot study to investigate the effect of short-term oral probiotic administration on the metabolism of sulfasalazine (SSZ) in patients with rheumatoid arthritis (RA) stabilized on SSZ." | 9.14 | The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study. ( Fawcett, JP; Highton, J; Lee, HJ; Orlovich, DA; Schmierer, D; Stebbings, S; Waller, RD, 2010) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 7.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "The pharmacokinetic disposition of sulfasalazine and its metabolites was studied in 8 young and 12 elderly patients with active rheumatoid arthritis." | 7.68 | The effect of age and acetylator phenotype on the pharmacokinetics of sulfasalazine in patients with rheumatoid arthritis. ( McDermott, BJ; Roberts, SD; Taggart, AJ, 1992) |
| "Sulfasalazine is now an established 2nd line agent in the treatment of rheumatoid arthritis (RA) but its mode of action is unknown." | 7.67 | Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis. ( Bacon, PA; Farr, M; Salmon, M; Symmons, DP, 1988) |
| "To carry out a pilot study to investigate the effect of short-term oral probiotic administration on the metabolism of sulfasalazine (SSZ) in patients with rheumatoid arthritis (RA) stabilized on SSZ." | 5.14 | The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study. ( Fawcett, JP; Highton, J; Lee, HJ; Orlovich, DA; Schmierer, D; Stebbings, S; Waller, RD, 2010) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 3.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "The pharmacokinetic disposition of sulfasalazine and its metabolites was studied in 8 young and 12 elderly patients with active rheumatoid arthritis." | 3.68 | The effect of age and acetylator phenotype on the pharmacokinetics of sulfasalazine in patients with rheumatoid arthritis. ( McDermott, BJ; Roberts, SD; Taggart, AJ, 1992) |
| "The effects of sulfasalazine (SASP) and its metabolites sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) were investigated on release of prostaglandins (PG) and leukotrienes (LT) from synovial tissue of 37 patients with osteoarthritis, chondrocalcinosis and rheumatoid arthritis." | 3.68 | [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue]. ( Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR, 1991) |
| "Sulfasalazine is now an established 2nd line agent in the treatment of rheumatoid arthritis (RA) but its mode of action is unknown." | 3.67 | Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis. ( Bacon, PA; Farr, M; Salmon, M; Symmons, DP, 1988) |
| "We assessed the in vitro effects of sulfasalazine and its 2 main metabolites, sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) on functional aspects of peripheral blood lymphocytes (PBM) of normal controls and patients with rheumatoid arthritis (RA)." | 3.67 | In vitro immunomodulatory effects of sulfasalazine and its metabolites. ( Comer, SS; Jasin, HE, 1988) |
| " The elimination half-life of sulphasalazine was prolonged in the elderly whilst renal clearance was increased in slow acetylators at 'steady-state'." | 2.66 | The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis. ( Ahnfelt, NO; Delargy, M; Elborn, S; Forbes, J; McDermott, B; Roberts, SD; Taggart, AJ, 1987) |
| "Current treatment for Rheumatoid arthritis (RA) utilizes Disease-modifying antirheumatic drugs, non-steroidal anti-inflammatory drugs or its combination, to decrease joint inflammation." | 1.72 | Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund's adjuvant induced arthritis rats. ( Babasahib, SK; Born, RW; Raghavendra, NM, 2022) |
| " Synovial tissue explants from RA patients secreted a decreased amount of the chemokines IL-8 and growth-related gene product alpha (GROalpha) when treated with SASP over a broad range of concentrations based on the typical clinical dosage of 2 g/day." | 1.31 | The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production. ( Campbell, PL; Connors, MA; Koch, AE; Volin, MV; Woodruff, DC, 2002) |
| "Cells were dosed with each compound for 24 h in the presence or absence of PMA inducer and messenger RNA (mRNA) extracted and subjected to Northern blot analysis." | 1.31 | Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts. ( Blackburn, WD; Minghetti, PP, 2000) |
| "Nausea was a frequent problem in patients taking SP." | 1.27 | A study to determine the active moiety of sulphasalazine in rheumatoid arthritis. ( Astbury, C; Bird, HA; Hill, J; Le Gallez, P; Neumann, VC; Taggart, AJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (46.15) | 18.7374 |
| 1990's | 8 (30.77) | 18.2507 |
| 2000's | 3 (11.54) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Knuckley, B | 1 |
| Luo, Y | 1 |
| Thompson, PR | 1 |
| Babasahib, SK | 1 |
| Born, RW | 1 |
| Raghavendra, NM | 1 |
| Kapoor, B | 1 |
| Gulati, M | 1 |
| Singh, SK | 1 |
| Khatik, GL | 1 |
| Gupta, R | 1 |
| Kumar, R | 2 |
| Gowthamarajan, K | 1 |
| Mahajan, S | 1 |
| Gupta, S | 1 |
| Lee, HJ | 1 |
| Waller, RD | 1 |
| Stebbings, S | 1 |
| Highton, J | 1 |
| Orlovich, DA | 1 |
| Schmierer, D | 1 |
| Fawcett, JP | 1 |
| Volin, MV | 2 |
| Campbell, PL | 2 |
| Connors, MA | 1 |
| Woodruff, DC | 1 |
| Koch, AE | 2 |
| Sheldon, P | 2 |
| Pell, P | 1 |
| Pirmohamed, M | 1 |
| Coleman, MD | 1 |
| Galvani, D | 1 |
| Bucknall, RC | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Box, SA | 1 |
| Pullar, T | 3 |
| Bradley, SM | 1 |
| le Gallez, P | 3 |
| Throughton, PR | 1 |
| Gooi, HC | 1 |
| Astbury, C | 5 |
| Bird, HA | 4 |
| Harlow, LA | 1 |
| Woods, JM | 1 |
| Amin, MA | 1 |
| Tokuhira, M | 1 |
| Minghetti, PP | 1 |
| Blackburn, WD | 1 |
| Taggart, AJ | 5 |
| McDermott, BJ | 1 |
| Roberts, SD | 2 |
| Wittenberg, HR | 1 |
| Kleemeyer, K | 1 |
| Peskar, BM | 1 |
| Peskar, BA | 1 |
| Juby, L | 1 |
| Zebouni, L | 1 |
| Hunter, JA | 2 |
| Capell, HA | 2 |
| Situnayake, RD | 1 |
| McConkey, B | 1 |
| Neumann, VC | 2 |
| Hill, J | 3 |
| Dixon, JS | 1 |
| Sheldon, PJ | 1 |
| Webb, C | 2 |
| Grindulis, KA | 2 |
| McDermott, B | 1 |
| Delargy, M | 1 |
| Elborn, S | 1 |
| Forbes, J | 1 |
| Ahnfelt, NO | 1 |
| Symmons, DP | 1 |
| Salmon, M | 1 |
| Farr, M | 2 |
| Bacon, PA | 2 |
| Comer, SS | 1 |
| Jasin, HE | 1 |
| Brodrick, A | 1 |
1 review available for sulfapyridine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Sulphasalazine in the treatment of rheumatoid arthritis.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Sulfapyridine; Sulfasala | 1997 |
7 trials available for sulfapyridine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The effects of an orally administered probiotic on sulfasalazine metabolism in individuals with rheumatoid arthritis: a preliminary study.
Topics: Administration, Oral; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Bifidobacterium; Bio | 2010 |
Sulphasalazine in the treatment of rheumatoid arthritis.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Sulfapyridine; Sulfasala | 1997 |
The effect of sulphasalazine on neutrophil superoxide generation in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Neutrophils; Severity of Illness Index; Sulfani | 1997 |
Which component of sulphasalazine is active in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Humans; Mesalamine; Middle Aged; Sulfanila | 1985 |
Sulphasalazine in the treatment of rheumatoid arthritis: relationship of dose and serum levels to efficacy.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; Dose-Response Rel | 1985 |
The pharmacokinetics of sulphasalazine in young and elderly patients with rheumatoid arthritis.
Topics: Acetylation; Adult; Aged; Aging; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Half-Life; | 1987 |
Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridine.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Combinations; Humans; Sulfamethoxazole; Sulfap | 1988 |
19 other studies available for sulfapyridine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Flu | 2008 |
Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund's adjuvant induced arthritis rats.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; | 2022 |
Fail-safe nano-formulation of prodrug of sulfapyridine: Preparation and evaluation for treatment of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Liposomes; Prodrugs; Rats; Sulfapyridine; Synovial Membrane | 2021 |
The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C | 2002 |
Comparison of the effects of sulphasalazine, 5-aminosalicylic acid and sulphapyridine on the humoral response to antigen in vivo.
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibo | 1995 |
Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; | 1993 |
Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicyclic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biocompatible | 1999 |
Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Fibroblasts; Homeostasis; Humans; Inflammation Me | 2000 |
The effect of age and acetylator phenotype on the pharmacokinetics of sulfasalazine in patients with rheumatoid arthritis.
Topics: Acetylation; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Drug Administration Schedule; Female; | 1992 |
[Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue].
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthrit | 1991 |
Comparison of the single dose pharmacokinetics of sulphasalazine in rheumatoid arthritis and inflammatory bowel disease.
Topics: Adult; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Female; Humans; Male; Middle Aged; | 1990 |
Which component of sulphasalazine is active in rheumatoid arthritis?
Topics: Arthritis, Rheumatoid; Humans; Sulfapyridine; Sulfasalazine | 1985 |
A study to determine the active moiety of sulphasalazine in rheumatoid arthritis.
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Female; Humans; Male; Mesalamine; Middle A | 1986 |
5-Aminosalicylic acid or sulphapyridine. Which is the active moiety of sulphasalazine in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; F | 1986 |
Sulphasalazine in rheumatoid arthritis: pointers to a gut-mediated immune effect.
Topics: Arthritis, Rheumatoid; Humans; Intestines; Lymphocyte Activation; Lymphocytes; Salicylates; Salicyli | 1987 |
Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Survival; Female; Humans; Lectins; Leukocyte Count | 1988 |
In vitro immunomodulatory effects of sulfasalazine and its metabolites.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Humans; Immune System; | 1988 |
Effect of sulphasalazine and its metabolites on mitogen induced transformation of lymphocytes--clues to its clinical action?
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells | 1988 |
Plasma and synovial fluid concentrations of sulphasalazine and two of its metabolites in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Sulfapyridine; Sulfasalazine; | 1985 |