succinylacetone has been researched along with Porphyrias in 3 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Defective heme synthesis may cause acute porphyrias, which are associated with a wide array of neurological disturbances involving both the central and peripheral nervous systems." | 3.73 | Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death. ( Hon, T; Sengupta, A; Zhang, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sengupta, A | 1 |
| Hon, T | 1 |
| Zhang, L | 1 |
| Silbergeld, EK | 1 |
| Hruska, RE | 1 |
| Bradley, D | 1 |
| Lamon, JM | 1 |
| Frykholm, BC | 1 |
| Russo, SM | 1 |
| Pepe, JA | 1 |
| Cable, EE | 1 |
| Lambrecht, RW | 1 |
| Bonkovsky, HL | 1 |
3 other studies available for succinylacetone and Porphyrias
| Article | Year |
|---|---|
Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death.
Topics: Animals; Apoptosis; Caspases; Cell Survival; Collagen Type XI; Cyclic AMP Response Element-Binding P | 2005 |
Neurotoxic aspects of porphyrinopathies: lead and succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Brain; gamma-Aminobutyric Acid; Heme; Heptanoates; Heptanoic | 1982 |
Repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Dr | 1994 |