Page last updated: 2024-11-04

sulfamethoxazole and Allergy, Drug

sulfamethoxazole has been researched along with Allergy, Drug in 116 studies

Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.

Research Excerpts

ExcerptRelevanceReference
"A randomised single-blind clinical trial compared cinoxacin (500 mg every 12 hours) to co-trimoxazole (160 mg trimethoprim, 800 mg sulphamethoxazole every 12 hours) in the treatment of 63 patients with urinary tract infections."9.05Comparison of cinoxacin and co-trimoxazole in the treatment of urinary tract infections. ( de Jersey, P; Wooller, HO, 1982)
"To utilize T cells from sulfamethoxazole (SMX) hypersensitive patients with cystic fibrosis to examine the HLA molecules that interact with nitroso SMX (SMX-NO)-derived antigens."7.81HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. ( Alfirevic, A; Baker, DM; Faulkner, L; Naisbitt, DJ; Ogese, MO; Park, BK; Peckham, D; Pirmohamed, M; Saide, K; Sette, A; Whitaker, P, 2015)
"To compare mechanisms of antigen presentation and characterize the phenotype and function of T cells from sulfamethoxazole-hypersensitive patients with and without cystic fibrosis."7.77Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. ( Callan, H; Castrejon, L; El-Ghaiesh, S; Elsheikh, A; Farrell, J; Lavergne, SN; Monshi, M; Naisbitt, DJ; Park, BK; Peckham, D; Pichler, WJ; Whitaker, P, 2011)
"Sulfamethoxazole (SMX) is an important antibiotic in the management of patients with cystic fibrosis, but allergic reactions may develop thus restricting therapy."7.76Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis. ( Conway, S; Lavergne, SN; Naisbitt, DJ; Park, BK; Peckham, D; Whitaker, P, 2010)
"Intravenous administration of trimethoprim-sulfamethoxazole (TMS) on three occasions resulted in fever, rash, and wheezing in a 30-year-old man with acquired immunodeficiency syndrome with Pneumocytis carinii pneumonia."7.67Oral desensitization to trimethoprim-sulfamethoxazole in a patient with acquired immunodeficiency syndrome. ( Finegold, I, 1986)
"In three of eight patients with the acquired immune deficiency syndrome the Pneumocystis carinii pneumonia treated with intravenous trimethoprim sulfamethoxazole, drug-related reactions occurred 9, 10, and 13 days after therapy."7.67Desensitization to trimethoprim sulfamethoxazole in patients with acquired immune deficiency syndrome and Pneumocystis carinii pneumonia. ( Brunner, E; Haddad, ZH; Sainz, C; White, MV, 1989)
" Only 5 of 37 patients started on trimethoprim-sulfamethoxazole were able to complete treatment; in 29 patients drug toxicity occurred and in 19 treatment was changed due to adverse reactions that included rash, fever, neutropenia, thrombocytopenia, and transaminase elevation."7.67Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. ( Gordin, FM; Mills, J; Simon, GL; Wofsy, CB, 1984)
"Hypersensitivity adverse drug reactions are much more common among patients with acquired immunodeficiency syndrome (AIDS) than in the general population."5.33Differential toxicity of reactive metabolites of clindamycin and sulfonamides in HIV-infected cells: influence of HIV infection on clindamycin toxicity in vitro. ( Dekaban, GA; Rieder, MJ; Wijsman, JA, 2005)
"A randomised single-blind clinical trial compared cinoxacin (500 mg every 12 hours) to co-trimoxazole (160 mg trimethoprim, 800 mg sulphamethoxazole every 12 hours) in the treatment of 63 patients with urinary tract infections."5.05Comparison of cinoxacin and co-trimoxazole in the treatment of urinary tract infections. ( de Jersey, P; Wooller, HO, 1982)
"To utilize T cells from sulfamethoxazole (SMX) hypersensitive patients with cystic fibrosis to examine the HLA molecules that interact with nitroso SMX (SMX-NO)-derived antigens."3.81HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. ( Alfirevic, A; Baker, DM; Faulkner, L; Naisbitt, DJ; Ogese, MO; Park, BK; Peckham, D; Pirmohamed, M; Saide, K; Sette, A; Whitaker, P, 2015)
"To compare mechanisms of antigen presentation and characterize the phenotype and function of T cells from sulfamethoxazole-hypersensitive patients with and without cystic fibrosis."3.77Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. ( Callan, H; Castrejon, L; El-Ghaiesh, S; Elsheikh, A; Farrell, J; Lavergne, SN; Monshi, M; Naisbitt, DJ; Park, BK; Peckham, D; Pichler, WJ; Whitaker, P, 2011)
"Sulfonamide antimicrobials such as sulfamethoxazole (SMX) have been associated with drug hypersensitivity reactions, particularly in patients with AIDS."3.76Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine. ( Abouraya, M; Bhusari, S; Drescher, NJ; Padilla, ML; Pinkerton, ME; Sacco, JC; Trepanier, LA, 2010)
"Sulfamethoxazole (SMX) is an important antibiotic in the management of patients with cystic fibrosis, but allergic reactions may develop thus restricting therapy."3.76Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis. ( Conway, S; Lavergne, SN; Naisbitt, DJ; Park, BK; Peckham, D; Whitaker, P, 2010)
" the LTA by using trypan blue exclusion and to determine the utility of the assay to confirm drug hypersensitivity syndrome (DHS) to sulphonamides (SMX) and aromatic anticonvulsants."3.70A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. ( Malkiewicz, IM; Neuman, MG; Shear, NH, 2000)
"Intravenous administration of trimethoprim-sulfamethoxazole (TMS) on three occasions resulted in fever, rash, and wheezing in a 30-year-old man with acquired immunodeficiency syndrome with Pneumocytis carinii pneumonia."3.67Oral desensitization to trimethoprim-sulfamethoxazole in a patient with acquired immunodeficiency syndrome. ( Finegold, I, 1986)
"An immunoassay was developed for the detection of sulfamethoxazole reactive IgE antibodies in the sera of patients who experienced life threatening anaphylactic reactions following the ingestion of co-trimoxazole (trimethoprim and sulfamethoxazole)."3.67Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole. ( Baldo, BA; Harle, DG; Wells, JV, 1988)
"A patient with acquired immunodeficiency syndrome (AIDS) developed rash, fever, neutropenia, and elevated liver function tests during an initial course of trimethoprim-sulfamethoxazole (TMP-SMX) therapy."3.67Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS. ( Arnold, PA; Guglielmo, BJ; Hollander, H, 1988)
"In three of eight patients with the acquired immune deficiency syndrome the Pneumocystis carinii pneumonia treated with intravenous trimethoprim sulfamethoxazole, drug-related reactions occurred 9, 10, and 13 days after therapy."3.67Desensitization to trimethoprim sulfamethoxazole in patients with acquired immune deficiency syndrome and Pneumocystis carinii pneumonia. ( Brunner, E; Haddad, ZH; Sainz, C; White, MV, 1989)
" Only 5 of 37 patients started on trimethoprim-sulfamethoxazole were able to complete treatment; in 29 patients drug toxicity occurred and in 19 treatment was changed due to adverse reactions that included rash, fever, neutropenia, thrombocytopenia, and transaminase elevation."3.67Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. ( Gordin, FM; Mills, J; Simon, GL; Wofsy, CB, 1984)
"A patient with several episodes of jaundice associated with sulfamethoxazole therapy is described."3.66Sulfamethoxazole-induced hepatic injury. ( Mishkin, S; Steinbrecher, UP, 1981)
"After an acute course of pharyngitis and bronchitis treated with Bactrim (trimethoprim and sulfamethoxazol), a 52 year old woman suddenly developed a widespread, sterile pustular eruption with predilection of the distal parts of the extremities."3.66[Generalized acute pustulosis. An unusual presentation of leukocytoclastic vasculitis]. ( Braun-Falco, O; Luderschmidt, C; Maciejewski, W; Scherer, R, 1978)
"Sulfamethoxazole (SMX) is an effective drug for the management of opportunistic infections, but its use is limited by hypersensitivity reactions, particularly in HIV-infected patients."2.72Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso. ( Bajad, SU; Graziano, FM; Guzinski, MV; Kurian, JR; Lavergne, SN; Maki, JE; Trepanier, LA; Yoder, AR, 2006)
"The differential incidence of adverse drug reactions (ADR) between trimethoprim-sulfamethoxazole and dapsone might be explained, in part, by differences in the inherent toxicity of the hydroxylamine metabolites of sulfamethoxazole and dapsone."2.69Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone. ( Bellevue, FH; Reilly, TP; Svensson, CK; Woster, PM, 1998)
"The onset of cutaneous adverse effects attributable to sulfamethoxazole-trimethoprim therapy within 3 months after desensitization."2.68Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus. ( Bricaire, F; Caumes, E; Guermonprez, G; Katlama, C; Lecomte, C, 1997)
"Hypersensitivity syndromes are severe drug induced side effects with skin rashes, fever and/or multiorgan-system abnormalities which are not pharmacologically related."2.40[Drug-induced hypersensitivity syndrome. A review and presentation of 2 personal cases]. ( Pichler, WJ; Schnyder, B; Zanni, MP, 1997)
" The data also provide evidence that accumulation of toxic reactive metabolites could be an important component in the cascade of events leading to the development of DHRs in CF patients."1.91Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk. ( Abuzgaia, AM; Elzagallaai, AA; Mullowney, T; Rieder, MJ, 2023)
"Drug hypersensitivity reactions (DHRs) are rare but potentially fatal adverse drug reactions (ADRs)."1.39The predictive value of the in vitro platelet toxicity assay (iPTA) for the diagnosis of hypersensitivity reactions to sulfonamides. ( Elzagallaai, AA; Koren, G; Rieder, MJ, 2013)
" Anti-drug antibodies were also found in dogs experimentally dosed with SMX-nitroso followed by SMX, but not in a dog dosed with drug vehicle, followed by SMX."1.33Association of drug-serum protein adducts and anti-drug antibodies in dogs with sulphonamide hypersensitivity: a naturally occurring model of idiosyncratic drug toxicity. ( Danhof, RS; Lavergne, SN; Trepanier, LA; Volkman, EM, 2006)
"Hypersensitivity adverse drug reactions are much more common among patients with acquired immunodeficiency syndrome (AIDS) than in the general population."1.33Differential toxicity of reactive metabolites of clindamycin and sulfonamides in HIV-infected cells: influence of HIV infection on clindamycin toxicity in vitro. ( Dekaban, GA; Rieder, MJ; Wijsman, JA, 2005)
" Dosing was by the intraperitoneal route, once daily for four consecutive days per week, for 2 weeks total, followed by a third week of observation."1.33Evaluation of the clinical, immunologic, and biochemical effects of nitroso sulfamethoxazole administration to dogs: a pilot study. ( Lavergne, SN; Maki, JE; Trepanier, LA; Volkman, EM; Yoder, AR, 2005)
" Male Wistar rats were dosed with sulphamethoxazole, sulphamethoxazole hydroxylamine or nitroso sulphamethoxazole."1.31Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo. ( Burkhart, C; Cribb, AE; Gordon, SF; Naisbitt, DJ; Park, BK; Pichler, WJ; Pirmohamed, M, 2001)
" The immunogenic potential of SMX and its metabolites, SMX-NOH and SMX-NO, were assessed in rats by analyzing serum samples for the presence of anti-SMX IgG antibodies during a 4-week dosing period."1.30The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat. ( Gill, HJ; Hough, SJ; Kitteringham, NR; Maggs, JL; Naisbitt, DJ; Park, BK; Pirmohamed, M, 1997)
" For a better understanding of the molecular basis of the recognition of such drugs by specific TCC, we investigated 1) the fine specificity of the recognizing TCR, 2) the dose-response relationship for the induction of proliferation or cytokine production, and 3) the mechanism of TCR triggering."1.30Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones. ( Burkhart, C; Frutig, K; Pichler, WJ; Schnyder, B; von Greyerz, S; Zanni, MP, 1999)
"It has been suggested that the high rates of adverse reactions to sulfonamides among patients with AIDS may be related to an increased sensitivity to reactive drug metabolites among HIV-infected cells."1.29Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells. ( Bird, IA; Dekaban, GA; Krause, R; Rieder, MJ, 1995)
"An undoubtable role of the melioidosis germ persistence in the form of L-variants with the development of DTH in the relapses of the disease was stated."1.29[Laboratory control of effectiveness of chemotherapy in melioidosis]. ( Antonov, IuV; Batmanov, VP; Iliukhin, VI, 1995)
" In addition, heterogeneity in cellular repair mechanisms and the diversity of the human immune response [22] may also contribute to the manifestation of the toxic effects of sulphonamides."1.28Glutathione transferase mu deficiency is not a marker for predisposition to sulphonamide toxicity. ( Cribb, AE; Riley, RJ; Spielberg, SP, 1991)
"Thirty-four homosexual patients with AIDS were treated for Pneumocystis carinii pneumonia between April 1984 and November 1985."1.28Successful prophylaxis of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole in AIDS patients with previous allergic reactions. ( Seitzman, PA; Shafer, RW; Tapper, ML, 1989)
"Clinical features of 49 episodes of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome were compared with those of 39 episodes in patients with other immunosuppressive diseases."1.27Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. ( Hiemenz, JW; Honig, C; Kovacs, JA; Lane, HC; Longo, DL; Macher, AM; Murray, HW; Shelhamer, J; Stover, D; Urmacher, C, 1984)
"Sulfamethoxazole (SMX) was coupled to CNBr-activated cellulose disks to form a matrix predominantly substituted with isourea-linked N4-SMX determinants."1.27Studies of human IgE to a sulfonamide determinant. ( Carrington, DM; Earl, HS; Sullivan, TJ, 1987)

Research

Studies (116)

TimeframeStudies, this research(%)All Research%
pre-199055 (47.41)18.7374
1990's24 (20.69)18.2507
2000's19 (16.38)29.6817
2010's15 (12.93)24.3611
2020's3 (2.59)2.80

Authors

AuthorsStudies
Abuzgaia, AM2
Elzagallaai, AA4
Mullowney, T1
Rieder, MJ9
Sultan, EA1
Bend, JR1
Loubani, E1
Pereira, ARF1
Aun, MV1
Kelmann, NCP1
Motta, AA1
Kalil, J1
Giavina-Bianchi, P1
Gibson, A2
Faulkner, L3
Lichtenfels, M1
Ogese, M1
Al-Attar, Z1
Alfirevic, A4
Esser, PR1
Martin, SF1
Pirmohamed, M10
Park, BK14
Naisbitt, DJ17
Monroy-Arreola, A1
Durán-Figueroa, NV1
Méndez-Flores, S1
Domínguez-Cherit, J1
Watkinson, J1
Badillo-Corona, JA1
Whitaker, P4
Castrejón-Flores, JL1
Tamura, A1
Miyawaki, I1
Yamada, T1
Kimura, J1
Funabashi, H1
Koren, G2
Ogese, MO1
Saide, K1
Peckham, D3
Baker, DM1
Sette, A1
Sullivan, A1
Tailor, A1
Usui, T1
Kevin Park, B1
Kuretski, J1
Dahya, V1
Cason, L1
Chalasani, P1
Ramgopal, M1
Lavergne, SN6
Wang, H1
Callan, HE1
Pichler, WJ11
Castrejon, JL1
Berry, N1
El-Ghaiesh, S2
Gerber, B1
Bhusari, S1
Abouraya, M2
Padilla, ML1
Pinkerton, ME1
Drescher, NJ1
Sacco, JC2
Trepanier, LA6
Zawodniak, A1
Lochmatter, P1
Beeler, A1
Conway, S1
Kahl, BS1
Elsheikh, A1
Castrejon, L1
Monshi, M1
Callan, H1
Farrell, J2
Eyanagi, R1
Toda, A1
Imoto, M1
Uchiyama, H1
Ishii, Y1
Kuroki, H1
Kuramoto, Y1
Soeda, S1
Shimeno, H1
Gordon, F1
Burkhart, C4
Britschgi, M2
Strasser, I1
Depta, JP2
von Greyerz, S4
Barnaba, V1
Stalford, AC2
Vilar, FJ2
Wilkins, EG2
Hopkins, JE1
Humphreys, N1
Dearman, RJ1
Kimber, I1
Volkman, EM2
Maki, JE2
Yoder, AR2
Wijsman, JA1
Dekaban, GA2
Kurian, JR1
Bajad, SU1
Guzinski, MV1
Graziano, FM1
Danhof, RS1
Figueroa, J1
Ortega, N1
Almeida, L1
Blanco, C1
Castillo, R1
Sanderson, JP1
Ashby, CA1
Tucker, MJ1
Clarke, SE1
Dujovne, CA1
Chan, CH1
Zimmerman, HJ1
Schainuck, LI1
Hano, JE1
Clark, AJ1
Mouchizadeh, J1
Faunch, R1
McMichael, HB1
Lennon, D1
Gordin, FM1
Simon, GL1
Wofsy, CB1
Mills, J1
Kovacs, JA1
Hiemenz, JW1
Macher, AM1
Stover, D1
Murray, HW1
Shelhamer, J1
Lane, HC1
Urmacher, C1
Honig, C1
Longo, DL1
Burt, RA1
Boghaert, A1
Moulaert, P1
Nollet, G1
Bellon, A1
Kremer, I1
Ritz, R1
Brunner, F1
Cohn, DL1
Penley, KA1
Judson, FN1
Kirkpatrick, CH1
Horsburgh, CR1
Davis, KC1
Warrington, RJ1
Sauder, PJ1
McPhillips, S1
Adiga, KM1
de Jersey, P1
Wooller, HO1
Steinbrecher, UP1
Mishkin, S1
Chanu, B1
Kernbaum, S1
Uzzan, B1
Faille, A1
Blasetti, A1
Rouffy, J1
Nenci, GG1
Agnelli, G1
Berrettini, M1
Hertl, M1
Jugert, F1
Merk, HF1
Batmanov, VP1
Iliukhin, VI1
Antonov, IuV1
Daftarian, MP1
Filion, LG1
Cameron, W1
Conway, B1
Roy, R1
Tropper, F1
Diaz-Mitoma, F1
Meekins, CV1
Sullivan, TJ2
Gruchalla, RS2
Krause, R1
Bird, IA1
Agarwal, BR1
Sathe, AS1
Currimbhoy, Z1
Carr, A1
Tindall, B1
Penny, R1
Cooper, DA1
Cribb, AE4
Lee, BL1
Spielberg, SP4
Zanni, MP3
Schnyder, B4
Mauri-Hellweg, D2
Brander, C1
Kalbermatten, C1
Caumes, E1
Guermonprez, G1
Lecomte, C1
Katlama, C1
Bricaire, F1
Zanni, M1
Bettens, F1
Gill, HJ2
Hough, SJ2
Maggs, JL1
Kitteringham, NR2
Rich, JD1
Sullivan, T1
Greineder, D1
Kazanjian, PH1
Pesenko, RD1
Do, TT1
Skiest, DJ1
Reilly, TP2
Bellevue, FH1
Woster, PM2
Svensson, CK2
Frutig, K1
MacArthur, RD1
Farrough, MJ1
Crane, LR1
Bedard, K1
Smith, S1
Cribb, A1
Neuman, MG1
Malkiewicz, IM1
Shear, NH3
Park, KB1
Choquet-Kastylevsky, G1
Santolaria, N1
Tedone, R1
Aujoulat, M1
Descotes, J1
Gordon, SF1
Richmond, JM1
Whitworth, JA1
Fairley, KF1
Kincaid-Smith, P1
Kunz, HD1
Friess, G1
Hirschfeld, E1
Azinge, NO1
Garrick, GA1
Stevenson, DK1
Christie, DL1
Haas, JE1
Braun-Falco, O1
Luderschmidt, C1
Maciejewski, W1
Scherer, R1
Juul, P1
Lynn, KL1
Little, PJ1
Brathwaite, AR1
Dry, J1
Leynadier, F1
Herman, D1
Pradalier, A1
André, JM1
Hofer, T1
Becker, EW1
Weigand, K1
Berg, PA2
Gupta, A1
Eggo, MC1
Uetrecht, JP1
Daneman, D1
Cannon, M2
Riley, RJ1
O'Neil, CE1
Reed, MA1
Lopez, M1
Hyslop, N1
Gutierrez, E1
Salvaggio, J1
Greenberger, PA1
Carrington, DM1
Earl, HS1
White, MV1
Haddad, ZH1
Brunner, E1
Sainz, C1
Shafer, RW1
Seitzman, PA1
Tapper, ML1
Ulstad, DR1
Ampel, NM1
Shon, BY1
Galgiani, JN1
Cutcher, AB1
Papakonstantinou, G2
Füessl, H2
Matuschke, A1
Hehlmann, R2
Gottlieb, MS1
Young, LS1
Uetrecht, J1
Miller, M1
Arnold, PA1
Guglielmo, BJ1
Hollander, H1
Pioda, GB2
Del Favero, A2
Menichetti, F2
Spinozzi, F1
Gernini, I2
Rambotti, P2
Tanabe, K1
Nakagawa, A1
Kimura, S1
Mitamura, K1
Shimada, K1
Mori, S1
Wakabayashi, T1
Inagaki, M1
Miura, T1
Harle, DG2
Baldo, BA2
Wells, JV1
Sanders, PS1
Daniel, PT1
Guerciolini, R1
Wälti, M1
Neftel, KA1
Cohen, M1
Winkler, P1
de Weck, AL1
Smal, MA1
Van Nunen, SA1
Finegold, I1
Gibbons, RB1
Lindauer, JA1
Acero, D1
Masabeu, A1
Alabern, C1
Oterino, A1
Mayer, KH1
DeTorres, OH1
Christiansen, AH1
Klein, U1
Gikalov, I1
Keller, M1
Hoigné, R1
Halpern, G1
Münnich, D1
Brumfitt, W1
Pursell, R1
Gavras, H1
Lawson, DH1
Linton, AL1

Reviews

5 reviews available for sulfamethoxazole and Allergy, Drug

ArticleYear
The danger hypothesis--potential role in idiosyncratic drug reactions.
    Toxicology, 2002, Dec-27, Volume: 181-182

    Topics: Animals; Anti-Infective Agents; Antigen-Presenting Cells; Drug Hypersensitivity; Drug-Related Side E

2002
Drug hypersensitivity reactions in skin: understanding mechanisms and the development of diagnostic and predictive tests.
    Toxicology, 2004, Jan-15, Volume: 194, Issue:3

    Topics: Animals; Anti-Infective Agents; Cells, Cultured; Dermatitis, Allergic Contact; Drug Hypersensitivity

2004
Adverse reactions to sulphonamide and sulphonamide-trimethoprim antimicrobials: clinical syndromes and pathogenesis.
    Adverse drug reactions and toxicological reviews, 1996, Volume: 15, Issue:1

    Topics: Anti-Infective Agents; Drug Combinations; Drug Hypersensitivity; Humans; Sulfamethoxazole; Sulfamoxo

1996
[Drug-induced hypersensitivity syndrome. A review and presentation of 2 personal cases].
    Schweizerische medizinische Wochenschrift, 1997, Mar-01, Volume: 127, Issue:9

    Topics: Adult; Aged; Allopurinol; CD8 Antigens; Drug Eruptions; Drug Hypersensitivity; Female; HLA-DR Antige

1997
Current guidelines on the use of antibacterial drugs in patients with malignancies.
    Drugs, 1985, Volume: 29, Issue:3

    Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Antibody Formation; Bacterial Infecti

1985

Trials

11 trials available for sulfamethoxazole and Allergy, Drug

ArticleYear
Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso.
    Toxicology, 2006, May-01, Volume: 222, Issue:1-2

    Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Cell Separation; Cyclic N-Oxides; Drug Hypersensitivity; F

2006
Sulfonamide allergy without cross-reactivity to celecoxib.
    Allergy, 2007, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Bronchial Provocation Tests; Celecoxib; Cross Reactions; Drug Hypersensitivity; F

2007
Trimethoprim alone.
    Lancet (London, England), 1980, May-10, Volume: 1, Issue:8176

    Topics: Adult; Clinical Trials as Topic; Drug Combinations; Drug Hypersensitivity; Humans; Male; Sulfamethox

1980
Review of adverse reactions associated with cinoxacin and other drugs used to treat urinary tract infections.
    Urology, 1984, Volume: 23, Issue:1

    Topics: Adult; Aged; Amoxicillin; Anti-Infective Agents, Urinary; Central Nervous System Diseases; Cinoxacin

1984
Comparison of cinoxacin and co-trimoxazole in the treatment of urinary tract infections.
    The Medical journal of Australia, 1982, Mar-20, Volume: 1, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Urinary; Bacteriuria; Cinoxacin; Clinical Trials as

1982
Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus.
    Archives of dermatology, 1997, Volume: 133, Issue:4

    Topics: Adult; Anti-Infective Agents; Desensitization, Immunologic; Drug Administration Schedule; Drug Erupt

1997
Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone.
    Biochemical pharmacology, 1998, Mar-15, Volume: 55, Issue:6

    Topics: Cell Survival; Dapsone; Drug Hypersensitivity; Erythrocytes; Humans; Hydroxylamine; In Vitro Techniq

1998
Is hydroxylamine-induced cytotoxicity a valid marker for hypersensitivity reactions to sulfamethoxazole in human immunodeficiency virus-infected individuals?
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:3

    Topics: Adult; Anti-Infective Agents; Benzoxazoles; Biomarkers; Cell Separation; Cell Survival; Dapsone; Dru

1999
Treatment of gonorrhea in the male with trimethoprim-sulfamethoxazole using a one- or two-dose regimen.
    Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No

    Topics: Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Drug Combinations; Drug Evaluatio

1975
[Radioimmunologic detection of IgE and IgG antibodies against drugs. Conclusions after experience with over 1200 patients].
    Schweizerische medizinische Wochenschrift, 1986, Mar-08, Volume: 116, Issue:10

    Topics: Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Drug Hypersensitivity; Flavonoids; Hum

1986
Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole, and trimethoprim in treatment of urinary infection.
    British medical journal, 1972, Jun-17, Volume: 2, Issue:5815

    Topics: Ampicillin; Bacteriuria; Cephalexin; Cephalosporins; Drug Hypersensitivity; Escherichia coli Infecti

1972

Other Studies

100 other studies available for sulfamethoxazole and Allergy, Drug

ArticleYear
Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk.
    Molecular diagnosis & therapy, 2023, Volume: 27, Issue:3

    Topics: Anti-Bacterial Agents; Cystic Fibrosis; Drug Hypersensitivity; Humans; Lymphocytes; Sulfamethoxazole

2023
Role of Oxidative Stress in Hypersensitivity Reactions to Sulfonamides.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Blood Platelets; Cell Survival; Child; Drug Hypersen

2020
Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction.
    Einstein (Sao Paulo, Brazil), 2020, Volume: 18

    Topics: Aged; Desensitization, Immunologic; Drug Eruptions; Drug Hypersensitivity; Humans; Male; Sulfamethox

2020
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 08-15, Volume: 199, Issue:4

    Topics: CD4-Positive T-Lymphocytes; CTLA-4 Antigen; Drug Hypersensitivity; Haptens; Hepatitis A Virus Cellul

2017
Up-Regulation of T-Cell Activation MicroRNAs in Drug-Specific CD4
    Chemical research in toxicology, 2018, 06-18, Volume: 31, Issue:6

    Topics: Adult; Carbamazepine; CD4-Positive T-Lymphocytes; Cytokines; Drug Hypersensitivity; Female; Humans;

2018
Oral administration of drugs with hypersensitivity potential induces germinal center hyperplasia in secondary lymphoid organ/tissue in Brown Norway rats, and this histological lesion is a promising candidate as a predictive biomarker for drug hypersensiti
    Toxicology and applied pharmacology, 2013, Aug-15, Volume: 271, Issue:1

    Topics: Administration, Oral; Amoxicillin; Animals; Biomarkers; Carbamazepine; Drug Hypersensitivity; Flow C

2013
The predictive value of the in vitro platelet toxicity assay (iPTA) for the diagnosis of hypersensitivity reactions to sulfonamides.
    Journal of clinical pharmacology, 2013, Volume: 53, Issue:6

    Topics: Adolescent; Adult; Aged; Blood Platelets; Case-Control Studies; Child; Dose-Response Relationship, D

2013
HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015, Volume: 45, Issue:8

    Topics: Alleles; CD4-Positive T-Lymphocytes; Cell Proliferation; Cystic Fibrosis; Drug Hypersensitivity; Fem

2015
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 154, Issue:2

    Topics: Adult; Biological Specimen Banks; Cell Proliferation; Cells, Cultured; Coculture Techniques; Cytokin

2016
Nocardia Bacteremia and Endocarditis in a Patient With a Sulfa Allergy.
    The American journal of the medical sciences, 2016, Volume: 352, Issue:5

    Topics: Amikacin; Anti-Bacterial Agents; Bacteremia; Ciprofloxacin; Drug Hypersensitivity; Dyspnea; Endocard

2016
"Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2

    Topics: Anti-Infective Agents; Antigen-Presenting Cells; B-Lymphocytes; Cell Line; Cyclohexanones; Cytokines

2009
Predicting drug hypersensitivity by in vitro tests.
    ALTEX, 2007, Volume: 24 Spec No

    Topics: Allergens; Antigen-Antibody Reactions; Antigens; Drug Hypersensitivity; Haptens; Humans; Nitroso Com

2007
Stimulation of human T cells with sulfonamides and sulfonamide metabolites.
    The Journal of allergy and clinical immunology, 2010, Volume: 125, Issue:2

    Topics: Anti-Infective Agents; Antigen Presentation; Clone Cells; Drug Hypersensitivity; Humans; Lymphocyte

2010
Combined ascorbate and glutathione deficiency leads to decreased cytochrome b5 expression and impaired reduction of sulfamethoxazole hydroxylamine.
    Archives of toxicology, 2010, Volume: 84, Issue:8

    Topics: Animals; Anti-Infective Agents; Antioxidants; Ascorbic Acid; Ascorbic Acid Deficiency; Cell Prolifer

2010
The in vitro platelet toxicity assay (iPTA): a novel approach for assessment of drug hypersensitivity syndrome.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:3

    Topics: Adult; Animals; Anti-Infective Agents; Anticonvulsants; Blood Platelets; Carbamazepine; Cell Surviva

2011
Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole.
    International archives of allergy and immunology, 2010, Volume: 153, Issue:2

    Topics: Adult; Aged; Anti-Infective Agents; Cross Reactions; Drug Hypersensitivity; Female; Humans; Male; Mi

2010
Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis.
    Chemical research in toxicology, 2010, Jun-21, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Anti-Infective Agents; Cystic Fibrosis; Drug Hypersensitivity; Female; Humans; Hy

2010
Evaluation of sulfonamide detoxification pathways in haematologic malignancy patients prior to intermittent trimethoprim-sulfamethoxazole prophylaxis.
    British journal of clinical pharmacology, 2011, Volume: 71, Issue:4

    Topics: Adult; Aged; Anti-Infective Agents; Ascorbic Acid; Case-Control Studies; Cell Proliferation; Cytochr

2011
Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis.
    The Journal of allergy and clinical immunology, 2011, Volume: 127, Issue:6

    Topics: Anti-Bacterial Agents; Antigen Presentation; Antigen-Presenting Cells; Case-Control Studies; Cell Pr

2011
Covalent binding of nitroso-sulfonamides to glutathione S-transferase in guinea pigs with delayed type hypersensitivity.
    International immunopharmacology, 2012, Volume: 12, Issue:4

    Topics: Animals; Drug Hypersensitivity; Female; Glutathione Transferase; Guinea Pigs; Haptens; Hypersensitiv

2012
Non-covalent presentation of sulfamethoxazole to human CD4+ T cells is independent of distinct human leucocyte antigen-bound peptides.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:11

    Topics: Allergens; Antigen-Presenting Cells; CD4-Positive T-Lymphocytes; Cell Division; Coculture Techniques

2002
Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity.
    British journal of clinical pharmacology, 2003, Volume: 55, Issue:2

    Topics: Acetylation; Adult; Drug Hypersensitivity; Genotype; HIV Infections; Humans; Middle Aged; Phenotype;

2003
Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.
    Toxicology, 2005, Jan-15, Volume: 206, Issue:2

    Topics: Animals; Anti-Infective Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; D

2005
Evaluation of the clinical, immunologic, and biochemical effects of nitroso sulfamethoxazole administration to dogs: a pilot study.
    Toxicology, 2005, Mar-01, Volume: 208, Issue:1

    Topics: Animals; Anti-Infective Agents; Antibody Formation; Ascorbic Acid; Biotransformation; Cysteine; Dogs

2005
Differential toxicity of reactive metabolites of clindamycin and sulfonamides in HIV-infected cells: influence of HIV infection on clindamycin toxicity in vitro.
    Journal of clinical pharmacology, 2005, Volume: 45, Issue:3

    Topics: Animals; Anti-Infective Agents; Biotransformation; Cell Line; Cell Survival; Clindamycin; Coculture

2005
Association of drug-serum protein adducts and anti-drug antibodies in dogs with sulphonamide hypersensitivity: a naturally occurring model of idiosyncratic drug toxicity.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:7

    Topics: Animals; Anti-Infective Agents; Antibody Specificity; Blood Proteins; Cross Reactions; Disease Model

2006
Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling.
    Journal of immunology (Baltimore, Md. : 1950), 2007, May-01, Volume: 178, Issue:9

    Topics: Animals; Anti-Infective Agents; Aryl Hydrocarbon Hydroxylases; CD40 Antigens; CD40 Ligand; Cytochrom

2007
Sulfonamide hepatic injury. Review of the literature and report of a case due to sulfamethoxazole.
    The New England journal of medicine, 1967, Oct-12, Volume: 277, Issue:15

    Topics: Adult; Anuria; Drug Hypersensitivity; Eosinophilia; Humans; Jaundice; Male; Sulfamethoxazole; Sulfon

1967
Bilateral ureteral obstruction following sulfamethoxazole.
    The Journal of urology, 1967, Volume: 98, Issue:4

    Topics: Aged; Diuresis; Drug Hypersensitivity; Humans; Male; Radiography; Sulfamethoxazole; Ureteral Obstruc

1967
Co-trimoxazole toxicity.
    Lancet (London, England), 1984, Nov-17, Volume: 2, Issue:8412

    Topics: Adult; Drug Combinations; Drug Hypersensitivity; Humans; Sulfamethoxazole; Trimethoprim; Trimethopri

1984
Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.
    Annals of internal medicine, 1984, Volume: 100, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Drug Eruptions; Drug Hypersensitivity;

1984
Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies.
    Annals of internal medicine, 1984, Volume: 100, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Child; Drug Combinations; Drug Eruption

1984
Identification of the causative antigen in immune complex allergy. A simple method.
    Acta anaesthesiologica Belgica, 1980, Volume: 31, Issue:2

    Topics: Antigens; Complement System Proteins; Drug Hypersensitivity; Female; Humans; Immune Complex Diseases

1980
Aseptic meningitis as an adverse effect of co-trimoxazole.
    The New England journal of medicine, 1983, Jun-16, Volume: 308, Issue:24

    Topics: Adult; Drug Combinations; Drug Hypersensitivity; Female; Humans; Meningitis; Meningitis, Aseptic; Su

1983
The acquired immunodeficiency syndrome and a trimethoprim-sulfamethoxazole adverse reaction.
    Annals of internal medicine, 1984, Volume: 100, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Drug Hypersensitivity; Humans; Male; P

1984
Lymphocyte transformation studies in suspected hypersensitivity to trimethoprim-sulphamethoxazole.
    Clinical allergy, 1983, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Male;

1983
Conjunctival photosensitivity to co-trimoxazole.
    The Medical journal of Australia, 1982, Jul-24, Volume: 2, Issue:2

    Topics: Conjunctival Diseases; Drug Combinations; Drug Hypersensitivity; Humans; Male; Middle Aged; Sulfamet

1982
Sulfamethoxazole-induced hepatic injury.
    Digestive diseases and sciences, 1981, Volume: 26, Issue:8

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Female; Humans; Jaundice

1981
[Bone marrow aplasia induced by sulfamethoxazole-trimethoprim. Evidence of an allergic mechanism].
    La Nouvelle presse medicale, 1981, Nov-21, Volume: 10, Issue:42

    Topics: Drug Hypersensitivity; Female; Humans; Middle Aged; Pancytopenia; Sulfamethoxazole; Trimethoprim

1981
[Acute immunoallergic thrombopenia due to sulfamethoxazole-trimethoprim].
    La Nouvelle presse medicale, 1980, Feb-16, Volume: 9, Issue:8

    Topics: Acute Disease; Drug Hypersensitivity; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethoprim

1980
CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes.
    The British journal of dermatology, 1995, Volume: 132, Issue:2

    Topics: Aged; Animals; CD8 Antigens; CD8-Positive T-Lymphocytes; Cytochrome P-450 Enzyme System; Drug Hypers

1995
[Laboratory control of effectiveness of chemotherapy in melioidosis].
    Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1995, Volume: 40, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Burkholderia pseudomallei; Complement System Proteins; Drug Hypersen

1995
Immune response to sulfamethoxazole in patients with AIDS.
    Clinical and diagnostic laboratory immunology, 1995, Volume: 2, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibody Formation; Antibody Specificity; Drug Hypersensi

1995
Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins.
    The Journal of allergy and clinical immunology, 1994, Volume: 94, Issue:6 Pt 1

    Topics: Animals; Blood Proteins; Blotting, Western; Drug Hypersensitivity; Goats; Haptens; Protein Binding;

1994
Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1995, Feb-01, Volume: 8, Issue:2

    Topics: Adult; Cells, Cultured; Deltaretrovirus Infections; Dose-Response Relationship, Drug; Drug Hypersens

1995
Marked atypical lymphocytosis and skin rash following sulfamethoxazole.
    Indian pediatrics, 1993, Volume: 30, Issue:8

    Topics: Drug Eruptions; Drug Hypersensitivity; Humans; Infant; Lymphocytosis; Male; Sulfamethoxazole; Trimet

1993
In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV.
    Clinical and experimental immunology, 1993, Volume: 94, Issue:1

    Topics: Adult; CD4-CD8 Ratio; Cytokines; Cytotoxicity, Immunologic; Drug Hypersensitivity; Glutathione; HIV

1993
T cell reactions in patients showing adverse immune reactions to drugs.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996, Volume: 45 Suppl 2

    Topics: Adult; Anesthetics, Local; Anti-Infective Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphoc

1996
Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.
    The Journal of clinical investigation, 1997, Jul-01, Volume: 100, Issue:1

    Topics: Antigen-Presenting Cells; Antigens, CD; B-Lymphocytes; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8

1997
The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: Animals; Antibody Specificity; Biotransformation; Drug Hypersensitivity; Immunoglobulin G; Male; Rat

1997
Trimethoprim/sulfamethoxazole incremental dose regimen in human immunodeficiency virus-infected persons.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:5

    Topics: Administration, Oral; Adult; CD4-Positive T-Lymphocytes; Dose-Response Relationship, Drug; Drug Admi

1997
Sulfonamide-induced reactions in desensitized patients with AIDS--the role of covalent protein haptenation by sulfamethoxazole.
    The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Anti-Infective Agents; CD4 Lymphocyte Count; Drug Hypersensitivi

1998
Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Jan-01, Volume: 162, Issue:1

    Topics: Clone Cells; Cross Reactions; Dose-Response Relationship, Immunologic; Drug Hypersensitivity; Epitop

1999
Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Adult; Animals; Anti-Infective Agents; Cattle; Cysteine; Dicumarol; Drug Hypersensitivity; Enzyme In

1999
Sequential assessment of an antidrug antibody response in a patient with a systemic delayed-onset sulphonamide hypersensitivity syndrome reaction.
    The British journal of dermatology, 2000, Volume: 142, Issue:2

    Topics: Adult; Anti-Infective Agents; Blotting, Western; Drug Hypersensitivity; Enzyme-Linked Immunosorbent

2000
A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes.
    Clinical biochemistry, 2000, Volume: 33, Issue:7

    Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Carbamazepine; Case-Control Studies; Cell Surviva

2000
Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection.
    AIDS research and human retroviruses, 2000, Dec-10, Volume: 16, Issue:18

    Topics: Adult; Chromatography, High Pressure Liquid; Cysteine; Disease Progression; Drug Hypersensitivity; H

2000
Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells.
    British journal of pharmacology, 2001, Volume: 132, Issue:3

    Topics: Adult; Anti-Infective Agents; CD4-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Colony-For

2001
Induction of delayed-type hypersensitivity to sulfamethoxazole in mice: role of metabolites.
    Toxicology letters, 2001, Mar-08, Volume: 119, Issue:3

    Topics: Animals; Anti-Infective Agents; CD4 Lymphocyte Count; Disease Models, Animal; Drug Hypersensitivity;

2001
Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo.
    British journal of pharmacology, 2001, Volume: 133, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Antigen Presentation; Antigens, Surface; Cell Division; Cytokines;

2001
Co-trimoxazole nephrotoxicity.
    Lancet (London, England), 1979, Mar-03, Volume: 1, Issue:8114

    Topics: Acute Kidney Injury; Drug Combinations; Drug Hypersensitivity; Erythema; Humans; Kidney; Stevens-Joh

1979
[Allergic-toxic agranulocytosis].
    MMW, Munchener medizinische Wochenschrift, 1979, Dec-14, Volume: 121, Issue:50

    Topics: Abscess; Agranulocytosis; Diagnosis, Differential; Drug Hypersensitivity; Female; Humans; Leukemia;

1979
[Allergic vasculitis with arthritis due to bactrim allergy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1977, Jul-15, Volume: 119, Issue:28

    Topics: Aged; Arthritis; Blood Coagulation; Blood Platelets; Bronchitis; Drug Combinations; Drug Hypersensit

1977
Stevens-Johnson syndrome (erythema multiforme) following ingestion of trimethoprim-sulfamethoxazole on two separate occasions in the same person: a case report.
    The Journal of allergy and clinical immunology, 1978, Volume: 62, Issue:2

    Topics: Drug Combinations; Drug Hypersensitivity; Erythema Multiforme; Humans; Male; Middle Aged; Sulfametho

1978
Hepatic injury in a child caused by trimethoprim-sulfamethoxazole.
    Pediatrics, 1978, Volume: 61, Issue:6

    Topics: Adolescent; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Combinations; Drug Hyp

1978
[Generalized acute pustulosis. An unusual presentation of leukocytoclastic vasculitis].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1978, Volume: 29, Issue:7

    Topics: Basement Membrane; Bronchitis; Complement C3; Drug Combinations; Drug Hypersensitivity; Female; Huma

1978
[Adverse effects of treatment with sulfamethoxazole and trimethoprim. Report to the Adverse Drug Reaction Committee of the National Board of Health and Welfare].
    Ugeskrift for laeger, 1977, Jan-31, Volume: 139, Issue:5

    Topics: Aged; Chemical and Drug Induced Liver Injury; Denmark; Drug Combinations; Drug Hypersensitivity; Fem

1977
Letter: Reaction to trimoxazole.
    The New Zealand medical journal, 1976, May-26, Volume: 83, Issue:564

    Topics: Aged; Drug Combinations; Drug Hypersensitivity; Humans; Male; Sulfamethoxazole; Trimethoprim

1976
[Letter: Sulfamethoxazole-trimethoprim combination (cotrimoxazole). Unusual immuno-allergic reaction].
    La Nouvelle presse medicale, 1975, Jan-04, Volume: 4, Issue:1

    Topics: Blood Platelet Disorders; Drug Combinations; Drug Hypersensitivity; Drug Tolerance; Female; Humans;

1975
[Letter: Acute iatrogenic colitis following clindamycin and various antibiotics].
    La Nouvelle presse medicale, 1975, Oct-04, Volume: 4, Issue:32

    Topics: Acute Disease; Anti-Bacterial Agents; Bone Diseases; Clindamycin; Colistin; Colitis; Drug Combinatio

1975
Demonstration of sensitized lymphocytes to trimethoprim/sulfamethoxazole and ofloxacin in a patient with cholestatic hepatitis.
    Journal of hepatology, 1992, Volume: 15, Issue:1-2

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Female; Humans; O

1992
Drug-induced hypothyroidism: the thyroid as a target organ in hypersensitivity reactions to anticonvulsants and sulfonamides.
    Clinical pharmacology and therapeutics, 1992, Volume: 51, Issue:1

    Topics: Adolescent; Animals; Antibody Formation; Anticonvulsants; Cells, Cultured; Child; Child, Preschool;

1992
Glutathione transferase mu deficiency is not a marker for predisposition to sulphonamide toxicity.
    Biochemical pharmacology, 1991, Jul-15, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Cell Survival; Child; Child, Preschool; Disease Susceptibility; Drug Evaluation,

1991
Evaluation of immune parameters in HIV+ subjects reporting adverse reactions to sulfamethoxazole.
    International archives of allergy and applied immunology, 1991, Volume: 94, Issue:1-4

    Topics: Antigen-Antibody Complex; Drug Hypersensitivity; HIV Seropositivity; Humans; Immunoglobulin G; Sulfa

1991
Allergy to sulfa drugs with postcoital urticaria.
    JAMA, 1991, Mar-20, Volume: 265, Issue:11

    Topics: Coitus; Drug Hypersensitivity; Female; Humans; Male; Prostatitis; Sulfamethoxazole; Trimethoprim; Ur

1991
Studies of human IgE to a sulfonamide determinant.
    The Journal of allergy and clinical immunology, 1987, Volume: 79, Issue:3

    Topics: Adolescent; Adult; Antibody Specificity; Cellulose; Child; Child, Preschool; Drug Hypersensitivity;

1987
Desensitization to trimethoprim sulfamethoxazole in patients with acquired immune deficiency syndrome and Pneumocystis carinii pneumonia.
    Annals of allergy, 1989, Volume: 62, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Anti-Infective Agents; Desensitizat

1989
Successful prophylaxis of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole in AIDS patients with previous allergic reactions.
    Journal of acquired immune deficiency syndromes, 1989, Volume: 2, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Anti-Infective Agents; Cohort Studi

1989
Reaction after re-exposure to trimethoprim-sulfamethoxazole.
    Chest, 1989, Volume: 95, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Drug Hypersensitivity; Humans; Male; P

1989
Therapy of pneumocystis carinii pneumonia after trimethoprim-sulfamethoxazole desensitization.
    Klinische Wochenschrift, 1989, Mar-01, Volume: 67, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Combined Modality Therapy; Desensitization, Immunologic;

1989
Adverse reactions to pyrimethamine-sulfadoxine in context of AIDS.
    Lancet (London, England), 1985, Jun-15, Volume: 1, Issue:8442

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Drug Hypersensitivity; Humans; Pyrimethamine;

1985
Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites.
    Annals of internal medicine, 1989, Feb-15, Volume: 110, Issue:4

    Topics: Adult; Dose-Response Relationship, Immunologic; Drug Hypersensitivity; Female; Humans; Hydroxylamine

1989
Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS.
    Drug intelligence & clinical pharmacy, 1988, Volume: 22, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Dermatitis, Exfoliative; Drug Combinations; Drug Hypersen

1988
[Allergy to trimethoprim-sulfamethoxazole in normal, atopic and immunodepressed subjects].
    La Clinica terapeutica, 1987, Aug-15, Volume: 122, Issue:3

    Topics: Anti-Infective Agents; Drug Combinations; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate

1987
[A case report of acquired immunodeficiency syndrome (AIDS) with hypersensitivity reactions to trimethoprim-sulfamethoxazole].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 1988, Volume: 62, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Drug Combinations; Drug Hypersensi

1988
Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole.
    Molecular immunology, 1988, Volume: 25, Issue:12

    Topics: Adult; Aged; Allergens; Anaphylaxis; Binding, Competitive; Drug Hypersensitivity; Female; Humans; Im

1988
Trimethoprim-sulfamethoxazole desensitization in AIDS.
    Klinische Wochenschrift, 1988, Apr-15, Volume: 66, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Adult; Desensitization, Immunologic; Drug Hypersensitivity; Huma

1988
Malpractice claim review. Pediatrics, urology.
    Minnesota medicine, 1987, Volume: 70, Issue:2

    Topics: Child; Drug Combinations; Drug Hypersensitivity; Humans; Male; Malpractice; Sulfamethoxazole; Trimet

1987
Co-trimoxazole-induced hepatic injury--an analysis of cases with hypersensitivity-like reactions.
    Infection, 1987, Volume: 15 Suppl 5

    Topics: Adult; Aged; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Drug Combinations; Drug

1987
[Immuno-allergic reactions to cotrimoxazole in a hospital population].
    Quaderni Sclavo di diagnostica clinica e di laboratorio, 1987, Volume: 23, Issue:1

    Topics: Anti-Infective Agents; Complement Activation; Drug Combinations; Drug Hypersensitivity; Hospitalizat

1987
An immunoassay for the detection of IgE antibodies to trimethoprim in the sera of allergic patients.
    Clinical allergy, 1987, Volume: 17, Issue:3

    Topics: Adult; Drug Combinations; Drug Hypersensitivity; Female; Humans; Immunoglobulin E; Radioimmunoassay;

1987
Oral desensitization to trimethoprim-sulfamethoxazole in a patient with acquired immunodeficiency syndrome.
    The Journal of allergy and clinical immunology, 1986, Volume: 78, Issue:5 Pt 1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Hypersensitivity; Humans; Male; Sulfamethoxazole; Tr

1986
Successful treatment of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole in hypersensitive AIDS patients.
    JAMA, 1985, Mar-01, Volume: 253, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Adult; Diphenhydramine; Drug Combinations; Drug Hypersensitivity

1985
[Cholestasis caused by co-trimoxazole. Presentation of a new patient and review of the literature].
    Revista espanola de las enfermedades del aparato digestivo, 1985, Volume: 68, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Drug Hyp

1985
Precipitating antibodies to sulfathiazole in serum of patients with suspected allergy to sulfonamides.
    Acta dermato-venereologica, 1974, Volume: 54, Issue:6

    Topics: Aged; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Immunodiffusion; Male; Middle Aged; Pre

1974
[Drug monitoring in the medical ward of a regional hospital].
    Schweizerische medizinische Wochenschrift, 1972, Aug-05, Volume: 102, Issue:31

    Topics: Adult; Ampicillin; Anticoagulants; Antidepressive Agents; Central Nervous System Stimulants; Chemica

1972
[Allergic reactons and composite drugs].
    La Presse medicale, 1971, Oct-16, Volume: 79, Issue:43

    Topics: Adult; Anti-Infective Agents; Drug Combinations; Drug Eruptions; Drug Hypersensitivity; Female; Foli

1971
The treatment of salmonellosis with trimethoprim-sulphamethoxazole and their combination with polymyxin B in adult patients.
    Chemotherapy, 1973, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Drug Combinations; Drug Hypersensitivity; Feces; Fem

1973
Extended therapy with a trimethoprim-sulphonamide for the treatment of established urinary tract infection.
    Scottish medical journal, 1971, Volume: 16, Issue:12

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Drug Combinations; Drug Hypersensitivity; Escherichi

1971
Adverse effects of drugs commonly used in the treatment of urinary tract infection. A report from the Australian Drug Evaluation Committee.
    The Medical journal of Australia, 1972, Feb-26, Volume: 1, Issue:9

    Topics: Ampicillin; Anti-Infective Agents, Urinary; Australia; Chloramphenicol; Drug Hypersensitivity; Human

1972