sulfamethoxazole has been researched along with Adverse Drug Event in 24 studies
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This exploratory study assessed the safety of the combination of sulfamethoxazole, trimethoprim and guaifenesin (STG) in adult and pediatric patients with acute bronchitis according to local labelling in Peru." | 7.91 | A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis. ( Carrasco, R; Casas, A; de Los Ríos, J; Diaz, ME; Falcon, M; Felix, E; Flores, M; Guerra, F; Iberico, C; Reyes, I; Sanchez-Gambetta, S, 2019) |
| "Although there is a lack of data in trimethoprim-sulfamethoxazole (TMP-SMX) serum monitoring utility for invasive nocardial infections, therapeutic drug monitoring is widely used to optimize dosing and avoid adverse reactions that may cause treatment interruption." | 5.72 | Observational study of the clinical utility of sulfamethoxazole serum level monitoring in the treatment of brain abscesses due to Nocardia species. ( Abu Saleh, O; Corsini Campioli, C; Mara, KC; Rivera, CG, 2022) |
| "A spectrum of adverse drug reactions that are caused by the combined action of drugs and viruses has been described: ampicillin rash in acute infectious mononucleosis; Reye's syndrome; hypersensitivity reactions to sulphonamides in patients with HIV infection; drug-induced agranulocytosis; paracetamol (acetaminophen) hepatotoxicity; aspirin (acetylsalicyclic acid)-induced asthma; Epstein-Barr virus-associated lymphoma and methotrexate; and AIDS-related Kaposi's sarcoma and nitrite use." | 4.79 | Role of viral infections in the induction of adverse drug reactions. ( Levy, M, 1997) |
| "This exploratory study assessed the safety of the combination of sulfamethoxazole, trimethoprim and guaifenesin (STG) in adult and pediatric patients with acute bronchitis according to local labelling in Peru." | 3.91 | A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis. ( Carrasco, R; Casas, A; de Los Ríos, J; Diaz, ME; Falcon, M; Felix, E; Flores, M; Guerra, F; Iberico, C; Reyes, I; Sanchez-Gambetta, S, 2019) |
| "Although there is a lack of data in trimethoprim-sulfamethoxazole (TMP-SMX) serum monitoring utility for invasive nocardial infections, therapeutic drug monitoring is widely used to optimize dosing and avoid adverse reactions that may cause treatment interruption." | 1.72 | Observational study of the clinical utility of sulfamethoxazole serum level monitoring in the treatment of brain abscesses due to Nocardia species. ( Abu Saleh, O; Corsini Campioli, C; Mara, KC; Rivera, CG, 2022) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Zonisamide (ZNS) is an anticonvulsant (AC) that contains a sulpha moiety potentially triggering hypersensitivity syndrome reactions (HSR)." | 1.35 | Predicting possible zonisamide hypersensitivity syndrome. ( Cohen, L; Kessas, M; Lee, AW; Malkiewicz, IM; Neuman, MG; Shear, NH, 2008) |
| "Sulfamethoxazole hydroxylamine (SMX-HA) was used as a model toxic drug metabolite to explore the validity of the BCECF procedure." | 1.28 | Fluorescence-based viability assay for studies of reactive drug intermediates. ( Dosch, HM; Harper, PA; Lam, P; Leeder, JS; Spielberg, SP, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (33.33) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Corsini Campioli, C | 1 |
| Abu Saleh, O | 1 |
| Mara, KC | 1 |
| Rivera, CG | 1 |
| Usui, T | 1 |
| Faulkner, L | 1 |
| Farrell, J | 1 |
| French, NS | 1 |
| Alfirevic, A | 1 |
| Pirmohamed, M | 2 |
| Park, BK | 2 |
| Naisbitt, DJ | 2 |
| Falcon, M | 1 |
| Iberico, C | 1 |
| Guerra, F | 1 |
| Reyes, I | 1 |
| Felix, E | 1 |
| Flores, M | 1 |
| de Los Ríos, J | 1 |
| Diaz, ME | 1 |
| Casas, A | 1 |
| Sanchez-Gambetta, S | 1 |
| Carrasco, R | 1 |
| Neuman, MG | 1 |
| Shear, NH | 1 |
| Malkiewicz, IM | 1 |
| Kessas, M | 1 |
| Lee, AW | 1 |
| Cohen, L | 1 |
| Iaccheri, B | 1 |
| Fiore, T | 1 |
| Papadaki, T | 1 |
| Androudi, S | 1 |
| Janjua, S | 1 |
| Bhaila, I | 1 |
| Stephen Foster, C | 1 |
| Snyder, SA | 1 |
| Benotti, MJ | 1 |
| Ognongo-Ibiaho, AN | 1 |
| Atanda, HL | 1 |
| Gordon, F | 1 |
| Depta, JP | 1 |
| Altznauer, F | 1 |
| Gamerdinger, K | 1 |
| Burkhart, C | 1 |
| Weltzien, HU | 1 |
| Pichler, WJ | 1 |
| Ferrari, B | 1 |
| Mons, R | 1 |
| Vollat, B | 1 |
| Fraysse, B | 1 |
| Paxéus, N | 1 |
| Lo Giudice, R | 1 |
| Pollio, A | 1 |
| Garric, J | 1 |
| Fountoulakis, M | 1 |
| Drillia, P | 1 |
| Stamatelatou, K | 1 |
| Lyberatos, G | 2 |
| Dokianakis, SN | 1 |
| Kornaros, ME | 1 |
| Wormser, GP | 1 |
| Krupp, LB | 1 |
| Hanrahan, JP | 1 |
| Gavis, G | 1 |
| Spira, TJ | 1 |
| Cunningham-Rundles, S | 1 |
| Levy, M | 1 |
| Masera, G | 1 |
| Baronciani, D | 1 |
| Conti, A | 1 |
| Jankovic, M | 1 |
| Uderzo, C | 1 |
| Leeder, JS | 1 |
| Dosch, HM | 1 |
| Harper, PA | 1 |
| Lam, P | 1 |
| Spielberg, SP | 1 |
| Mitchell, AS | 1 |
| Henry, DA | 1 |
| Sanson-Fisher, R | 1 |
| O'Connell, DL | 1 |
| Johnson, RA | 1 |
| McQueen, EG | 1 |
| Koch-Weser, J | 1 |
| Sidel, VW | 1 |
| Sweet, RH | 1 |
| Kanarek, P | 1 |
| Eaton, AE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Multicentric and Observational Study of Safety of Sulfamethoxazole + Trimethoprim + Guaifenesin (Balsamic Bactrim) in Adult Patients With Acute Bronchitis[NCT02902640] | 52 participants (Actual) | Observational | 2016-11-15 | Completed | |||
| A Pilot, Multicentric and Observational Study of Safety of Sulfamethoxazole + Trimethoprim + Guaifenesin (Balsamic Bactrim) in Pediatric Patients With Acute Bronchitis[NCT02879981] | 51 participants (Actual) | Observational | 2016-11-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for sulfamethoxazole and Adverse Drug Event
| Article | Year |
|---|---|
The danger hypothesis--potential role in idiosyncratic drug reactions.
Topics: Animals; Anti-Infective Agents; Antigen-Presenting Cells; Drug Hypersensitivity; Drug-Related Side E | 2002 |
Role of viral infections in the induction of adverse drug reactions.
Topics: Acquired Immunodeficiency Syndrome; Agranulocytosis; Ampicillin; Caffeine; Drug-Related Side Effects | 1997 |
22 other studies available for sulfamethoxazole and Adverse Drug Event
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Observational study of the clinical utility of sulfamethoxazole serum level monitoring in the treatment of brain abscesses due to Nocardia species.
Topics: Brain Abscess; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; N | 2022 |
Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.
Topics: Anti-Infective Agents; Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactio | 2018 |
A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Bronchitis; Child; Child, Preschool; Drug Combinations; | 2019 |
A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Bronchitis; Child; Child, Preschool; Drug Combinations; | 2019 |
A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Bronchitis; Child; Child, Preschool; Drug Combinations; | 2019 |
A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis.
Topics: Acute Disease; Adult; Anti-Infective Agents; Bronchitis; Child; Child, Preschool; Drug Combinations; | 2019 |
Predicting possible zonisamide hypersensitivity syndrome.
Topics: Adult; Age Factors; Aged; Animals; Anticonvulsants; Cell Survival; Diagnostic Techniques and Procedu | 2008 |
Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.
Topics: Adolescent; Adult; Atovaquone; Clindamycin; Drug Combinations; Drug-Related Side Effects and Adverse | 2008 |
Endocrine disruptors and pharmaceuticals: implications for water sustainability.
Topics: Colorado; Droughts; Drug-Related Side Effects and Adverse Reactions; Endocrine Disruptors; Fresh Wat | 2010 |
Epidemiological study of fixed drug eruption in Pointe-Noire.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Child, Preschool; Congo; Counterfeit Drugs; D | 2012 |
Drug interaction with T-cell receptors: T-cell receptor density determines degree of cross-reactivity.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Base Sequence; Cross Reactions; DNA, Recomb | 2004 |
Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?
Topics: Animals; Carbamazepine; Clofibric Acid; Diclofenac; Drug-Related Side Effects and Adverse Reactions; | 2004 |
Toxic effect of pharmaceuticals on methanogenesis.
Topics: Bacteria, Anaerobic; Biomass; Carbamazepine; Clofibric Acid; Diclofenac; Drug-Related Side Effects a | 2004 |
On the effect of pharmaceuticals on bacterial nitrite oxidation.
Topics: Bacteria, Anaerobic; Biodegradation, Environmental; Bioreactors; Carbamazepine; Cities; Clofibrate; | 2004 |
Acquired immunodeficiency syndrome in male prisoners. New insights into an emerging syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Candida albicans; Drug-Related Side Effects and Adverse R | 1983 |
[Hemopathies caused by drugs in children: aplastic anemia, agranulocytosis, megaloblastic anemia].
Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; | 1978 |
Fluorescence-based viability assay for studies of reactive drug intermediates.
Topics: Cell Survival; Cells, Cultured; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse | 1989 |
Patients as a direct source of information on adverse drug reactions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Infective Agents; Australia; Child; Ch | 1988 |
Adverse reactions in ten years' general practice, computer analysed.
Topics: Ampicillin; Computers; Contraceptives, Oral; Contraceptives, Oral, Combined; Drug Combinations; Drug | 1986 |
CSM update. Blood dyscrasias.
Topics: Adult; Age Factors; Aged; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Hemato | 1985 |
New Zealand Committee on Adverse Drug Reactions: Ninth Annual Report 1974.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Interactions; Drug | 1974 |
Factors determining physician reporting of adverse drug reactions. Comparison of 2000 spontaneous reports with surveillance studies at the Massachusetts General Hospital.
Topics: Age Factors; Colistin; Drug-Related Side Effects and Adverse Reactions; Hospitalization; Humans; Mas | 1969 |