Compounds > sulfamethoxazole
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sulfamethoxazole and Stevens-Johnson Syndrome

sulfamethoxazole has been researched along with Stevens-Johnson Syndrome in 27 studies

Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
"Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported."1.48Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States. ( Agarwal, A; Aleshin, M; Boggs, J; Cardones, AR; Chen, JK; Chiesa-Fuxench, Z; Cotliar, J; Davis, MDP; Dominguez, A; Fox, LP; Gelfand, JM; Gordon, S; Hamrick, R; Ho, B; Hughey, LC; John, JS; Jones, LM; Kaffenberger, BH; Kindley, K; Kroshinsky, D; Kwong, BY; Margolis, DJ; Micheletti, RG; Miller, DD; Mostaghimi, A; Musiek, A; Noe, MH; Ortega-Loayza, AG; Patel, R; Posligua, A; Rani, M; Rosenbach, M; Saluja, S; Sharon, VR; Shinkai, K; Stephen, S; Strickland, N; Summers, EM; Sun, N; Wanat, KA; Wetter, DA; Worswick, S; Yang, C, 2018)
"The 3 patients had a severe dry eye syndrome."1.31[Lyell's syndrome and its ophthalmologic manifestations in Cameroon]. ( Beharcohen, F; Dighiero, P; Moussala, M; Renard, G, 2000)
"Silver nitrate was selected over silver sulfadiazine (Silvadene) and mafenide in view of the nature of the offending agent."1.26Toxic epidermal necrolysis-case report and review of the literature. ( Horn, MS; Ortiz, JE; Peterson, HD, 1982)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199020 (74.07)18.7374
1990's2 (7.41)18.2507
2000's2 (7.41)29.6817
2010's2 (7.41)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Nakamura, R1
Ozeki, T1
Hirayama, N1
Sekine, A1
Yamashita, T1
Mashimo, Y1
Mizukawa, Y1
Shiohara, T1
Watanabe, H1
Sueki, H1
Ogawa, K1
Asada, H1
Kaniwa, N1
Tsukagoshi, E1
Matsunaga, K1
Niihara, H1
Yamaguchi, Y1
Aihara, M1
Mushiroda, T1
Saito, Y1
Morita, E1
Micheletti, RG1
Chiesa-Fuxench, Z1
Noe, MH1
Stephen, S1
Aleshin, M1
Agarwal, A1
Boggs, J1
Cardones, AR1
Chen, JK1
Cotliar, J1
Davis, MDP1
Dominguez, A1
Fox, LP1
Gordon, S1
Hamrick, R1
Ho, B1
Hughey, LC1
Jones, LM1
Kaffenberger, BH1
Kindley, K1
Kroshinsky, D1
Kwong, BY1
Miller, DD1
Mostaghimi, A1
Musiek, A1
Ortega-Loayza, AG1
Patel, R1
Posligua, A1
Rani, M1
Saluja, S1
Sharon, VR1
Shinkai, K1
John, JS1
Strickland, N1
Summers, EM1
Sun, N1
Wanat, KA1
Wetter, DA1
Worswick, S1
Yang, C1
Margolis, DJ1
Gelfand, JM1
Rosenbach, M1
Atipo-Tsiba, PW1
Bayonne, S1
Messe Ambia Koulimaya, R1
Naisbitt, DJ1
Pirmohamed, M1
Park, BK1
Nagy, G1
Meszáros, A1
Fong, PH1
Ratnagopal, P1
Wong, KL1
Petersen, P1
Kastrup, J1
Bartram, R1
Brettle, RP1
Gray, JA1
Sangster, G1
Murdoch, JM1
Dick, HM1
Ortiz, JE1
Horn, MS1
Peterson, HD1
Klein, CE2
Trautmann, A2
Zillikens, D2
Bröcker, EB2
Moussala, M1
Beharcohen, F1
Dighiero, P1
Renard, G1
Thorpe, JA1
Nysenbaum, A1
Kikuchi, S1
Okazaki, T1
Richmond, JM1
Whitworth, JA1
Fairley, KF1
Kincaid-Smith, P1
Petricević, I1
Tomljenović, V1
Soldo, I1
Caumes, E1
Feyeux, C1
Garrouste, MT1
Schlemmer, B1
Wallach, D1
Whittington, RM1
Carmichael, AJ1
Tan, CY1
Romeu, J1
Clotet, B1
Tural, C1
Carles, J1
Foz, M1
Schöpf, E1
Baird, BJ1
De Villez, RL1
Roujeau, JC1
Albengres, E1
Moritz, S1
Piacentino, A1
Cuny, M1
Revuz, J1
Touraine, R1
Chanial, G2
Gayet, J2
Campagni, JP2
Gallet, M2
Hugues, M2
Barnay, C1
Shaw, DJ1
Jacobs, RP1

Other Studies

27 other studies available for sulfamethoxazole and Stevens-Johnson Syndrome

ArticleYear
Association of HLA-A*11:01 with Sulfonamide-Related Severe Cutaneous Adverse Reactions in Japanese Patients.
    The Journal of investigative dermatology, 2020, Volume: 140, Issue:8

    Topics: Adult; Drug Hypersensitivity Syndrome; Female; Genetic Predisposition to Disease; HLA-A11 Antigen; H

2020
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:11

    Topics: Adrenal Cortex Hormones; Adult; Aged; Cohort Studies; Critical Care; Female; Humans; Immunoglobulins

2018
[Eye involvement of drug eruptions: report of 10 cases].
    Le Mali medical, 2011, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Anti-Infective Agents; Blindness; Child; Conjunctivitis; Female; Humans; Male; St

2011
Drug presentation to T cells.
    The Journal of allergy and clinical immunology, 2005, Volume: 115, Issue:4

    Topics: Animals; Anti-Infective Agents; Cells, Cultured; Humans; Lymphocyte Activation; Nitroso Compounds; S

2005
[Acetylsalicylic acid intolerance in Lyell syndrome].
    Dermatologische Monatschrift, 1984, Volume: 170, Issue:5

    Topics: Aspirin; Drug Combinations; Drug Eruptions; Female; Humans; Middle Aged; Respiratory Tract Infection

1984
Drug induced toxic epidermal necrolysis.
    Singapore medical journal, 1984, Volume: 25, Issue:3

    Topics: Adult; Allopurinol; Burns; Critical Care; Drug Combinations; Emergencies; Female; Humans; Middle Age

1984
[Toxic epidermal necrolysis. A case caused by sulphamethoxazole combined with trimethoprim].
    Ugeskrift for laeger, 1983, Oct-24, Volume: 145, Issue:43

    Topics: Anti-Infective Agents, Urinary; Drug Combinations; Humans; Male; Middle Aged; Stevens-Johnson Syndro

1983
The mucocutaneous syndromes--Erythema multiforme, Stevens-Johnson and Ectodermosis erosiva pluriorificialis.
    The Journal of infection, 1982, Volume: 4, Issue:2

    Topics: Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Drug Combinations; Erythema

1982
Toxic epidermal necrolysis-case report and review of the literature.
    Annals of plastic surgery, 1982, Volume: 9, Issue:3

    Topics: Adult; Drug Therapy, Combination; Humans; Male; Resuscitation; Silver Nitrate; Stevens-Johnson Syndr

1982
Patch testing in an unusual case of toxic epidermal necrolysis.
    Contact dermatitis, 1995, Volume: 33, Issue:6

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Diagnosis, Differential; Humans; Male; Patc

1995
Patch testing in an unusual case of toxic epidermal necrolysis.
    Contact dermatitis, 1996, Volume: 35, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Infective Agents, Urinary; Humans; Male; Patch

1996
[Lyell's syndrome and its ophthalmologic manifestations in Cameroon].
    Journal francais d'ophtalmologie, 2000, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Anti-Infective Agents; Anticonvulsants; Blindness; Cameroon; Child; Child, Presch

2000
Co-trimoxazole fatality.
    Lancet (London, England), 1978, Feb-04, Volume: 1, Issue:8058

    Topics: Drug Combinations; Female; Humans; Middle Aged; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimetho

1978
Stevens-Johnson syndrome due to co-trimoxazole.
    Lancet (London, England), 1978, Sep-09, Volume: 2, Issue:8089

    Topics: Adult; Drug Combinations; Female; Humans; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimethoprim

1978
Co-trimoxazole nephrotoxicity.
    Lancet (London, England), 1979, Mar-03, Volume: 1, Issue:8114

    Topics: Acute Kidney Injury; Drug Combinations; Drug Hypersensitivity; Erythema; Humans; Kidney; Stevens-Joh

1979
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1978.
    The New England journal of medicine, 1978, Jul-06, Volume: 299, Issue:1

    Topics: Adult; Diagnosis, Differential; Female; Humans; Lupus Erythematosus, Systemic; Skin; Stevens-Johnson

1978
[Lyell's disease. Report of a case (author's transl)].
    Lijecnicki vjesnik, 1978, Volume: 100, Issue:10

    Topics: Aged; Drug Combinations; Humans; Male; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimethoprim

1978
[Bullous toxic skin disease with fatal outcome in AIDS].
    Presse medicale (Paris, France : 1983), 1989, Oct-21, Volume: 18, Issue:34

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Joh

1989
Toxic epidermal necrolysis and co-trimoxazole.
    Lancet (London, England), 1989, Sep-02, Volume: 2, Issue:8662

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Drug Combinations; Humans; Male; Postope

1989
Fatal toxic epidermal necrolysis associated with co-trimoxazole.
    Lancet (London, England), 1989, Sep-30, Volume: 2, Issue:8666

    Topics: Aged; Drug Combinations; Humans; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimethoprim; Trimethop

1989
Therapeutic challenge for Isospora belli enteritis in an AIDS patient who developed Lyell syndrome after co-trimoxazole therapy.
    The American journal of gastroenterology, 1989, Volume: 84, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Coccidiosis; Drug Combinations; Enteritis; Humans; Male;

1989
Skin reactions to co-trimoxazole.
    Infection, 1987, Volume: 15 Suppl 5

    Topics: Anti-Infective Agents; Drug Combinations; Drug Eruptions; Humans; Skin; Stevens-Johnson Syndrome; Su

1987
Widespread bullous fixed drug eruption mimicking toxic epidermal necrolysis.
    International journal of dermatology, 1988, Volume: 27, Issue:3

    Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; Female; Humans; Male; Phen

1988
Lymphocyte transformation test in drug-induced toxic epidermal necrolysis.
    International archives of allergy and applied immunology, 1985, Volume: 78, Issue:1

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dipyrone; Drug Combinations; Female; Flurbiprofen; Hu

1985
[Lyell's syndrome in the 2nd month of viral hepatitis after administration of sulfamethoxazole-trimethoprim; associated cardiac rhythm disorders].
    Journal de medecine de Lyon, 1972, Jun-05, Volume: 53, Issue:230

    Topics: Aged; Anti-Infective Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Folic Acid Antagonis

1972
[Lyell's syndrome in the 2d month of a viral hepatitis following ingestion of sulfamethoxazole-trimethoprime; associated heart rhythm disorders].
    Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1971, Volume: 78, Issue:5

    Topics: Aged; Anti-Infective Agents; Arrhythmias, Cardiac; Bradycardia; Drug Combinations; Female; Heart Blo

1971
Simultaneous occurrence of toxic hepatitis and Stevens-Johnson syndrome following therapy with sulfisoxazole and sulfamethoxazole.
    The Johns Hopkins medical journal, 1970, Volume: 126, Issue:3

    Topics: Adult; Biopsy; Chemical and Drug Induced Liver Injury; Eosinophilia; Erythema Multiforme; Female; Hu

1970