succinylacetone has been researched along with Porphyria in 3 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Defective heme synthesis may cause acute porphyrias, which are associated with a wide array of neurological disturbances involving both the central and peripheral nervous systems." | 3.73 | Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death. ( Hon, T; Sengupta, A; Zhang, L, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sengupta, A | 1 |
| Hon, T | 1 |
| Zhang, L | 1 |
| Silbergeld, EK | 1 |
| Hruska, RE | 1 |
| Bradley, D | 1 |
| Lamon, JM | 1 |
| Frykholm, BC | 1 |
| Russo, SM | 1 |
| Pepe, JA | 1 |
| Cable, EE | 1 |
| Lambrecht, RW | 1 |
| Bonkovsky, HL | 1 |
3 other studies available for succinylacetone and Porphyria
| Article | Year |
|---|---|
Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death.
Topics: Animals; Apoptosis; Caspases; Cell Survival; Collagen Type XI; Cyclic AMP Response Element-Binding P | 2005 |
Neurotoxic aspects of porphyrinopathies: lead and succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Brain; gamma-Aminobutyric Acid; Heme; Heptanoates; Heptanoic | 1982 |
Repression of ALA synthase by heme and zinc-mesoporphyrin in a chick embryo liver cell culture model of acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Dr | 1994 |