sulfadimethoxine has been researched along with Kernicterus in 11 studies
Sulfadimethoxine: A sulfanilamide that is used as an anti-infective agent.
sulfadimethoxine : A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute brainstem auditory evoked potential (BAEP) abnormalities occur after giving sulfadimethoxine to 16-day-old jaundiced Gunn rats to displace bilirubin into tissue including brain." | 7.74 | Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats. ( Geiger, AS; Rice, AC; Shapiro, SM, 2007) |
| " We hypothesized that the antioxidants taurourosdeoxycholic acid (TUDCA), 12S-hydroxy-1,12-pyrazolinominocycline (PMIN), and minocycline (MNC) inhibit oxidative stress and block BIND in hyperbilirubinemic j/j Gunn rat pups that were given sulfadimethoxine to induce bilirubin encephalopathy." | 3.78 | Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. ( Daood, MJ; Hoyson, M; Watchko, JF, 2012) |
| "Spontaneously jaundiced Gunn rats exposed to sulfadimethoxine develop bilirubin encephalopathy (kernicterus) with hearing loss and dystonia, closely resembling the human syndrome." | 3.75 | Quantification of gait in dystonic Gunn rats. ( Baron, MS; Chaniary, KD; Ramakrishnan, V; Rice, AC; Shapiro, SM; Wetzel, PA, 2009) |
| " Acute brainstem auditory evoked potential (BAEP) abnormalities occur after giving sulfadimethoxine to 16-day-old jaundiced Gunn rats to displace bilirubin into tissue including brain." | 3.74 | Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats. ( Geiger, AS; Rice, AC; Shapiro, SM, 2007) |
| "Bilirubin encephalopathy or kernicterus is a potentially serious complication of neonatal hyperbilirubinemia." | 3.74 | NMDA channel antagonist MK-801 does not protect against bilirubin neurotoxicity. ( Geiger, A; Rice, AC; Shapiro, SM; Sombati, S, 2007) |
| "Bilirubin encephalopathy results from the entry of bilirubin into the brain and is expressed by motor, sensory, and/or behavioral impairment." | 3.69 | Postnatal development of somatosensory evoked potential in jaundiced Gunn rats and effects of sulfadimethoxine administration. ( Kapitulnik, J; Silver, S; Sohmer, H, 1996) |
| "Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans." | 1.35 | Electromyographic characterization in an animal model of dystonia. ( Baron, M; Chaniary, K; Rice, A; Shapiro, S; Wetzel, P, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaniary, KD | 1 |
| Baron, MS | 1 |
| Rice, AC | 3 |
| Wetzel, PA | 1 |
| Ramakrishnan, V | 1 |
| Shapiro, SM | 5 |
| Daood, MJ | 1 |
| Hoyson, M | 1 |
| Watchko, JF | 1 |
| Geiger, AS | 1 |
| Sombati, S | 1 |
| Geiger, A | 1 |
| Chaniary, K | 1 |
| Baron, M | 1 |
| Rice, A | 1 |
| Wetzel, P | 1 |
| Shapiro, S | 1 |
| Silver, S | 1 |
| Sohmer, H | 1 |
| Kapitulnik, J | 1 |
| McDonald, JW | 1 |
| Silverstein, FS | 1 |
| Johnston, MV | 1 |
| Rose, AL | 1 |
| Wisniewski, H | 1 |
| Hanefeld, F | 1 |
| Natzschka, J | 1 |
| Schutta, HS | 1 |
| Johnson, L | 1 |
11 other studies available for sulfadimethoxine and Kernicterus
| Article | Year |
|---|---|
Quantification of gait in dystonic Gunn rats.
Topics: Animals; Anti-Infective Agents; Biomechanical Phenomena; Disability Evaluation; Disease Models, Anim | 2009 |
Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups.
Topics: Aldehydes; Animals; Animals, Newborn; Antioxidants; Behavior, Animal; Bilirubin; Cerebellum; Disease | 2012 |
Somatosensory and brainstem auditory evoked potentials in the Gunn rat model of acute bilirubin neurotoxicity.
Topics: Animals; Bilirubin; Brain; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Evoked P | 2002 |
Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Infective Agents; Bilirubin; Disease Models, | 2007 |
NMDA channel antagonist MK-801 does not protect against bilirubin neurotoxicity.
Topics: Animals; Animals, Newborn; Anti-Infective Agents; Bilirubin; Cell Survival; Disease Models, Animal; | 2007 |
Electromyographic characterization in an animal model of dystonia.
Topics: Animals; Disease Models, Animal; Dystonia; Electromyography; Fourier Analysis; Kernicterus; Motor Ne | 2008 |
Postnatal development of somatosensory evoked potential in jaundiced Gunn rats and effects of sulfadimethoxine administration.
Topics: Animals; Bilirubin; Body Weight; Disease Models, Animal; Evoked Potentials, Somatosensory; Humans; I | 1996 |
Role of glutamate receptor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model.
Topics: Animals; Apoptosis; Bilirubin; Brain Damage, Chronic; Disease Models, Animal; Dizocilpine Maleate; D | 1998 |
Acute bilirubin encephalopathy induced with sulfadimethoxine in Gunn rats.
Topics: Acute Disease; Animals; Brain; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hippocampus; Hum | 1979 |
Histochemical studies in infant Gunn rats with kernicterus.
Topics: Acid Phosphatase; Animals; Animals, Newborn; Bilirubin; Brain; Cerebellum; Cochlear Nerve; Cytochrom | 1971 |
Clinical signs and morphologic abnormalities in Gunn rats treated with sulfadimethoxine.
Topics: Age Factors; Animals; Bilirubin; Brain; Brain Damage, Chronic; Disease Models, Animal; Humans; Hyper | 1969 |