sulfamethoxazole and Cirrhosis, Liver studies

sulfamethoxazole and Cirrhosis, Liver

Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.

Research Excerpts

Excerpt	Relevance	Reference
"The extensive use of invasive procedures and of long-term norfloxacin prophylaxis in the management of cirrhotic patients may have influenced the epidemiology of bacterial infections in cirrhosis."	7.71	Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. ( Arroyo, V; Colmenero, J; Fernández, J; Gómez, J; Navasa, M; Rodés, J; Vila, J, 2002)
"The extensive use of invasive procedures and of long-term norfloxacin prophylaxis in the management of cirrhotic patients may have influenced the epidemiology of bacterial infections in cirrhosis."	3.71	Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. ( Arroyo, V; Colmenero, J; Fernández, J; Gómez, J; Navasa, M; Rodés, J; Vila, J, 2002)

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (83.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

5 (83.33)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (16.67)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Ransohoff, DF	1
Jacobs, G	1
Fernández, J	1
Navasa, M	1
Gómez, J	1
Colmenero, J	1
Vila, J	1
Arroyo, V	1
Rodés, J	1
Quietzsch, J	1
Siegert, E	1
Günther, J	1
Angelucci, L	1
Baldieri, M	1
Barba, C	1
Lentini, S	1
Linari, G	1
Stocchi, F	1
Destaing, F	1
Villand, J	1
Carli, H	1
Carli, PM	1
Martin, F	1
Klepping, C	1

Studies

Ransohoff, DF

Jacobs, G

Fernández, J

Navasa, M

Gómez, J

Colmenero, J

Vila, J

Arroyo, V

Rodés, J

Quietzsch, J

Siegert, E

Günther, J

Angelucci, L

Baldieri, M

Barba, C

Lentini, S

Linari, G

Stocchi, F

Destaing, F

Villand, J

Carli, H

Carli, PM

Martin, F

Klepping, C

Clinical Trials (4)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Patterns of Antibiotic Resistant Bacterial Infections in Liver Intensive Care Unit[NCT03855709]		200 participants (Anticipated)	Observational	2019-05-31	Not yet recruiting
Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding[NCT00838864]	Phase 4	79 participants (Actual)	Interventional	2009-03-31	Completed
Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients[NCT01542801]	Phase 4	124 participants (Actual)	Interventional	2011-08-31	Completed
Rifaximin Versus Norfloxacin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis[NCT04159870]	Phase 3	322 participants (Anticipated)	Interventional	2019-11-05	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Patterns of Antibiotic Resistant Bacterial Infections in Liver Intensive Care Unit[NCT03855709]

200 participants (Anticipated)

Observational

2019-05-31

Not yet recruiting

Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis in Patients With Acute Variceal Bleeding[NCT00838864]

Phase 4

79 participants (Actual)

Interventional

2009-03-31

Completed

Comparison of Daily Norfloxacin Versus Weekly Ciprofloxacin for the Prevention of Spontaneous Bacterial Peritonitis in Cirrhotic Patients[NCT01542801]

Phase 4

124 participants (Actual)

Interventional

2011-08-31

Completed

Rifaximin Versus Norfloxacin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis[NCT04159870]

Phase 3

322 participants (Anticipated)

Interventional

2019-11-05

Active, not recruiting

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for sulfamethoxazole and Cirrhosis, Liver

Article	Year
Terminal hepatic failure following a small dose of sulfamethoxazole-trimethoprim. Gastroenterology, 1981, Volume: 80, Issue:4 Topics: Aged; Ascites; Diagnostic Errors; Hepatitis; Humans; Jaundice; Liver; Liver Cirrhosis; Male; Sulfame	1981
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology (Baltimore, Md.), 2002, Volume: 35, Issue:1 Topics: Aged; Anti-Infective Agents; Bacterial Infections; Critical Care; Drug Resistance, Microbial; Escher	2002
[Multilobular biliary liver cirrhosis as a purely hepatic form of mucoviscidosis]. Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten, 1979, Volume: 37, Issue:4 Topics: Child; Cholangitis; Cholecystitis; Cystic Fibrosis; Drug Combinations; Humans; Liver Cirrhosis; Male	1979
[Plasma levels of cotrimoxazole in patients with hepatic insufficiency]. La Clinica terapeutica, 1977, Apr-30, Volume: 81, Issue:2 Topics: Aged; Biotransformation; Bronchitis; Drug Combinations; Female; Humans; Liver Cirrhosis; Male; Middl	1977
[Transient agranulocytosis in the course of treatment with sulfamethoxazole-trimethoprim]. Annales de medecine interne, 1972, Volume: 123, Issue:2 Topics: Adolescent; Adult; Aged; Agranulocytosis; Anemia, Hemolytic; Anti-Infective Agents; Bone Marrow; Bon	1972
[Clinical study of a new nonfungal antibiotic: the trimethoprim-sulfamethoxazole combination in gastroenterology]. Revue medico-chirurgicale des maladies du foie, 1971, Volume: 46, Issue:6 Topics: Adult; Aged; Anti-Infective Agents; Biliary Tract Diseases; Female; Folic Acid Antagonists; Humans;	1971

Article

Year

Terminal hepatic failure following a small dose of sulfamethoxazole-trimethoprim.

Gastroenterology, 1981, Volume: 80, Issue:4

Topics: Aged; Ascites; Diagnostic Errors; Hepatitis; Humans; Jaundice; Liver; Liver Cirrhosis; Male; Sulfame

1981

Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis.