sulfadiazine and Group A Strep Infection studies

Sulfadiazine: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
sulfadiazine : A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
diazine : The parent structure of the diazines.

Research Excerpts

Excerpt	Relevance	Reference
"Horses with lower respiratory tract infections caused by S equi subsp zooepidemicus were treated with a new formulation of combined trimethoprim-sulfadiazine oral suspension at a dosage of 24 mg/kg (10."	5.20	A randomized controlled field trial of a novel trimethoprim-sulfadiazine oral suspension for treatment of Streptococcus equi subsp zooepidemicus infection of the lower respiratory tract in horses. ( Hawkins, PA; Koenig, R; McClure, SR, 2015)
"Trimethoprim/sulfadiazine treatment resulted in a marked reduction of viable bacteria in the tissue chamber but did not eliminate the infection, resulting in abscessation from day 19 onwards in all six ponies."	1.33	Clinical efficacy of prophylactic administration of trimethoprim/sulfadiazine in a Streptococcus equi subsp. zooepidemicus infection model in ponies. ( Bosch, G; Ensink, JM; van Duijkeren, E, 2005)
"Prospective studies of recurrences of streptoccal infection and acute rheumatic fever were conducted among patients attending the acute rheumatic fever prophylaxis clinic (City of Memphis Hospitals, Memphis, Tennessee) between 1965 and 1972."	1.26	Streptococcal infections that fail to cause recurrences of rheumatic fever. ( Bisno, AL; Pearce, IA; Stollerman, GH, 1977)

Timeframe	Studies, this research(%)	All Research%
pre-1990	52 (94.55)	18.7374
1990's	1 (1.82)	18.2507
2000's	1 (1.82)	29.6817
2010's	1 (1.82)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
McClure, SR	1
Koenig, R	1
Hawkins, PA	1
WARREN, HA	1
HARTMAN, TL	2
VAN RAVENSWAAY, AC	1
WESTWATER, JA	1
HOLBROOK, WP	1
HAMBURGER, M	1
MATTMAN, LH	1
SIEGEL, M	1
YOUNG, DC	1
BREESE, RB	1
TROWBRIDGE, M	1
RANTZ, LA	2
BOISVERT, PJ	1
SPINK, WW	2
CHESTNUT, JL	1
LINDBERG, RB	1
COYLE, FR	1
GEZON, HM	1
COOK, JS	1
MAGOFFIN, RL	1
MILLER, CH	1
SAINT-MARTIN, M	1
GAUTHIER, LJ	1
MORRIS, AJ	1
CHAMOVITZ, R	1
CATANZARO, FJ	1
RAMMELKAMP, CH	1
STAHLMAN, MT	1
DENNY, FW	1
CARROLL, G	1
GIBAS, D	1
KARELLOS, D	1
SCHUBART, AF	1
ROTHSCHILD, HJ	1
SCHROEDER, WC	1
EWALD, RW	1
TUERK, JD	1
BRADEN, B	1
COLMORE, JP	1
STUCKI, D	1
GROSS, J	1
FEINSTEIN, AR	3
SPAGNUOLO, M	3
WOOD, HF	3
TARANTA, A	6
TURSKY, E	3
KLEINBERG, E	2
SIMPSON, R	1
STOLLERMAN, G	1
SELL, SH	1
BAUM, D	1
SENECA, H	1
SMITH, JF	1
CHANDRA, T	1
PRAKASH, A	1
Ensink, JM	1
Bosch, G	1
van Duijkeren, E	1
Johnson, RD	1
Hoskins, TW	1
Bernstein, LS	1
Speck, WT	1
Driscoll, JM	1
O'Neil, J	1
Rosenkranz, HS	1
Powers, TE	1
Powers, JD	1
Garg, RC	1
Scialli, VT	1
Hajian, GH	1
Berrios, X	1
del Campo, E	1
Guzman, B	1
Bisno, AL	2
Pearce, IA	1
Stollerman, GH	1
Kaplan, EL	1
Bisno, A	1
Derrick, W	1
Facklam, R	1
Gordis, L	2
Houser, HB	1
Jackson, WH	1
Millard, HD	1
Shulman, ST	2
Taranta, AV	1
Wannamaker, LW	1
Ayoub, EM	1
Librach, IM	1
Guise, HJ	2
Penny, RH	2
Petherick, DJ	1
Duthie, AN	1
Pryles, CV	1
Pasternack, B	1
Nuzzolo, L	1
Donati, G	1
Calabrò, R	1
Villanti, P	1
Pierangeli, L	1
Renschler, HE	1
Schumacher, K	1
Blackman, NS	1
Kuskin, L	1
Alexander, JW	1
Ollstein, RN	1
Symonds, FC	1
Crikelair, GF	1
Pelle, L	1
Redin, GS	1
McCoy, ME	1
Linton, RG	1
Vaisman, S	1
Griffith, GC	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Efficacy of Streptococcus Salivarius BLIS (Bacteriocin-like Inhibitory Substance) K12 as Preventive Measure for Rheumatic Children.[NCT02407106]				30 participants (Anticipated)	Interventional	2015-09-30	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
RHEUMATIC FEVER. Pediatric clinics of North America, 1963, Volume: 10 Topics: Child; Electrocardiography; Ethylenediamines; Humans; Penicillin G; Penicillin G Benzathine; Prognos	1963
The prevention of rheumatic fever: opportunities, frustrations, and challenges. Cardiovascular clinics, 1972, Volume: 4, Issue:3 Topics: Administration, Oral; Adolescent; Child; Humans; Penicillin G; Penicillin G Benzathine; Rheumatic Fe	1972

Article	Year
A randomized controlled field trial of a novel trimethoprim-sulfadiazine oral suspension for treatment of Streptococcus equi subsp zooepidemicus infection of the lower respiratory tract in horses. Journal of the American Veterinary Medical Association, 2015, Jun-15, Volume: 246, Issue:12 Topics: Administration, Oral; Animals; Drug Combinations; Female; Horse Diseases; Horses; Male; Respiratory	2015
Trimethoprim/sulphadiazine compared with penicillin V in the treatment of streptococcal throat infections. The Journal of antimicrobial chemotherapy, 1981, Volume: 8, Issue:6 Topics: Adolescent; Child; Drug Therapy, Combination; Humans; Male; Penicillin V; Streptococcal Infections;	1981
Effect of antiseptic cord care on bacterial colonization in the newborn infant. Chemotherapy, 1980, Volume: 26, Issue:5 Topics: Anti-Infective Agents, Local; Bacterial Infections; Clinical Trials as Topic; Coloring Agents; Human	1980

sulfadiazine and Group A Strep Infection

Research Excerpts

Research

Studies (55)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Sulfadiazine prophylaxis; a comparison of the effect on beta hemolytic streptococcic infections and on virus infections. Proceedings. American Federation for Clinical Research, 1945, Volume: 2 Topics: Disease; Humans; Infections; Streptococcal Infections; Streptococcus; Sulfadiazine; Virus Diseases;	1945
Sulfonamide sensitivity determinations of hemolytic streptococci isolated from patients before and after treatment with sulfadiazine. Bulletin of the Johns Hopkins Hospital, 1946, Volume: 79, Issue:5 Topics: Humans; Streptococcal Infections; Streptococcus; Sulfadiazine; Sulfanilamide; Sulfanilamides; Sulfon	1946
An epidemic caused by a sulfadiazine-resistant strain of Group A Type 17 streptococcus. The Medical clinics of North America, 1946 Topics: Epidemics; Humans; Infections; Streptococcal Infections; Streptococcus; Streptococcus pyogenes; Sulf	1946
Susceptibility to sulfadiazine of hemolytic streptococci recovered in Army camps. The American journal of medicine, 1946, Volume: 1 Topics: Disease Susceptibility; Humans; Streptococcal Infections; Streptococcus; Streptococcus pyogenes; Sul	1946
The epidemiology of acute respiratory infections conditioned by sulfonamides; effects of sulfadiazine on groups A and G hemolytic streptococci. American journal of hygiene, 1946, Volume: 44, Issue:2 Topics: Humans; Respiratory System; Respiratory Tract Diseases; Respiratory Tract Infections; Streptococcal	1946
Sulfadiazine resistant strains of beta hemolytic streptococci; appearance during the course of sulfadiazine prophylaxis at a large naval training center. Journal of the American Medical Association, 1945, Dec-01, Volume: 129 Topics: Humans; Streptococcal Infections; Streptococcus; Sulfadiazine	1945
An in vitro method for determining the resistance of beta hemolytic streptococci to sulfadiazine. The Journal of laboratory and clinical medicine, 1946, Volume: 31 Topics: Humans; In Vitro Techniques; Streptococcal Infections; Streptococcus; Sulfadiazine	1946
Hemolytic streptococcal sore throat; antibody response following treatment with penicillin, sulfadiazine, and salicylates. Science (New York, N.Y.), 1946, Mar-22, Volume: 103, Issue:2673 Topics: Antibody Formation; Humans; Infections; Penicillins; Pharyngitis; Pharynx; Salicylates; Streptococca	1946
Beta-hemolytic streptococcic septicemia, acute bacterial endocarditis, acute mastoiditis and embolic brain abscess successfully treated with sulfadiazine and penicillin; report of case. The Journal of the Tennessee State Medical Association. Tennessee State Medical Association, 1946, Volume: 39 Topics: Abscess; Brain; Brain Abscess; Endocarditis; Endocarditis, Bacterial; Humans; Infections; Mastoiditi	1946
Sulfadiazine and penicillin for hemolytic streptococcus infections of the upper respiratory tract; an evaluation in tonsillitis, nasopharyngitis and scarlet fever. Archives of internal medicine (Chicago, Ill. : 1908), 1946, Volume: 77 Topics: Disease; Nasopharyngeal Diseases; Nasopharyngitis; Palatine Tonsil; Penicillins; Pharyngeal Diseases	1946
Outbreak of hemolytic streptococcus throat infection controlled by sulfadiazine. The Journal of laboratory and clinical medicine, 1946, Volume: 31 Topics: Disease Outbreaks; Humans; Infections; Pharyngitis; Pharynx; Streptococcal Infections; Streptococcus	1946
The use of penicillin and sulfadiazine as prophylactic agents against streptococcal and non-specific respiratory infections among recruits at a naval training center. American journal of hygiene, 1953, Volume: 57, Issue:1 Topics: Penicillins; Respiratory System; Respiratory Tract Diseases; Respiratory Tract Infections; Streptoco	1953
CHEMOPROPHYLAXIS against infections with the hemolytic streptococcus. The New England journal of medicine, 1953, Jul-02, Volume: 249, Issue:1 Topics: Chemoprevention; Humans; Penicillins; Streptococcal Infections; Streptococcus; Sulfadiazine	1953
[Meningitis caused by Streptococcus pyogenes and cured by penicillin-terramycin-sulfadiazine combination]. L'union medicale du Canada, 1953, Volume: 82, Issue:5 Topics: Bacteriology; Humans; Meningitis; Oxytetracycline; Penicillins; Streptococcal Infections; Streptococ	1953
Prevention of rheumatic fever by treatment of previous streptococcic infections; effect of sulfadiazine. Journal of the American Medical Association, 1956, Jan-14, Volume: 160, Issue:2 Topics: Humans; Rheumatic Fever; Streptococcal Infections; Streptococcus; Sulfadiazine	1956
The prophylaxis of streptococcal infections in patients with rheumatic fever; a comparison between sulfadiazine and erythromycin. A.M.A. journal of diseases of children, 1959, Volume: 98, Issue:1 Topics: Child; Erythromycin; Humans; Infant; Rheumatic Fever; Streptococcal Infections; Sulfadiazine; Sulfan	1959
Triacetyloleandomycin with triple sulfa. Its role in the control of staphylococcus and streptococcus infections in the urinary tract. JAMA, 1960, Nov-19, Volume: 174 Topics: Drug Combinations; Oleandomycin; Staphylococcal Infections; Staphylococcus; Streptococcal Infections	1960
EFFECT OF PENICILLIN TREATMENT ON SERUM COMPLEMENT LEVELS IN ACUTE RHEUMATIC FEVER. Annals of the rheumatic diseases, 1963, Volume: 22 Topics: Aspirin; Complement System Proteins; Erythromycin; Humans; Penicillins; Rheumatic Fever; Streptococc	1963
COMPARISON OF A NEW SULFONAMIDE AND OF PENICILLIN IN THE TREATMENT OF ACUTE STREPTOCOCCAL PHARYNGITIS. The Journal of the Oklahoma State Medical Association, 1964, Volume: 57 Topics: Anti-Bacterial Agents; Erythromycin; Humans; Penicillins; Pharyngitis; Streptococcal Infections; Sul	1964
[WHAT CAN THE GYNECOLOGIST EXPECT FROM NEW SULFONAMIDES IN THE TREATMENT OF SIMPLE URINARY TRACT INFECTIONS?]. Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie, 1964, Volume: 157 Topics: Cystitis; Escherichia coli Infections; Gynecology; Humans; Proteus Infections; Pyelitis; Staphylococ	1964
RHEUMATIC FEVER IN CHILDREN AND ADOLESCENTS. A LONG-TERM EPIDEMIOLOGIC STUDY OF SUBSEQUENT PROPHYLAXIS, STREPTOCOCCAL INFECTIONS, AND CLINICAL SEQUELAE. VI. CLINICAL FEATURES OF STREPTOCOCCAL INFECTIONS AND RHEUMATIC RECURRENCES. Annals of internal medicine, 1964, Volume: 60 Topics: Adolescent; Antibody Formation; Child; Communicable Disease Control; Diagnosis; Epidemiologic Studie	1964
RHEUMATIC FEVER IN CHILDREN AND ADOLESCENTS. A LONG-TERM EPIDEMIOLOGIC STUDY OF SUBSEQUENT PROPHYLAXIS, STREPTOCOCCAL INFECTIONS, AND CLINICAL SEQUELAE. I. DESCRIPTION OF THE INVESTIGATIVE TECHNIQUES AND OF THE POPULATION STUDIED. Annals of internal medicine, 1964, Volume: 60 Topics: Adolescent; Black People; Child; Classification; Communicable Disease Control; Dosage Forms; Epidemi	1964
BACTERIAL ASPECTS OF RESPIRATORY INFECTIONS IN YOUNG CHILDREN; DIAGNOSIS AND THERAPY. Medical science, 1964, Volume: 15 Topics: Bacteriology; Bronchitis; Child; Chloramphenicol; Erythromycin; Haemophilus influenzae; Humans; Infa	1964
ORAL PROPHYLAXIS OF RECURRENT RHEUMATIC FEVER. SULFADIAZINE VS A DOUBLE DAILY DOSE OF PENICILLIN. JAMA, 1964, May-11, Volume: 188 Topics: Adolescent; Biomedical Research; Child; Ethylenediamines; Humans; New York; Penicillin G; Penicillin	1964
SULFADIMETHOXYDIAZINE IN THE THERAPY OF URINARY TRACT INFECTIONS. Western medicine; the medical journal of the west, 1964, Volume: 5 Topics: Drug Hypersensitivity; Drug Therapy; Enterobacter; Enterobacteriaceae; Escherichia coli Infections;	1964
TREATMENT OF ACUTE NECROTIZING GINGIVITIS. Oral surgery, oral medicine, and oral pathology, 1964, Volume: 18 Topics: Ascorbic Acid; Borrelia Infections; Dental Prophylaxis; Diet; Diet Therapy; Drug Therapy; Folic Acid	1964
SUPPURATIVE PARENCHYMATOUS GLOSSITIS. The British journal of surgery, 1965, Volume: 52 Topics: Child; Chloramphenicol; Chlortetracycline; Drug Therapy; Glossitis; Humans; Penicillins; Pseudomonas	1965
Clinical efficacy of prophylactic administration of trimethoprim/sulfadiazine in a Streptococcus equi subsp. zooepidemicus infection model in ponies. Journal of veterinary pharmacology and therapeutics, 2005, Volume: 28, Issue:1 Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Disease Models, Animal	2005
SULFADIAZINE RESISTANT STREPTOCOCCAL INFECTIONS IN A CIVILIAN COMMUNITY. The Journal of clinical investigation, 1947, Volume: 26, Issue:2 Topics: Humans; Infections; Streptococcal Infections; Streptococcus; Sulfadiazine	1947
Trimethoprim and sulfadiazine: experimental infection of Beagles. American journal of veterinary research, 1980, Volume: 41, Issue:7 Topics: Animals; Blood; Dog Diseases; Dogs; Drug Combinations; Female; Injections, Subcutaneous; Male; Strep	1980
Discontinuing rheumatic fever prophylaxis in selected adolescents and young adults. A prospective study. Annals of internal medicine, 1993, Mar-15, Volume: 118, Issue:6 Topics: Adolescent; Adult; Age Factors; Chile; Female; Humans; Male; Penicillin G Benzathine; Prospective St	1993
Streptococcal infections that fail to cause recurrences of rheumatic fever. The Journal of infectious diseases, 1977, Volume: 136, Issue:2 Topics: Adolescent; Adult; Antibodies, Bacterial; Child, Preschool; Erythromycin; Female; Humans; Male; Peni	1977
A.H.A. committee report. Prevention of rheumatic fever. Circulation, 1977, Volume: 55, Issue:1 Suppl Topics: Anti-Bacterial Agents; Antibodies, Bacterial; Endocarditis, Bacterial; Humans; Penicillin G; Penicil	1977
The control of rheumatic fever. Clinical pediatrics, 1975, Volume: 14, Issue:4 Topics: Acute Disease; Adolescent; Computers; Erythromycin; Humans; Male; Penicillin G Benzathine; Penicilli	1975
Subarachnoid haemorrhage, some pitfalls. The British journal of clinical practice, 1975, Volume: 29, Issue:2 Topics: Adult; Aneurysm; Autopsy; Coxsackievirus Infections; Female; Headache; Humans; Pain; Penicillins; St	1975
Streptococcal meningitis in pigs: field trial to study the prophylactic effect of trimethoprim/sulphadiazine medication in feed. The Veterinary record, 1986, Oct-18, Volume: 119, Issue:16 Topics: Animal Feed; Animals; Female; Male; Meningitis; Streptococcal Infections; Sulfadiazine; Swine; Swine	1986
Streptococcal meningitis in pigs: field trial to compare the effects of two different treatments. The Veterinary record, 1985, Jul-20, Volume: 117, Issue:3 Topics: Animals; Drug Combinations; Female; Male; Meningitis; Penicillins; Streptococcal Infections; Sulfadi	1985
The use of sulfonamides in urinary tract infection. The Medical clinics of North America, 1970, Volume: 54, Issue:5 Topics: Anemia, Hemolytic; Drug Eruptions; Hematuria; Humans; Kidney Diseases; Nephrosis; Streptococcal Infe	1970
Risk of rheumatic-fever recurrences after streptococcal infections. Prospective study of clinical and social factors. The New England journal of medicine, 1971, Sep-16, Volume: 285, Issue:12 Topics: Administration, Oral; Adolescent; Age Factors; Antibodies; Antistreptolysin; Black or African Americ	1971
[Research on the antibacterial activity in vitro, and on blood concentrations in man, of an association of erythromycin with sulfadiazine, sulfamerazine and sulfamethazine]. La Clinica terapeutica, 1968, Jul-31, Volume: 46, Issue:2 Topics: Bacteria; Erythromycin; Escherichia coli Infections; Humans; In Vitro Techniques; Infections; Staphy	1968
[Streptococcus angina, myocarditis and toxoplasmosis following splenectomy]. Der Internist, 1970, Volume: 11, Issue:4 Topics: Accidents, Traffic; Administration, Oral; Adult; Antistreptolysin; Biopsy; Complement Fixation Tests	1970
Should prophylactic therapy be given to patients with an uncertain history of rheumatic fever? Clinical pediatrics, 1972, Volume: 11, Issue:1 Topics: Adolescent; Child; Child, Preschool; Diagnosis, Differential; Endocarditis, Bacterial; Erythromycin;	1972
Control of infection following burn injury. Archives of surgery (Chicago, Ill. : 1960), 1971, Volume: 103, Issue:4 Topics: Anti-Bacterial Agents; Burns; Catheterization; Gentamicins; Humans; Immunotherapy; Pseudomonas Infec	1971
Alternate case study of topical sulfamylon and silver sulfadiazine in burns. Plastic and reconstructive surgery, 1971, Volume: 48, Issue:4 Topics: Acidosis; Adolescent; Adult; Anemia; Burns; Child; Child, Preschool; Female; Humans; Male; Pseudomon	1971
An evaluation of sulfasymazine in infections in mice. Chemotherapy, 1966, Volume: 11, Issue:6 Topics: Animals; Escherichia coli Infections; Infections; Klebsiella; Mice; Pasteurella Infections; Pneumoco	1966
Prophylactic treatment of recurrent attacks of uveitis due to I. toxoplasmosis and 2. streptococci. Transactions of the Australian College of Ophthalmologists, 1969, Volume: 1 Topics: Chronic Disease; Humans; Penicillins; Prednisolone; Pyrimethamine; Streptococcal Infections; Sulfadi	1969
Prevention of rheumatic fever. A statement prepared by the Rheumatic Fever Committee of the Council on Rheumatic Fever and Congenital Heart Disease of the American Heart Association. Circulation, 1971, Volume: 43, Issue:6 Topics: Administration, Oral; Humans; Injections, Intramuscular; Penicillin G Benzathine; Penicillins; Phary	1971
[Current problems in the prevention of recurrences of rheumatic fever]. Revista medica de Chile, 1968, Volume: 96, Issue:10 Topics: Adult; Child; Humans; Penicillin G Benzathine; Penicillins; Rheumatic Fever; Streptococcal Infection	1968
[Experience in the prevention of rheumatic fever, treatment of streptococcal infection and prevention of recurrence of rheumatic fever]. Reumatizam, 1964, Volume: 11, Issue:2 Topics: Humans; Penicillin G Benzathine; Rheumatic Fever; Streptococcal Infections; Sulfadiazine	1964
Should adults with rheumatic heart disease be kept on continuous penicillin prophylaxis? The American journal of cardiology, 1966, Volume: 18, Issue:4 Topics: Chronic Disease; Humans; Injections, Intramuscular; Penicillin G Benzathine; Rheumatic Fever; Rheuma	1966