sulbutiamine and Amnesia

The effect of a sulbutiamine chronic treatment on memory was studied in rats with a spatial delayed-non-match-to-sample (DNMTS) task in a radial maze and a two trial object recognition task. After completion of training in the DNMTS task, animals were subjected for 9 weeks to daily injections of either saline or sulbutiamine (12.5 or 25 mg/kg). Sulbutiamine did not modify memory in the DNMTS task but improved it in the object recognition task. Dizocilpine, impaired both acquisition and retention of the DNMTS task in the saline-treated group, but not in the two sulbutiamine-treated groups, suggesting that sulbutiamine may counteract the amnesia induced by a blockade of the N-methyl-D-aspartate glutamate receptors. Taken together, these results are in favor of a beneficial effect of sulbutiamine on working and episodic memory.

Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Maze Learning; Memory, Short-Term; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Recognition, Psychology; Space Perception; Thiamine; Time Factors