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sulfamethazine and Aging

sulfamethazine has been researched along with Aging in 9 studies

Sulfamethazine: A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
sulfamethazine : A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Acetylator phenotypes were determined with sulfamethazine in 114 healthy volunteers, 87 patients with immunogenic hyperthyroidism (Graves' disease) and 38 patients with disseminated thyroid autonomies."3.67N-acetylator phenotypes in hyperthyroidism. ( Franke, G; Gothe, P; Meng, S; Meng, W; Siegmund, W, 1988)
" Differences were found between one-three-weeks-old calves and seven-fifteen-weeks-old calves, in pharmacokinetic parameters (clearance, area under the concentration-time curve and elimination half-life) and in the PK/PD integration."2.73Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle. ( Baroni, EE; Boggio, JC; Díaz, DC; Picco, E; Rodríguez, C; San Andrés, MI; Waxman, S, 2008)
" The inducer dose of 150 mg SMZ/kg and the inhibitory dose of 300 mg SMZ/kg were selected for dosing young male, old male and adult female rats."1.30In vivo and in vitro effect of sulfamethazine on hepatic mixed function oxidases in rats. ( Govindwar, SP; Kodam, KM, 1997)
"In 41 patients aged 3-15 y with phenylketonuria, the acetylation indices showed a significantly higher proportion of fast acetylators - 24 (58."1.28N-acetylation in healthy and diseased children. ( Brysová, V; Hadasová, E; Kadlcáková, E, 1990)
"Plasma disposition, protein binding, urinary recovery, and renal clearance of sulfamethazine (SMZ), its N4-acetylsulfamethazine (N4-SMZ), and its 2 hydroxy metabolites--6-hydroxymethylsulfamethazine (SCH2OH) and 5-hydroxysulfamethazine (SOL)--and the glucuronide of the latter were studied in 7 cows and 7 calves to determine the relationship between these values and the age of the animal and dosage applied."1.27Age and dosage dependency in the plasma disposition and the renal clearance of sulfamethazine and its N4-acetyl and hydroxy metabolites in calves and cows. ( Baakman, M; Breukink, HJ; Driessens, F; Mevius, D; Nouws, JF; Vree, TB, 1986)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kuenzel, WJ1
Baroni, EE1
Díaz, DC1
Picco, E1
Waxman, S1
Rodríguez, C1
San Andrés, MI1
Boggio, JC1
Gachályi, B1
Vas, A1
Hajós, P1
Káldor, A1
Gupta, RC1
Nair, CR1
Jindal, SK1
Malik, SK1
Kodam, KM1
Govindwar, SP1
Hadasová, E1
Brysová, V1
Kadlcáková, E1
Siegmund, W1
Franke, G1
Meng, S1
Gothe, P1
Meng, W1
Nouws, JF1
Vree, TB1
Baakman, M1
Driessens, F1
Breukink, HJ1
Mevius, D1
Pontiroli, AE1
De Pasqua, A1
Bonisolli, L1
Pozza, G1

Trials

1 trial available for sulfamethazine and Aging

ArticleYear
Effects of age on the pharmacokinetics of single dose sulfamethazine after intravenous administration in cattle.
    Veterinary research communications, 2008, Volume: 32, Issue:7

    Topics: Aging; Animals; Anti-Bacterial Agents; Area Under Curve; Cattle; Dose-Response Relationship, Drug; F

2008

Other Studies

8 other studies available for sulfamethazine and Aging

ArticleYear
A landmark contribution to poultry science--a possible mode of action of sulfamethazine on the reproductive system of Leghorn cockerels.
    Poultry science, 2009, Volume: 88, Issue:4

    Topics: Aging; Animals; Anti-Bacterial Agents; Chickens; History, 20th Century; Male; Publishing; Sulfametha

2009
Acetylator phenotypes: effect of age.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:1

    Topics: Acetylation; Adult; Aged; Aging; Chemistry, Organic; Female; Humans; Hungary; Kinetics; Male; Middle

1984
Incidence of isoniazid acetylation phenotypes in North Indians.
    International journal of clinical pharmacology, therapy, and toxicology, 1984, Volume: 22, Issue:5

    Topics: Acetylation; Adult; Aging; Alcohol Drinking; Female; Humans; India; Isoniazid; Kinetics; Male; Middl

1984
In vivo and in vitro effect of sulfamethazine on hepatic mixed function oxidases in rats.
    Veterinary and human toxicology, 1997, Volume: 39, Issue:3

    Topics: Aging; Aminopyrine N-Demethylase; Animals; Anti-Infective Agents; Dose-Response Relationship, Drug;

1997
N-acetylation in healthy and diseased children.
    European journal of clinical pharmacology, 1990, Volume: 39, Issue:1

    Topics: Acetylation; Adolescent; Aging; Child; Child, Preschool; Czechoslovakia; Diabetes Mellitus, Type 1;

1990
N-acetylator phenotypes in hyperthyroidism.
    International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:8

    Topics: Acetylation; Adult; Aged; Aging; Female; Humans; Hyperthyroidism; Male; Middle Aged; Phenotype; Sulf

1988
Age and dosage dependency in the plasma disposition and the renal clearance of sulfamethazine and its N4-acetyl and hydroxy metabolites in calves and cows.
    American journal of veterinary research, 1986, Volume: 47, Issue:3

    Topics: Aging; Animals; Cattle; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fema

1986
Ageing and acetylator phenotype as determined by administration of sulphadimidine.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:4

    Topics: Acetylation; Adolescent; Adult; Aged; Aging; Humans; Middle Aged; Phenotype; Sulfamethazine

1985