Page last updated: 2024-11-04

sulfamethoxazole and Symptom Cluster

sulfamethoxazole has been researched along with Symptom Cluster in 6 studies

Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.

Research Excerpts

ExcerptRelevanceReference
"Hypersensitivity syndromes are severe drug induced side effects with skin rashes, fever and/or multiorgan-system abnormalities which are not pharmacologically related."2.40[Drug-induced hypersensitivity syndrome. A review and presentation of 2 personal cases]. ( Pichler, WJ; Schnyder, B; Zanni, MP, 1997)
"If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease."2.37Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986)
"The syndrome is characterised by fever, an itchy erythema with edema, confluent papules and purpura of the hands and feet in a "gloves and socks" distribution."1.30[Drug-induced papular-purpuric gloves and socks syndrome]. ( Ballmer-Weber, BK; Brand, CU; Hunziker, TK; van Rooijen, MM; Yawalkar, N, 1999)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nolph, MB1
Dion, MW1
Schnyder, B1
Zanni, MP1
Pichler, WJ1
van Rooijen, MM1
Brand, CU1
Ballmer-Weber, BK1
Yawalkar, N1
Hunziker, TK1
Leavitt, RY1
Fauci, AS1
First, LR1
Smith, BR1
Lipton, J1
Nathan, DG1
Parkman, R1
Rappeport, JM1
Böhm, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Azacitidine (AZA) Combined With N-Acetyl-L-cysteine (NAC) for Prolonged Isolated Thrombocytopenia (PIT) After Hematopoietic Stem Cell Transplantation (HSCT)[NCT05126004]Phase 2100 participants (Anticipated)Interventional2021-12-01Not yet recruiting
A Prospective Study of Patients With Isolated Thrombocytopenia Following Hematopoietic Stem Cell Transplantation[NCT02487563]Phase 397 participants (Actual)Interventional2015-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Megakaryocyte Count

The total number of megakaryocytes as well as the platelet-shedding megakaryocytes of bone marrow smears (per cm2) was counted and cross-checked by blinded observers. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment

Interventioncells/cm^2 (Median)
Experimental Group 16.7
Experimental Group 27.5
Control Group3.3

Number of Participants With Platelet Count Recovery

Platelet response refers to a sustained increase (stable or increasing level) of at least 30×10E9/L independent of transfusion for 3 days. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment

InterventionParticipants (Count of Participants)
Experimental Group 120
Experimental Group 222
Control Group6

Reviews

2 reviews available for sulfamethoxazole and Symptom Cluster

ArticleYear
[Drug-induced hypersensitivity syndrome. A review and presentation of 2 personal cases].
    Schweizerische medizinische Wochenschrift, 1997, Mar-01, Volume: 127, Issue:9

    Topics: Adult; Aged; Allopurinol; CD8 Antigens; Drug Eruptions; Drug Hypersensitivity; Female; HLA-DR Antige

1997
Pulmonary vasculitis.
    The American review of respiratory disease, 1986, Volume: 134, Issue:1

    Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy

1986

Other Studies

4 other studies available for sulfamethoxazole and Symptom Cluster

ArticleYear
Raeder's syndrome associated with internal carotid artery dilation and sinusitis.
    The Laryngoscope, 1982, Volume: 92, Issue:10 Pt 1

    Topics: Adult; Carotid Artery Diseases; Carotid Artery, Internal; Dilatation, Pathologic; Facial Neuralgia;

1982
[Drug-induced papular-purpuric gloves and socks syndrome].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1999, Volume: 50, Issue:4

    Topics: Aged; Edema; Erythema; Foot Dermatoses; Hand Dermatoses; Humans; Male; Pruritus; Purpura; Skin Disea

1999
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
    Blood, 1985, Volume: 65, Issue:2

    Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child

1985
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
    Blood, 1985, Volume: 65, Issue:2

    Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child

1985
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
    Blood, 1985, Volume: 65, Issue:2

    Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child

1985
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
    Blood, 1985, Volume: 65, Issue:2

    Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child

1985
[Attack prevention and exacerbation therapy of the chronic bronchitis syndrome].
    Zeitschrift fur Allgemeinmedizin, 1974, Aug-31, Volume: 50, Issue:24

    Topics: Adult; Age Factors; Aged; Anti-Bacterial Agents; Bronchitis; Chronic Disease; Disability Evaluation;

1974