sulfadimethoxine has been researched along with Disease Models, Animal in 27 studies
Sulfadimethoxine: A sulfanilamide that is used as an anti-infective agent.
sulfadimethoxine : A sulfonamide consisting of pyrimidine having methoxy substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute brainstem auditory evoked potential (BAEP) abnormalities occur after giving sulfadimethoxine to 16-day-old jaundiced Gunn rats to displace bilirubin into tissue including brain." | 7.74 | Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats. ( Geiger, AS; Rice, AC; Shapiro, SM, 2007) |
| "The prophylactic effect of in-feed medication of conventional pigs with sulphadimethoxine (SDM), sulphamethoxazole (SMX), and trimethoprim (TMP) was tested by using an Actinobacillus pleuropneumoniae infection model." | 7.70 | Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim. ( Kuiper, HA; Mengelers, MJ; Pijpers, A; van Miert, AS; Verheijden, JH, 2000) |
| "Bilirubin content was analyzed by high-performance liquid chromatography and Cyp1a1, 1a2, and 2a3 mRNA expression was analyzed by quantitative PCR (qPCR) in cortex (Cx), cerebellum (Cll), superior colliculi (SC), and inferior colliculi (IC) of 17-d-old hyperbilirubinemic (jj) Gunn rat pups before and after administration of sulphadimethoxine to acutely displace bilirubin from plasma albumin." | 5.38 | Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups. ( Berengeno, AL; Gazzin, S; Giraudi, PJ; Konickova, R; Raseni, A; Robert, MC; Tiribelli, C; Vitek, L; Zabetta, CC; Zdrahalova, L; Zelenka, J, 2012) |
| " We hypothesized that the antioxidants taurourosdeoxycholic acid (TUDCA), 12S-hydroxy-1,12-pyrazolinominocycline (PMIN), and minocycline (MNC) inhibit oxidative stress and block BIND in hyperbilirubinemic j/j Gunn rat pups that were given sulfadimethoxine to induce bilirubin encephalopathy." | 3.78 | Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups. ( Daood, MJ; Hoyson, M; Watchko, JF, 2012) |
| "Excessive hyperbilirubinemia in human neonates can cause permanent dysfunction of the auditory system, as assessed with brainstem auditory evoked potentials (BAEPs)." | 3.77 | Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction. ( Chiou, VL; Rice, AC; Shapiro, SM; Zuckoff, SB, 2011) |
| "Spontaneously jaundiced Gunn rats exposed to sulfadimethoxine develop bilirubin encephalopathy (kernicterus) with hearing loss and dystonia, closely resembling the human syndrome." | 3.75 | Quantification of gait in dystonic Gunn rats. ( Baron, MS; Chaniary, KD; Ramakrishnan, V; Rice, AC; Shapiro, SM; Wetzel, PA, 2009) |
| " Acute brainstem auditory evoked potential (BAEP) abnormalities occur after giving sulfadimethoxine to 16-day-old jaundiced Gunn rats to displace bilirubin into tissue including brain." | 3.74 | Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats. ( Geiger, AS; Rice, AC; Shapiro, SM, 2007) |
| "Bilirubin encephalopathy or kernicterus is a potentially serious complication of neonatal hyperbilirubinemia." | 3.74 | NMDA channel antagonist MK-801 does not protect against bilirubin neurotoxicity. ( Geiger, A; Rice, AC; Shapiro, SM; Sombati, S, 2007) |
| "We have previously reported that thyroid capsular inflammation induced by sulfadimethoxine (SDM), a goitrogen, might play a role in development of invasive follicular cell adenocarcinomas in rats initiated with N-bis(2-hydroxypropyl)nitrosamine (DHPN)." | 3.73 | Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression. ( Cho, YM; Hasumura, M; Hirose, M; Imai, T; Onose, J; Takizawa, T; Ueda, M, 2005) |
| "At 15 days of age, jj and nonjaundiced (Nj) littermates were injected with sulfadimethoxine (sulfa) and killed 3 days later by transcardial perfusion." | 3.73 | The jaundiced gunn rat model of auditory neuropathy/dyssynchrony. ( Shaia, WT; Shapiro, SM; Spencer, RF, 2005) |
| "The prophylactic effect of in-feed medication of conventional pigs with sulphadimethoxine (SDM), sulphamethoxazole (SMX), and trimethoprim (TMP) was tested by using an Actinobacillus pleuropneumoniae infection model." | 3.70 | Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim. ( Kuiper, HA; Mengelers, MJ; Pijpers, A; van Miert, AS; Verheijden, JH, 2000) |
| "Bilirubin encephalopathy results from the entry of bilirubin into the brain and is expressed by motor, sensory, and/or behavioral impairment." | 3.69 | Postnatal development of somatosensory evoked potential in jaundiced Gunn rats and effects of sulfadimethoxine administration. ( Kapitulnik, J; Silver, S; Sohmer, H, 1996) |
| " Abnormal BAEP occur in jaundiced Gunn rats after injection of sulfadimethoxine (sulfa) 100 mg/kg intraperitoneally, which displaces bilirubin from blood albumin binding sites and promotes the net transfer of bilirubin into brain tissue." | 3.68 | Reversible brainstem auditory evoked potential abnormalities in jaundiced Gunn rats given sulfonamide. ( Shapiro, SM, 1993) |
| " Two of the 5 agents with prophylactic activity, sulfadimethoxine and sulfamethazine, were effective also against an established infection, indicating that some sulfonamides may have therapeutic value in immunosuppressed patients with cryptosporidiosis." | 3.68 | Anticryptosporidial activity is associated with specific sulfonamides in immunosuppressed rats. ( Rehg, JE, 1991) |
| "Bilirubin content was analyzed by high-performance liquid chromatography and Cyp1a1, 1a2, and 2a3 mRNA expression was analyzed by quantitative PCR (qPCR) in cortex (Cx), cerebellum (Cll), superior colliculi (SC), and inferior colliculi (IC) of 17-d-old hyperbilirubinemic (jj) Gunn rat pups before and after administration of sulphadimethoxine to acutely displace bilirubin from plasma albumin." | 1.38 | Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups. ( Berengeno, AL; Gazzin, S; Giraudi, PJ; Konickova, R; Raseni, A; Robert, MC; Tiribelli, C; Vitek, L; Zabetta, CC; Zdrahalova, L; Zelenka, J, 2012) |
| "Kernicterus is known to produce damage to the auditory system and the basal ganglia in humans." | 1.35 | Electromyographic characterization in an animal model of dystonia. ( Baron, M; Chaniary, K; Rice, A; Shapiro, S; Wetzel, P, 2008) |
| " The pharmacokinetic parameters of the sulfonamides as well as their main metabolites (acetyl sulfonamides) were not significantly different in healthy and febrile pigs." | 1.29 | Pharmacokinetics of sulfadimethoxine and sulfamethoxazole in combination with trimethoprim after intravenous administration to healthy and pneumonic pigs. ( Kuiper, HA; Mengelers, MJ; Pijpers, A; Van Gogh, ER; Van Miert, AS; Verheijden, JH, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (11.11) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Waddell, J | 1 |
| He, M | 1 |
| Tang, N | 1 |
| Rizzuto, C | 1 |
| Bearer, CF | 1 |
| Paśko, P | 1 |
| Prochownik, E | 1 |
| Krośniak, M | 1 |
| Tyszka-Czochara, M | 1 |
| Francik, R | 1 |
| Marcinkowska, M | 1 |
| Sikora, J | 1 |
| Malinowski, M | 1 |
| Zagrodzki, P | 1 |
| Woo, GH | 1 |
| Takahashi, M | 1 |
| Inoue, K | 1 |
| Fujimoto, H | 1 |
| Igarashi, K | 1 |
| Kanno, J | 1 |
| Hirose, M | 3 |
| Nishikawa, A | 1 |
| Shibutani, M | 3 |
| Chaniary, KD | 1 |
| Baron, MS | 1 |
| Rice, AC | 4 |
| Wetzel, PA | 1 |
| Ramakrishnan, V | 1 |
| Shapiro, SM | 8 |
| Chiou, VL | 1 |
| Zuckoff, SB | 1 |
| Gazzin, S | 1 |
| Zelenka, J | 1 |
| Zdrahalova, L | 1 |
| Konickova, R | 1 |
| Zabetta, CC | 1 |
| Giraudi, PJ | 1 |
| Berengeno, AL | 1 |
| Raseni, A | 1 |
| Robert, MC | 1 |
| Vitek, L | 1 |
| Tiribelli, C | 1 |
| Kemmochi, S | 2 |
| Shimamoto, K | 2 |
| Shiraki, A | 1 |
| Onda, N | 2 |
| Hasumi, K | 2 |
| Suzuki, K | 2 |
| Mitsumori, K | 3 |
| Yamamichi, S | 1 |
| Daood, MJ | 1 |
| Hoyson, M | 1 |
| Watchko, JF | 1 |
| Imai, T | 1 |
| Hasumura, M | 1 |
| Onose, J | 1 |
| Ueda, M | 1 |
| Takizawa, T | 1 |
| Cho, YM | 1 |
| Shaia, WT | 1 |
| Spencer, RF | 1 |
| Geiger, AS | 1 |
| Sombati, S | 1 |
| Geiger, A | 1 |
| Chaniary, K | 1 |
| Baron, M | 1 |
| Rice, A | 1 |
| Wetzel, P | 1 |
| Shapiro, S | 1 |
| Silver, S | 2 |
| Sohmer, H | 2 |
| Kapitulnik, J | 2 |
| Mengelers, MJ | 2 |
| Van Gogh, ER | 1 |
| Kuiper, HA | 2 |
| Pijpers, A | 2 |
| Verheijden, JH | 2 |
| Van Miert, AS | 2 |
| McDonald, JW | 1 |
| Silverstein, FS | 1 |
| Johnston, MV | 1 |
| Takagi, H | 1 |
| Onodera, H | 1 |
| Nasu, M | 1 |
| Tamura, T | 1 |
| Yasuhara, K | 1 |
| Takegawa, K | 1 |
| Rose, AL | 1 |
| Wisniewski, H | 1 |
| Davidson, DE | 1 |
| Johnsen, DO | 1 |
| Tanticharoenyos, P | 1 |
| Hickman, RL | 1 |
| Kinnamon, KE | 1 |
| Rehg, JE | 1 |
| Schutta, HS | 1 |
| Johnson, L | 1 |
27 other studies available for sulfadimethoxine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
A Gunn rat model of preterm hyperbilirubinemia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Bilirubin; Biomarkers; Cerebellum; Disease Models, Anim | 2020 |
Animals in Iodine Deficiency or Sulfadimethoxine Models of Thyroid Damage Are Differently Affected by the Consumption of Brassica Sprouts.
Topics: Animals; Brassica napus; Creatinine; Disease Models, Animal; Goiter; Heme Oxygenase (Decyclizing); I | 2020 |
Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model.
Topics: Adenoma; Animals; Cadherins; Cell Adhesion Molecules; Cell Transformation, Neoplastic; Ceruloplasmin | 2009 |
Quantification of gait in dystonic Gunn rats.
Topics: Animals; Anti-Infective Agents; Biomechanical Phenomena; Disability Evaluation; Disease Models, Anim | 2009 |
Profile of minocycline neuroprotection in bilirubin-induced auditory system dysfunction.
Topics: Animals; Animals, Newborn; Bilirubin; Brain; Disease Models, Animal; Evoked Potentials, Auditory, Br | 2011 |
Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups.
Topics: Albumins; Animals; Animals, Newborn; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter | 2012 |
Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats.
Topics: Angiogenesis Inducing Agents; Animals; Carmine; Disease Models, Animal; Drinking Water; Hypoxia-Indu | 2012 |
Lac color inhibits development of rat thyroid carcinomas through targeting activation of plasma hyaluronan-binding protein.
Topics: Animals; Azo Compounds; Carcinoma, Papillary, Follicular; Cell Proliferation; Disease Models, Animal | 2012 |
Lipid peroxidation is not the primary mechanism of bilirubin-induced neurologic dysfunction in jaundiced Gunn rat pups.
Topics: Aldehydes; Animals; Animals, Newborn; Antioxidants; Behavior, Animal; Bilirubin; Cerebellum; Disease | 2012 |
Somatosensory and brainstem auditory evoked potentials in the Gunn rat model of acute bilirubin neurotoxicity.
Topics: Animals; Bilirubin; Brain; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Evoked P | 2002 |
Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression.
Topics: Adenocarcinoma, Follicular; Animals; Anti-Infective Agents; Antithyroid Agents; Blotting, Western; C | 2005 |
The jaundiced gunn rat model of auditory neuropathy/dyssynchrony.
Topics: Animals; Animals, Newborn; Auditory Cortex; Axons; Brain Stem; Cochlear Nerve; Disease Models, Anima | 2005 |
Minocycline blocks acute bilirubin-induced neurological dysfunction in jaundiced Gunn rats.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Anti-Infective Agents; Bilirubin; Disease Models, | 2007 |
NMDA channel antagonist MK-801 does not protect against bilirubin neurotoxicity.
Topics: Animals; Animals, Newborn; Anti-Infective Agents; Bilirubin; Cell Survival; Disease Models, Animal; | 2007 |
Electromyographic characterization in an animal model of dystonia.
Topics: Animals; Disease Models, Animal; Dystonia; Electromyography; Fourier Analysis; Kernicterus; Motor Ne | 2008 |
Visual evoked potential abnormalities in jaundiced Gunn rats treated with sulfadimethoxine.
Topics: Animals; Bilirubin; Disease Models, Animal; Evoked Potentials, Visual; Female; Humans; Infant, Newbo | 1995 |
Reversible brainstem auditory evoked potential abnormalities in jaundiced Gunn rats given sulfonamide.
Topics: Animals; Bilirubin; Brain; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Humans; | 1993 |
Pharmacokinetics of sulfadimethoxine and sulfamethoxazole in combination with trimethoprim after intravenous administration to healthy and pneumonic pigs.
Topics: Actinobacillus Infections; Actinobacillus pleuropneumoniae; Animals; Anti-Bacterial Agents; Bacteria | 1995 |
Postnatal development of somatosensory evoked potential in jaundiced Gunn rats and effects of sulfadimethoxine administration.
Topics: Animals; Bilirubin; Body Weight; Disease Models, Animal; Evoked Potentials, Somatosensory; Humans; I | 1996 |
Role of glutamate receptor-mediated excitotoxicity in bilirubin-induced brain injury in the Gunn rat model.
Topics: Animals; Apoptosis; Bilirubin; Brain Damage, Chronic; Disease Models, Animal; Dizocilpine Maleate; D | 1998 |
Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim.
Topics: Actinobacillus Infections; Actinobacillus pleuropneumoniae; Animal Feed; Animals; Anti-Bacterial Age | 2000 |
Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats.
Topics: Adenoma; Animals; Benzhydryl Compounds; Body Weight; Carcinogens; Cholesterol; Disease Models, Anima | 2002 |
Acute bilirubin encephalopathy induced with sulfadimethoxine in Gunn rats.
Topics: Acute Disease; Animals; Brain; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hippocampus; Hum | 1979 |
Evaluating new antimalarial drugs against trophozoite induced Plasmodium cynomolgi malaria in rhesus monkeys.
Topics: Amodiaquine; Animals; Antimalarials; Dapsone; Disease Models, Animal; Dose-Response Relationship, Dr | 1976 |
Anticryptosporidial activity is associated with specific sulfonamides in immunosuppressed rats.
Topics: Animals; Cryptosporidiosis; Dexamethasone; Disease Models, Animal; Female; Immunosuppression Therapy | 1991 |
Clinical signs and morphologic abnormalities in Gunn rats treated with sulfadimethoxine.
Topics: Age Factors; Animals; Bilirubin; Brain; Brain Damage, Chronic; Disease Models, Animal; Humans; Hyper | 1969 |