sulfamethoxazole has been researched along with Thrombocytopenia in 43 studies
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.
Thrombocytopenia: A subnormal level of BLOOD PLATELETS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of orally administered trimethoprim-sulfamethoxazole was compared with that of oral amoxicillin in therapy of typhoid fever due to both epidemic chloramphenicol-resistant and endemic chloramphenicol-sensitive Salmonella typhi." | 9.04 | Comparison of trimethoprim-sulfamethoxazole and amoxicillin in therapy of chloramphenicol-resistant and chloramphenicol-sensitive typhoid fever. ( Calderone, E; Gilman, RH; Hernandez-Mendosa, P; Hornick, RB; Levine, MM; Martinez, E; Snyder, MJ; Terminel, M; Vasquez, V, 1975) |
| "Two patients had severe thrombocytopenia while taking trimethoprim-sulfamethoxazole." | 7.66 | Thrombocytopenia secondary to trimethoprim-sulfamethoxazole. ( Hagen, MD; White, RD, 1983) |
| "A 3-year-old white boy had symptomatic thrombocytopenia after receiving trimethoprim-sulfamethoxazole in recommended doses for one week." | 7.66 | Thrombocytopenia associated with PF3 antiplatelet activity against the sulfa component of trimethoprim-sulfamethoxazole. ( Luban, NL; Rodriguez, WJ; Schwartz, RH, 1981) |
| "Thrombocytopenia is an uncommon but serious side effect of the antimicrobial combination of trimethoprim and sulphamethoxazole." | 7.66 | Trimethoprim-sulphamethoxazole and thrombocytopenia. ( Dickson, HG, 1978) |
| "The efficacy of orally administered trimethoprim-sulfamethoxazole was compared with that of oral amoxicillin in therapy of typhoid fever due to both epidemic chloramphenicol-resistant and endemic chloramphenicol-sensitive Salmonella typhi." | 5.04 | Comparison of trimethoprim-sulfamethoxazole and amoxicillin in therapy of chloramphenicol-resistant and chloramphenicol-sensitive typhoid fever. ( Calderone, E; Gilman, RH; Hernandez-Mendosa, P; Hornick, RB; Levine, MM; Martinez, E; Snyder, MJ; Terminel, M; Vasquez, V, 1975) |
| "Drug-dependent IgG antibodies (DDAb) induced by sulfamethoxazole (SMX) and sulfisoxazole (SIX) were identified by flow cytometry in 15 patients who developed thrombocytopenia while taking one of these medications." | 3.69 | Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. ( Aster, RH; Curtis, BR; McFarland, JG; Visentin, GP; Wu, GG, 1994) |
| " A 52-year-old woman developed severe thrombocytopenia shortly after receiving a sulfamethoxazole-containing antibiotic." | 3.67 | Acquired toxoplasmic retinochoroiditis after platelet transfusions. ( Ciavarella, D; Kauffmann, DJ; Nelson, JC; Senisi, WJ, 1989) |
| "Two patients had severe thrombocytopenia while taking trimethoprim-sulfamethoxazole." | 3.66 | Thrombocytopenia secondary to trimethoprim-sulfamethoxazole. ( Hagen, MD; White, RD, 1983) |
| "A 3-year-old white boy had symptomatic thrombocytopenia after receiving trimethoprim-sulfamethoxazole in recommended doses for one week." | 3.66 | Thrombocytopenia associated with PF3 antiplatelet activity against the sulfa component of trimethoprim-sulfamethoxazole. ( Luban, NL; Rodriguez, WJ; Schwartz, RH, 1981) |
| " He developed severe thrombocytopenia when pentamidine was added to the regimen." | 3.66 | Treatment of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole and pentamidine: efficacy and toxicity. ( Milder, JE; Powell, RD; Walzer, PD, 1979) |
| "Thrombocytopenia is an uncommon but serious side effect of the antimicrobial combination of trimethoprim and sulphamethoxazole." | 3.66 | Trimethoprim-sulphamethoxazole and thrombocytopenia. ( Dickson, HG, 1978) |
| "12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia." | 1.27 | Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. ( Bygbjerg, IC; Hørding, M; Lund, JT, 1988) |
| "Thrombocytopenia is a common serious adverse effect of drug treatment." | 1.26 | Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro. ( Barr, R; Bianchi, F; Carter, CJ; Giles, AR; Hirsh, J; Kelton, JG; Meltzer, D; Moore, J; Neame, PB; Powers, PJ; Walker, I; Wilson, WE, 1981) |
| "Thrombocytopenia was noted between the seventh and 16th day (mean, 10." | 1.26 | Hematologic abnormalities after oral trimethoprim-sulfamethoxazole therapy in children. ( Asmar, BI; Dajani, AS; Maqbool, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (90.70) | 18.7374 |
| 1990's | 2 (4.65) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (4.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nixon, CP | 1 |
| Cheves, TA | 1 |
| Sweeney, JD | 1 |
| Bougie, DW | 1 |
| Nayak, D | 1 |
| Boylan, B | 1 |
| Newman, PJ | 2 |
| Aster, RH | 3 |
| Ahmad, S | 1 |
| McGeady, SJ | 1 |
| Murphey, SA | 1 |
| Hagen, MD | 1 |
| White, RD | 1 |
| Barr, AL | 1 |
| Whineray, M | 1 |
| Kelton, JG | 1 |
| Meltzer, D | 1 |
| Moore, J | 1 |
| Giles, AR | 1 |
| Wilson, WE | 1 |
| Barr, R | 1 |
| Hirsh, J | 1 |
| Neame, PB | 1 |
| Powers, PJ | 1 |
| Walker, I | 1 |
| Bianchi, F | 1 |
| Carter, CJ | 1 |
| Lanzkowsky, P | 1 |
| Schaeffer, J | 1 |
| Bradley, PP | 1 |
| Warden, GD | 1 |
| Maxwell, JG | 1 |
| Rothstein, G | 1 |
| Guess, HA | 1 |
| Cohen, MS | 1 |
| Schwartz, RH | 1 |
| Rodriguez, WJ | 1 |
| Luban, NL | 1 |
| Stockman, JA | 1 |
| Asmar, BI | 1 |
| Maqbool, S | 1 |
| Dajani, AS | 1 |
| Nenci, GG | 1 |
| Agnelli, G | 1 |
| Berrettini, M | 1 |
| Nielsen, HV | 1 |
| Curtis, BR | 1 |
| McFarland, JG | 1 |
| Wu, GG | 1 |
| Visentin, GP | 2 |
| Peterson, JA | 1 |
| Gilman, RH | 1 |
| Terminel, M | 1 |
| Levine, MM | 1 |
| Hernandez-Mendosa, P | 1 |
| Calderone, E | 1 |
| Vasquez, V | 1 |
| Martinez, E | 1 |
| Snyder, MJ | 1 |
| Hornick, RB | 1 |
| Milder, JE | 1 |
| Walzer, PD | 1 |
| Powell, RD | 1 |
| Dickson, HG | 1 |
| Bosset, JF | 1 |
| Faivre, R | 1 |
| Rozenbaum, A | 1 |
| Flesch, M | 1 |
| Leconte Des Floris, R | 1 |
| Girdwood, RH | 1 |
| Nelson, JC | 1 |
| Kauffmann, DJ | 1 |
| Ciavarella, D | 1 |
| Senisi, WJ | 1 |
| Israel, HL | 1 |
| Bygbjerg, IC | 1 |
| Lund, JT | 1 |
| Hørding, M | 1 |
| Heimpel, H | 1 |
| Raghavachar, A | 1 |
| First, LR | 1 |
| Smith, BR | 1 |
| Lipton, J | 1 |
| Nathan, DG | 1 |
| Parkman, R | 1 |
| Rappeport, JM | 1 |
| Nielsen, ML | 1 |
| Laursen, H | 1 |
| Christensen, P | 1 |
| Böse, W | 1 |
| Karama, A | 1 |
| Linzenmeier, G | 1 |
| Olbing, H | 1 |
| Wellmann, P | 1 |
| Hoigné, R | 1 |
| Müller, U | 1 |
| Schneider, HR | 1 |
| Frisch, JM | 1 |
| Kerstan, J | 1 |
| Wolf, H | 1 |
| Casey, TP | 1 |
| Matthews, JR | 1 |
| Buchanan, JG | 1 |
| Herbert, V | 1 |
| Raik, E | 2 |
| Vincent, PC | 1 |
| Veen, MR | 1 |
| Jenkins, GC | 1 |
| Hughes, DT | 1 |
| Hall, PC | 1 |
| Toghill, PJ | 1 |
| Ryrie, DR | 1 |
| Tanna, MK | 1 |
| Tattersall, RB | 1 |
| Maier, C | 1 |
| Heer, HR | 1 |
| Hammett, JF | 1 |
| McPherson, VJ | 1 |
| Wegmüller, E | 1 |
| Mohan, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Azacitidine (AZA) Combined With N-Acetyl-L-cysteine (NAC) for Prolonged Isolated Thrombocytopenia (PIT) After Hematopoietic Stem Cell Transplantation (HSCT)[NCT05126004] | Phase 2 | 100 participants (Anticipated) | Interventional | 2021-12-01 | Not yet recruiting | ||
| A Prospective Study of Patients With Isolated Thrombocytopenia Following Hematopoietic Stem Cell Transplantation[NCT02487563] | Phase 3 | 97 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The total number of megakaryocytes as well as the platelet-shedding megakaryocytes of bone marrow smears (per cm2) was counted and cross-checked by blinded observers. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment
| Intervention | cells/cm^2 (Median) |
|---|---|
| Experimental Group 1 | 6.7 |
| Experimental Group 2 | 7.5 |
| Control Group | 3.3 |
Platelet response refers to a sustained increase (stable or increasing level) of at least 30×10E9/L independent of transfusion for 3 days. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental Group 1 | 20 |
| Experimental Group 2 | 22 |
| Control Group | 6 |
2 reviews available for sulfamethoxazole and Thrombocytopenia
| Article | Year |
|---|---|
Hematological side effects of co-trimoxazole.
Topics: Anemia; Anti-Infective Agents; Blood Cells; Drug Combinations; Humans; Leukopenia; Risk; Sulfamethox | 1987 |
Trimethoprim-sulfamethoxazole. Metabolism of folic acid in man.
Topics: Agranulocytosis; Aminobenzoates; Anemia; Bile; Biological Transport, Active; Bone Marrow; Bone Marro | 1973 |
3 trials available for sulfamethoxazole and Thrombocytopenia
| Article | Year |
|---|---|
Comparison of trimethoprim-sulfamethoxazole and amoxicillin in therapy of chloramphenicol-resistant and chloramphenicol-sensitive typhoid fever.
Topics: Adolescent; Adult; Amoxicillin; Ampicillin; Child; Chloramphenicol; Clinical Trials as Topic; Drug C | 1975 |
Controlled trial of co-trimoxazole in children with urinary-tract infection. Bacteriological efficacy and haematological toxicity.
Topics: Adolescent; Ampicillin; Bacteriuria; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Cli | 1974 |
A haematological study of patients receiving long-term treatment with trimethoprim and sulphonamide.
Topics: Aged; Blood Cell Count; Blood Platelets; Bronchitis; Clinical Trials as Topic; Erythrocyte Count; Fe | 1970 |
38 other studies available for sulfamethoxazole and Thrombocytopenia
| Article | Year |
|---|---|
Sulfamethoxazole-induced thrombocytopenia masquerading as posttransfusion purpura: a case report.
Topics: Aged; Humans; Male; Platelet Transfusion; Purpura, Thrombocytopenic; Sulfamethoxazole; Thrombocytope | 2015 |
Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Infective Agents; Antibodies; Antibodies, Monoclonal; Blood | 2010 |
Severe thrombocytopenia-hemorrhage due to trimethoprim-sulfamethoxazole: a case report.
Topics: Aged; Anti-Infective Agents, Urinary; Drug Combinations; Escherichia coli Infections; Female; Hematu | 1984 |
Disseminated Mycobacterium kansasii infection.
Topics: Cardiomegaly; Child, Preschool; Disseminated Intravascular Coagulation; Heart Failure; Humans; Immun | 1981 |
Thrombocytopenia secondary to trimethoprim-sulfamethoxazole.
Topics: Acute Disease; Child, Preschool; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Middle | 1983 |
Immune thrombocytopenia induced by cotrimoxazole.
Topics: Adult; Autoantibodies; Autoimmune Diseases; Blood Platelets; Drug Combinations; Female; Humans; Sulf | 1980 |
Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro.
Topics: Adult; Aged; Antibodies, Antinuclear; Binding Sites, Antibody; Blood Platelets; Child; Convalescence | 1981 |
Prophylactic use of TMP-SMZ in leukemia.
Topics: Agranulocytosis; Child; Drug Combinations; Humans; Leukemia, Lymphoid; Neutropenia; Pulmonary Fibros | 1982 |
Neutropenia and thrombocytopenia in renal allograft recipients treated with trimethoprim-sulfamethoxazole.
Topics: Adult; Agranulocytosis; Azathioprine; Bone Marrow; Drug Combinations; Drug Synergism; Humans; Kidney | 1980 |
Drug treatment of otitis media and urinary tract infections.
Topics: Agranulocytosis; Child; Humans; Neutropenia; Otitis Media; Sulfamethoxazole; Thrombocytopenia; Trime | 1982 |
Thrombocytopenia associated with PF3 antiplatelet activity against the sulfa component of trimethoprim-sulfamethoxazole.
Topics: Blood Coagulation Factors; Child, Preschool; Humans; Male; Platelet Factor 3; Sulfamethoxazole; Thro | 1981 |
Trimethoprim-sulfamethoxazole therapy. Everything's not turning up roses.
Topics: Bacterial Infections; Child; Drug Combinations; Humans; Neutropenia; Sulfamethoxazole; Thrombocytope | 1981 |
Hematologic abnormalities after oral trimethoprim-sulfamethoxazole therapy in children.
Topics: Amoxicillin; Anemia; Blood; Child; Child, Preschool; Drug Therapy, Combination; Eosinophilia; Female | 1981 |
[Acute immunoallergic thrombopenia due to sulfamethoxazole-trimethoprim].
Topics: Acute Disease; Drug Hypersensitivity; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethoprim | 1980 |
[Thrombocytopenia during treatment with sulphamethoxazole with trimethoprim].
Topics: Aged; Drug Combinations; Female; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethoprim | 1980 |
Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Calcium; Child; Child, Preschool; Edetic Aci | 1994 |
A recombinant soluble form of the integrin alpha IIb beta 3 (GPIIb-IIIa) assumes an active, ligand-binding conformation and is recognized by GPIIb-IIIa-specific monoclonal, allo-, auto-, and drug-dependent platelet antibodies.
Topics: Antibodies, Monoclonal; Autoantibodies; Dimerization; Humans; Isoantibodies; Ligands; Platelet Glyco | 1998 |
Treatment of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole and pentamidine: efficacy and toxicity.
Topics: Adult; Amidines; Drug Combinations; Drug Therapy, Combination; Humans; Male; Pentamidine; Pneumonia, | 1979 |
Trimethoprim-sulphamethoxazole and thrombocytopenia.
Topics: Adolescent; Adult; Age Factors; Animals; Child, Preschool; Drug Combinations; Female; Humans; Infant | 1978 |
[Acute thrombopenia during treatment with sulfamethoxazole-trimethoprim].
Topics: Acute Disease; Adult; Drug Combinations; Female; Humans; Sulfamethoxazole; Thrombocytopenia; Trimeth | 1978 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Hu | 1976 |
Acquired toxoplasmic retinochoroiditis after platelet transfusions.
Topics: Adrenal Cortex Hormones; Chorioretinitis; Female; Fluorescein Angiography; Humans; Macular Edema; Mi | 1989 |
Sulfamethoxazole-trimethoprim therapy for Wegener's granulomatosis.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Granulom | 1988 |
Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anemia; Drug Combinations; Folic Acid; Hem | 1988 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Control of bacteriuria with sulphamethoxazole-trimethoprim in patients with urinary tract obstruction and chronic infection. A preliminary report.
Topics: Adult; Aged; Anti-Infective Agents; Bacteriuria; Female; Folic Acid Antagonists; Humans; Male; Middl | 1972 |
[Bactrim Roche, a combination preparation of sulfamethoxazole and trimethoprim].
Topics: Drug Eruptions; Drug Synergism; Enteritis; Escherichia coli; Folic Acid Antagonists; Humans; Klebsie | 1969 |
Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Child; Depression; Drug Combinations; D | 1973 |
[Therapeutic experience with trimethoprim and sulfamethoxazole in infections of infancy and childhood].
Topics: Adolescent; Anti-Infective Agents; Bacterial Infections; Bronchitis; Child; Child, Preschool; Drug S | 1972 |
Adverse haematological effects and trimethoprim-sulphamethoxazole administration.
Topics: Aged; Agranulocytosis; Anemia; Child; Drug Combinations; Female; Hematologic Diseases; Humans; Male; | 1973 |
Letter: Thrombocytopenia with combined trimethoprim-sulphamethoxazole and allopurinol therapy.
Topics: Aged; Allopurinol; Drug Combinations; Female; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethopr | 1973 |
[Side effects of trimethoprim-sulfamethoxazole (co-trimoxazole)].
Topics: Adult; Aged; Crystallization; Humans; Leukopenia; Male; Sulfamethoxazole; Thrombocytopenia; Trimetho | 1973 |
Induction of remission in myeloblastic and monoblastic leukaemia in adults with rubidomycin.
Topics: Adolescent; Adult; Aged; Alopecia; Ampicillin; Anemia, Aplastic; Antibiotics, Antineoplastic; Blood | 1971 |
[Studies on the hematologic tolerance of Bactrim].
Topics: Anti-Infective Agents; Erythrocytes; Folic Acid Antagonists; Folic Acid Deficiency; Hematologic Dise | 1972 |
Thrombocytopenia following administration of 'Bactrim'.
Topics: Adult; Female; Folic Acid Antagonists; Humans; Male; Pyrimidines; Respiratory Tract Infections; Sulf | 1970 |
Thrombocytopenia following administration of "septrin".
Topics: Female; Folic Acid Antagonists; Hematopoiesis; Humans; Male; Pyrimidines; Sulfamethoxazole; Thromboc | 1970 |
[Treatment of chronically recurring urinary tract infection with trimethoprim sulfamethoxazole (Eusaprim)].
Topics: Adult; Aged; Anti-Infective Agents; Chronic Disease; Female; Folic Acid Antagonists; Gastrointestina | 1970 |
Thrombocytopenia and agranulocytosis following "septrin".
Topics: Adult; Agranulocytosis; Female; Folic Acid Antagonists; Humans; Pregnancy; Pyrimidines; Sulfamethoxa | 1969 |