succinylacetone has been researched along with Liver Neoplasms in 9 studies
succinylacetone: inhibitor of heme biosynthesis
4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For example, the odds ratio to develop hepatocellular carcinoma is 12." | 2.55 | Diagnosing Hepatorenal Tyrosinaemia in Europe: Newborn Mass Screening Versus Selective Screening. ( Das, AM; Janzen, N; Mayorandan, S, 2017) |
| "ABCB6 expression is upregulated in hepatocellular carcinoma (HCC) but the significance of this upregulation to HCC is not known." | 1.37 | Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma. ( Abdulkarim, BA; Chavan, H; Krishnamurthy, P; Polireddy, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Das, AM | 1 |
| Mayorandan, S | 1 |
| Janzen, N | 1 |
| Yang, F | 1 |
| Li, J | 1 |
| Deng, H | 1 |
| Wang, Y | 1 |
| Lei, C | 1 |
| Wang, Q | 1 |
| Xiang, J | 1 |
| Liang, L | 1 |
| Xia, J | 1 |
| Pan, X | 1 |
| Li, X | 1 |
| Long, Q | 1 |
| Chang, L | 1 |
| Xu, P | 1 |
| Huang, A | 1 |
| Wang, K | 1 |
| Tang, N | 1 |
| Blackburn, PR | 1 |
| Hickey, RD | 1 |
| Nace, RA | 1 |
| Giama, NH | 1 |
| Kraft, DL | 1 |
| Bordner, AJ | 1 |
| Chaiteerakij, R | 1 |
| McCormick, JB | 1 |
| Radulovic, M | 1 |
| Graham, RP | 1 |
| Torbenson, MS | 1 |
| Tortorelli, S | 1 |
| Scott, CR | 1 |
| Lindor, NM | 1 |
| Milliner, DS | 1 |
| Oglesbee, D | 1 |
| Al-Qabandi, W | 1 |
| Grompe, M | 2 |
| Gavrilov, DK | 1 |
| El-Youssef, M | 1 |
| Clark, KJ | 1 |
| Atwal, PS | 1 |
| Roberts, LR | 1 |
| Klee, EW | 1 |
| Ekker, SC | 1 |
| Polireddy, K | 1 |
| Chavan, H | 1 |
| Abdulkarim, BA | 1 |
| Krishnamurthy, P | 1 |
| Takahashi, S | 1 |
| Takahashi, T | 1 |
| Mizobuchi, S | 1 |
| Matsumi, M | 1 |
| Yokoyama, M | 1 |
| Morita, K | 1 |
| Miyazaki, M | 1 |
| Namba, M | 1 |
| Akagi, R | 1 |
| Sassa, S | 2 |
| Lindstedt, S | 1 |
| al-Dhalimy, M | 1 |
| Kennaway, NG | 1 |
| Papaconstantinou, J | 1 |
| Torres-Ramos, CA | 1 |
| Ou, CN | 1 |
| Finegold, M | 1 |
| Kolluri, S | 1 |
| Elbirt, KK | 1 |
| Bonkovsky, HL | 1 |
| Iwasa, F | 1 |
| Kappas, A | 1 |
| Tuchman, M | 1 |
| Freese, DK | 1 |
| Sharp, HL | 1 |
| Whitley, CB | 1 |
| Ramnaraine, ML | 1 |
| Ulstrom, RA | 1 |
| Najarian, JS | 1 |
| Ascher, N | 1 |
| Buist, NR | 1 |
| Terry, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for succinylacetone and Liver Neoplasms
| Article | Year |
|---|---|
Diagnosing Hepatorenal Tyrosinaemia in Europe: Newborn Mass Screening Versus Selective Screening.
Topics: Carcinoma, Hepatocellular; Europe; Heptanoates; Humans; Infant, Newborn; Liver Neoplasms; Neonatal S | 2017 |
8 other studies available for succinylacetone and Liver Neoplasms
| Article | Year |
|---|---|
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Diethylnitrosamine; Down-R | 2019 |
Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
Topics: Adolescent; Animals; Carcinoma, Hepatocellular; Catalytic Domain; Cell Line, Tumor; Child; Child, Pr | 2016 |
Functional significance of the ATP-binding cassette transporter B6 in hepatocellular carcinoma.
Topics: ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; | 2011 |
CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1.
Topics: 5-Aminolevulinate Synthetase; Carcinoma, Hepatocellular; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; | 2003 |
Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I.
Topics: alpha-Fetoproteins; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cyclohexanones; Dise | 1995 |
Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC).
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Chick Embryo; Chickens; Enzyme Ind | 1999 |
delta-Aminolaevulinate synthase in human HepG2 hepatoma cells. Repression by haemin and induction by chemicals.
Topics: 5-Aminolevulinate Synthetase; Carcinoma, Hepatocellular; Dimethyl Sulfoxide; Dose-Response Relations | 1989 |
Persistent succinylacetone excretion after liver transplantation in a patient with hereditary tyrosinaemia type I.
Topics: alpha-Fetoproteins; Carcinoma, Hepatocellular; Child, Preschool; Female; Heptanoates; Heptanoic Acid | 1985 |