succinylcholine has been researched along with Body Weight in 31 studies
Succinylcholine: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.
succinylcholine : A quaternary ammonium ion that is the bis-choline ester of succinic acid.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The current study attempts to characterize the contributory roles of chronic administration of nondepolarizing muscle relaxants typified by d-tubocurarine (dTC) and/or of immobilization on AChR upregulation and the relationship of these AChR changes to SCh-induced hyperkalemia." | 7.69 | Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats. ( Martyn, JA; Yanez, P, 1996) |
| "(1) To investigate changes in arterial oxygen saturation via pulse oximeter (SpO2) during apnea and after reinstitution of manual ventilation at SpO2 of 95% or 90% following rapid sequence induction of anesthesia in children after 2-minute preoxygenation; (2) to determine whether the setting of a safe threshold of apneic period to an SpO2 of 95% is appropriate in children during anesthetic induction; and (3) to evaluate the influences of age, body weight, and height on the time from the start of apnea to SpO2 of 95%." | 5.08 | Study of the safe threshold of apneic period in children during anesthesia induction. ( An, G; Deng, XM; Liao, X; Luo, LK; Tong, SY; Xue, FS, 1996) |
| " The current study attempts to characterize the contributory roles of chronic administration of nondepolarizing muscle relaxants typified by d-tubocurarine (dTC) and/or of immobilization on AChR upregulation and the relationship of these AChR changes to SCh-induced hyperkalemia." | 3.69 | Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats. ( Martyn, JA; Yanez, P, 1996) |
| " No evidence supporting the concept that dosage should be related to patient's weight was found." | 2.65 | Reduction of post-suxamethonium pain by pretreatment with four non-depolarizing agents. ( Bennetts, FE; Khalil, KI, 1981) |
| "Atracurium was infused for the first 1 h to maintain a target steady state plasma concentration of 1." | 1.28 | Pharmacokinetics of atracurium during continuous infusion. ( Beemer, GH; Bjorksten, AR; Crankshaw, DP, 1990) |
| " When dosage was calculated on a surface area basis, there was a linear relationship for infants and children as a single group between the log dose and the times to recover to 50 and 90 per cent neuromuscular transmission." | 1.25 | Neuromuscular blocking effects of succinylcholine in infants and children. ( Cook, DR; Fisher, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (80.65) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Almeida, MC | 1 |
| Pederneiras, SG | 1 |
| Chiaroni, S | 1 |
| de Souza, L | 1 |
| Locks, GF | 1 |
| Lemmens, HJ | 1 |
| Brodsky, JB | 1 |
| Bain, JA | 1 |
| Catton, DV | 1 |
| Cox, JM | 1 |
| Spoerel, WE | 1 |
| Bennetts, FE | 1 |
| Khalil, KI | 1 |
| Mirakhur, RK | 1 |
| Elliott, P | 1 |
| Lavery, TD | 1 |
| Sutherland, GA | 1 |
| Bevan, JC | 1 |
| Bevan, DR | 1 |
| Bentley, JB | 1 |
| Borel, JD | 1 |
| Vaughan, RW | 1 |
| Gandolfi, AJ | 1 |
| Iwatsuki, N | 1 |
| Kuroda, N | 1 |
| Amaha, K | 1 |
| Iwatsuki, K | 1 |
| Yanez, P | 1 |
| Martyn, JA | 1 |
| Xue, FS | 1 |
| Luo, LK | 1 |
| Tong, SY | 1 |
| Liao, X | 1 |
| Deng, XM | 1 |
| An, G | 1 |
| Wig, J | 1 |
| Bali, IM | 1 |
| Castañeda Casado, J | 1 |
| Palomo Delgado, M | 1 |
| Almazán Duro, A | 1 |
| Hatch, DJ | 1 |
| Kerr, AA | 1 |
| Cook, DR | 1 |
| Fisher, CG | 1 |
| Vanlinthout, LE | 1 |
| van Egmond, J | 1 |
| de Boo, T | 1 |
| Lerou, JG | 1 |
| Wevers, RA | 1 |
| Booij, LH | 1 |
| Beemer, GH | 1 |
| Bjorksten, AR | 1 |
| Crankshaw, DP | 1 |
| Chestnut, RJ | 1 |
| Healy, TE | 1 |
| Harper, NJ | 1 |
| Faragher, EB | 1 |
| Gyasi, HK | 1 |
| Mohy, O | 1 |
| Adu-Gyamfi, Y | 1 |
| Naguib, M | 1 |
| Loftness, SL | 1 |
| Lockhart, CH | 1 |
| Dietzel, W | 1 |
| Wiedemann, K | 1 |
| Hordern, A | 1 |
| Telivuo, L | 1 |
| Ertama, P | 1 |
| Aalto-Setälä, M | 1 |
| Appelqvist, R | 1 |
| Kaljunen, A | 1 |
| Karhunen, U | 1 |
| Nuuttila, K | 1 |
| Welling, I | 1 |
| Wisborg, K | 1 |
| Hanel, HK | 1 |
| Viby-Mogensen, J | 1 |
| Scanlon, PF | 1 |
| Rousos, AP | 1 |
| Hazlewood, R | 1 |
| Orr, R | 1 |
| Wulfsohn, NL | 1 |
| Neumann, HW | 1 |
| Dippold, A | 1 |
| Cabarrocas Gafarot, E | 1 |
| Castells Baqué, JM | 1 |
| Pitts, FN | 1 |
| Woodruff, RA | 1 |
| Craig, AG | 1 |
| Rich, CL | 1 |
| Kronschwitz, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Randomized, Crossover Design Study To Compare The Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)[NCT03532178] | Phase 2 | 44 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The time of neuromuscular recovery from sugammadex 4mg/kg dose reversal rocuronium at 0.6 mg/kg compared with traditionally used succinylcholine in electroconvulsive therapy (ECT). (NCT03532178)
Timeframe: 30 minutes
| Intervention | minutes (Mean) |
|---|---|
| Muscle Relaxant #1 | 6.79 |
| Muscle Relaxant #2 | 10.97 |
To document the side-effect profiles of sugammadex reversal of rocuronium and succhinylcholine in the ECT patient population (NCT03532178)
Timeframe: 24 hours after the procedure
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Nausea | Myalgia | Headache | |
| Rocuronium + Sugammadex | 1 | 1 | 7 |
| Succinylcholine + Normal Saline | 3 | 2 | 9 |
2 reviews available for succinylcholine and Body Weight
| Article | Year |
|---|---|
Pitfalls in the use of anesthetic agents in children.
Topics: Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Barbiturates; Body | 1985 |
Depressive disorders.
Topics: Amines; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Body Weight; Depression; Electr | 1974 |
6 trials available for succinylcholine and Body Weight
| Article | Year |
|---|---|
[Evaluation of tracheal intubation conditions in morbidly obese patients: a comparison of succinylcholine and rocuronium].
Topics: Adult; Androstanols; Body Weight; Cough; Diaphragm; Dose-Response Relationship, Drug; Female; Humans | 2009 |
The dose of succinylcholine in morbid obesity.
Topics: Adult; Anesthesia, General; Body Mass Index; Body Weight; Double-Blind Method; Female; Gastric Bypas | 2006 |
Reduction of post-suxamethonium pain by pretreatment with four non-depolarizing agents.
Topics: Adolescent; Adult; Aged; Body Weight; Female; Gallamine Triethiodide; Humans; Male; Middle Aged; Neu | 1981 |
Neuromuscular blockade in infants following intramuscular succinylcholine in two or five per cent concentration.
Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Body Weight; Halothane; Humans; Infant; Injections, I | 1983 |
Study of the safe threshold of apneic period in children during anesthesia induction.
Topics: Age Factors; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Body Height; Body Weight; Bra | 1996 |
Intramuscular diazepam as anti-anxiety agent in SCC-modified EST.
Topics: Adult; Age Factors; Anxiety; Body Weight; Clinical Trials as Topic; Diazepam; Electroconvulsive Ther | 1969 |
23 other studies available for succinylcholine and Body Weight
| Article | Year |
|---|---|
[PROBLEMS INHERENT IN DRUG THERAPY AND POSOLOGY OF THE NEWBORN].
Topics: Birth Weight; Body Weight; Dosage Forms; Drug Therapy; Ephedrine; Humans; Infant; Infant, Newborn; O | 1964 |
The effect of general anaesthesia on the tolerance of cerebral ischaemia in rabbits.
Topics: Anesthesia, General; Animals; Blood Gas Analysis; Blood Pressure; Body Weight; Electroencephalograph | 1967 |
Plasma cholinesterase activity and the duration of suxamethonium apnoea in children.
Topics: Adult; Aged; Body Weight; Child; Child, Preschool; Cholinesterases; Humans; Infant; Middle Aged; Suc | 1984 |
Weight, pseudocholinesterase activity, and succinylcholine requirement.
Topics: Adult; Anesthesia, General; Body Surface Area; Body Weight; Butyrylcholinesterase; Cholinesterases; | 1982 |
Succinylcholine-induced hyperkalemia in patients with ruptured cerebral aneurysms.
Topics: Adult; Aged; Body Weight; Female; Hemiplegia; Humans; Hyperkalemia; Intracranial Aneurysm; Male; Mid | 1980 |
Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats.
Topics: Animals; Body Weight; Hyperkalemia; Immobilization; Male; Neuromuscular Depolarizing Agents; Neuromu | 1996 |
Relation of precurarization to suxamethonium to provide ease of intubation and to prevent post-suxamethonium muscle pains.
Topics: Adult; Body Weight; Fasciculation; Gallamine Triethiodide; Humans; Intubation, Intratracheal; Muscle | 1979 |
[Interaction of suxamethonium and D-tubocurarine with respect to hyperkalemia. Analysis of phase II of dual block].
Topics: Animals; Body Weight; Cats; Drug Antagonism; Female; Hyperkalemia; Male; Nerve Block; Succinylcholin | 1978 |
Change in end-tidal position in children after suxamethonium.
Topics: Age Factors; Anesthesia, General; Body Height; Body Weight; Child; Child, Preschool; Cyclopropanes; | 1975 |
Neuromuscular blocking effects of succinylcholine in infants and children.
Topics: Adult; Age Factors; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; | 1975 |
Factors affecting magnitude and time course of neuromuscular block produced by suxamethonium.
Topics: Adolescent; Adult; Age Factors; Aged; Body Weight; Butyrylcholinesterase; Dose-Response Relationship | 1992 |
Pharmacokinetics of atracurium during continuous infusion.
Topics: Anesthesia, Intravenous; Atracurium; Body Mass Index; Body Weight; Female; Humans; Infusions, Intrav | 1990 |
Suxamethonium--the relation between dose and response.
Topics: Adolescent; Adult; Aged; Body Surface Area; Body Weight; Cold Temperature; Dose-Response Relationshi | 1989 |
Plasma cholinesterase in pregnancy--effect of enzyme activity on the duration of action of succinylcholine.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Obstetrical; Body Weight; Cesarean Section; Cholinest | 1986 |
[Intraoperative muscle relaxation in infants and small children].
Topics: Anesthesia; Arrhythmias, Cardiac; Body Weight; Bronchial Spasm; Female; Histamine Release; Humans; H | 1972 |
Clinical study of pancuronium bromide as a neuromuscular blocking agent in anaesthesia.
Topics: Adult; Androstanes; Anesthesia; Atropine; Blood Pressure; Body Weight; Female; Heart Rate; Humans; I | 1971 |
Variations in serum potassium and serum cholinesterase activity after induction with Althesin-suxamethonium and thiopentone-suxamethonium.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, General; Atropine; Body Height; Body Weight; Carbon Dioxid | 1974 |
Observations on the immobilisation of fallow deer with powdered succinylcholine chloride injected by dart.
Topics: Animals; Body Weight; Deer; Female; Immobilization; Injections, Subcutaneous; Male; Powders; Succiny | 1973 |
Succinylcholine dosage based on lean body mass.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Apnea; Body Weight; Female; Halothane; Humans; Intubat | 1972 |
[Plasma cholinesterase activity in transverse paralysis].
Topics: Adolescent; Adult; Anesthesia; Arrhythmias, Cardiac; Body Weight; Cholinesterases; Humans; Injection | 1971 |
[d-tubocurarine and propanidid].
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, Intravenous; Blood Pressure; Body Weight; Child; D | 1969 |
The drug modification of ECT. II. Succinylcholine dosage.
Topics: Adult; Apnea; Arrhythmias, Cardiac; Atropine; Body Weight; Electroconvulsive Therapy; Electrokymogra | 1968 |
[The clinical dosage of suxamethonium].
Topics: Adolescent; Adult; Aged; Anesthesia, Endotracheal; Body Weight; Child; Child, Preschool; Cholinester | 1968 |