succinylcholine has been researched along with Metabolism, Inborn Errors in 61 studies
Succinylcholine: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
succinylcholine : A quaternary ammonium ion that is the bis-choline ester of succinic acid.
Metabolism, Inborn Errors: Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rarely, patients with butyrylcholinesterase deficiency may show marked sensitivity to succinylcholine, manifested clinically by severely prolonged neuromuscular paralysis and apnea." | 7.77 | Prolonged neuromuscular paralysis following rapid-sequence intubation with succinylcholine. ( Aiken, DC; Donnell, RW; Kaufman, SE; Magee, C, 2011) |
| "Ventricular tachycardia was defibrillated and Gordon syndrome, which was diagnosed subsequently, was treated successfully." | 5.33 | Gordon syndrome and succinylcholine. ( Puura, A; Schultz, R, 2005) |
| " BChE deficiency induces a slower hydrolysis of the drug and consequently prolonged neuromuscular block, leading to apnea." | 3.83 | [Prolonged neuromuscular block in a patient with butyrylcholinesterase deficiency]. ( Ceppa, F; Courcelle, S; Delacour, H; Hary, B; Mabboux, I, 2016) |
| " Rarely, patients with butyrylcholinesterase deficiency may show marked sensitivity to succinylcholine, manifested clinically by severely prolonged neuromuscular paralysis and apnea." | 3.77 | Prolonged neuromuscular paralysis following rapid-sequence intubation with succinylcholine. ( Aiken, DC; Donnell, RW; Kaufman, SE; Magee, C, 2011) |
| "We describe a child who developed a malignant hyperthermia-like syndrome after exposure to succinylcholine and halothane." | 3.75 | Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation. ( Hogan, KJ; Vladutiu, GD, 2009) |
| "The mitochondrial disturbance in Reye syndrome is well documented but the pathophysiologic sequence linking the antecedent viral illness to the mitochondrial injury remains obscure." | 2.37 | Reye syndrome. ( De Vivo, DC, 1985) |
| "Ventricular tachycardia was defibrillated and Gordon syndrome, which was diagnosed subsequently, was treated successfully." | 1.33 | Gordon syndrome and succinylcholine. ( Puura, A; Schultz, R, 2005) |
| " Atypical pseudocholinesterases were identified using quantitative dosage of enzymatic activity and inhibition of atypical pseudocholinesterases by dibucaine, fluoride, chloride, scoline and urea." | 1.27 | [Congenital anomaly of serum pseudocholinesterase originating in neonatal respiratory distress]. ( Canis, M; Gutknecht, JL; Haberer, JP; Monteillard, C; Schoeffler, P; Viallard, JL, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (68.85) | 18.7374 |
| 1990's | 2 (3.28) | 18.2507 |
| 2000's | 3 (4.92) | 29.6817 |
| 2010's | 12 (19.67) | 24.3611 |
| 2020's | 2 (3.28) | 2.80 |
| Authors | Studies |
|---|---|
| Acharya, S | 1 |
| Bhattarai, S | 1 |
| Shrimanker, I | 1 |
| Gupta, SS | 1 |
| Cornelius, BW | 1 |
| Jacobs, TM | 1 |
| Robles, A | 1 |
| Michael, M | 1 |
| McCallum, R | 1 |
| Andersson, ML | 1 |
| Møller, AM | 1 |
| Wildgaard, K | 1 |
| Dillon, D | 1 |
| Lee, P | 1 |
| Yuksel, E | 1 |
| Sergin, D | 1 |
| Tanatti, B | 1 |
| Alper, I | 1 |
| Zoller, M | 1 |
| Walther, S | 1 |
| Cassel, J | 1 |
| Staehr-Rye, AK | 1 |
| Nielsen, CV | 2 |
| Gätke, MR | 2 |
| Brozović, G | 1 |
| Mazul Sunko, B | 1 |
| Hafner, T | 1 |
| Bekavac, I | 1 |
| Thomsen, JL | 1 |
| Palmqvist, DF | 1 |
| Alvarellos, ML | 1 |
| McDonagh, EM | 1 |
| Patel, S | 1 |
| McLeod, HL | 1 |
| Altman, RB | 1 |
| Klein, TE | 1 |
| Mabboux, I | 1 |
| Hary, B | 1 |
| Courcelle, S | 1 |
| Ceppa, F | 1 |
| Delacour, H | 1 |
| Binkley, C | 1 |
| Hogan, KJ | 1 |
| Vladutiu, GD | 1 |
| Kaufman, SE | 1 |
| Donnell, RW | 1 |
| Aiken, DC | 1 |
| Magee, C | 1 |
| HODGES, RJ | 1 |
| HARKNESS, J | 1 |
| LEHMANN, H | 2 |
| LIDDELL, J | 2 |
| HARRIS, H | 1 |
| PORTER, IH | 1 |
| KAUFMAN, L | 1 |
| SILK, E | 1 |
| RUDDELL, JS | 1 |
| Puura, A | 1 |
| Schultz, R | 1 |
| Williams, J | 1 |
| Rosenquist, P | 1 |
| Arias, L | 1 |
| McCall, WV | 1 |
| Deam, D | 1 |
| Emmanuel, ER | 1 |
| Schoeffler, P | 1 |
| Viallard, JL | 1 |
| Monteillard, C | 1 |
| Canis, M | 1 |
| Gutknecht, JL | 1 |
| Haberer, JP | 1 |
| Dell, DD | 1 |
| Kehoe, C | 1 |
| Ho, VW | 1 |
| Osiovich, H | 1 |
| Skakun, NP | 1 |
| Oleĭnik, AN | 1 |
| Shendevitskiĭ, VI | 1 |
| Brown, BR | 1 |
| Walson, PD | 1 |
| Taussig, LM | 1 |
| Pronk, IR | 1 |
| van der Wal, SJ | 1 |
| Thé, TH | 1 |
| De Vivo, DC | 1 |
| La Du, BN | 2 |
| Bush, GH | 1 |
| Lemaire, WJ | 1 |
| Nagel, EL | 1 |
| Smith, JC | 1 |
| Maurer, HJ | 1 |
| Hald, J | 1 |
| Cherington, M | 1 |
| Lasater, G | 1 |
| Baraka, A | 1 |
| Bikhazi, G | 1 |
| Abu-Haidar, G | 1 |
| Ernst, FW | 1 |
| Pembrey, ME | 1 |
| Prince, LC | 2 |
| Garry, PJ | 2 |
| Lubin, AH | 1 |
| Rink, RA | 1 |
| Husain, M | 1 |
| Purry, NA | 1 |
| Jardine, WI | 1 |
| Ferguson, AS | 1 |
| Mukuno, K | 1 |
| Ishikawa, S | 1 |
| Tanaka, R | 1 |
| Cousin, MT | 1 |
| Viars, P | 1 |
| Notari, RE | 1 |
| Du, BN | 1 |
| Mogensen, JV | 1 |
| Hanel, HK | 1 |
| Peck, AW | 1 |
| Garcia, CH | 1 |
| Diaz, PM | 1 |
| Szeinberg, A | 1 |
| Pipano, S | 1 |
| Assa, M | 1 |
| Medalie, JH | 1 |
| Neufeld, HN | 1 |
| Baer, G | 1 |
| Litwiller, RW | 1 |
| Whittaker, M | 1 |
| Vickers, MD | 1 |
| Jenkins, T | 1 |
| Balinsky, D | 1 |
| Patient, DW | 1 |
| Zsigmond, EK | 1 |
| Eilderton, TE | 1 |
| Schimke, RN | 1 |
| Neitlich, HW | 1 |
| Schärli, A | 1 |
| Bettex, M | 1 |
13 reviews available for succinylcholine and Metabolism, Inborn Errors
| Article | Year |
|---|---|
Pseudocholinesterase Deficiency: What the Proceduralist Needs to Know.
Topics: Anesthesia, General; Apnea; Butyrylcholinesterase; Dilatation; Endoscopy; Esophageal Achalasia; Huma | 2019 |
Butyrylcholinesterase deficiency and its clinical importance in anaesthesia: a systematic review.
Topics: Anesthesia; Apnea; Butyrylcholinesterase; Humans; Metabolism, Inborn Errors; Mivacurium; Neuromuscul | 2019 |
PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics.
Topics: Apnea; Butyrylcholinesterase; Calcium Channels; Calcium Channels, L-Type; Humans; Hyperkalemia; Mali | 2015 |
GENETIC BASIS OF DRUG METABOLISM IN MAN.
Topics: Barbiturates; Catalase; Drug Tolerance; Genetics, Medical; Humans; Isoniazid; Metabolism; Metabolism | 1964 |
Plasma cholinesterase deficiency.
Topics: Cholinesterases; Humans; Metabolism, Inborn Errors; Neuromuscular Depolarizing Agents; Neuromuscular | 1996 |
Reye syndrome.
Topics: Aflatoxins; Anesthesia, General; Animals; Child; Child, Preschool; Disease Models, Animal; Disease O | 1985 |
Pharmacogenetics: defective enzymes in relation to reactions to drugs.
Topics: Acetylation; Cholinesterases; Coumarins; Dicumarol; Dose-Response Relationship, Drug; Female; Geneti | 1972 |
Pharmacogenetics and anaesthesia.
Topics: Anemia, Sickle Cell; Anesthetics; Animals; Barbiturates; Cholinesterases; Fever; Genetics, Medical; | 1968 |
Genetic determimants in drug action.
Topics: Acetylation; Acetyltransferases; Cholinesterases; Coumarins; Dealkylation; Drug Resistance; Genes; G | 1972 |
Pharmacogenetics.
Topics: Acetyltransferases; Administration, Topical; Alleles; Analgesics; Anemia, Hemolytic; Anti-Inflammato | 1974 |
Pharmacogenetics. Cholinesterase variants and suxamethonium apnoea.
Topics: Alleles; Apnea; Cholinesterase Inhibitors; Cholinesterases; Dibucaine; Drug Hypersensitivity; Electr | 1968 |
Pharmacogenetics.
Topics: Biotransformation; Cholinesterases; Coumarins; Genetic Variation; Genetics, Medical; Humans; Isoniaz | 1969 |
[Cholinesterase. A survey with particular reference to inherited increase in sensitivity to suxamethonium].
Topics: Apnea; Blood Transfusion; Cholinesterases; Drug Hypersensitivity; Genes, Recessive; Humans; Metaboli | 1970 |
48 other studies available for succinylcholine and Metabolism, Inborn Errors
| Article | Year |
|---|---|
A prolonged paralysis with succinylcholine in pseudocholinesterase deficiency: an undesired effect.
Topics: Apnea; Butyrylcholinesterase; Humans; Metabolism, Inborn Errors; Paralysis; Succinylcholine | 2022 |
Pseudocholinesterase Deficiency Considerations: A Case Study.
Topics: Apnea; Butyrylcholinesterase; Female; Humans; Metabolism, Inborn Errors; Mivacurium; Succinylcholine | 2020 |
Patient information sheet for plasma cholinesterase deficiency.
Topics: Apnea; Butyrylcholinesterase; Cholinesterases; Documentation; Drug Hypersensitivity; Follow-Up Studi | 2013 |
Rocuronium-sugammadex use in electroconvulsive therapy of patients with pseudocholinesterase enzyme deficiency.
Topics: Androstanols; Apnea; Butyrylcholinesterase; Contraindications; Electroconvulsive Therapy; gamma-Cycl | 2013 |
[Residual relaxant block due to pseudocholinesterase deficiency - First manifestation in an elderly patient].
Topics: Aged; Anesthesia Recovery Period; Anesthesia, General; Apnea; Butyrylcholinesterase; Humans; Intraop | 2014 |
Use of neuromuscular monitoring to detect prolonged effect of succinylcholine or mivacurium: three case reports.
Topics: Accelerometry; Aged; Antidotes; Apnea; Appendicitis; Butyrylcholinesterase; Cholecystectomy, Laparos | 2014 |
Allergic reaction to suxamethonium during emergency caesarean section and pseudocholinesterase deficiency in the same patient.
Topics: Anesthesia, Obstetrical; Apnea; Butyrylcholinesterase; Cesarean Section; Diagnosis, Differential; Dr | 2014 |
Premature awakening and underuse of neuromuscular monitoring in a registry of patients with butyrylcholinesterase deficiency.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Apnea; Butyrylcholinesterase; Child; Child, Preschool; F | 2015 |
[Prolonged neuromuscular block in a patient with butyrylcholinesterase deficiency].
Topics: Adolescent; Apnea; Butyrylcholinesterase; Humans; Male; Metabolism, Inborn Errors; Neuromuscular Dep | 2016 |
Unknown Pseudocholinesterase Deficiency in a Patient Undergoing TIVA with Planned Motor Evoked Potential Monitoring: A Case Report.
Topics: Aged, 80 and over; Anesthesia, Intravenous; Apnea; Butyrylcholinesterase; Cervical Vertebrae; Diskec | 2016 |
Malignant hyperthermia-like syndrome and carnitine palmitoyltransferase II deficiency with heterozygous R503C mutation.
Topics: Amino Acid Substitution; Anesthetics, Inhalation; Arginine; Carnitine O-Palmitoyltransferase; Child, | 2009 |
Prolonged neuromuscular paralysis following rapid-sequence intubation with succinylcholine.
Topics: Apnea; Butyrylcholinesterase; Female; Humans; Intubation, Intratracheal; Metabolism, Inborn Errors; | 2011 |
Suxamethonium sensitivity in health and disease; a clinical evaluation of pseudo-cholinesterase levels.
Topics: Apnea; Butyrylcholinesterase; Cholinesterases; Drug Hypersensitivity; Health; Humans; Metabolism, In | 1954 |
SUXAMETHONIUM SENSITIVITY.
Topics: Apnea; Blood; Butyrylcholinesterase; Cholinesterases; Drug Hypersensitivity; Fluorides; Genetics, Me | 1964 |
ENZYMES AND DRUG SENSITIVITY. THE GENETICS OF SERUM CHOLINESTERASE 'DEFICIENCY' IN RELATION TO SUXAMETHONIUM APNOEA.
Topics: Apnea; Blood; Cholinesterases; Drug Tolerance; Genetics, Medical; Humans; Metabolism, Inborn Errors; | 1964 |
Suxamethonium apnoea in an infant; expression of familial pseudocholinesterase deficiency in three generations.
Topics: Apnea; Bis-Trimethylammonium Compounds; Butyrylcholinesterase; Child; Cholinesterases; Humans; Infan | 1960 |
Apnoea due to suxamethonium associated with familial pseudocholinesterase deficiency.
Topics: Apnea; Butyrylcholinesterase; Cholinesterases; Humans; Metabolism, Inborn Errors; Muscular Diseases; | 1962 |
Gordon syndrome and succinylcholine.
Topics: Child; Humans; Hyperkalemia; Male; Metabolism, Inborn Errors; Potassium; Pseudohypoaldosteronism; Ri | 2005 |
Pseudocholinesterase deficiency and electroconvulsive therapy.
Topics: Aged; Butyrylcholinesterase; Depressive Disorder; Electroconvulsive Therapy; Humans; Male; Metabolis | 2007 |
A family with the silent cholinesterase gene.
Topics: Adult; Alleles; Anesthesia, Endotracheal; Apnea; Cholinesterases; Female; Heterozygote; Humans; Meta | 1983 |
[Congenital anomaly of serum pseudocholinesterase originating in neonatal respiratory distress].
Topics: Anesthesia, Obstetrical; Butyrylcholinesterase; Cholinesterases; Female; Humans; Infant, Newborn; Me | 1984 |
A case of pseudocholinesterase deficiency in the neonate.
Topics: Apnea; Butyrylcholinesterase; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Neuromuscula | 1999 |
[Adverse effect of muscle relaxants and narcotics in hereditary diseases (literature survey)].
Topics: Arrhythmias, Cardiac; Barbiturates; Butyrylcholinesterase; Drug Synergism; Drug Tolerance; Dysautono | 1976 |
Congenital metabolic diseases of pediatric patients: anesthetic implications.
Topics: Acidosis; Anesthesia; Child; Cystic Fibrosis; Dysautonomia, Familial; Glycogen Storage Disease Type | 1975 |
[Familial examinations for the presence of atypical cholinesterase].
Topics: Adolescent; Anesthesia, General; Apnea; Appendectomy; Child, Preschool; Cholinesterase Inhibitors; C | 1975 |
Suxamethonium apnoea.
Topics: Anesthesia; Apnea; Cholinesterase Inhibitors; Cholinesterases; Drug Synergism; Humans; Liver; Metabo | 1973 |
Plasma cholinesterase deficiency. A possible complication during anesthesia.
Topics: Adolescent; Anesthesia, General; Apnea; Cholinesterases; Endoscopy; Female; Genotype; Humans; Intuba | 1972 |
[Contrast reaction--reaction to anaesthetic?].
Topics: Adolescent; Anesthesia, Inhalation; Angiography; Bone Cysts; Contrast Media; Creatine Kinase; Femur | 1972 |
Prolonged paralysis in pseudocholinesterase deficiency.
Topics: Cholecystectomy; Cholinesterases; Electric Stimulation; Erythrocytes; Evoked Potentials; Female; Hum | 1973 |
Succinylcholine block in a patient with atypical serum cholinesterase.
Topics: Child; Cholinesterases; Humans; Metabolism, Inborn Errors; Pedigree; Phenotype; Succinylcholine | 1974 |
Abnormal response to a muscle relaxant. Report of three cases.
Topics: Apnea; Cholinesterases; Metabolism, Inborn Errors; Succinylcholine | 1973 |
Silent cholinesterase gene--report of a family.
Topics: Adult; Cholinesterases; Female; Humans; Metabolism, Inborn Errors; Succinylcholine | 1972 |
Apnea and atypical pseudocholinesterase.
Topics: Adult; Apnea; Cholinesterases; Female; Humans; Male; Metabolism, Inborn Errors; Succinylcholine | 1973 |
Scoline apnoea.
Topics: Anesthesia, General; Apnea; Cholinesterases; Humans; Male; Metabolism, Inborn Errors; Middle Aged; S | 1973 |
[Hypocholinesterasemia with oculomuscular paralysis].
Topics: Adult; Cholinesterases; Drug Hypersensitivity; Humans; Male; Metabolism, Inborn Errors; Ophthalmople | 1973 |
[Prolonged curarization with succinylcholine].
Topics: Anesthesia; Cholinesterases; Humans; Metabolism, Inborn Errors; Muscle Contraction; Neuromuscular Ju | 1974 |
Half-life of human serum cholinesterase following blood transfusion.
Topics: Adult; Albumins; Apnea; Blood Proteins; Blood Transfusion; Cholinesterases; Female; Half-Life; Human | 1974 |
Aspects of suxamethonium hydrolysis in man and animals.
Topics: Acetylcholine; Acetylcholinesterase; Alleles; Animals; Apnea; Cats; Cholinesterase Inhibitors; Choli | 1970 |
Atypical cholinesterase: frequency in a Puerto Rican population.
Topics: Adjuvants, Anesthesia; Cholinesterases; Genetics, Population; Humans; Mass Screening; Metabolism, In | 1972 |
High frequency of atypical pseudocholinesterase gene among Iraqi and Iranian Jews.
Topics: Adult; Cholinesterases; Chromosome Aberrations; Chromosome Disorders; Drug Hypersensitivity; Female; | 1972 |
[Pseudocholinesterase].
Topics: Anesthesia; Apnea; Cholinesterase Inhibitors; Cholinesterases; Enzyme Activation; Genotype; Humans; | 1972 |
A family study of atypical plasma cholinesterase activity.
Topics: Adult; Apnea; Child; Cholinesterases; Clinical Enzyme Tests; Diagnosis, Differential; Dibucaine; Fem | 1970 |
Initial experiences with the Cholinesterase Research Unit.
Topics: Apnea; Child; Cholinesterases; Dibucaine; Female; Fluorides; Genotype; Heterozygote; Humans; Male; M | 1970 |
Cholinesterase in plasma: first reported absence in the Bantu; half-life determination.
Topics: Adolescent; Black People; Cholinesterases; Dibucaine; Female; Fluorides; Genes, Regulator; Heterozyg | 1967 |
Abnormal reaction to procaine and succinylcholine in a patient with inherited atypical plasma cholinesterase: case report.
Topics: Abdomen; Adjuvants, Anesthesia; Adult; Anesthesia, Local; Apnea; Cholinesterases; Drug Hypersensitiv | 1968 |
Drugs and heredity. Pharmacogenetics--the study of heritable variations in drug response.
Topics: Drug Hypersensitivity; Genetics, Medical; Humans; Isoniazid; Metabolic Diseases; Metabolism, Inborn | 1969 |
Increased plasma cholinesterase activity and succinylcholine resistance: a genetic variant.
Topics: Adult; Cholinesterases; Humans; Isoflurophate; Male; Metabolism, Inborn Errors; Succinylcholine | 1966 |
[Prolonged apnea caused by atypical pseudocholinesterase].
Topics: Adolescent; Anesthesia, General; Apnea; Appendectomy; Cholinesterases; Female; Homozygote; Humans; M | 1966 |