Page last updated: 2024-11-04

succinylcholine and Myoglobinuria

succinylcholine has been researched along with Myoglobinuria in 31 studies

Succinylcholine: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
succinylcholine : A quaternary ammonium ion that is the bis-choline ester of succinic acid.

Myoglobinuria: The presence of MYOGLOBIN in URINE usually as a result of rhabdomyolysis.

Research Excerpts

ExcerptRelevanceReference
"An 8-year-old asthmatic child on theophylline was anesthetized with enflurane in nitrous oxide and oxygen."8.79[Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline]. ( Dan, K; Higa, K; Shono, S; Watanabe, R, 1996)
"An 8-year-old asthmatic child on theophylline was anesthetized with enflurane in nitrous oxide and oxygen."4.79[Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline]. ( Dan, K; Higa, K; Shono, S; Watanabe, R, 1996)
"Masseter spasm is often associated with severe rhabdomyolysis in patients with muscle dystrophy, especially Duchenne's dystrophy."2.38[Clinical features of malignant hyperthermia crisis]. ( Cornet, C; Laxenaire, MC; Moeller, R, 1989)
"No myoglobinuria was detected in any of the patients tested."1.26Changes in plasma potassium and calcium levels and in the electrocardiogram after a single dose of succinylcholine preceded by d-tubocurarine. ( Evers, W; Levy, AA; Racz, GB, 1976)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199026 (83.87)18.7374
1990's4 (12.90)18.2507
2000's1 (3.23)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rawicz, M1
Brandom, BW1
Wolf, A1
BENNIKE, KA2
JARNUM, S1
Schwartz, L1
Rockoff, MA1
Koka, BV1
Matsubara, I1
Sumiya, T1
Yoshimura, T1
Yamazaki, R1
Kubota, M1
Goto, Y1
Chaboche, C1
Nordmann, Y1
Fontaine, JL1
Lejeune, C1
Bernhardt, D1
Hörder, MH1
Lewandowski, KB1
Plötz, J1
Braun, J1
Gericke, B1
Friedman, S1
Baker, T1
Gatti, M1
Simon, G1
Paskin, S1
Sullivan, M1
Thompson, WK1
Hill, GD1
Acquarone, N1
Garibotto, G1
Tegazzin, V1
Sofia, A1
Gurreri, G1
Shono, S1
Higa, K1
Watanabe, R1
Dan, K1
Wattel, F1
Chopin, C1
Durocher, A1
Berzin, B1
Bomholt, A1
Mezzano, S1
Gibbs, JM1
Zuurmond, WW1
de Waal, FC1
Stamenkovic, L1
Schaer, H1
Steinmann, B1
Jerusalem, S1
Maier, C1
Yazaki, S1
Suziki, H1
Ogawa, S1
Kuniyoshi, K1
Tai, K1
Evers, W1
Racz, GB1
Levy, AA1
Cornet, C1
Moeller, R1
Laxenaire, MC1
Birmingham, PK1
Stevenson, GW1
Uejima, T1
Hall, SC1
Lee, SC1
Furutani, M1
Yoshitake, K1
Sato, T1
Lin, YS1
Shong, KL1
Wang, MH1
Thomas, ET1
Dobkin, AB1
Miller, RD1
Way, WL1
Hamilton, WK1
Layzer, RB1
Tammisto, T1
Brander, P1
Airaksinen, MM1
Tommila, V1
Listola, J1
Barlow, MB1
Isaacs, H1
Oppermann, C1
Podlesch, I1
Purschke, R1
Jensen, K1
Hanel, HK1
Olesen, H1
McLaren, CA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Randomized, Crossover Design Study To Compare The Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)[NCT03532178]Phase 244 participants (Actual)Interventional2019-01-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Recovery Time of T1 to 90% Baseline

The time of neuromuscular recovery from sugammadex 4mg/kg dose reversal rocuronium at 0.6 mg/kg compared with traditionally used succinylcholine in electroconvulsive therapy (ECT). (NCT03532178)
Timeframe: 30 minutes

Interventionminutes (Mean)
Muscle Relaxant #16.79
Muscle Relaxant #210.97

Number of Participants With Treatment or Emergent Adverse Events of the Drugs

To document the side-effect profiles of sugammadex reversal of rocuronium and succhinylcholine in the ECT patient population (NCT03532178)
Timeframe: 24 hours after the procedure

,
InterventionParticipants (Count of Participants)
NauseaMyalgiaHeadache
Rocuronium + Sugammadex117
Succinylcholine + Normal Saline329

Reviews

3 reviews available for succinylcholine and Myoglobinuria

ArticleYear
[Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline].
    Masui. The Japanese journal of anesthesiology, 1996, Volume: 45, Issue:1

    Topics: Anesthesia, Inhalation; Asthma; Bronchodilator Agents; Child; Enflurane; Humans; Male; Muscle Rigidi

1996
[Rhabdomyolysis in acute intoxications (author's transl)].
    La Nouvelle presse medicale, 1978, Sep-09, Volume: 7, Issue:29

    Topics: Alcoholic Intoxication; Anesthesia, General; Animals; Carbon Monoxide Poisoning; Foodborne Diseases;

1978
[Clinical features of malignant hyperthermia crisis].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Anesthesia, General; Arrhythmias, Cardiac; Carbon Dioxide; Child; Child, Preschoo

1989

Other Studies

28 other studies available for succinylcholine and Myoglobinuria

ArticleYear
The place of suxamethonium in pediatric anesthesia.
    Paediatric anaesthesia, 2009, Volume: 19, Issue:6

    Topics: Anesthesia; Child; Humans; Hyperkalemia; Malignant Hyperthermia; Masseter Muscle; Muscular Diseases;

2009
MYOGLOBINURIA WITH ACUTE RENAL FAILURE POSSIBLY INDUCED BY SUXAMETHONIUM. A CASE REPORT.
    British journal of anaesthesia, 1964, Volume: 36

    Topics: Acute Kidney Injury; Anesthesia; Biopsy; Child; Humans; Muscles; Myoglobinuria; Pathology; Postopera

1964
Masseter spasm with anesthesia: incidence and implications.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Anesthetics; Child; Child, Preschool; Creatine Kinase; Halothane; Humans; Infant; Malignant Hyperthe

1984
[Atypical malignant hyperthermia].
    Masui. The Japanese journal of anesthesiology, 1983, Volume: 32, Issue:3

    Topics: Anesthesia, General; Child; Child, Preschool; Creatine Kinase; Female; Humans; Isoenzymes; L-Lactate

1983
[Myoglobinuria following anesthesia (author's transl)].
    Archives francaises de pediatrie, 1982, Volume: 39, Issue:3

    Topics: Anesthesia, General; Child; Humans; Male; Myoglobinuria; Succinylcholine

1982
[Creatininphosphokinase isoenzymes in anaesthesia-induced myoglobinuria (AIM) (author's transl)].
    Der Anaesthesist, 1981, Volume: 30, Issue:3

    Topics: Anesthesia, General; Child; Child, Preschool; Creatine Kinase; Female; Humans; Isoenzymes; Male; Myo

1981
Rhabdomyolysis, myoglobinuria and hyperpyrexia caused by suxamethonium in a child with increased serum creatine kinase concentrations.
    British journal of anaesthesia, 1981, Volume: 53, Issue:9

    Topics: Anesthesia, Inhalation; Child, Preschool; Creatine Kinase; Female; Halothane; Humans; Male; Malignan

1981
[Malignant hyperthermia. I. Observations in connection with its pathogenesis and course (author's transl)].
    Der Anaesthesist, 1980, Volume: 29, Issue:2

    Topics: Anesthesia, General; Child, Preschool; Creatine Kinase; Electromyography; Female; Halothane; Humans;

1980
Probable succinylcholine-induced rhabdomyolysis in a male athlete.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:2

    Topics: Adolescent; Collateral Ligaments; Fasciculation; Football; Humans; Knee Injuries; Male; Myoglobinuri

1995
Succinylcholine-induced cardiac arrest in children with undiagnosed myopathy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:6

    Topics: Anesthesia, Intravenous; Arrhythmia, Sinus; Bradycardia; Child, Preschool; Creatine Kinase; Heart Ar

1994
Postanaesthetic myoglobinuric renal failure: an isolated expression of malignant hyperthermia.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9, Issue:5

    Topics: Acute Kidney Injury; Adult; Anesthesia; Enflurane; Hemorrhoids; Humans; Male; Malignant Hyperthermia

1994
[Myoglobinuria after halothane-suxamethone anesthesia].
    Ugeskrift for laeger, 1979, Apr-02, Volume: 141, Issue:14

    Topics: Adjuvants, Anesthesia; Child, Preschool; Halothane; Humans; Male; Myoglobinuria; Succinylcholine

1979
[Acute renal failure due to post anesthetic rabdomyolysis (author's transl)].
    Revista medica de Chile, 1979, Volume: 107, Issue:11

    Topics: Acute Kidney Injury; Creatine Kinase; Humans; Male; Middle Aged; Myoglobinuria; Postoperative Compli

1979
A case of rhabdomyolysis associated with suxamethonium.
    Anaesthesia and intensive care, 1978, Volume: 6, Issue:2

    Topics: Child; Diagnosis, Differential; Esophagoscopy; Humans; Male; Malignant Hyperthermia; Muscles; Muscul

1978
[Transient myoglobinuria following general anesthesia].
    Nederlands tijdschrift voor geneeskunde, 1978, Dec-16, Volume: 122, Issue:50

    Topics: Age Factors; Anesthesia, General; Child, Preschool; Humans; Male; Myoglobinuria; Succinylcholine

1978
Rhabdomyolysis induced by anaesthesia with intraoperative cardiac arrest.
    British journal of anaesthesia, 1977, Volume: 49, Issue:5

    Topics: Acute Disease; Anesthesia, General; Child; Halothane; Heart Arrest; Humans; Male; Muscular Diseases;

1977
[Generalized muscular stiffness with myoglobinuria and increased serum enzymes induced by succinylcholine: a case report (author's transl)].
    Masui. The Japanese journal of anesthesiology, 1977, Volume: 26, Issue:8

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Creatine Kinase; Humans; Male; Malignant H

1977
Changes in plasma potassium and calcium levels and in the electrocardiogram after a single dose of succinylcholine preceded by d-tubocurarine.
    Canadian Anaesthetists' Society journal, 1976, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Arrhythmias, Cardiac; Calcium; Creatine Kinase; El

1976
Isolated postoperative myoglobinuria in a pediatric outpatient. A case report of malignant hyperthermia.
    Anesthesia and analgesia, 1989, Volume: 69, Issue:6

    Topics: Ambulatory Surgical Procedures; Child; Gastroscopy; Humans; Male; Malignant Hyperthermia; Myoglobinu

1989
Succinylcholine in children.
    Anesthesia and analgesia, 1988, Volume: 67, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Heart Arrest; Humans; Infant; Myoglobinuria; Succinylcholine

1988
[Rhabdomyolysis with myoglobinuric acute renal failure following the use of succinylcholine chloride and enflurane in a mentally-retarded patient: a case report].
    Ma zui xue za zhi = Anaesthesiologica Sinica, 1987, Volume: 25, Issue:2

    Topics: Acute Kidney Injury; Adult; Enflurane; Humans; Intellectual Disability; Male; Myoglobinuria; Rhabdom

1987
Untoward effects of muscle relaxant drugs.
    International anesthesiology clinics, 1972,Spring, Volume: 10, Issue:1

    Topics: Adjuvants, Anesthesia; Amyotrophic Lateral Sclerosis; Anesthesia, Inhalation; Anti-Bacterial Agents;

1972
Succinylcholine-induced hyperkalemia in patients with renal failure?
    Anesthesiology, 1972, Volume: 36, Issue:2

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, General; Creatine Kinase; Humans; Hyperkalemia; Kidney Fai

1972
Strabismus as a possible sign of latent muscular disease predisposing to suxamethonium-induced muscular injury.
    Annals of clinical research, 1970, Volume: 2, Issue:2

    Topics: Child; Creatine Kinase; Female; Humans; Male; Muscular Diseases; Myoglobinuria; Strabismus; Stress,

1970
Malignant hyperpyrexial deaths in a family. Reports of three cases.
    British journal of anaesthesia, 1970, Volume: 42, Issue:12

    Topics: Acidosis; Adult; Anesthesia, General; Child; Creatine Kinase; Female; Fever; Humans; Male; Muscles;

1970
[Malignant hyperthermia during general anesthesia with rigor, myoglobinuria and disturbance of the blood coagulation mechanism].
    Der Anaesthesist, 1971, Volume: 20, Issue:8

    Topics: Anesthesia, General; Aspartate Aminotransferases; Blood Coagulation Disorders; Child, Preschool; Cre

1971
Myoglobinuria following anaesthesia including suxamethonium.
    British journal of anaesthesia, 1968, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Aged; Alanine Transaminase; Anesthesia, Endotracheal; Aspartate Aminotransferases

1968
Myoglobinuria following the use of suxamethonium chloride. A case report.
    British journal of anaesthesia, 1968, Volume: 40, Issue:11

    Topics: Anesthesia, Inhalation; Child; Humans; Male; Myoglobinuria; Succinylcholine

1968