sulfamethoxazole has been researched along with HIV Coinfection in 36 studies
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis in HIV-uninfected, exposed (HUE) children variably reduces clinical malaria burden despite antifolate resistance, but data regarding achieved serum levels and adherence are lacking." | 7.88 | Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children. ( Anok, A; Duffy, PE; Eastman, RT; Gabriel, EE; Hobbs, CV; Kasule, J; Neal, J; Newell, K; Penzak, S; Reynolds, SJ; Serwadda, D, 2018) |
| "PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance." | 7.69 | The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients. ( Borleffs, JC; Hoepelman, AI; Schneider, MM; van Dooyeweert, DA, 1996) |
| "Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states." | 5.38 | Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients. ( Curtis, A; Koletar, SL; Papp, AC; Para, MF; Wang, D, 2012) |
| "Intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine is contra-indicated in HIV-positive pregnant women receiving sulfamethoxazole/trimethoprim prophylaxis." | 5.22 | Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya. ( Desai, M; González, R; Green, M; Kariuki, S; Katana, A; Menendez, C; Otieno, K; Ouma, P; Slutsker, L; ter Kuile, F, 2016) |
| "Trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis in HIV-uninfected, exposed (HUE) children variably reduces clinical malaria burden despite antifolate resistance, but data regarding achieved serum levels and adherence are lacking." | 3.88 | Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children. ( Anok, A; Duffy, PE; Eastman, RT; Gabriel, EE; Hobbs, CV; Kasule, J; Neal, J; Newell, K; Penzak, S; Reynolds, SJ; Serwadda, D, 2018) |
| " Treatment failure rates for culture-proven chancroid were 19% for trimethoprim-sulfamethoxazole, 12." | 3.69 | Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease. ( Behets, FM; Cohen, MS; Dallabetta, G; Hamilton, HA; Hoffman, IF; Liomba, G; Lule, G; Moeng, S, 1995) |
| "PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance." | 3.69 | The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients. ( Borleffs, JC; Hoepelman, AI; Schneider, MM; van Dooyeweert, DA, 1996) |
| "Sulfamethoxazole (SMX) is an effective drug for the management of opportunistic infections, but its use is limited by hypersensitivity reactions, particularly in HIV-infected patients." | 2.72 | Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso. ( Bajad, SU; Graziano, FM; Guzinski, MV; Kurian, JR; Lavergne, SN; Maki, JE; Trepanier, LA; Yoder, AR, 2006) |
| "The onset of cutaneous adverse effects attributable to sulfamethoxazole-trimethoprim therapy within 3 months after desensitization." | 2.68 | Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus. ( Bricaire, F; Caumes, E; Guermonprez, G; Katlama, C; Lecomte, C, 1997) |
| "cepa root tip revealed chromosomal aberrations on exposure to each compound." | 1.91 | Evaluation of the probable synergistic toxicity of selected potentiated antiretroviral and antibiotics on some aquatic biomarker organisms. ( Genthe, B; Ndlela, L; Olatunji, OS; Omotola, EO, 2023) |
| "Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states." | 1.38 | Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients. ( Curtis, A; Koletar, SL; Papp, AC; Para, MF; Wang, D, 2012) |
| "aureus bacteremia were compared against 188 controls selected from patients with CD4 cell counts < 200 x 10(6)/l." | 1.30 | Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients. ( Chaisson, RE; Moore, RD; Styrt, BA, 1997) |
| "It has been suggested that the high rates of adverse reactions to sulfonamides among patients with AIDS may be related to an increased sensitivity to reactive drug metabolites among HIV-infected cells." | 1.29 | Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells. ( Bird, IA; Dekaban, GA; Krause, R; Rieder, MJ, 1995) |
| " The mean time to first side effect was 12." | 1.29 | Crossover of human immunodeficiency virus-infected patients from aerosolized pentamidine to trimethoprim-sulfamethoxazole: lack of hematologic toxicity and relationship of side effects to CD4+ lymphocyte count. ( Anderson, MD; Kennedy, CA; Lewis, DE; Oldfield, EC; Pimentel, JA; Weiss, PJ, 1993) |
| "Major aphthous ulcers are associated with a high degree of morbidity in patients infected with human immunodeficiency virus." | 1.29 | Major aphthous ulcers in patients with HIV disease. ( Glick, M; Muzyka, BC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (41.67) | 18.2507 |
| 2000's | 10 (27.78) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 5 (13.89) | 2.80 |
| Authors | Studies |
|---|---|
| Washino, T | 1 |
| Mikita, K | 1 |
| Kosaka, A | 1 |
| Sakamoto, N | 1 |
| Iwabuchi, S | 1 |
| Nakamura-Uchiyama, F | 1 |
| Omotola, EO | 1 |
| Genthe, B | 1 |
| Ndlela, L | 1 |
| Olatunji, OS | 1 |
| Li, Y | 1 |
| Zeng, YM | 1 |
| Lu, YQ | 1 |
| Qin, YY | 1 |
| Chen, YK | 1 |
| Nibamureke, UMC | 1 |
| Wagenaar, GM | 1 |
| Liu, Y | 1 |
| Hu, Z | 1 |
| Wei, H | 1 |
| Chen, Y | 1 |
| Cheng, C | 1 |
| Chi, Y | 1 |
| Kasule, J | 1 |
| Gabriel, EE | 1 |
| Anok, A | 1 |
| Neal, J | 1 |
| Eastman, RT | 1 |
| Penzak, S | 1 |
| Newell, K | 1 |
| Serwadda, D | 1 |
| Duffy, PE | 1 |
| Reynolds, SJ | 1 |
| Hobbs, CV | 1 |
| Parker, SR | 1 |
| Correnti, C | 1 |
| Sikora, K | 1 |
| Parker, DC | 1 |
| Green, M | 1 |
| Otieno, K | 1 |
| Katana, A | 1 |
| Slutsker, L | 1 |
| Kariuki, S | 1 |
| Ouma, P | 1 |
| González, R | 1 |
| Menendez, C | 1 |
| ter Kuile, F | 1 |
| Desai, M | 1 |
| Suárez, I | 1 |
| Roderus, L | 1 |
| van Gumpel, E | 1 |
| Jung, N | 1 |
| Lehmann, C | 1 |
| Fätkenheuer, G | 1 |
| Hartmann, P | 1 |
| Plum, G | 1 |
| Rybniker, J | 1 |
| Thomas, M | 1 |
| Rupali, P | 1 |
| Woodhouse, A | 1 |
| Ellis-Pegler, R | 1 |
| Wang, D | 1 |
| Curtis, A | 1 |
| Papp, AC | 1 |
| Koletar, SL | 1 |
| Para, MF | 1 |
| Mutua, FM | 1 |
| M'imunya, JM | 1 |
| Wiysonge, CS | 1 |
| Alfirevic, A | 1 |
| Stalford, AC | 2 |
| Vilar, FJ | 2 |
| Wilkins, EG | 2 |
| Park, BK | 3 |
| Pirmohamed, M | 3 |
| Trepanier, LA | 2 |
| Yoder, AR | 2 |
| Bajad, S | 1 |
| Beckwith, MD | 1 |
| Bellehumeur, JL | 1 |
| Graziano, FM | 2 |
| Winter, HR | 1 |
| Trapnell, CB | 1 |
| Slattery, JT | 1 |
| Jacobson, M | 1 |
| Greenspan, DL | 1 |
| Hooton, TM | 1 |
| Unadkat, JD | 1 |
| Lavergne, SN | 1 |
| Kurian, JR | 1 |
| Bajad, SU | 1 |
| Maki, JE | 1 |
| Guzinski, MV | 1 |
| Laufer, MK | 1 |
| Plowe, CV | 1 |
| Blossom, DB | 1 |
| Namayanja-Kaye, G | 1 |
| Nankya-Mutyoba, J | 1 |
| Mukasa, JB | 1 |
| Bakka, H | 1 |
| Rwambuya, S | 1 |
| Windau, A | 1 |
| Bajaksouzian, S | 1 |
| Walker, CJ | 1 |
| Joloba, ML | 1 |
| Kityo, C | 1 |
| Mugyenyi, P | 1 |
| Whalen, CC | 1 |
| Jacobs, MR | 1 |
| Salata, RA | 1 |
| Sanderson, JP | 1 |
| Naisbitt, DJ | 2 |
| Farrell, J | 1 |
| Ashby, CA | 1 |
| Tucker, MJ | 1 |
| Rieder, MJ | 2 |
| Clarke, SE | 1 |
| Krause, R | 1 |
| Bird, IA | 1 |
| Dekaban, GA | 1 |
| Behets, FM | 1 |
| Liomba, G | 1 |
| Lule, G | 1 |
| Dallabetta, G | 1 |
| Hoffman, IF | 1 |
| Hamilton, HA | 1 |
| Moeng, S | 1 |
| Cohen, MS | 1 |
| Kennedy, CA | 1 |
| Pimentel, JA | 1 |
| Lewis, DE | 1 |
| Anderson, MD | 1 |
| Weiss, PJ | 1 |
| Oldfield, EC | 1 |
| Muzyka, BC | 1 |
| Glick, M | 1 |
| Carr, A | 1 |
| Tindall, B | 1 |
| Penny, R | 1 |
| Cooper, DA | 1 |
| van Dooyeweert, DA | 1 |
| Schneider, MM | 1 |
| Borleffs, JC | 1 |
| Hoepelman, AI | 1 |
| Caumes, E | 1 |
| Guermonprez, G | 1 |
| Lecomte, C | 1 |
| Katlama, C | 1 |
| Bricaire, F | 1 |
| Styrt, BA | 1 |
| Chaisson, RE | 2 |
| Moore, RD | 2 |
| Rich, JD | 1 |
| Sullivan, T | 1 |
| Greineder, D | 1 |
| Kazanjian, PH | 1 |
| Lehmann, DF | 1 |
| Newman, N | 1 |
| Morse, PD | 1 |
| Eldred, LJ | 1 |
| Wu, AW | 1 |
| ter Hofstede, HJ | 1 |
| van der Ven, AJ | 2 |
| Koopmans, PP | 2 |
| Reilly, TP | 1 |
| MacArthur, RD | 1 |
| Farrough, MJ | 1 |
| Crane, LR | 1 |
| Woster, PM | 1 |
| Svensson, CK | 1 |
| Abad, S | 1 |
| Moachon, L | 1 |
| Blanche, P | 1 |
| Bavoux, F | 1 |
| Sicard, D | 1 |
| Salmon-Céron, D | 1 |
| Vree, TB | 1 |
| van der Meer, JW | 1 |
| Stein, DS | 1 |
| Stevens, RC | 1 |
| Terry, D | 1 |
| Laizure, SC | 1 |
| Palte, S | 1 |
| Lancaster, DJ | 1 |
| Weems, JJ | 1 |
| Williams, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Trimethoprim-sulfamethoxazole Prophylaxis on Malaria Infection and Immunity in Children in Uganda[NCT02094508] | 173 participants (Actual) | Observational | 2014-03-07 | Completed | |||
| Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole and Dapsone and Their Hydroxylamine Metabolites[NCT00000826] | Phase 1 | 48 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sulfamethoxazole and HIV Coinfection
| Article | Year |
|---|---|
Disseminated Toxoplasmosis associated with Haemophagocytic Lymphohistiocytosis in a Patient with the Human Immunodeficiency Virus: A Case Report and Literature Review.
Topics: Adult; Clindamycin; Female; HIV; HIV Infections; Humans; Lymphohistiocytosis, Hemophagocytic; Sulfam | 2022 |
Genital ulcer disease treatment for reducing sexual acquisition of HIV.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; Chancroid; Female; Fleroxacin; HIV Infec | 2012 |
8 trials available for sulfamethoxazole and HIV Coinfection
| Article | Year |
|---|---|
A study for precision diagnosing and treatment strategies in difficult-to-treat AIDS cases and HIV-infected patients with highly fatal or highly disabling opportunistic infections.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; AIDS-Related Opportunistic Infections; Anti-I | 2020 |
Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.
Topics: Adolescent; Adult; Antimalarials; Double-Blind Method; Female; HIV Infections; Humans; Kenya; Malari | 2016 |
The effect of clarithromycin, fluconazole, and rifabutin on sulfamethoxazole hydroxylamine formation in individuals with human immunodeficiency virus infection (AACTG 283).
Topics: Adult; Anti-Infective Agents; Area Under Curve; CD4 Lymphocyte Count; Clarithromycin; Drug Interacti | 2004 |
Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cell Separation; Cyclic N-Oxides; Drug Hypersensitivity; F | 2006 |
Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus.
Topics: Adult; Anti-Infective Agents; Desensitization, Immunologic; Drug Administration Schedule; Drug Erupt | 1997 |
The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus.
Topics: Adult; Anti-Infective Agents; Anti-Ulcer Agents; Antibiotic Prophylaxis; Cimetidine; Double-Blind Me | 1998 |
Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals?
Topics: Adult; Anti-Infective Agents; Benzoxazoles; Biomarkers; Cell Separation; Cell Survival; Dapsone; Dru | 1999 |
Use of low-dose trimethoprim-sulfamethoxazole thrice weekly for primary and secondary prophylaxis of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients.
Topics: Adult; Chromatography, High Pressure Liquid; Complement C4; Drug Administration Schedule; Female; HI | 1991 |
26 other studies available for sulfamethoxazole and HIV Coinfection
| Article | Year |
|---|---|
Evaluation of the probable synergistic toxicity of selected potentiated antiretroviral and antibiotics on some aquatic biomarker organisms.
Topics: Anti-Bacterial Agents; Aquatic Organisms; Biomarkers; Chromosome Aberrations; Ecosystem; Environment | 2023 |
Histopathological changes in Oreochromis mossambicus (Peters, 1852) ovaries after a chronic exposure to a mixture of the HIV drug nevirapine and the antibiotics sulfamethoxazole and trimethoprim.
Topics: Africa; Animals; Anti-Bacterial Agents; COVID-19; Female; HIV Infections; Humans; Nevirapine; Ovary; | 2021 |
Disseminated nocardiosis involving the central nervous system in the context of newly diagnosed HIV infection: A case report.
Topics: Adult; Brain; HIV Infections; Humans; Male; Nocardia; Nocardia Infections; Sulfamethoxazole | 2021 |
Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children.
Topics: Anti-Retroviral Agents; Antimalarials; Drug Resistance; Female; Folic Acid Antagonists; HIV; HIV Inf | 2018 |
Seronegative syphilis: another case for the great imitator.
Topics: Adult; HIV Infections; Humans; Male; Sulfamethoxazole; Syphilis; Treatment Outcome; Treponema; Trime | 2014 |
Low prevalence of DHFR and DHPS mutations in Pneumocystis jirovecii strains obtained from a German cohort.
Topics: Anti-Infective Agents; Dihydropteroate Synthase; Drug Resistance, Bacterial; Female; Fungal Proteins | 2017 |
Good outcome with trimethoprim 10 mg/kg/day-sulfamethoxazole 50 mg/kg/day for Pneumocystis jirovecii pneumonia in HIV infected patients.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Female; HIV Infections; H | 2009 |
Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Catalytic Domain; Female; Genot | 2012 |
Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity.
Topics: Acetylation; Adult; Drug Hypersensitivity; Genotype; HIV Infections; Humans; Middle Aged; Phenotype; | 2003 |
Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection.
Topics: Adult; Anti-Infective Agents; Ascorbic Acid; Ascorbic Acid Deficiency; Case-Control Studies; CD4-CD8 | 2004 |
Cotrimoxazole prophylaxis and malaria in Africa: Have the important questions been answered?
Topics: HIV Infections; Humans; Malaria, Falciparum; Pyrimethamine; Sulfadoxine; Sulfamethoxazole; Trimethop | 2006 |
Oropharyngeal colonization by Streptococcus pneumoniae among HIV-infected adults in Uganda: assessing prevalence and antimicrobial susceptibility.
Topics: Adult; Ambulatory Care Facilities; Anti-Infective Agents; Carrier State; Cross-Sectional Studies; Dr | 2006 |
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.
Topics: Animals; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; CD40 Antigens; CD40 Ligand; Cytochrom | 2007 |
Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells.
Topics: Adult; Cells, Cultured; Deltaretrovirus Infections; Dose-Response Relationship, Drug; Drug Hypersens | 1995 |
Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease.
Topics: Chancroid; Ciprofloxacin; Erythromycin; Genital Diseases, Male; HIV Infections; Humans; Malawi; Male | 1995 |
Crossover of human immunodeficiency virus-infected patients from aerosolized pentamidine to trimethoprim-sulfamethoxazole: lack of hematologic toxicity and relationship of side effects to CD4+ lymphocyte count.
Topics: Adult; Aerosols; Aged; CD4-Positive T-Lymphocytes; Drug Combinations; Female; HIV Infections; Humans | 1993 |
Major aphthous ulcers in patients with HIV disease.
Topics: Adult; Biomarkers; CD4-CD8 Ratio; Dapsone; Ethnicity; Female; HIV Infections; Humans; Immune Toleran | 1994 |
In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV.
Topics: Adult; CD4-CD8 Ratio; Cytokines; Cytotoxicity, Immunologic; Drug Hypersensitivity; Glutathione; HIV | 1993 |
The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients.
Topics: Bacteriuria; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; Humans; Male; Pn | 1996 |
Prior antimicrobials and staphylococcal bacteremia in HIV-infected patients.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Bacteremia; Case-Control Studie | 1997 |
Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons.
Topics: Administration, Oral; Adult; CD4-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Drug Admi | 1997 |
Adherence to antiretroviral and pneumocystis prophylaxis in HIV disease.
Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Anti-Infective Agents; An | 1998 |
Drug reactions to contrimoxazole in HIV infection: possibly not due to the hydroxylamine metabolites of sulphamethoxazole.
Topics: Anti-Infective Agents; HIV Infections; Humans; Hydroxylamine; Pneumonia, Pneumocystis; Sulfamethoxaz | 1999 |
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.
Topics: Adult; Chromatography, High Pressure Liquid; Cysteine; Disease Progression; Drug Hypersensitivity; H | 2000 |
Possible interaction between gliclazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia.
Topics: Anti-Infective Agents; Antifungal Agents; Diabetes Complications; Diabetes Mellitus; Drug Interactio | 2001 |
[Frequent side effects of cotrimoxazole in persons infected with HIV, possibly due to metabolites of sulfamethoxazole].
Topics: HIV Infections; Humans; Pneumonia, Pneumocystis; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Dr | 1992 |